Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication
Identifieur interne : 000667 ( Pmc/Checkpoint ); précédent : 000666; suivant : 000668Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication
Auteurs : Jianfang Niu [République populaire de Chine] ; Taiqiang Yan [République populaire de Chine] ; Wei Guo [République populaire de Chine] ; Wei Wang [République populaire de Chine] ; Zhiqing Zhao [République populaire de Chine]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
Osteosarcoma is an aggressive bone cancer that frequently metastasizes to the lungs. The cytotoxicity of most chemotherapeutics and targeted drugs in the treatment of osteosarcoma is partially lessened. Furthermore, there is a poor response to current chemo- and radiotherapy for both primary lesions and pulmonary metastases of osteosarcoma. There is a clear need to explore promising drug candidates that could improve the efficacy of osteosarcoma treatment. Autophagy, a dynamic and highly conserved catabolic process, has dual roles in promoting cell survival as well as cell death. The role of autophagy has been investigated extensively in different tumor types, and a growing body of research has highlighted the potential value of using autophagy in clinical therapy. Here, we address significant aspects of autophagy in osteosarcoma, including its functions, modulation, and possible therapeutic applications.
Url:
DOI: 10.3389/fonc.2019.01232
PubMed: 31803616
PubMed Central: 6873391
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:6873391Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication</title>
<author><name sortKey="Niu, Jianfang" sort="Niu, Jianfang" uniqKey="Niu J" first="Jianfang" last="Niu">Jianfang Niu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yan, Taiqiang" sort="Yan, Taiqiang" uniqKey="Yan T" first="Taiqiang" last="Yan">Taiqiang Yan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Wei" sort="Guo, Wei" uniqKey="Guo W" first="Wei" last="Guo">Wei Guo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Zhiqing" sort="Zhao, Zhiqing" uniqKey="Zhao Z" first="Zhiqing" last="Zhao">Zhiqing Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31803616</idno>
<idno type="pmc">6873391</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6873391</idno>
<idno type="RBID">PMC:6873391</idno>
<idno type="doi">10.3389/fonc.2019.01232</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000985</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000985</idno>
<idno type="wicri:Area/Pmc/Curation">000985</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000985</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000667</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000667</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication</title>
<author><name sortKey="Niu, Jianfang" sort="Niu, Jianfang" uniqKey="Niu J" first="Jianfang" last="Niu">Jianfang Niu</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Yan, Taiqiang" sort="Yan, Taiqiang" uniqKey="Yan T" first="Taiqiang" last="Yan">Taiqiang Yan</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Guo, Wei" sort="Guo, Wei" uniqKey="Guo W" first="Wei" last="Guo">Wei Guo</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Zhao, Zhiqing" sort="Zhao, Zhiqing" uniqKey="Zhao Z" first="Zhiqing" last="Zhao">Zhiqing Zhao</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Frontiers in Oncology</title>
<idno type="eISSN">2234-943X</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Osteosarcoma is an aggressive bone cancer that frequently metastasizes to the lungs. The cytotoxicity of most chemotherapeutics and targeted drugs in the treatment of osteosarcoma is partially lessened. Furthermore, there is a poor response to current chemo- and radiotherapy for both primary lesions and pulmonary metastases of osteosarcoma. There is a clear need to explore promising drug candidates that could improve the efficacy of osteosarcoma treatment. Autophagy, a dynamic and highly conserved catabolic process, has dual roles in promoting cell survival as well as cell death. The role of autophagy has been investigated extensively in different tumor types, and a growing body of research has highlighted the potential value of using autophagy in clinical therapy. Here, we address significant aspects of autophagy in osteosarcoma, including its functions, modulation, and possible therapeutic applications.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Harting, Mt" uniqKey="Harting M">MT Harting</name>
</author>
<author><name sortKey="Blakely, Ml" uniqKey="Blakely M">ML Blakely</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Hj" uniqKey="Kim H">HJ Kim</name>
</author>
<author><name sortKey="Lee, Sg" uniqKey="Lee S">SG Lee</name>
</author>
<author><name sortKey="Kim, Y J" uniqKey="Kim Y">Y-J Kim</name>
</author>
<author><name sortKey="Park, J E" uniqKey="Park J">J-E Park</name>
</author>
<author><name sortKey="Lee, Ky" uniqKey="Lee K">KY Lee</name>
</author>
<author><name sortKey="Yoo, Yh" uniqKey="Yoo Y">YH Yoo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bishop, Mw" uniqKey="Bishop M">MW Bishop</name>
</author>
<author><name sortKey="Janeway, Ka" uniqKey="Janeway K">KA Janeway</name>
</author>
<author><name sortKey="Gorlick, R" uniqKey="Gorlick R">R Gorlick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
<author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
<author><name sortKey="Abdalla, Fc" uniqKey="Abdalla F">FC Abdalla</name>
