Tenosynovitis Induced by an Immune Checkpoint Inhibitor: A Case Report and Literature Review
Identifieur interne : 000339 ( Pmc/Checkpoint ); précédent : 000338; suivant : 000340Tenosynovitis Induced by an Immune Checkpoint Inhibitor: A Case Report and Literature Review
Auteurs : Shoko Murakami [Japon] ; Tatsuya Nagano [Japon] ; Kyosuke Nakata [Japon] ; Akira Onishi [Japon] ; Kanoko Umezawa [Japon] ; Naoko Katsurada [Japon] ; Masatsugu Yamamoto [Japon] ; Motoko Tachihara [Japon] ; Kazuyuki Kobayashi [Japon] ; Yoshihiro Nishimura [Japon]Source :
- Internal Medicine [ 0918-2918 ] ; 2019.
Abstract
A 51-year-old man underwent second-line treatment for non-small-cell lung cancer (NSCLC) with the immune checkpoint inhibitor (ICI) pembrolizumab. On day 2 after two cycles of pembrolizumab, he presented with edema limited to the left third, fourth, and fifth fingers. Based on symptoms, laboratory results, and contrast-enhanced magnetic resonance imaging (MRI) findings, we diagnosed him with tenosynovitis. We prescribed oral prednisolone (0.5 mg/kg/day), and pembrolizumab was continued. Prednisolone immediately relieved the symptoms, and the tumor was still shrinking on day 21 after eight cycles of pembrolizumab. ICI-induced tenosynovitis was managed while continuing ICI usage, suggesting that 0.5 mg/kg/day prednisone might be effective for tenosynovitis without ICI cessation.
Url:
DOI: 10.2169/internalmedicine.2556-19
PubMed: 31243239
PubMed Central: 6815895
Affiliations:
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Akira" uniqKey="Onishi A" first="Akira" last="Onishi">Akira Onishi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Umezawa, Kanoko" sort="Umezawa, Kanoko" uniqKey="Umezawa K" first="Kanoko" last="Umezawa">Kanoko Umezawa</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of 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sort="Kobayashi, Kazuyuki" uniqKey="Kobayashi K" first="Kazuyuki" last="Kobayashi">Kazuyuki Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Nishimura, Yoshihiro" sort="Nishimura, Yoshihiro" uniqKey="Nishimura Y" first="Yoshihiro" last="Nishimura">Yoshihiro Nishimura</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department 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level="a" type="main">Tenosynovitis Induced by an Immune Checkpoint Inhibitor: A Case Report and Literature Review</title><author><name sortKey="Murakami, Shoko" sort="Murakami, Shoko" uniqKey="Murakami S" first="Shoko" last="Murakami">Shoko Murakami</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Nagano, Tatsuya" sort="Nagano, Tatsuya" uniqKey="Nagano T" first="Tatsuya" last="Nagano">Tatsuya Nagano</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Nakata, Kyosuke" sort="Nakata, Kyosuke" uniqKey="Nakata K" first="Kyosuke" last="Nakata">Kyosuke Nakata</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Onishi, Akira" sort="Onishi, Akira" uniqKey="Onishi A" first="Akira" last="Onishi">Akira Onishi</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Umezawa, Kanoko" sort="Umezawa, Kanoko" uniqKey="Umezawa K" first="Kanoko" last="Umezawa">Kanoko Umezawa</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Katsurada, Naoko" sort="Katsurada, Naoko" uniqKey="Katsurada N" first="Naoko" last="Katsurada">Naoko Katsurada</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Yamamoto, Masatsugu" sort="Yamamoto, Masatsugu" uniqKey="Yamamoto M" first="Masatsugu" last="Yamamoto">Masatsugu Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Tachihara, Motoko" sort="Tachihara, Motoko" uniqKey="Tachihara M" first="Motoko" last="Tachihara">Motoko Tachihara</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Kobayashi, Kazuyuki" sort="Kobayashi, Kazuyuki" uniqKey="Kobayashi K" first="Kazuyuki" last="Kobayashi">Kazuyuki Kobayashi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Nishimura, Yoshihiro" sort="Nishimura, Yoshihiro" uniqKey="Nishimura Y" first="Yoshihiro" last="Nishimura">Yoshihiro Nishimura</name><affiliation wicri:level="1"><nlm:aff id="aff1">Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine</wicri:regionArea><wicri:noRegion>Kobe University Graduate School of Medicine</wicri:noRegion></affiliation></author></analytic><series><title level="j">Internal Medicine</title><idno type="ISSN">0918-2918</idno><idno type="eISSN">1349-7235</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A 51-year-old man underwent second-line treatment for non-small-cell lung cancer (NSCLC) with the immune checkpoint inhibitor (ICI) pembrolizumab. On day 2 after two cycles of pembrolizumab, he presented with edema limited to the left third, fourth, and fifth fingers. Based on symptoms, laboratory results, and contrast-enhanced magnetic resonance imaging (MRI) findings, we diagnosed him with tenosynovitis. We prescribed oral prednisolone (0.5 mg/kg/day), and pembrolizumab was continued. Prednisolone immediately relieved the symptoms, and the tumor was still shrinking on day 21 after eight cycles of pembrolizumab. ICI-induced tenosynovitis was managed while continuing ICI usage, suggesting that 0.5 mg/kg/day prednisone might be effective for tenosynovitis without ICI cessation. </p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Haanen, Jb" uniqKey="Haanen J">JB Haanen</name></author><author><name sortKey="Thienen, H" uniqKey="Thienen H">H Thienen</name></author><author><name sortKey="Blank, Cu" uniqKey="Blank C">CU Blank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Good Jacobson, Kl" uniqKey="Good Jacobson K">KL Good-Jacobson</name></author><author><name