Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy
Identifieur interne : 000522 ( Pmc/Checkpoint ); précédent : 000521; suivant : 000523Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy
Auteurs : Mohsen Keshavarz [Iran] ; Farid Solaymani-Mohammadi [Iran] ; Seyed Mohammad Miri [Iran] ; Amir Ghaemi [Iran]Source :
- Journal of Biomedical Science [ 1021-7770 ] ; 2019.
Abstract
Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intrinsic oncolytic capability, which makes them excellent candidates to be widely used in oncolytic virotherapy. The mechanisms through which these viruses destroy the cancerous cells involve triggering the autophagic machinery and apoptosis in target cells. Interestingly, oncolytic paramyxoviruses have been found to induce autophagy and lead to tumor cells death rather than their survival. Indeed, the induction of autophagy has been revealed to enhance the immunogenicity of tumor cells via the release of damage-associated molecular patterns (DAMPs) and the activation of autophagy-related immunogenic cell death (ICD). Subsequent cross-presentation of tumor-associated antigens (TAA) through the MHC-I complex to CD8+ T cells results in the productive priming of the tumor-specific immune response. In this review, we first briefly discuss autophagy and explain the process of viral xenophagy. Finally, we focus on the interactions between virus and autophagy proteins, elaborating on the global preclinical studies on oncolytic paramyxoviruses.
Url:
DOI: 10.1186/s12929-019-0542-9
PubMed: 31217023
PubMed Central: 6585078
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="Par1">Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intrinsic oncolytic capability, which makes them excellent candidates to be widely used in oncolytic virotherapy. The mechanisms through which these viruses destroy the cancerous cells involve triggering the autophagic machinery and apoptosis in target cells. Interestingly, oncolytic paramyxoviruses have been found to induce autophagy and lead to tumor cells death rather than their survival. Indeed, the induction of autophagy has been revealed to enhance the immunogenicity of tumor cells via the release of damage-associated molecular patterns (DAMPs) and the activation of autophagy-related immunogenic cell death (ICD). Subsequent cross-presentation of tumor-associated antigens (TAA) through the MHC-I complex to CD8+ T cells results in the productive priming of the tumor-specific immune response. In this review, we first briefly discuss autophagy and explain the process of viral xenophagy. Finally, we focus on the interactions between virus and autophagy proteins, elaborating on the global preclinical studies on oncolytic paramyxoviruses.</p>
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<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Toporcov, Tn" uniqKey="Toporcov T">TN Toporcov</name>
</author>
<author><name sortKey="Wunsch Filho, V" uniqKey="Wunsch Filho V">V Wunsch Filho</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fukuhara, H" uniqKey="Fukuhara H">H Fukuhara</name>
</author>
<author><name sortKey="Ino, Y" uniqKey="Ino Y">Y Ino</name>
</author>
<author><name sortKey="Todo, T" uniqKey="Todo T">T Todo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lawler, Se" uniqKey="Lawler S">SE Lawler</name>
</author>
<author><name sortKey="Speranza, Mc" uniqKey="Speranza M">MC Speranza</name>
</author>
<author><name sortKey="Cho, Cf" uniqKey="Cho C">CF Cho</name>
</author>
<author><name sortKey="Chiocca, Ea" uniqKey="Chiocca E">EA Chiocca</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ogata, M" uniqKey="Ogata M">M Ogata</name>
</author>
<author><name sortKey="Hino, S" uniqKey="Hino S">S Hino</name>
</author>
<author><name sortKey="Saito, A" uniqKey="Saito A">A Saito</name>
</author>
<author><name sortKey="Morikawa, K" uniqKey="Morikawa K">K Morikawa</name>
</author>
<author><name sortKey="Kondo, S" uniqKey="Kondo S">S Kondo</name>
</author>
<author><name sortKey="Kanemoto, S" uniqKey="Kanemoto S">S Kanemoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Conry, Rm" uniqKey="Conry R">RM Conry</name>
</author>
<author><name sortKey="Westbrook, B" uniqKey="Westbrook B">B Westbrook</name>
</author>
<author><name sortKey="Mckee, S" uniqKey="Mckee S">S McKee</name>
</author>
<author><name sortKey="Norwood, Tg" uniqKey="Norwood T">TG Norwood</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lech, Pj" uniqKey="Lech P">PJ Lech</name>
</author>
<author><name sortKey="Russell, Sj" uniqKey="Russell S">SJ Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Matveeva, Olga V" uniqKey="Matveeva O">Olga V Matveeva</name>
</author>
<author><name sortKey="Guo, Zong S" uniqKey="Guo Z">Zong S Guo</name>
</author>
<author><name sortKey="Shabalina, Svetlana A" uniqKey="Shabalina S">Svetlana A Shabalina</name>
</author>
<author><name sortKey="Chumakov, Peter M" uniqKey="Chumakov P">Peter M Chumakov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Steele, S" uniqKey="Steele S">S Steele</name>
</author>
<author><name sortKey="Brunton, J" uniqKey="Brunton J">J Brunton</name>
</author>
<author><name sortKey="Kawula, T" uniqKey="Kawula T">T Kawula</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcewan, Dg" uniqKey="Mcewan D">DG McEwan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deretic, V" uniqKey="Deretic V">V Deretic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, D" uniqKey="Tang D">D Tang</name>