</author>
<author><name sortKey="Abeliovich, H" uniqKey="Abeliovich H">H Abeliovich</name>
</author>
<author><name sortKey="Abraham, Rt" uniqKey="Abraham R">RT Abraham</name>
</author>
<author><name sortKey="Acevedo Arozena, A" uniqKey="Acevedo Arozena A">A Acevedo-Arozena</name>
</author>
<author><name sortKey="Adeli, K" uniqKey="Adeli K">K Adeli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sui, X" uniqKey="Sui X">X Sui</name>
</author>
<author><name sortKey="Jin, L" uniqKey="Jin L">L Jin</name>
</author>
<author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name>
</author>
<author><name sortKey="Geng, S" uniqKey="Geng S">S Geng</name>
</author>
<author><name sortKey="He, C" uniqKey="He C">C He</name>
</author>
<author><name sortKey="Hu, X" uniqKey="Hu X">X Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Z" uniqKey="Yang Z">Z Yang</name>
</author>
<author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hu, Y L" uniqKey="Hu Y">Y-L Hu</name>
</author>
<author><name sortKey="Jahangiri, A" uniqKey="Jahangiri A">A Jahangiri</name>
</author>
<author><name sortKey="Delay, M" uniqKey="Delay M">M DeLay</name>
</author>
<author><name sortKey="Aghi, Mk" uniqKey="Aghi M">MK Aghi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Duprez, L" uniqKey="Duprez L">L Duprez</name>
</author>
<author><name sortKey="Wirawan, E" uniqKey="Wirawan E">E Wirawan</name>
</author>
<author><name sortKey="Vanden Berghe, T" uniqKey="Vanden Berghe T">T Vanden Berghe</name>
</author>
<author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name>
</author>
<author><name sortKey="Zeh, Hj" uniqKey="Zeh H">HJ Zeh</name>
</author>
<author><name sortKey="Lotze, Mt" uniqKey="Lotze M">MT Lotze</name>
</author>
<author><name sortKey="Tang, D" uniqKey="Tang D">D Tang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gozuacik, D" uniqKey="Gozuacik D">D Gozuacik</name>
</author>
<author><name sortKey="Kimchi, A" uniqKey="Kimchi A">A Kimchi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Ey" uniqKey="Liu E">EY Liu</name>
</author>
<author><name sortKey="Ryan, Km" uniqKey="Ryan K">KM Ryan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kabeya, Y" uniqKey="Kabeya Y">Y Kabeya</name>
</author>
<author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name>
</author>
<author><name sortKey="Uero, T" uniqKey="Uero T">T Uero</name>
</author>
<author><name sortKey="Yamamoto, A" uniqKey="Yamamoto A">A Yamamoto</name>
</author>
<author><name sortKey="Kirisako, T" uniqKey="Kirisako T">T Kirisako</name>
</author>
<author><name sortKey="Noda, T" uniqKey="Noda T">T Noda</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ichimura, Y" uniqKey="Ichimura Y">Y Ichimura</name>
</author>
<author><name sortKey="Kominami, E" uniqKey="Kominami E">E Kominami</name>
</author>
<author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K Tanaka</name>
</author>
<author><name sortKey="Komatsu, M" uniqKey="Komatsu M">M Komatsu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, Xh" uniqKey="Liang X">XH Liang</name>
</author>
<author><name sortKey="Kleeman, Lk" uniqKey="Kleeman L">LK Kleeman</name>
</author>
<author><name sortKey="Jiang, Hh" uniqKey="Jiang H">HH Jiang</name>
</author>
<author><name sortKey="Gordon, G" uniqKey="Gordon G">G Gordon</name>
</author>
<author><name sortKey="Goldman, Je" uniqKey="Goldman J">JE Goldman</name>
</author>
<author><name sortKey="Berry, G" uniqKey="Berry G">G Berry</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qu, Xp" uniqKey="Qu X">XP Qu</name>
</author>
<author><name sortKey="Yu, J" uniqKey="Yu J">J Yu</name>
</author>
<author><name sortKey="Bhagat, G" uniqKey="Bhagat G">G Bhagat</name>
</author>
<author><name sortKey="Furuya, N" uniqKey="Furuya N">N Furuya</name>
</author>
<author><name sortKey="Hibshoosh, H" uniqKey="Hibshoosh H">H Hibshoosh</name>
</author>
<author><name sortKey="Troxel, A" uniqKey="Troxel A">A Troxel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liang, Xh" uniqKey="Liang X">XH Liang</name>
</author>
<author><name sortKey="Jackson, S" uniqKey="Jackson S">S Jackson</name>
</author>
<author><name sortKey="Seaman, M" uniqKey="Seaman M">M Seaman</name>
</author>
<author><name sortKey="Brown, K" uniqKey="Brown K">K Brown</name>
</author>
<author><name sortKey="Kempkes, B" uniqKey="Kempkes B">B Kempkes</name>
</author>
<author><name sortKey="Hibshoosh, H" uniqKey="Hibshoosh H">H Hibshoosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saito, H" uniqKey="Saito H">H Saito</name>
</author>
<author><name sortKey="Inazawa, J" uniqKey="Inazawa J">J Inazawa</name>
</author>
<author><name sortKey="Saito, S" uniqKey="Saito S">S Saito</name>
</author>
<author><name sortKey="Kasumi, F" uniqKey="Kasumi F">F Kasumi</name>
</author>
<author><name sortKey="Koi, S" uniqKey="Koi S">S Koi</name>
</author>
<author><name sortKey="Sagae, S" uniqKey="Sagae S">S Sagae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name>
</author>
<author><name sortKey="Zacharek, A" uniqKey="Zacharek A">A Zacharek</name>
</author>
<author><name sortKey="Salkowski, A" uniqKey="Salkowski A">A Salkowski</name>
</author>
<author><name sortKey="Grignon, Dj" uniqKey="Grignon D">DJ Grignon</name>
</author>
<author><name sortKey="Sakr, W" uniqKey="Sakr W">W Sakr</name>
</author>
<author><name sortKey="Porter, At" uniqKey="Porter A">AT Porter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, F" uniqKey="Zhang F">F Zhang</name>
</author>