sortKey="Szumilas, Cg" uniqKey="Szumilas C">CG Szumilas</name></author><author><name sortKey="Chen, L" uniqKey="Chen L">L Chen</name></author><author><name sortKey="Sharpe, Ah" uniqKey="Sharpe A">AH Sharpe</name></author><author><name sortKey="Tomayko, Mm" uniqKey="Tomayko M">MM Tomayko</name></author><author><name sortKey="Shlomchik, Mj" 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Santini</name></author><author><name sortKey="Rizvi, H" uniqKey="Rizvi H">H Rizvi</name></author><author><name sortKey="Plodkowski, Aj" uniqKey="Plodkowski A">AJ Plodkowski</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Intern Med</journal-id><journal-id journal-id-type="iso-abbrev">Intern. Med</journal-id><journal-title-group><journal-title>Internal Medicine</journal-title></journal-title-group><issn pub-type="ppub">0918-2918</issn><issn pub-type="epub">1349-7235</issn><publisher><publisher-name>The Japanese Society of Internal Medicine</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31243239</article-id><article-id pub-id-type="pmc">6815895</article-id><article-id pub-id-type="doi">10.2169/internalmedicine.2556-19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Tenosynovitis Induced by an Immune Checkpoint Inhibitor: A Case Report and Literature Review</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Murakami</surname><given-names>Shoko</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nagano</surname><given-names>Tatsuya</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nakata</surname><given-names>Kyosuke</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Onishi</surname><given-names>Akira</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Umezawa</surname><given-names>Kanoko</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Katsurada</surname><given-names>Naoko</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Yamamoto</surname><given-names>Masatsugu</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Tachihara</surname><given-names>Motoko</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kobayashi</surname><given-names>Kazuyuki</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nishimura</surname><given-names>Yoshihiro</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><aff id="aff1"><label>1</label>Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan</aff><aff id="aff2"><label>2</label>Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Japan</aff></contrib-group><author-notes><fn><p>Correspondence to Dr. Tatsuya Nagano, <email>tnagano@med.kobe-u.ac.jp</email></p></fn></author-notes><pub-date pub-type="epub"><day>27</day><month>6</month><year>2019</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>10</month><year>2019</year></pub-date><volume>58</volume><issue>19</issue><fpage>2839</fpage><lpage>2843</lpage><history><date date-type="received"><day>12</day><month>1</month><year>2019</year></date><date date-type="accepted"><day>14</day><month>4</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 by The Japanese Society of Internal Medicine</copyright-statement><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by-nc-nd/4.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link>).</license-p></license></permissions><abstract><p>A 51-year-old man underwent second-line treatment for non-small-cell lung cancer (NSCLC) with the immune checkpoint inhibitor (ICI) pembrolizumab. On day 2 after two cycles of pembrolizumab, he presented with edema limited to the left third, fourth, and fifth fingers. Based on symptoms, laboratory results, and contrast-enhanced magnetic resonance imaging (MRI) findings, we diagnosed him with tenosynovitis. We prescribed oral prednisolone (0.5 mg/kg/day), and pembrolizumab was continued. Prednisolone immediately relieved the symptoms, and the tumor was still shrinking on day 21 after eight cycles of pembrolizumab. ICI-induced tenosynovitis was managed while continuing ICI usage, suggesting that 0.5 mg/kg/day prednisone might be effective for tenosynovitis without ICI cessation. </p></abstract><kwd-group kwd-group-type="author"><kwd>tenosynovitis</kwd><kwd>pembrolizumab</kwd><kwd>prednisolone</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Murakami, Shoko" sort="Murakami, Shoko" uniqKey="Murakami S" first="Shoko" last="Murakami">Shoko Murakami</name></noRegion><name sortKey="Katsurada, Naoko" sort="Katsurada, Naoko" uniqKey="Katsurada N" first="Naoko" last="Katsurada">Naoko Katsurada</name><name sortKey="Kobayashi, Kazuyuki" sort="Kobayashi, Kazuyuki" uniqKey="Kobayashi K" first="Kazuyuki" last="Kobayashi">Kazuyuki Kobayashi</name><name sortKey="Nagano, Tatsuya" sort="Nagano, Tatsuya" uniqKey="Nagano T" first="Tatsuya" last="Nagano">Tatsuya Nagano</name><name sortKey="Nakata, Kyosuke" sort="Nakata, Kyosuke" uniqKey="Nakata K" first="Kyosuke" last="Nakata">Kyosuke Nakata</name><name sortKey="Nishimura, Yoshihiro" sort="Nishimura, Yoshihiro" uniqKey="Nishimura Y" first="Yoshihiro" last="Nishimura">Yoshihiro Nishimura</name><name sortKey="Onishi, Akira" sort="Onishi, Akira" uniqKey="Onishi A" first="Akira" last="Onishi">Akira Onishi</name><name sortKey="Tachihara, Motoko" sort="Tachihara, Motoko" uniqKey="Tachihara M" first="Motoko" last="Tachihara">Motoko Tachihara</name><name sortKey="Umezawa, Kanoko" sort="Umezawa, Kanoko" uniqKey="Umezawa K" first="Kanoko" last="Umezawa">Kanoko Umezawa</name><name sortKey="Yamamoto, Masatsugu" sort="Yamamoto, Masatsugu" uniqKey="Yamamoto M" first="Masatsugu" last="Yamamoto">Masatsugu Yamamoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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