</author>
<author><name sortKey="Kang, R" uniqKey="Kang R">R Kang</name>
</author>
<author><name sortKey="Coyne, Cb" uniqKey="Coyne C">CB Coyne</name>
</author>
<author><name sortKey="Zeh, Hj" uniqKey="Zeh H">HJ Zeh</name>
</author>
<author><name sortKey="Lotze, Mt" uniqKey="Lotze M">MT Lotze</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Jiang, K" uniqKey="Jiang K">K Jiang</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
<author><name sortKey="Meng, S" uniqKey="Meng S">S Meng</name>
</author>
<author><name sortKey="Ding, C" uniqKey="Ding C">C Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
<author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name>
</author>
<author><name sortKey="Vandenabeele, P" uniqKey="Vandenabeele P">P Vandenabeele</name>
</author>
<author><name sortKey="Abrams, J" uniqKey="Abrams J">J Abrams</name>
</author>
<author><name sortKey="Alnemri, Es" uniqKey="Alnemri E">ES Alnemri</name>
</author>
<author><name sortKey="Baehrecke, Eh" uniqKey="Baehrecke E">EH Baehrecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
<author><name sortKey="Emr, Sd" uniqKey="Emr S">SD Emr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rubinsztein, Dc" uniqKey="Rubinsztein D">DC Rubinsztein</name>
</author>
<author><name sortKey="Codogno, P" uniqKey="Codogno P">P Codogno</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bauckman, Ka" uniqKey="Bauckman K">KA Bauckman</name>
</author>
<author><name sortKey="Owusu Boaitey, N" uniqKey="Owusu Boaitey N">N Owusu-Boaitey</name>
</author>
<author><name sortKey="Mysorekar, Iu" uniqKey="Mysorekar I">IU Mysorekar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chandra, P" uniqKey="Chandra P">P Chandra</name>
</author>
<author><name sortKey="Kumar, D" uniqKey="Kumar D">D Kumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gomes, Lc" uniqKey="Gomes L">LC Gomes</name>
</author>
<author><name sortKey="Dikic, I" uniqKey="Dikic I">I Dikic</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G Kroemer</name>
</author>
<author><name sortKey="Marino, G" uniqKey="Marino G">G Marino</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
<author><name sortKey="Cuervo, Am" uniqKey="Cuervo A">AM Cuervo</name>
</author>
<author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Russell, Rc" uniqKey="Russell R">RC Russell</name>
</author>
<author><name sortKey="Yuan, Hx" uniqKey="Yuan H">HX Yuan</name>
</author>
<author><name sortKey="Guan, Kl" uniqKey="Guan K">KL Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mizushima, N" uniqKey="Mizushima N">N Mizushima</name>
</author>
<author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yin, Z" uniqKey="Yin Z">Z Yin</name>
</author>
<author><name sortKey="Pascual, C" uniqKey="Pascual C">C Pascual</name>
</author>
<author><name sortKey="Klionsky, Dj" uniqKey="Klionsky D">DJ Klionsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Anding, Al" uniqKey="Anding A">AL Anding</name>
</author>
<author><name sortKey="Baehrecke, Eh" uniqKey="Baehrecke E">EH Baehrecke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Davis, S" uniqKey="Davis S">S Davis</name>
</author>
<author><name sortKey="Wang, J" uniqKey="Wang J">J Wang</name>
</author>
<author><name sortKey="Ferro Novick, S" uniqKey="Ferro Novick S">S Ferro-Novick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kn Velsrud, H" uniqKey="Kn Velsrud H">H Knævelsrud</name>
</author>
<author><name sortKey="S Reng, K" uniqKey="S Reng K">K Søreng</name>
</author>
<author><name sortKey="Raiborg, C" uniqKey="Raiborg C">C Raiborg</name>
</author>
<author><name sortKey="H Berg, K" uniqKey="H Berg K">K Håberg</name>
</author>
<author><name sortKey="Rasmuson, F" uniqKey="Rasmuson F">F Rasmuson</name>
</author>
<author><name sortKey="Brech, A" uniqKey="Brech A">A Brech</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakatogawa, H" uniqKey="Nakatogawa H">H Nakatogawa</name>
</author>
<author><name sortKey="Ichimura, Y" uniqKey="Ichimura Y">Y Ichimura</name>
</author>
<author><name sortKey="Ohsumi, Y" uniqKey="Ohsumi Y">Y Ohsumi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Grumati, P" uniqKey="Grumati P">P Grumati</name>
</author>
<author><name sortKey="Dikic, I" uniqKey="Dikic I">I Dikic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Levine, B" uniqKey="Levine B">B Levine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galluzzi, Lorenzo" uniqKey="Galluzzi L">Lorenzo Galluzzi</name>
</author>
<author><name sortKey="Baehrecke, Eric H" uniqKey="Baehrecke E">Eric H Baehrecke</name>
</author>
<author><name sortKey="Ballabio, Andrea" uniqKey="Ballabio A">Andrea Ballabio</name>
</author>
<author><name sortKey="Boya, Patricia" uniqKey="Boya P">Patricia Boya</name>
</author>
<author><name sortKey="Bravo An Pedro, Jose Manuel" uniqKey="Bravo An Pedro J">José Manuel Bravo‐San Pedro</name>
</author>
<author><name sortKey="Cecconi, Francesco" uniqKey="Cecconi F">Francesco Cecconi</name>
</author>
<author><name sortKey="Choi, Augustine M" uniqKey="Choi A">Augustine M Choi</name>
</author>
<author><name sortKey="Chu, Charleen T" uniqKey="Chu C">Charleen T Chu</name>
</author>
<author><name sortKey="Codogno, Patrice" uniqKey="Codogno P">Patrice Codogno</name>