<author><name sortKey="Yan, T" uniqKey="Yan T">T Yan</name>
</author>
<author><name sortKey="Guo, W" uniqKey="Guo W">W Guo</name>
</author>
<author><name sortKey="Sun, K" uniqKey="Sun K">K Sun</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
<author><name sortKey="Bao, X" uniqKey="Bao X">X Bao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bailey, Km" uniqKey="Bailey K">KM Bailey</name>
</author>
<author><name sortKey="Wojtkowiak, Jw" uniqKey="Wojtkowiak J">JW Wojtkowiak</name>
</author>
<author><name sortKey="Hashim, Ai" uniqKey="Hashim A">AI Hashim</name>
</author>
<author><name sortKey="Gillies, Rj" uniqKey="Gillies R">RJ Gillies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lum, Jj" uniqKey="Lum J">JJ Lum</name>
</author>
<author><name sortKey="Bauer, De" uniqKey="Bauer D">DE Bauer</name>
</author>
<author><name sortKey="Kong, M" uniqKey="Kong M">M Kong</name>
</author>
<author><name sortKey="Harris, Mh" uniqKey="Harris M">MH Harris</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Lindsten, T" uniqKey="Lindsten T">T Lindsten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gutierrez, Mg" uniqKey="Gutierrez M">MG Gutierrez</name>
</author>
<author><name sortKey="Master, Ss" uniqKey="Master S">SS Master</name>
</author>
<author><name sortKey="Singh, Sb" uniqKey="Singh S">SB Singh</name>
</author>
<author><name sortKey="Taylor, Ga" uniqKey="Taylor G">GA Taylor</name>
</author>
<author><name sortKey="Colombo, Mi" uniqKey="Colombo M">MI Colombo</name>
</author>
<author><name sortKey="Deretic, V" uniqKey="Deretic V">V Deretic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shimizu, S" uniqKey="Shimizu S">S Shimizu</name>
</author>
<author><name sortKey="Kanaseki, T" uniqKey="Kanaseki T">T Kanaseki</name>
</author>
<author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name>
</author>
<author><name sortKey="Mizuta, T" uniqKey="Mizuta T">T Mizuta</name>
</author>
<author><name sortKey="Arakawa Kobayashi, S" uniqKey="Arakawa Kobayashi S">S Arakawa-Kobayashi</name>
</author>
<author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Notte, A" uniqKey="Notte A">A Notte</name>
</author>
<author><name sortKey="Leclere, L" uniqKey="Leclere L">L Leclere</name>
</author>
<author><name sortKey="Michiels, C" uniqKey="Michiels C">C Michiels</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, L" uniqKey="Yu L">L Yu</name>
</author>
<author><name sortKey="Alva, A" uniqKey="Alva A">A Alva</name>
</author>
<author><name sortKey="Su, H" uniqKey="Su H">H Su</name>
</author>
<author><name sortKey="Dutt, P" uniqKey="Dutt P">P Dutt</name>
</author>
<author><name sortKey="Freundt, E" uniqKey="Freundt E">E Freundt</name>
</author>
<author><name sortKey="Welsh, S" uniqKey="Welsh S">S Welsh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shang, Lb" uniqKey="Shang L">LB Shang</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Du, Fh" uniqKey="Du F">FH Du</name>
</author>
<author><name sortKey="Li, S" uniqKey="Li S">S Li</name>
</author>
<author><name sortKey="Zhao, Lp" uniqKey="Zhao L">LP Zhao</name>
</author>
<author><name sortKey="Wang, Xd" uniqKey="Wang X">XD Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shimobayashi, M" uniqKey="Shimobayashi M">M Shimobayashi</name>
</author>
<author><name sortKey="Hall, Mn" uniqKey="Hall M">MN Hall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, G" uniqKey="Liu G">G Liu</name>
</author>
<author><name sortKey="Pei, F" uniqKey="Pei F">F Pei</name>
</author>
<author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Amin, Ad" uniqKey="Amin A">AD Amin</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Q" uniqKey="Liu Q">Q Liu</name>
</author>
<author><name sortKey="Thoreen, C" uniqKey="Thoreen C">C Thoreen</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Sabatini, D" uniqKey="Sabatini D">D Sabatini</name>
</author>
<author><name sortKey="Gray, Ns" uniqKey="Gray N">NS Gray</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anavi, S" uniqKey="Anavi S">S Anavi</name>
</author>
<author><name sortKey="Ni, Z" uniqKey="Ni Z">Z Ni</name>
</author>
<author><name sortKey="Tirosh, O" uniqKey="Tirosh O">O Tirosh</name>
</author>
<author><name sortKey="Fedorova, M" uniqKey="Fedorova M">M Fedorova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, S" uniqKey="Gupta S">S Gupta</name>
</author>
<author><name sortKey="Goswami, P" uniqKey="Goswami P">P Goswami</name>
</author>
<author><name sortKey="Biswas, J" uniqKey="Biswas J">J Biswas</name>
</author>
<author><name sortKey="Joshi, N" uniqKey="Joshi N">N Joshi</name>
</author>
<author><name sortKey="Sharma, S" uniqKey="Sharma S">S Sharma</name>
</author>
<author><name sortKey="Nath, C" uniqKey="Nath C">C Nath</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, C" uniqKey="Yang C">C Yang</name>
</author>
<author><name sortKey="Yang, Qo" uniqKey="Yang Q">QO Yang</name>
</author>
<author><name sortKey="Kong, Qj" uniqKey="Kong Q">QJ Kong</name>
</author>
<author><name sortKey="Yuan, W" uniqKey="Yuan W">W Yuan</name>
</author>
<author><name sortKey="Yang, Ypo" uniqKey="Yang Y">YPO Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, Hm" uniqKey="Shen H">HM Shen</name>
</author>
<author><name sortKey="Liu, Zg" uniqKey="Liu Z">ZG Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name>
</author>
<author><name sortKey="Di Malta, C" uniqKey="Di Malta C">C Di Malta</name>
</author>
<author><name sortKey="Polito, Va" uniqKey="Polito V">VA Polito</name>
</author>
