Receptor targeting drug delivery strategies and prospects in the treatment of rheumatoid arthritis
Identifieur interne : 000436 ( Pmc/Checkpoint ); précédent : 000435; suivant : 000437Receptor targeting drug delivery strategies and prospects in the treatment of rheumatoid arthritis
Auteurs : Jaber Emami ; Zahra AnsarypourSource :
- Research in Pharmaceutical Sciences [ 1735-5362 ] ; 2019.
Abstract
Rheumatoid arthritis (RA), a chronic inflammatory disease, is characterized by cartilage damage, bone tissue destruction, morphological changes in synovial fluids, and synovial joint inflammation. The inflamed synovial tissue has potential for passive and active targeting because of enhanced permeability and retention effect and the existence of RA synovial macrophages and fibroblasts that selectively express surface receptors such as folate receptor β, CD44 and integrin αVβ. Although there are numerous interventions in RA treatment, they are not safe and effective. Therefore, it is important to develop new drug or drug delivery systems that specifically targets inflamed/swollen joints but attenuates other possible damages to healthy tissues. Recently some receptors such as toll-like receptors (TLRs), the nucleotide-binding oligomerization domain-like receptors, and Fc-γ receptor have been identified in synovial tissue and immune cells that are involved in induction or suppression of arthritis. Analysis of the TLR pathway has moreover suggested new insights into the pathogenesis of RA. In the present paper, we have reviewed drug delivery strategies based on receptor targeting with novel ligand-anchored carriers exploiting CD44, folate and integrin αVβ as well as TLRs expressed on synovial monocytes and macrophages and antigen presenting cells, for possible active targeting in RA. TLRs could not only open a new horizon for developing new drugs but also their antagonists or humanized monoclonal antibodies that block TLRS specially TLR4 and TLR9 signaling could be used as targeting agents to antigen presenting cells and dendritic cells. As a conclusion, common conventional receptors and multifunctional ligands that arte involved in targeting receptors or developing nanocarriers with appropriate ligands for TLRs can provide profoundly targeting drug delivery systems for the effective treatment of RA.
Url:
DOI: 10.4103/1735-5362.272534
PubMed: 32038727
PubMed Central: 6937749
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Rheumatoid arthritis (RA), a chronic inflammatory disease, is characterized by cartilage damage, bone tissue destruction, morphological changes in synovial fluids, and synovial joint inflammation. The inflamed synovial tissue has potential for passive and active targeting because of enhanced permeability and retention effect and the existence of RA synovial macrophages and fibroblasts that selectively express surface receptors such as folate receptor β, CD44 and integrin αVβ. Although there are numerous interventions in RA treatment, they are not safe and effective. Therefore, it is important to develop new drug or drug delivery systems that specifically targets inflamed/swollen joints but attenuates other possible damages to healthy tissues. Recently some receptors such as toll-like receptors (TLRs), the nucleotide-binding oligomerization domain-like receptors, and Fc-γ receptor have been identified in synovial tissue and immune cells that are involved in induction or suppression of arthritis. Analysis of the TLR pathway has moreover suggested new insights into the pathogenesis of RA. In the present paper, we have reviewed drug delivery strategies based on receptor targeting with novel ligand-anchored carriers exploiting CD44, folate and integrin αVβ as well as TLRs expressed on synovial monocytes and macrophages and antigen presenting cells, for possible active targeting in RA. TLRs could not only open a new horizon for developing new drugs but also their antagonists or humanized monoclonal antibodies that block TLRS specially TLR4 and TLR9 signaling could be used as targeting agents to antigen presenting cells and dendritic cells. As a conclusion, common conventional receptors and multifunctional ligands that arte involved in targeting receptors or developing nanocarriers with appropriate ligands for TLRs can provide profoundly targeting drug delivery systems for the effective treatment of RA.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Res Pharm Sci</journal-id>