</author>
<author><name sortKey="Colombo, Maria Isabel" uniqKey="Colombo M">Maria Isabel Colombo</name>
</author>
<author><name sortKey="Cuervo, Ana Maria" uniqKey="Cuervo A">Ana Maria Cuervo</name>
</author>
<author><name sortKey="Debnath, Jayanta" uniqKey="Debnath J">Jayanta Debnath</name>
</author>
<author><name sortKey="Deretic, Vojo" uniqKey="Deretic V">Vojo Deretic</name>
</author>
<author><name sortKey="Dikic, Ivan" uniqKey="Dikic I">Ivan Dikic</name>
</author>
<author><name sortKey="Eskelinen, Eeva Iisa" uniqKey="Eskelinen E">Eeva‐Liisa Eskelinen</name>
</author>
<author><name sortKey="Fimia, Gian Maria" uniqKey="Fimia G">Gian Maria Fimia</name>
</author>
<author><name sortKey="Fulda, Simone" uniqKey="Fulda S">Simone Fulda</name>
</author>
<author><name sortKey="Gewirtz, David A" uniqKey="Gewirtz D">David A Gewirtz</name>
</author>
<author><name sortKey="Green, Douglas R" uniqKey="Green D">Douglas R Green</name>
</author>
<author><name sortKey="Hansen, Malene" uniqKey="Hansen M">Malene Hansen</name>
</author>
<author><name sortKey="Harper, J Wade" uniqKey="Harper J">J Wade Harper</name>
</author>
<author><name sortKey="J Ttel, Marja" uniqKey="J Ttel M">Marja Jäättelä</name>
</author>
<author><name sortKey="Johansen, Terje" uniqKey="Johansen T">Terje Johansen</name>
</author>
<author><name sortKey="Juhasz, Gabor" uniqKey="Juhasz G">Gabor Juhasz</name>
</author>
<author><name sortKey="Kimmelman, Alec C" uniqKey="Kimmelman A">Alec C Kimmelman</name>
</author>
<author><name sortKey="Kraft, Claudine" uniqKey="Kraft C">Claudine Kraft</name>
</author>
<author><name sortKey="Ktistakis, Nicholas T" uniqKey="Ktistakis N">Nicholas T Ktistakis</name>
</author>
<author><name sortKey="Kumar, Sharad" uniqKey="Kumar S">Sharad Kumar</name>
</author>
<author><name sortKey="Levine, Beth" uniqKey="Levine B">Beth Levine</name>
</author>
<author><name sortKey="Lopez Tin, Carlos" uniqKey="Lopez Tin C">Carlos Lopez‐Otin</name>
</author>
<author><name sortKey="Madeo, Frank" uniqKey="Madeo F">Frank Madeo</name>
</author>
<author><name sortKey="Martens, Sascha" uniqKey="Martens S">Sascha Martens</name>
</author>
<author><name sortKey="Martinez, Jennifer" uniqKey="Martinez J">Jennifer Martinez</name>
</author>
<author><name sortKey="Melendez, Alicia" uniqKey="Melendez A">Alicia Melendez</name>
</author>
<author><name sortKey="Mizushima, Noboru" uniqKey="Mizushima N">Noboru Mizushima</name>
</author>
<author><name sortKey="Munz, Christian" uniqKey="Munz C">Christian Münz</name>
</author>
<author><name sortKey="Murphy, Leon O" uniqKey="Murphy L">Leon O Murphy</name>
</author>
<author><name sortKey="Penninger, Josef M" uniqKey="Penninger J">Josef M Penninger</name>
</author>
<author><name sortKey="Piacentini, Mauro" uniqKey="Piacentini M">Mauro Piacentini</name>
</author>
<author><name sortKey="Reggiori, Fulvio" uniqKey="Reggiori F">Fulvio Reggiori</name>
</author>
<author><name sortKey="Rubinsztein, David C" uniqKey="Rubinsztein D">David C Rubinsztein</name>
</author>
<author><name sortKey="Ryan, Kevin M" uniqKey="Ryan K">Kevin M Ryan</name>
</author>
<author><name sortKey="Santambrogio, Laura" uniqKey="Santambrogio L">Laura Santambrogio</name>
</author>
<author><name sortKey="Scorrano, Luca" uniqKey="Scorrano L">Luca Scorrano</name>
</author>
<author><name sortKey="Simon, Anna Katharina" uniqKey="Simon A">Anna Katharina Simon</name>
</author>
<author><name sortKey="Simon, Hans We" uniqKey="Simon H">Hans‐Uwe Simon</name>
</author>
<author><name sortKey="Simonsen, Anne" uniqKey="Simonsen A">Anne Simonsen</name>
</author>
<author><name sortKey="Tavernarakis, Nektarios" uniqKey="Tavernarakis N">Nektarios Tavernarakis</name>
</author>
<author><name sortKey="Tooze, Sharon A" uniqKey="Tooze S">Sharon A Tooze</name>
</author>
<author><name sortKey="Yoshimori, Tamotsu" uniqKey="Yoshimori T">Tamotsu Yoshimori</name>
</author>
<author><name sortKey="Yuan, Junying" uniqKey="Yuan J">Junying Yuan</name>
</author>
<author><name sortKey="Yue, Zhenyu" uniqKey="Yue Z">Zhenyu Yue</name>
</author>
<author><name sortKey="Zhong, Qing" uniqKey="Zhong Q">Qing Zhong</name>
</author>
<author><name sortKey="Kroemer, Guido" uniqKey="Kroemer G">Guido Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kyei, Gb" uniqKey="Kyei G">GB Kyei</name>
</author>
<author><name sortKey="Dinkins, C" uniqKey="Dinkins C">C Dinkins</name>
</author>
<author><name sortKey="Davis, As" uniqKey="Davis A">AS Davis</name>
</author>
<author><name sortKey="Roberts, E" uniqKey="Roberts E">E Roberts</name>
</author>
<author><name sortKey="Singh, Sb" uniqKey="Singh S">SB Singh</name>
</author>
<author><name sortKey="Dong, C" uniqKey="Dong C">C Dong</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Manuse, Mj" uniqKey="Manuse M">MJ Manuse</name>
</author>
<author><name sortKey="Briggs, Cm" uniqKey="Briggs C">CM Briggs</name>
</author>
<author><name sortKey="Parks, Gd" uniqKey="Parks G">GD Parks</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Delpeut, S" uniqKey="Delpeut S">S Delpeut</name>
</author>
<author><name sortKey="Rudd, Pa" uniqKey="Rudd P">PA Rudd</name>
</author>
<author><name sortKey="Labonte, P" uniqKey="Labonte P">P Labonte</name>
</author>
<author><name sortKey="Von Messling, V" uniqKey="Von Messling V">V von Messling</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jackson, Wt" uniqKey="Jackson W">WT Jackson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ding, B" uniqKey="Ding B">B Ding</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