<author><name sortKey="Garcia Arencibia, M" uniqKey="Garcia Arencibia M">M Garcia Arencibia</name>
</author>
<author><name sortKey="Vetrini, F" uniqKey="Vetrini F">F Vetrini</name>
</author>
<author><name sortKey="Erdin" uniqKey="Erdin">Erdin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martina, Ja" uniqKey="Martina J">JA Martina</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Gucek, M" uniqKey="Gucek M">M Gucek</name>
</author>
<author><name sortKey="Puertollano, R" uniqKey="Puertollano R">R Puertollano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Roczniak Ferguson, A" uniqKey="Roczniak Ferguson A">A Roczniak-Ferguson</name>
</author>
<author><name sortKey="Petit, Cs" uniqKey="Petit C">CS Petit</name>
</author>
<author><name sortKey="Froehlich, F" uniqKey="Froehlich F">F Froehlich</name>
</author>
<author><name sortKey="Qian, S" uniqKey="Qian S">S Qian</name>
</author>
<author><name sortKey="Ky, J" uniqKey="Ky J">J Ky</name>
</author>
<author><name sortKey="Angarola, B" uniqKey="Angarola B">B Angarola</name>
</author>
<author><name sortKey="Walther, Tc" uniqKey="Walther T">TC Walther</name>
</author>
<author><name sortKey="Ferguson, Sm" uniqKey="Ferguson S">SM Ferguson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Settembre, C" uniqKey="Settembre C">C Settembre</name>
</author>
<author><name sortKey="De Cegli, R" uniqKey="De Cegli R">R De Cegli</name>
</author>
<author><name sortKey="Mansueto, G" uniqKey="Mansueto G">G Mansueto</name>
</author>
<author><name sortKey="Saha, Pk" uniqKey="Saha P">PK Saha</name>
</author>
<author><name sortKey="Vetrini, F" uniqKey="Vetrini F">F Vetrini</name>
</author>
<author><name sortKey="Visvikis, O" uniqKey="Visvikis O">O Visvikis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Bw" uniqKey="Wu B">BW Wu</name>
</author>
<author><name sortKey="Tan, Md" uniqKey="Tan M">MD Tan</name>
</author>
<author><name sortKey="Cai, Wl" uniqKey="Cai W">WL Cai</name>
</author>
<author><name sortKey="Wang, B" uniqKey="Wang B">B Wang</name>
</author>
<author><name sortKey="He, Ph" uniqKey="He P">PH He</name>
</author>
<author><name sortKey="Zhang, Xp" uniqKey="Zhang X">XP Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koustas, E" uniqKey="Koustas E">E Koustas</name>
</author>
<author><name sortKey="Karamouzis, Mv" uniqKey="Karamouzis M">MV Karamouzis</name>
</author>
<author><name sortKey="Mihailidou, C" uniqKey="Mihailidou C">C Mihailidou</name>
</author>
<author><name sortKey="Schizas, D" uniqKey="Schizas D">D Schizas</name>
</author>
<author><name sortKey="Papavassiliou, Ag" uniqKey="Papavassiliou A">AG Papavassiliou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, G S" uniqKey="Zhao G">G-S Zhao</name>
</author>
<author><name sortKey="Gao, Z R" uniqKey="Gao Z">Z-R Gao</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
<author><name sortKey="Tang, X F" uniqKey="Tang X">X-F Tang</name>
</author>
<author><name sortKey="Lv, Y F" uniqKey="Lv Y">Y-F Lv</name>
</author>
<author><name sortKey="Zhang, Z S" uniqKey="Zhang Z">Z-S Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, S H" uniqKey="Kim S">S-H Kim</name>
</author>
<author><name sortKey="Son, K M" uniqKey="Son K">K-M Son</name>
</author>
<author><name sortKey="Kim, K Y" uniqKey="Kim K">K-Y Kim</name>
</author>
<author><name sortKey="Yu, S N" uniqKey="Yu S">S-N Yu</name>
</author>
<author><name sortKey="Park, S G" uniqKey="Park S">S-G Park</name>
</author>
<author><name sortKey="Kim, Y W" uniqKey="Kim Y">Y-W Kim</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Horie, R" uniqKey="Horie R">R Horie</name>
</author>
<author><name sortKey="Nakamura, O" uniqKey="Nakamura O">O Nakamura</name>
</author>
<author><name sortKey="Yamagami, Y" uniqKey="Yamagami Y">Y Yamagami</name>
</author>
<author><name sortKey="Mori, M" uniqKey="Mori M">M Mori</name>
</author>
<author><name sortKey="Nishimura, H" uniqKey="Nishimura H">H Nishimura</name>
</author>
<author><name sortKey="Fukuoka, N" uniqKey="Fukuoka N">N Fukuoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mori, M" uniqKey="Mori M">M Mori</name>
</author>
<author><name sortKey="Hitora, T" uniqKey="Hitora T">T Hitora</name>
</author>
<author><name sortKey="Nakamura, O" uniqKey="Nakamura O">O Nakamura</name>
</author>
<author><name sortKey="Yamagami, Y" uniqKey="Yamagami Y">Y Yamagami</name>
</author>
<author><name sortKey="Horie, R" uniqKey="Horie R">R Horie</name>
</author>
<author><name sortKey="Nishimura, H" uniqKey="Nishimura H">H Nishimura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gao, J" uniqKey="Gao J">J Gao</name>
</author>
<author><name sortKey="Aksoy, Ba" uniqKey="Aksoy B">BA Aksoy</name>
</author>
<author><name sortKey="Dogrusoz, U" uniqKey="Dogrusoz U">U Dogrusoz</name>
</author>
<author><name sortKey="Dresdner, G" uniqKey="Dresdner G">G Dresdner</name>
</author>
<author><name sortKey="Gross, B" uniqKey="Gross B">B Gross</name>
</author>
<author><name sortKey="Sumer, So" uniqKey="Sumer S">SO Sumer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiao, X" uniqKey="Xiao X">X Xiao</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Shen, C" uniqKey="Shen C">C Shen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Sun, W" uniqKey="Sun W">W Sun</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Zuo, D" uniqKey="Zuo D">D Zuo</name>
</author>
<author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Krajarng, A" uniqKey="Krajarng A">A Krajarng</name>
</author>