<journal-id journal-id-type="iso-abbrev">Res Pharm Sci</journal-id>
<journal-id journal-id-type="publisher-id">RPS</journal-id>
<journal-title-group><journal-title>Research in Pharmaceutical Sciences</journal-title>
</journal-title-group>
<issn pub-type="ppub">1735-5362</issn>
<issn pub-type="epub">1735-9414</issn>
<publisher><publisher-name>Wolters Kluwer - Medknow</publisher-name>
<publisher-loc>India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32038727</article-id>
<article-id pub-id-type="pmc">6937749</article-id>
<article-id pub-id-type="publisher-id">RPS-14-471</article-id>
<article-id pub-id-type="doi">10.4103/1735-5362.272534</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Receptor targeting drug delivery strategies and prospects in the treatment of rheumatoid arthritis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Emami</surname>
<given-names>Jaber</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ansarypour</surname>
<given-names>Zahra</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
</contrib-group>
<aff id="aff1"><italic>Department of Pharmaceutics, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, I.R. Iran</italic>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author: J. Emami Tel: +98-3137927111, Fax: +98-3136680011 Email: <email xlink:href="Emami@pharm.mui.ac.ir">Emami@pharm.mui.ac.ir</email>
</corresp>
</author-notes>
<pub-date pub-type="collection"><month>12</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>12</month>
<year>2019</year>
</pub-date>
<volume>14</volume>
<issue>6</issue>
<fpage>471</fpage>
<lpage>487</lpage>
<history><date date-type="received"><month>9</month>
<year>2019</year>
</date>
<date date-type="accepted"><month>11</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2019 Research in Pharmaceutical Sciences</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0"><license-p>This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.</license-p>
</license>
</permissions>
<abstract><p>Rheumatoid arthritis (RA), a chronic inflammatory disease, is characterized by cartilage damage, bone tissue destruction, morphological changes in synovial fluids, and synovial joint inflammation. The inflamed synovial tissue has potential for passive and active targeting because of enhanced permeability and retention effect and the existence of RA synovial macrophages and fibroblasts that selectively express surface receptors such as folate receptor β, CD44 and integrin αVβ. Although there are numerous interventions in RA treatment, they are not safe and effective. Therefore, it is important to develop new drug or drug delivery systems that specifically targets inflamed/swollen joints but attenuates other possible damages to healthy tissues. Recently some receptors such as toll-like receptors (TLRs), the nucleotide-binding oligomerization domain-like receptors, and Fc-γ receptor have been identified in synovial tissue and immune cells that are involved in induction or suppression of arthritis. Analysis of the TLR pathway has moreover suggested new insights into the pathogenesis of RA. In the present paper, we have reviewed drug delivery strategies based on receptor targeting with novel ligand-anchored carriers exploiting CD44, folate and integrin αVβ as well as TLRs expressed on synovial monocytes and macrophages and antigen presenting cells, for possible active targeting in RA. TLRs could not only open a new horizon for developing new drugs but also their antagonists or humanized monoclonal antibodies that block TLRS specially TLR4 and TLR9 signaling could be used as targeting agents to antigen presenting cells and dendritic cells. As a conclusion, common conventional receptors and multifunctional ligands that arte involved in targeting receptors or developing nanocarriers with appropriate ligands for TLRs can provide profoundly targeting drug delivery systems for the effective treatment of RA.</p>
</abstract>
<kwd-group><kwd>Delivery</kwd>
<kwd>Drug</kwd>
<kwd>Inflammation</kwd>
<kwd>Receptor</kwd>
<kwd>Rheumatoid arthritis</kwd>
<kwd>Target</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Ansarypour, Zahra" sort="Ansarypour, Zahra" uniqKey="Ansarypour Z" first="Zahra" last="Ansarypour">Zahra Ansarypour</name>
<name sortKey="Emami, Jaber" sort="Emami, Jaber" uniqKey="Emami J" first="Jaber" last="Emami">Jaber Emami</name>
</noCountry>
</tree>
</affiliations>
</record>
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