<author><name sortKey="Yang, X" uniqKey="Yang X">X Yang</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name>
</author>
<author><name sortKey="Yan, Q" uniqKey="Yan Q">Q Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Galanis, E" uniqKey="Galanis E">E Galanis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bateman, A" uniqKey="Bateman A">A Bateman</name>
</author>
<author><name sortKey="Bullough, F" uniqKey="Bullough F">F Bullough</name>
</author>
<author><name sortKey="Murphy, S" uniqKey="Murphy S">S Murphy</name>
</author>
<author><name sortKey="Emiliusen, L" uniqKey="Emiliusen L">L Emiliusen</name>
</author>
<author><name sortKey="Lavillette, D" uniqKey="Lavillette D">D Lavillette</name>
</author>
<author><name sortKey="Cosset, Fl" uniqKey="Cosset F">FL Cosset</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bateman, Ar" uniqKey="Bateman A">AR Bateman</name>
</author>
<author><name sortKey="Harrington, Kj" uniqKey="Harrington K">KJ Harrington</name>
</author>
<author><name sortKey="Kottke, T" uniqKey="Kottke T">T Kottke</name>
</author>
<author><name sortKey="Ahmed, A" uniqKey="Ahmed A">A Ahmed</name>
</author>
<author><name sortKey="Melcher, Aa" uniqKey="Melcher A">AA Melcher</name>
</author>
<author><name sortKey="Gough, Mj" uniqKey="Gough M">MJ Gough</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Richetta, C" uniqKey="Richetta C">C Richetta</name>
</author>
<author><name sortKey="Gregoire, Ip" uniqKey="Gregoire I">IP Gregoire</name>
</author>
<author><name sortKey="Verlhac, P" uniqKey="Verlhac P">P Verlhac</name>
</author>
<author><name sortKey="Azocar, O" uniqKey="Azocar O">O Azocar</name>
</author>
<author><name sortKey="Baguet, J" uniqKey="Baguet J">J Baguet</name>
</author>
<author><name sortKey="Flacher, M" uniqKey="Flacher M">M Flacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meng, C" uniqKey="Meng C">C Meng</name>
</author>
<author><name sortKey="Qiu, X" uniqKey="Qiu X">X Qiu</name>
</author>
<author><name sortKey="Jin, S" uniqKey="Jin S">S Jin</name>
</author>
<author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H Chen</name>
</author>
<author><name sortKey="Ding, C" uniqKey="Ding C">C Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Siddiqui, Ma" uniqKey="Siddiqui M">MA Siddiqui</name>
</author>
<author><name sortKey="Malathi, K" uniqKey="Malathi K">K Malathi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bartlett, Dl" uniqKey="Bartlett D">DL Bartlett</name>
</author>
<author><name sortKey="Liu, Z" uniqKey="Liu Z">Z Liu</name>
</author>
<author><name sortKey="Sathaiah, M" uniqKey="Sathaiah M">M Sathaiah</name>
</author>
<author><name sortKey="Ravindranathan, R" uniqKey="Ravindranathan R">R Ravindranathan</name>
</author>
<author><name sortKey="Guo, Z" uniqKey="Guo Z">Z Guo</name>
</author>
<author><name sortKey="He, Y" uniqKey="He Y">Y He</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoire, Ip" uniqKey="Gregoire I">IP Gregoire</name>
</author>
<author><name sortKey="Richetta, C" uniqKey="Richetta C">C Richetta</name>
</author>
<author><name sortKey="Meyniel Schicklin, L" uniqKey="Meyniel Schicklin L">L Meyniel-Schicklin</name>
</author>
<author><name sortKey="Borel, S" uniqKey="Borel S">S Borel</name>
</author>
<author><name sortKey="Pradezynski, F" uniqKey="Pradezynski F">F Pradezynski</name>
</author>
<author><name sortKey="Diaz, O" uniqKey="Diaz O">O Diaz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gregoire, Ip" uniqKey="Gregoire I">IP Gregoire</name>
</author>
<author><name sortKey="Rabourdin Combe, C" uniqKey="Rabourdin Combe C">C Rabourdin-Combe</name>
</author>
<author><name sortKey="Faure, M" uniqKey="Faure M">M Faure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petkova, Ds" uniqKey="Petkova D">DS Petkova</name>
</author>
<author><name sortKey="Viret, C" uniqKey="Viret C">C Viret</name>
</author>
<author><name sortKey="Faure, M" uniqKey="Faure M">M Faure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meiffren, G" uniqKey="Meiffren G">G Meiffren</name>
</author>
<author><name sortKey="Joubert, Pe" uniqKey="Joubert P">PE Joubert</name>
</author>
<author><name sortKey="Gregoire, Ip" uniqKey="Gregoire I">IP Gregoire</name>
</author>
<author><name sortKey="Codogno, P" uniqKey="Codogno P">P Codogno</name>
</author>
<author><name sortKey="Rabourdin Combe, C" uniqKey="Rabourdin Combe C">C Rabourdin-Combe</name>
</author>
<author><name sortKey="Faure, M" uniqKey="Faure M">M Faure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Naniche, D" uniqKey="Naniche D">D Naniche</name>
</author>
<author><name sortKey="Varior Krishnan, G" uniqKey="Varior Krishnan G">G Varior-Krishnan</name>
</author>
<author><name sortKey="Cervoni, F" uniqKey="Cervoni F">F Cervoni</name>
</author>
<author><name sortKey="Wild, Tf" uniqKey="Wild T">TF Wild</name>
</author>
<author><name sortKey="Rossi, B" uniqKey="Rossi B">B Rossi</name>
</author>
<author><name sortKey="Rabourdin Combe, C" uniqKey="Rabourdin Combe C">C Rabourdin-Combe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stolz, A" uniqKey="Stolz A">A Stolz</name>
</author>
<author><name sortKey="Ernst, A" uniqKey="Ernst A">A Ernst</name>
</author>