<author><name sortKey="Imoto, M" uniqKey="Imoto M">M Imoto</name>
</author>
<author><name sortKey="Tashiro, E" uniqKey="Tashiro E">E Tashiro</name>
</author>
<author><name sortKey="Fujimaki, T" uniqKey="Fujimaki T">T Fujimaki</name>
</author>
<author><name sortKey="Shinjo, S" uniqKey="Shinjo S">S Shinjo</name>
</author>
<author><name sortKey="Watanapokasin, R" uniqKey="Watanapokasin R">R Watanapokasin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, K" uniqKey="Ma K">K Ma</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Huang, M Y" uniqKey="Huang M">M-Y Huang</name>
</author>
<author><name sortKey="Li, W Y" uniqKey="Li W">W-Y Li</name>
</author>
<author><name sortKey="Hu, G Q" uniqKey="Hu G">G-Q Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Hy" uniqKey="Li H">HY Li</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Sun, Ll" uniqKey="Sun L">LL Sun</name>
</author>
<author><name sortKey="Li, Bh" uniqKey="Li B">BH Li</name>
</author>
<author><name sortKey="Gao, Hl" uniqKey="Gao H">HL Gao</name>
</author>
<author><name sortKey="Xie, T" uniqKey="Xie T">T Xie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Sun, W" uniqKey="Sun W">W Sun</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, S H" uniqKey="Kim S">S-H Kim</name>
</author>
<author><name sortKey="Choi, Y J" uniqKey="Choi Y">Y-J Choi</name>
</author>
<author><name sortKey="Kim, K Y" uniqKey="Kim K">K-Y Kim</name>
</author>
<author><name sortKey="Yu, S N" uniqKey="Yu S">S-N Yu</name>
</author>
<author><name sortKey="Seo, Y K" uniqKey="Seo Y">Y-K Seo</name>
</author>
<author><name sortKey="Chun, S S" uniqKey="Chun S">S-S Chun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Zou, J" uniqKey="Zou J">J Zou</name>
</author>
<author><name sortKey="Yan, L" uniqKey="Yan L">L Yan</name>
</author>
<author><name sortKey="Yu, X" uniqKey="Yu X">X Yu</name>
</author>
<author><name sortKey="Lu, P" uniqKey="Lu P">P Lu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fu, L L" uniqKey="Fu L">L-L Fu</name>
</author>
<author><name sortKey="Wen, X" uniqKey="Wen X">X Wen</name>
</author>
<author><name sortKey="Bao, J K" uniqKey="Bao J">J-K Bao</name>
</author>
<author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hobert, O" uniqKey="Hobert O">O Hobert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yates, La" uniqKey="Yates L">LA Yates</name>
</author>
<author><name sortKey="Norbury, Cj" uniqKey="Norbury C">CJ Norbury</name>
</author>
<author><name sortKey="Gilbert, Rjc" uniqKey="Gilbert R">RJC Gilbert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
</author>
<author><name sortKey="Huang, J" uniqKey="Huang J">J Huang</name>
</author>
<author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weidhaas, Jb" uniqKey="Weidhaas J">JB Weidhaas</name>
</author>
<author><name sortKey="Babar, L" uniqKey="Babar L">L Babar</name>
</author>
<author><name sortKey="Nallur, Sm" uniqKey="Nallur S">SM Nallur</name>
</author>
<author><name sortKey="Trang, P" uniqKey="Trang P">P Trang</name>
</author>
<author><name sortKey="Roush, S" uniqKey="Roush S">S Roush</name>
</author>
<author><name sortKey="Boehm, N" uniqKey="Boehm N">N Boehm</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Zhu, W" uniqKey="Zhu W">W Zhu</name>
</author>
<author><name sortKey="Shi, D" uniqKey="Shi D">D Shi</name>
</author>
<author><name sortKey="Lv, L" uniqKey="Lv L">L Lv</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C Zhang</name>
</author>
<author><name sortKey="Liu, P" uniqKey="Liu P">P Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Jiang, W" uniqKey="Jiang W">W Jiang</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Da, Z" uniqKey="Da Z">Z Da</name>
</author>
<author><name sortKey="Zeng, C" uniqKey="Zeng C">C Zeng</name>
</author>
<author><name sortKey="Tu, M" uniqKey="Tu M">M Tu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wei, R" uniqKey="Wei R">R Wei</name>
</author>
<author><name sortKey="Cao, G" uniqKey="Cao G">G Cao</name>
</author>
<author><name sortKey="Deng, Z" uniqKey="Deng Z">Z Deng</name>
</author>
<author><name sortKey="Su, J" uniqKey="Su J">J Su</name>
</author>
<author><name sortKey="Cai, L" uniqKey="Cai L">L Cai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, R" uniqKey="Xu R">R Xu</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S Liu</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Lao, L" uniqKey="Lao L">L Lao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, Y" uniqKey="Yu Y">Y Yu</name>
</author>
<author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name>
</author>
<author><name sortKey="Zhao, M" uniqKey="Zhao M">M Zhao</name>
</author>
<author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name>
</author>
<author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name>
</author>
<author><name sortKey="Vernon, P" uniqKey="Vernon P">P Vernon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chang, Z" uniqKey="Chang Z">Z Chang</name>
</author>
<author><name sortKey="Huo, L" uniqKey="Huo L">L Huo</name>
</author>
<author><name sortKey="Li, K" uniqKey="Li K">K Li</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
<author><name sortKey="Hu, Z" uniqKey="Hu Z">Z Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schaaf, Mbe" uniqKey="Schaaf M">MBE Schaaf</name>
</author>
<author><name sortKey="Cojocari, D" uniqKey="Cojocari D">D Cojocari</name>
</author>
<author><name sortKey="Keulers, Tg" uniqKey="Keulers T">TG Keulers</name>
</author>
<author><name sortKey="Jutten, B" uniqKey="Jutten B">B Jutten</name>
</author>
<author><name sortKey="Starmans, Mh" uniqKey="Starmans M">MH Starmans</name>
</author>
<author><name sortKey="De Jong, Mc" uniqKey="De Jong M">MC de Jong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saito, S" uniqKey="Saito S">S Saito</name>
</author>
<author><name sortKey="Nakashima, A" uniqKey="Nakashima A">A Nakashima</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rahim, Saa" uniqKey="Rahim S">SAA Rahim</name>
</author>
<author><name sortKey="Dirkse, A" uniqKey="Dirkse A">A Dirkse</name>
</author>
<author><name sortKey="Oudin, A" uniqKey="Oudin A">A Oudin</name>
</author>
<author><name sortKey="Schuster, A" uniqKey="Schuster A">A Schuster</name>
</author>
<author><name sortKey="Bohler, J" uniqKey="Bohler J">J Bohler</name>
</author>
<author><name sortKey="Barthelemy, V" uniqKey="Barthelemy V">V Barthelemy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yan, J" uniqKey="Yan J">J Yan</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brocato, J" uniqKey="Brocato J">J Brocato</name>
</author>
<author><name sortKey="Chervona, Y" uniqKey="Chervona Y">Y Chervona</name>
</author>
<author><name sortKey="Costa, M" uniqKey="Costa M">M Costa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Monti, E" uniqKey="Monti E">E Monti</name>
</author>
<author><name sortKey="Gariboldi, Mb" uniqKey="Gariboldi M">MB Gariboldi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Generali, D" uniqKey="Generali D">D Generali</name>
</author>
<author><name sortKey="Buffa, Fm" uniqKey="Buffa F">FM Buffa</name>
</author>
<author><name sortKey="Berruti, A" uniqKey="Berruti A">A Berruti</name>
</author>
<author><name sortKey="Brizzi, Mp" uniqKey="Brizzi M">MP Brizzi</name>
</author>
<author><name sortKey="Campo, L" uniqKey="Campo L">L Campo</name>
</author>
<author><name sortKey="Bonardi, S" uniqKey="Bonardi S">S Bonardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gray, Lh" uniqKey="Gray L">LH Gray</name>
</author>
<author><name sortKey="Conger, Ad" uniqKey="Conger A">AD Conger</name>
</author>
<author><name sortKey="Ebert, M" uniqKey="Ebert M">M Ebert</name>
</author>
<author><name sortKey="Hornsey, S" uniqKey="Hornsey S">S Hornsey</name>
</author>
<author><name sortKey="Scott, Oca" uniqKey="Scott O">OCA Scott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Chen, G" uniqKey="Chen G">G Chen</name>
</author>
<author><name sortKey="Zhang, W" uniqKey="Zhang W">W Zhang</name>
</author>
<author><name sortKey="Xu, N" uniqKey="Xu N">N Xu</name>
</author>
<author><name sortKey="Zhu, J Y" uniqKey="Zhu J">J-Y Zhu</name>
</author>
<author><name sortKey="Jia, J" uniqKey="Jia J">J Jia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, H" uniqKey="Zhang H">H Zhang</name>
</author>
<author><name sortKey="Bosch Marce, M" uniqKey="Bosch Marce M">M Bosch-Marce</name>
</author>
<author><name sortKey="Shimoda, La" uniqKey="Shimoda L">LA Shimoda</name>
</author>
<author><name sortKey="Tan, Ys" uniqKey="Tan Y">YS Tan</name>
</author>
<author><name sortKey="Baek, Jh" uniqKey="Baek J">JH Baek</name>
</author>
<author><name sortKey="Wesley, Jb" uniqKey="Wesley J">JB Wesley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
<author><name sortKey="Huang, C" uniqKey="Huang C">C Huang</name>
</author>
<author><name sortKey="Li, G" uniqKey="Li G">G Li</name>
</author>
<author><name sortKey="Chen, T" uniqKey="Chen T">T Chen</name>
</author>
<author><name sortKey="Li, J" uniqKey="Li J">J Li</name>
</author>
<author><name sortKey="Huang, Z" uniqKey="Huang Z">Z Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feng, H" uniqKey="Feng H">H Feng</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W Chen</name>
</author>
<author><name sortKey="Shan, B" uniqKey="Shan B">B Shan</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mo, H" uniqKey="Mo H">H Mo</name>
</author>
<author><name sortKey="He, J" uniqKey="He J">J He</name>
</author>
<author><name sortKey="Yuan, Z" uniqKey="Yuan Z">Z Yuan</name>
</author>
<author><name sortKey="Mo, L" uniqKey="Mo L">L Mo</name>
</author>
<author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name>
</author>
<author><name sortKey="Lin, X" uniqKey="Lin X">X Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Jq" uniqKey="Zhang J">JQ Zhang</name>
</author>
<author><name sortKey="Li, Ym" uniqKey="Li Y">YM Li</name>
</author>
<author><name sortKey="Liu, T" uniqKey="Liu T">T Liu</name>
</author>
<author><name sortKey="He, Wt" uniqKey="He W">WT He</name>
</author>
<author><name sortKey="Chen, Yt" uniqKey="Chen Y">YT Chen</name>
</author>
<author><name sortKey="Chen, Xh" uniqKey="Chen X">XH Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, X S" uniqKey="Liu X">X-S Liu</name>
</author>
<author><name sortKey="Jiang, J" uniqKey="Jiang J">J Jiang</name>
</author>
<author><name sortKey="Jiao, X Y" uniqKey="Jiao X">X-Y Jiao</name>
</author>
<author><name sortKey="Wu, Y E" uniqKey="Wu Y">Y-E Wu</name>
</author>
<author><name sortKey="Lin, J H" uniqKey="Lin J">J-H Lin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ma, K" uniqKey="Ma K">K Ma</name>
</author>
<author><name sortKey="Huang, M Y" uniqKey="Huang M">M-Y Huang</name>
</author>
<author><name sortKey="Guo, Y X" uniqKey="Guo Y">Y-X Guo</name>
</author>
<author><name sortKey="Hu, G Q" uniqKey="Hu G">G-Q Hu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tao, H" uniqKey="Tao H">H Tao</name>
</author>
<author><name sortKey="Chen, F" uniqKey="Chen F">F Chen</name>
</author>