<author><name sortKey="Dikic, I" uniqKey="Dikic I">I Dikic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumbarello, Da" uniqKey="Tumbarello D">DA Tumbarello</name>
</author>
<author><name sortKey="Waxse, Bj" uniqKey="Waxse B">BJ Waxse</name>
</author>
<author><name sortKey="Arden, Sd" uniqKey="Arden S">SD Arden</name>
</author>
<author><name sortKey="Bright, Na" uniqKey="Bright N">NA Bright</name>
</author>
<author><name sortKey="Kendrick Jones, J" uniqKey="Kendrick Jones J">J Kendrick-Jones</name>
</author>
<author><name sortKey="Buss, F" uniqKey="Buss F">F Buss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chu, Ct" uniqKey="Chu C">CT Chu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johansen, T" uniqKey="Johansen T">T Johansen</name>
</author>
<author><name sortKey="Birgisdottir, " uniqKey="Birgisdottir ">Å Birgisdottir</name>
</author>
<author><name sortKey="Huber, J" uniqKey="Huber J">J Huber</name>
</author>
<author><name sortKey="Kniss, A" uniqKey="Kniss A">A Kniss</name>
</author>
<author><name sortKey="Dotsch, V" uniqKey="Dotsch V">V Dötsch</name>
</author>
<author><name sortKey="Kirkin, V" uniqKey="Kirkin V">V Kirkin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verlhac, P" uniqKey="Verlhac P">P Verlhac</name>
</author>
<author><name sortKey="Gregoire, Ip" uniqKey="Gregoire I">IP Gregoire</name>
</author>
<author><name sortKey="Azocar, O" uniqKey="Azocar O">O Azocar</name>
</author>
<author><name sortKey="Petkova, Ds" uniqKey="Petkova D">DS Petkova</name>
</author>
<author><name sortKey="Baguet, J" uniqKey="Baguet J">J Baguet</name>
</author>
<author><name sortKey="Viret, C" uniqKey="Viret C">C Viret</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verlhac, P" uniqKey="Verlhac P">P Verlhac</name>
</author>
<author><name sortKey="Viret, C" uniqKey="Viret C">C Viret</name>
</author>
<author><name sortKey="Faure, M" uniqKey="Faure M">M Faure</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tumbarello, Da" uniqKey="Tumbarello D">DA Tumbarello</name>
</author>
<author><name sortKey="Manna, Pt" uniqKey="Manna P">PT Manna</name>
</author>
<author><name sortKey="Allen, M" uniqKey="Allen M">M Allen</name>
</author>
<author><name sortKey="Bycroft, M" uniqKey="Bycroft M">M Bycroft</name>
</author>
<author><name sortKey="Arden, Sd" uniqKey="Arden S">SD Arden</name>
</author>
<author><name sortKey="Kendrick Jones, J" uniqKey="Kendrick Jones J">J Kendrick-Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Judith, D" uniqKey="Judith D">D Judith</name>
</author>
<author><name sortKey="Mostowy, S" uniqKey="Mostowy S">S Mostowy</name>
</author>
<author><name sortKey="Bourai, M" uniqKey="Bourai M">M Bourai</name>
</author>
<author><name sortKey="Gangneux, N" uniqKey="Gangneux N">N Gangneux</name>
</author>
<author><name sortKey="Lelek, M" uniqKey="Lelek M">M Lelek</name>
</author>
<author><name sortKey="Lucas Hourani, M" uniqKey="Lucas Hourani M">M Lucas-Hourani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sagnier, S" uniqKey="Sagnier S">S Sagnier</name>
</author>
<author><name sortKey="Daussy, Cf" uniqKey="Daussy C">CF Daussy</name>
</author>
<author><name sortKey="Borel, S" uniqKey="Borel S">S Borel</name>
</author>
<author><name sortKey="Robert Hebmann, V" uniqKey="Robert Hebmann V">V Robert-Hebmann</name>
</author>
<author><name sortKey="Faure, M" uniqKey="Faure M">M Faure</name>
</author>
<author><name sortKey="Blanchet, Fp" uniqKey="Blanchet F">FP Blanchet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Newman, Ac" uniqKey="Newman A">AC Newman</name>
</author>
<author><name sortKey="Scholefield, Cl" uniqKey="Scholefield C">CL Scholefield</name>
</author>
<author><name sortKey="Kemp, Aj" uniqKey="Kemp A">AJ Kemp</name>
</author>
<author><name sortKey="Newman, M" uniqKey="Newman M">M Newman</name>
</author>
<author><name sortKey="Mciver, Eg" uniqKey="Mciver E">EG McIver</name>
</author>
<author><name sortKey="Kamal, A" uniqKey="Kamal A">A Kamal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kachaner, D" uniqKey="Kachaner D">D Kachaner</name>
</author>
<author><name sortKey="Genin, P" uniqKey="Genin P">P Genin</name>
</author>
<author><name sortKey="Laplantine, E" uniqKey="Laplantine E">E Laplantine</name>
</author>
<author><name sortKey="Weil, R" uniqKey="Weil R">R Weil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansen, Md" uniqKey="Hansen M">MD Hansen</name>
</author>
<author><name sortKey="Johnsen, Ib" uniqKey="Johnsen I">IB Johnsen</name>
</author>
<author><name sortKey="Stiberg, Ka" uniqKey="Stiberg K">KA Stiberg</name>
</author>
<author><name sortKey="Sherstova, T" uniqKey="Sherstova T">T Sherstova</name>
</author>
<author><name sortKey="Wakita, T" uniqKey="Wakita T">T Wakita</name>
</author>
<author><name sortKey="Richard, Gm" uniqKey="Richard G">GM Richard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, Ym" uniqKey="Kim Y">YM Kim</name>
</author>
<author><name sortKey="Jung, Ch" uniqKey="Jung C">CH Jung</name>
</author>
<author><name sortKey="Seo, M" uniqKey="Seo M">M Seo</name>
</author>
<author><name sortKey="Kim, Ek" uniqKey="Kim E">EK Kim</name>
</author>
<author><name sortKey="Park, Jm" uniqKey="Park J">JM Park</name>
</author>
<author><name sortKey="Bae, Ss" uniqKey="Bae S">SS Bae</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jheng, Jr" uniqKey="Jheng J">JR Jheng</name>
</author>