<author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name>
</author>
<author><name sortKey="Hu, Y" uniqKey="Hu Y">Y Hu</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kubista, B" uniqKey="Kubista B">B Kubista</name>
</author>
<author><name sortKey="Schoefl, T" uniqKey="Schoefl T">T Schoefl</name>
</author>
<author><name sortKey="Mayr, L" uniqKey="Mayr L">L Mayr</name>
</author>
<author><name sortKey="Van Schoonhoven, S" uniqKey="Van Schoonhoven S">S van Schoonhoven</name>
</author>
<author><name sortKey="Heffeter, P" uniqKey="Heffeter P">P Heffeter</name>
</author>
<author><name sortKey="Windhager, R" uniqKey="Windhager R">R Windhager</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Lu, Q" uniqKey="Lu Q">Q Lu</name>
</author>
<author><name sortKey="Xie, W" uniqKey="Xie W">W Xie</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
<author><name sortKey="Chen, D" uniqKey="Chen D">D Chen</name>
</author>
<author><name sortKey="Zhu, K" uniqKey="Zhu K">K Zhu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cuervo, Am" uniqKey="Cuervo A">AM Cuervo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kundu, M" uniqKey="Kundu M">M Kundu</name>
</author>
<author><name sortKey="Thompson, Cb" uniqKey="Thompson C">CB Thompson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Yin, F" uniqKey="Yin F">F Yin</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Wang, G" uniqKey="Wang G">G Wang</name>
</author>
<author><name sortKey="Mao, M" uniqKey="Mao M">M Mao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W Li</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Zhang, T" uniqKey="Zhang T">T Zhang</name>
</author>
<author><name sortKey="Zuo, D" uniqKey="Zuo D">D Zuo</name>
</author>
<author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, M" uniqKey="Kim M">M Kim</name>
</author>
<author><name sortKey="Jung, J Y" uniqKey="Jung J">J-Y Jung</name>
</author>
<author><name sortKey="Choi, S" uniqKey="Choi S">S Choi</name>
</author>
<author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name>
</author>
<author><name sortKey="Morales, Ld" uniqKey="Morales L">LD Morales</name>
</author>
<author><name sortKey="Koh, J T" uniqKey="Koh J">J-T Koh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yen, J H" uniqKey="Yen J">J-H Yen</name>
</author>
<author><name sortKey="Huang, S T" uniqKey="Huang S">S-T Huang</name>
</author>
<author><name sortKey="Huang, H S" uniqKey="Huang H">H-S Huang</name>
</author>
<author><name sortKey="Fong, Y C" uniqKey="Fong Y">Y-C Fong</name>
</author>
<author><name sortKey="Wu, Y Y" uniqKey="Wu Y">Y-Y Wu</name>
</author>
<author><name sortKey="Chiang, J H" uniqKey="Chiang J">J-H Chiang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhu, J" uniqKey="Zhu J">J Zhu</name>
</author>
<author><name sortKey="Yu, W" uniqKey="Yu W">W Yu</name>
</author>
<author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Shao, J" uniqKey="Shao J">J Shao</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hicklin, Dj" uniqKey="Hicklin D">DJ Hicklin</name>
</author>
<author><name sortKey="Ellis, Lm" uniqKey="Ellis L">LM Ellis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, K" uniqKey="Liu K">K Liu</name>
</author>
<author><name sortKey="Ren, T" uniqKey="Ren T">T Ren</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
<author><name sortKey="Sun, K" uniqKey="Sun K">K Sun</name>
</author>
<author><name sortKey="Bao, X" uniqKey="Bao X">X Bao</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhou, P" uniqKey="Zhou P">P Zhou</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Li, B" uniqKey="Li B">B Li</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
<author><name sortKey="Xu, C" uniqKey="Xu C">C Xu</name>
</author>
<author><name sortKey="Liu, F" uniqKey="Liu F">F Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yamamoto, N" uniqKey="Yamamoto N">N Yamamoto</name>
</author>
<author><name sortKey="Tsuchiya, H" uniqKey="Tsuchiya H">H Tsuchiya</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Shao, Z" uniqKey="Shao Z">Z Shao</name>
</author>
<author><name sortKey="Xiong, L" uniqKey="Xiong L">L Xiong</name>
</author>
<author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sui, X" uniqKey="Sui X">X Sui</name>
</author>
<author><name sortKey="Chen, R" uniqKey="Chen R">R Chen</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z Wang</name>
</author>
<author><name sortKey="Huang, Z" uniqKey="Huang Z">Z Huang</name>
</author>
<author><name sortKey="Kong, N" uniqKey="Kong N">N Kong</name>
</author>
<author><name sortKey="Zhang, M" uniqKey="Zhang M">M Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Yb" uniqKey="Chen Y">YB Chen</name>
</author>
<author><name sortKey="Hou, Jh" uniqKey="Hou J">JH Hou</name>
</author>
<author><name sortKey="Feng, Xy" uniqKey="Feng X">XY Feng</name>
</author>
<author><name sortKey="Chen, S" uniqKey="Chen S">S Chen</name>
</author>
<author><name sortKey="Zhou, Zw" uniqKey="Zhou Z">ZW Zhou</name>
</author>
<author><name sortKey="Zhang, Xs" uniqKey="Zhang X">XS Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dong, M" uniqKey="Dong M">M Dong</name>
</author>
<author><name sortKey="Wan, Xb" uniqKey="Wan X">XB Wan</name>
</author>
<author><name sortKey="Yuan, Zy" uniqKey="Yuan Z">ZY Yuan</name>
</author>
<author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name>
</author>
<author><name sortKey="Fan, Xj" uniqKey="Fan X">XJ Fan</name>
</author>