<author><name sortKey="Ho, Jy" uniqKey="Ho J">JY Ho</name>
</author>
<author><name sortKey="Horng, Jt" uniqKey="Horng J">JT Horng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Yr" uniqKey="Lee Y">YR Lee</name>
</author>
<author><name sortKey="Kuo, Sh" uniqKey="Kuo S">SH Kuo</name>
</author>
<author><name sortKey="Lin, Cy" uniqKey="Lin C">CY Lin</name>
</author>
<author><name sortKey="Fu, Pj" uniqKey="Fu P">PJ Fu</name>
</author>
<author><name sortKey="Lin, Ys" uniqKey="Lin Y">YS Lin</name>
</author>
<author><name sortKey="Yeh, Tm" uniqKey="Yeh T">TM Yeh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Iranpour, M" uniqKey="Iranpour M">M Iranpour</name>
</author>
<author><name sortKey="Moghadam, Ar" uniqKey="Moghadam A">AR Moghadam</name>
</author>
<author><name sortKey="Yazdi, M" uniqKey="Yazdi M">M Yazdi</name>
</author>
<author><name sortKey="Ande, Sr" uniqKey="Ande S">SR Ande</name>
</author>
<author><name sortKey="Alizadeh, J" uniqKey="Alizadeh J">J Alizadeh</name>
</author>
<author><name sortKey="Wiechec, E" uniqKey="Wiechec E">E Wiechec</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y. Sun</name>
</author>
<author><name sortKey="Yu, S" uniqKey="Yu S">S. Yu</name>
</author>
<author><name sortKey="Ding, N" uniqKey="Ding N">N. Ding</name>
</author>
<author><name sortKey="Meng, C" uniqKey="Meng C">C. Meng</name>
</author>
<author><name sortKey="Meng, S" uniqKey="Meng S">S. Meng</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name>
</author>
<author><name sortKey="Zhan, Y" uniqKey="Zhan Y">Y. Zhan</name>
</author>
<author><name sortKey="Qiu, X" uniqKey="Qiu X">X. Qiu</name>
</author>
<author><name sortKey="Tan, L" uniqKey="Tan L">L. Tan</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name>
</author>
<author><name sortKey="Song, C" uniqKey="Song C">C. Song</name>
</author>
<author><name sortKey="Ding, C" uniqKey="Ding C">C. Ding</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meng, C" uniqKey="Meng C">C Meng</name>
</author>
<author><name sortKey="Zhou, Z" uniqKey="Zhou Z">Z Zhou</name>
</author>
<author><name sortKey="Jiang, K" uniqKey="Jiang K">K Jiang</name>
</author>
<author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name>
</author>
<author><name sortKey="Jia, L" uniqKey="Jia L">L Jia</name>
</author>
<author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Harrison, L" uniqKey="Harrison L">L Harrison</name>
</author>
<author><name sortKey="Brown, C" uniqKey="Brown C">C Brown</name>
</author>
<author><name sortKey="Afonso, C" uniqKey="Afonso C">C Afonso</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J Zhang</name>
</author>
<author><name sortKey="Susta, L" uniqKey="Susta L">L Susta</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bu, X" uniqKey="Bu X">X Bu</name>
</author>
<author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y Zhao</name>
</author>
<author><name sortKey="Zhang, Z" uniqKey="Zhang Z">Z Zhang</name>
</author>
<author><name sortKey="Wang, M" uniqKey="Wang M">M Wang</name>
</author>
<author><name sortKey="Li, M" uniqKey="Li M">M Li</name>
</author>
<author><name sortKey="Yan, Y" uniqKey="Yan Y">Y Yan</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
</author>
<author><name sortKey="Yu, S" uniqKey="Yu S">S Yu</name>
</author>
<author><name sortKey="Ding, N" uniqKey="Ding N">N Ding</name>
</author>
<author><name sortKey="Meng, C" uniqKey="Meng C">C Meng</name>
</author>
<author><name sortKey="Meng, S" uniqKey="Meng S">S Meng</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, K" uniqKey="Jiang K">K Jiang</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name>
</author>
<author><name sortKey="Zhu, Q" uniqKey="Zhu Q">Q Zhu</name>
</author>
<author><name sortKey="Xu, J" uniqKey="Xu J">J Xu</name>
</author>
<author><name sortKey="Wang, Y" uniqKey="Wang Y">Y Wang</name>
</author>
<author><name sortKey="Deng, W" uniqKey="Deng W">W Deng</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Inoue, H" uniqKey="Inoue H">H Inoue</name>
</author>
<author><name sortKey="Tani, K" uniqKey="Tani K">K Tani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Workenhe, St" uniqKey="Workenhe S">ST Workenhe</name>
</author>
<author><name sortKey="Mossman, Kl" uniqKey="Mossman K">KL Mossman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kepp, O" uniqKey="Kepp O">O Kepp</name>
</author>
<author><name sortKey="Senovilla, L" uniqKey="Senovilla L">L Senovilla</name>
</author>
<author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L Galluzzi</name>
</author>
<author><name sortKey="Panaretakis, T" uniqKey="Panaretakis T">T Panaretakis</name>
</author>
<author><name sortKey="Tesniere, A" uniqKey="Tesniere A">A Tesniere</name>
</author>
<author><name sortKey="Schlemmer, F" uniqKey="Schlemmer F">F Schlemmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ye, T" uniqKey="Ye T">T Ye</name>
</author>
<author><name sortKey="Jiang, K" uniqKey="Jiang K">K Jiang</name>
</author>
<author><name sortKey="Wei, L" uniqKey="Wei L">L Wei</name>
</author>
<author><name sortKey="Barr, Mp" uniqKey="Barr M">MP Barr</name>
</author>
<author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name>
</author>
<author><name sortKey="Zhang, G" uniqKey="Zhang G">G Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koks, Ca" uniqKey="Koks C">CA Koks</name>
</author>
<author><name sortKey="Garg, Ad" uniqKey="Garg A">AD Garg</name>
</author>
<author><name sortKey="Ehrhardt, M" uniqKey="Ehrhardt M">M Ehrhardt</name>
</author>
<author><name sortKey="Riva, M" uniqKey="Riva M">M Riva</name>
</author>
<author><name sortKey="Vandenberk, L" uniqKey="Vandenberk L">L Vandenberk</name>
</author>
<author><name sortKey="Boon, L" uniqKey="Boon L">L Boon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Biesbroeck, L" uniqKey="Biesbroeck L">L Biesbroeck</name>
</author>
<author><name sortKey="Sidbury, R" uniqKey="Sidbury R">R Sidbury</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ludlow, M" uniqKey="Ludlow M">M Ludlow</name>
</author>
<author><name sortKey="Mcquaid, S" uniqKey="Mcquaid S">S McQuaid</name>
</author>
<author><name sortKey="Milner, D" uniqKey="Milner D">D Milner</name>
</author>
<author><name sortKey="De Swart, Rl" uniqKey="De Swart R">RL de Swart</name>
</author>
<author><name sortKey="Duprex, Wp" uniqKey="Duprex W">WP Duprex</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Russell, Sj" uniqKey="Russell S">SJ Russell</name>
</author>
<author><name sortKey="Peng, Kw" uniqKey="Peng K">KW Peng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blechacz, B" uniqKey="Blechacz B">B Blechacz</name>
</author>
<author><name sortKey="Russell, Sj" uniqKey="Russell S">SJ Russell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xia, M" uniqKey="Xia M">M Xia</name>
</author>
<author><name sortKey="Gonzalez, P" uniqKey="Gonzalez P">P Gonzalez</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C Li</name>
</author>
<author><name sortKey="Meng, G" uniqKey="Meng G">G Meng</name>
</author>
<author><name sortKey="Jiang, A" uniqKey="Jiang A">A Jiang</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xia, M" uniqKey="Xia M">M Xia</name>
</author>
<author><name sortKey="Meng, G" uniqKey="Meng G">G Meng</name>
</author>
<author><name sortKey="Jiang, A" uniqKey="Jiang A">A Jiang</name>
</author>
<author><name sortKey="Chen, A" uniqKey="Chen A">A Chen</name>
</author>
<author><name sortKey="Dahlhaus, M" uniqKey="Dahlhaus M">M Dahlhaus</name>
</author>
<author><name sortKey="Gonzalez, P" uniqKey="Gonzalez P">P Gonzalez</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Henrickson, Kj" uniqKey="Henrickson K">KJ Henrickson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Branche, Ar" uniqKey="Branche A">AR Branche</name>
</author>
<author><name sortKey="Falsey, Ar" uniqKey="Falsey A">AR Falsey</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
<author><name sortKey="Zhu, H" uniqKey="Zhu H">H Zhu</name>
</author>
<author><name sortKey="Xu, X" uniqKey="Xu X">X Xu</name>
</author>
<author><name sortKey="Li, L" uniqKey="Li L">L Li</name>
</author>
<author><name sortKey="Tan, H" uniqKey="Tan H">H Tan</name>
</author>
<author><name sortKey="Cai, X" uniqKey="Cai X">X Cai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name>
</author>
<author><name sortKey="Yu, N" uniqKey="Yu N">N Yu</name>
</author>
<author><name sortKey="Qian, M" uniqKey="Qian M">M Qian</name>
</author>
<author><name sortKey="Feng, J" uniqKey="Feng J">J Feng</name>
</author>
<author><name sortKey="Cao, S" uniqKey="Cao S">S Cao</name>
</author>
<author><name sortKey="Yin, J" uniqKey="Yin J">J Yin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Qian, M" uniqKey="Qian M">M Qian</name>
</author>
<author><name sortKey="Tan, Hm" uniqKey="Tan H">HM Tan</name>
</author>
<author><name sortKey="Yu, N" uniqKey="Yu N">N Yu</name>
</author>
<author><name sortKey="Wang, T" uniqKey="Wang T">T Wang</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhirnov, O" uniqKey="Zhirnov O">O Zhirnov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tian, Y" uniqKey="Tian Y">Y Tian</name>
</author>
<author><name sortKey="Wang, M L" uniqKey="Wang M">M-L Wang</name>
</author>
<author><name sortKey="Zhao, J" uniqKey="Zhao J">J Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Subramanian, G" uniqKey="Subramanian G">G Subramanian</name>
</author>
<author><name sortKey="Kuzmanovic, T" uniqKey="Kuzmanovic T">T Kuzmanovic</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
<author><name sortKey="Peter, Cb" uniqKey="Peter C">CB Peter</name>
</author>
<author><name sortKey="Veleeparambil, M" uniqKey="Veleeparambil M">M Veleeparambil</name>
</author>
<author><name sortKey="Chakravarti, R" uniqKey="Chakravarti R">R Chakravarti</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kabak, Yb" uniqKey="Kabak Y">YB Kabak</name>
</author>
<author><name sortKey="Sozmen, M" uniqKey="Sozmen M">M Sozmen</name>
</author>
<author><name sortKey="Yarim, M" uniqKey="Yarim M">M Yarim</name>
</author>
<author><name sortKey="Guvenc, T" uniqKey="Guvenc T">T Guvenc</name>
</author>
<author><name sortKey="Karayigit, Mo" uniqKey="Karayigit M">MO Karayigit</name>
</author>
<author><name sortKey="Gulbahar, My" uniqKey="Gulbahar M">MY Gulbahar</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biomed Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Biomed. Sci</journal-id>
<journal-title-group><journal-title>Journal of Biomedical Science</journal-title>
</journal-title-group>
<issn pub-type="ppub">1021-7770</issn>
<issn pub-type="epub">1423-0127</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31217023</article-id>
<article-id pub-id-type="pmc">6585078</article-id>
<article-id pub-id-type="publisher-id">542</article-id>
<article-id pub-id-type="doi">10.1186/s12929-019-0542-9</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Oncolytic paramyxoviruses-induced autophagy; a prudent weapon for cancer therapy</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Keshavarz</surname>
<given-names>Mohsen</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Solaymani-Mohammadi</surname>
<given-names>Farid</given-names>
</name>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miri</surname>
<given-names>Seyed Mohammad</given-names>
</name>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Ghaemi</surname>
<given-names>Amir</given-names>
</name>
<address><email>ghaem_amir@yahoo.com</email>
<email>a_ghaemi@pasteur.ac.ir</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="GRID">grid.411832.d</institution-id>
<institution>The Persian Gulf Tropical Medicine Research Center, The Persian Gulf Biomedical Sciences Research Institute,</institution>
<institution>Bushehr University of Medical Sciences,</institution>
</institution-wrap>
Bushehr, Iran</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 4911 7066</institution-id>
<institution-id institution-id-type="GRID">grid.411746.1</institution-id>
<institution>Department of Virology, School of Medicine,</institution>
<institution>Iran University of Medical Sciences,</institution>
</institution-wrap>
Tehran, Iran</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0166 0922</institution-id>
<institution-id institution-id-type="GRID">grid.411705.6</institution-id>
<institution>Department of Virology, School of Public Health,</institution>
<institution>Tehran University of Medical Sciences,</institution>
</institution-wrap>
Tehran, Iran</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0740 9747</institution-id>
<institution-id institution-id-type="GRID">grid.412553.4</institution-id>
<institution>Department of Chemistry,</institution>
<institution>Sharif University of Technology,</institution>
</institution-wrap>
Tehran, Iran</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9562 2611</institution-id>
<institution-id institution-id-type="GRID">grid.420169.8</institution-id>
<institution>Department of Virology,</institution>
<institution>Pasteur Institute of Iran,</institution>
</institution-wrap>
P.O.Box: 1316943551, Tehran, Iran</aff>
</contrib-group>
<pub-date pub-type="epub"><day>19</day>
<month>6</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>19</day>
<month>6</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>26</volume>
<elocation-id>48</elocation-id>
<history><date date-type="received"><day>2</day>
<month>4</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>12</day>
<month>6</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Oncolytic virotherapy has currently emerged as a promising approach upon which scientists have been able to induce tumor-specific cell death in a broad spectrum of malignancies. Paramyxoviruses represent intrinsic oncolytic capability, which makes them excellent candidates to be widely used in oncolytic virotherapy. The mechanisms through which these viruses destroy the cancerous cells involve triggering the autophagic machinery and apoptosis in target cells. Interestingly, oncolytic paramyxoviruses have been found to induce autophagy and lead to tumor cells death rather than their survival. Indeed, the induction of autophagy has been revealed to enhance the immunogenicity of tumor cells via the release of damage-associated molecular patterns (DAMPs) and the activation of autophagy-related immunogenic cell death (ICD). Subsequent cross-presentation of tumor-associated antigens (TAA) through the MHC-I complex to CD8+ T cells results in the productive priming of the tumor-specific immune response. In this review, we first briefly discuss autophagy and explain the process of viral xenophagy. Finally, we focus on the interactions between virus and autophagy proteins, elaborating on the global preclinical studies on oncolytic paramyxoviruses.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Oncolytic virotherapy</kwd>
<kwd>Paramyxovirus</kwd>
<kwd>Autophagy</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100003968</institution-id>
<institution>Iran National Science Foundation</institution>
</institution-wrap>
</funding-source>
<award-id>95830094</award-id>
<principal-award-recipient><name><surname>Ghaemi</surname>
<given-names>Amir</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Iran</li>
</country>
</list>
<tree><country name="Iran"><noRegion><name sortKey="Keshavarz, Mohsen" sort="Keshavarz, Mohsen" uniqKey="Keshavarz M" first="Mohsen" last="Keshavarz">Mohsen Keshavarz</name>
</noRegion>
<name sortKey="Ghaemi, Amir" sort="Ghaemi, Amir" uniqKey="Ghaemi A" first="Amir" last="Ghaemi">Amir Ghaemi</name>
<name sortKey="Keshavarz, Mohsen" sort="Keshavarz, Mohsen" uniqKey="Keshavarz M" first="Mohsen" last="Keshavarz">Mohsen Keshavarz</name>
<name sortKey="Miri, Seyed Mohammad" sort="Miri, Seyed Mohammad" uniqKey="Miri S" first="Seyed Mohammad" last="Miri">Seyed Mohammad Miri</name>
<name sortKey="Solaymani Mohammadi, Farid" sort="Solaymani Mohammadi, Farid" uniqKey="Solaymani Mohammadi F" first="Farid" last="Solaymani-Mohammadi">Farid Solaymani-Mohammadi</name>
</country>
</tree>
</affiliations>
</record>
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