<author><name sortKey="Wang, Tt" uniqKey="Wang T">TT Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, H" uniqKey="Zhao H">H Zhao</name>
</author>
<author><name sortKey="Yang, M" uniqKey="Yang M">M Yang</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Oncol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Oncol.</journal-id>
<journal-title-group><journal-title>Frontiers in Oncology</journal-title>
</journal-title-group>
<issn pub-type="epub">2234-943X</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31803616</article-id>
<article-id pub-id-type="pmc">6873391</article-id>
<article-id pub-id-type="doi">10.3389/fonc.2019.01232</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Oncology</subject>
<subj-group><subject>Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Niu</surname>
<given-names>Jianfang</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/843659/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Yan</surname>
<given-names>Taiqiang</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/743179/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Guo</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Wei</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/790259/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Zhiqing</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/843674/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Musculoskeletal Tumor Center, Peking University People's Hospital</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Beijing Key Laboratory of Musculoskeletal Tumor</institution>
,<addr-line>Beijing</addr-line>
,<country>China</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Massimo Bonora, Albert Einstein College of Medicine, United States</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Daniele Vergara, University of Salento, Italy; Robert Friis, University of Bern, Switzerland</p>
</fn>
<corresp id="c001">*Correspondence: Taiqiang Yan <email>yantqzh@163.com</email>
</corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>15</day>
<month>11</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>9</volume>
<elocation-id>1232</elocation-id>
<history><date date-type="received"><day>31</day>
<month>5</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>28</day>
<month>10</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2019 Niu, Yan, Guo, Wang and Zhao.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Niu, Yan, Guo, Wang and Zhao</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Osteosarcoma is an aggressive bone cancer that frequently metastasizes to the lungs. The cytotoxicity of most chemotherapeutics and targeted drugs in the treatment of osteosarcoma is partially lessened. Furthermore, there is a poor response to current chemo- and radiotherapy for both primary lesions and pulmonary metastases of osteosarcoma. There is a clear need to explore promising drug candidates that could improve the efficacy of osteosarcoma treatment. Autophagy, a dynamic and highly conserved catabolic process, has dual roles in promoting cell survival as well as cell death. The role of autophagy has been investigated extensively in different tumor types, and a growing body of research has highlighted the potential value of using autophagy in clinical therapy. Here, we address significant aspects of autophagy in osteosarcoma, including its functions, modulation, and possible therapeutic applications.</p>
</abstract>
<kwd-group><kwd>osteosarcoma</kwd>
<kwd>autophagy</kwd>
<kwd>PI3K/AKT/mTOR pathway</kwd>
<kwd>ROS/JNK pathway</kwd>
<kwd>hypoxia</kwd>
<kwd>cancer therapy</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">National Natural Science Foundation of China<named-content content-type="fundref-id">10.13039/501100001809</named-content>
</funding-source>
</award-group>
</funding-group>
<counts><fig-count count="2"></fig-count>
<table-count count="1"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="100"></ref-count>
<page-count count="11"></page-count>
<word-count count="9395"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Niu, Jianfang" sort="Niu, Jianfang" uniqKey="Niu J" first="Jianfang" last="Niu">Jianfang Niu</name>
</noRegion>
<name sortKey="Guo, Wei" sort="Guo, Wei" uniqKey="Guo W" first="Wei" last="Guo">Wei Guo</name>
<name sortKey="Guo, Wei" sort="Guo, Wei" uniqKey="Guo W" first="Wei" last="Guo">Wei Guo</name>
<name sortKey="Niu, Jianfang" sort="Niu, Jianfang" uniqKey="Niu J" first="Jianfang" last="Niu">Jianfang Niu</name>
<name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
<name sortKey="Wang, Wei" sort="Wang, Wei" uniqKey="Wang W" first="Wei" last="Wang">Wei Wang</name>
<name sortKey="Yan, Taiqiang" sort="Yan, Taiqiang" uniqKey="Yan T" first="Taiqiang" last="Yan">Taiqiang Yan</name>
<name sortKey="Yan, Taiqiang" sort="Yan, Taiqiang" uniqKey="Yan T" first="Taiqiang" last="Yan">Taiqiang Yan</name>
<name sortKey="Zhao, Zhiqing" sort="Zhao, Zhiqing" uniqKey="Zhao Z" first="Zhiqing" last="Zhao">Zhiqing Zhao</name>
<name sortKey="Zhao, Zhiqing" sort="Zhao, Zhiqing" uniqKey="Zhao Z" first="Zhiqing" last="Zhao">Zhiqing Zhao</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000667 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000667 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:6873391 |texte= Insight Into the Role of Autophagy in Osteosarcoma and Its Therapeutic Implication }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:31803616" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |