The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
Identifieur interne : 000311 ( Pmc/Checkpoint ); précédent : 000310; suivant : 000312The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer
Auteurs : Yuanliang Yan ; Xi Chen ; Xiang Wang ; Zijin Zhao ; Wenfeng Hu ; Shuangshuang Zeng ; Jie Wei ; Xue Yang ; Long Qian ; Shuyi Zhou ; Lunquan Sun ; Zhicheng Gong ; Zhijie XuSource :
- Journal of Experimental & Clinical Cancer Research : CR [ 0392-9078 ] ; 2019.
Abstract
Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. Targeting autophagy has gained interest with multiple preclinical and clinical trials, such as the pharmacological inhibitor chloroquine or the inducer rapamycin, especially in exploiting its ability to modulate the secretory capability of CAFs to enhance drug delivery or inhibit it to prevent its influence on cancer cell chemoresistance. In this review, we summarize the reports on autophagy in cancer-associated fibroblasts by detailing the mechanism and role of autophagy in CAFs, including the hypoxic-autophagy positive feedback cycle, the metabolic cross-talk between CAFs and tumors induced by autophagy, CAFs secreted cytokines promote cancer survival by secretory autophagy, CAFs autophagy-induced EMT, stemness, senescence and treatment sensitivity, as well as the research of antitumor chemicals, miRNAs and lncRNAs. Additionally, we discuss the evidence of molecules in CAFs that are relevant to autophagy and the contribution to sensitive treatments as a potential target for cancer treatment.
Url:
DOI: 10.1186/s13046-019-1172-5
PubMed: 31014370
PubMed Central: 6480893
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer</title>
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<author><name sortKey="Zhao, Zijin" sort="Zhao, Zijin" uniqKey="Zhao Z" first="Zijin" last="Zhao">Zijin Zhao</name>
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<author><name sortKey="Hu, Wenfeng" sort="Hu, Wenfeng" uniqKey="Hu W" first="Wenfeng" last="Hu">Wenfeng Hu</name>
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<author><name sortKey="Wei, Jie" sort="Wei, Jie" uniqKey="Wei J" first="Jie" last="Wei">Jie Wei</name>
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<author><name sortKey="Yang, Xue" sort="Yang, Xue" uniqKey="Yang X" first="Xue" last="Yang">Xue Yang</name>
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<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>National Clinical Research Center for Geriatric Disorders,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</nlm:aff>
<wicri:noCountry code="subfield">410008 Hunan China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Zhou, Shuyi" sort="Zhou, Shuyi" uniqKey="Zhou S" first="Shuyi" last="Zhou">Shuyi Zhou</name>
<affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1806 9292</institution-id>
<institution-id institution-id-type="GRID">grid.477407.7</institution-id>
<institution>Hunan Provincial People’s Hospital Xingsha Branch (People’s Hospital of Changsha County),</institution>
</institution-wrap>
Changsha, 410008 Hunan China</nlm:aff>
<wicri:noCountry code="subfield">410008 Hunan China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Sun, Lunquan" sort="Sun, Lunquan" uniqKey="Sun L" first="Lunquan" last="Sun">Lunquan Sun</name>
<affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Center for Molecular Medicine,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
Changsha, 410008 Hunan China</nlm:aff>
<wicri:noCountry code="subfield">410008 Hunan China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gong, Zhicheng" sort="Gong, Zhicheng" uniqKey="Gong Z" first="Zhicheng" last="Gong">Zhicheng Gong</name>
<affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</nlm:aff>
<wicri:noCountry code="subfield">410008 Hunan China</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>National Clinical Research Center for Geriatric Disorders,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</nlm:aff>
<wicri:noCountry code="subfield">410008 Hunan China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Xu, Zhijie" sort="Xu, Zhijie" uniqKey="Xu Z" first="Zhijie" last="Xu">Zhijie Xu</name>
<affiliation><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Department of Pathology,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</nlm:aff>
<wicri:noCountry code="subfield">410008 Hunan China</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Experimental & Clinical Cancer Research : CR</title>
<idno type="ISSN">0392-9078</idno>
<idno type="eISSN">1756-9966</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="Par1">Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. Targeting autophagy has gained interest with multiple preclinical and clinical trials, such as the pharmacological inhibitor chloroquine or the inducer rapamycin, especially in exploiting its ability to modulate the secretory capability of CAFs to enhance drug delivery or inhibit it to prevent its influence on cancer cell chemoresistance. In this review, we summarize the reports on autophagy in cancer-associated fibroblasts by detailing the mechanism and role of autophagy in CAFs, including the hypoxic-autophagy positive feedback cycle, the metabolic cross-talk between CAFs and tumors induced by autophagy, CAFs secreted cytokines promote cancer survival by secretory autophagy, CAFs autophagy-induced EMT, stemness, senescence and treatment sensitivity, as well as the research of antitumor chemicals, miRNAs and lncRNAs. Additionally, we discuss the evidence of molecules in CAFs that are relevant to autophagy and the contribution to sensitive treatments as a potential target for cancer treatment.</p>
</div>
</front>
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<journal-id journal-id-type="iso-abbrev">J. Exp. Clin. Cancer Res</journal-id>
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<publisher-loc>London</publisher-loc>
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<article-id pub-id-type="pmc">6480893</article-id>
<article-id pub-id-type="publisher-id">1172</article-id>
<article-id pub-id-type="doi">10.1186/s13046-019-1172-5</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
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<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yang</surname>
<given-names>Xue</given-names>
</name>
<address><email>xyyangxue@csu.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qian</surname>
<given-names>Long</given-names>
</name>
<address><email>qianlong@csu.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhou</surname>
<given-names>Shuyi</given-names>
</name>
<address><email>a279991261@163.com</email>
</address>
<xref ref-type="aff" rid="Aff5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sun</surname>
<given-names>Lunquan</given-names>
</name>
<address><email>lunquansun@csu.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Gong</surname>
<given-names>Zhicheng</given-names>
</name>
<address><phone>+86 731 84327306</phone>
<email>gongzhicheng@csu.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Xu</surname>
<given-names>Zhijie</given-names>
</name>
<address><phone>+86 731 84327306</phone>
<email>xzj1322007@csu.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff6">6</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Department of Pharmacy,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</aff>
<aff id="Aff2"><label>2</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>National Clinical Research Center for Geriatric Disorders,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Department of Neurosurgery,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
Changsha, 410008 Hunan China</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Center for Molecular Medicine,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
Changsha, 410008 Hunan China</aff>
<aff id="Aff5"><label>5</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1806 9292</institution-id>
<institution-id institution-id-type="GRID">grid.477407.7</institution-id>
<institution>Hunan Provincial People’s Hospital Xingsha Branch (People’s Hospital of Changsha County),</institution>
</institution-wrap>
Changsha, 410008 Hunan China</aff>
<aff id="Aff6"><label>6</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1757 7615</institution-id>
<institution-id institution-id-type="GRID">grid.452223.0</institution-id>
<institution>Department of Pathology,</institution>
<institution>Xiangya Hospital, Central South University,</institution>
</institution-wrap>
87 Xiangya Road, Changsha, 410008 Hunan China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>23</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>38</volume>
<elocation-id>171</elocation-id>
<history><date date-type="received"><day>24</day>
<month>1</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>10</day>
<month>4</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Cancer-associated fibroblasts (CAFs) plays an essential role in cancer cell growth, metabolism and immunoreaction. Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. Targeting autophagy has gained interest with multiple preclinical and clinical trials, such as the pharmacological inhibitor chloroquine or the inducer rapamycin, especially in exploiting its ability to modulate the secretory capability of CAFs to enhance drug delivery or inhibit it to prevent its influence on cancer cell chemoresistance. In this review, we summarize the reports on autophagy in cancer-associated fibroblasts by detailing the mechanism and role of autophagy in CAFs, including the hypoxic-autophagy positive feedback cycle, the metabolic cross-talk between CAFs and tumors induced by autophagy, CAFs secreted cytokines promote cancer survival by secretory autophagy, CAFs autophagy-induced EMT, stemness, senescence and treatment sensitivity, as well as the research of antitumor chemicals, miRNAs and lncRNAs. Additionally, we discuss the evidence of molecules in CAFs that are relevant to autophagy and the contribution to sensitive treatments as a potential target for cancer treatment.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Autophagy</kwd>
<kwd>Cancer associated fibroblasts</kwd>
<kwd>Cancer treatment</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100001809</institution-id>
<institution>National Natural Science Foundation of China</institution>
</institution-wrap>
</funding-source>
<award-id>81803035</award-id>
<award-id>81572946</award-id>
<award-id>81703036</award-id>
<principal-award-recipient><name><surname>Yan</surname>
<given-names>Yuanliang</given-names>
</name>
<name><surname>Gong</surname>
<given-names>Zhicheng</given-names>
</name>
<name><surname>Xu</surname>
<given-names>Zhijie</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution>Youth Fund of Xiangya Hospital</institution>
</funding-source>
<award-id>2017Q17</award-id>
<principal-award-recipient><name><surname>Yan</surname>
<given-names>Yuanliang</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100010031</institution-id>
<institution>Postdoctoral Research Foundation of China</institution>
</institution-wrap>
</funding-source>
<award-id>2017M610510</award-id>
<principal-award-recipient><name><surname>Xu</surname>
<given-names>Zhijie</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100010021</institution-id>
<institution>Postdoctoral Science Foundation of Central South University</institution>
</institution-wrap>
</funding-source>
<award-id>185702</award-id>
<principal-award-recipient><name><surname>Xu</surname>
<given-names>Zhijie</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Chen, Xi" sort="Chen, Xi" uniqKey="Chen X" first="Xi" last="Chen">Xi Chen</name>
<name sortKey="Gong, Zhicheng" sort="Gong, Zhicheng" uniqKey="Gong Z" first="Zhicheng" last="Gong">Zhicheng Gong</name>
<name sortKey="Hu, Wenfeng" sort="Hu, Wenfeng" uniqKey="Hu W" first="Wenfeng" last="Hu">Wenfeng Hu</name>
<name sortKey="Qian, Long" sort="Qian, Long" uniqKey="Qian L" first="Long" last="Qian">Long Qian</name>
<name sortKey="Sun, Lunquan" sort="Sun, Lunquan" uniqKey="Sun L" first="Lunquan" last="Sun">Lunquan Sun</name>
<name sortKey="Wang, Xiang" sort="Wang, Xiang" uniqKey="Wang X" first="Xiang" last="Wang">Xiang Wang</name>
<name sortKey="Wei, Jie" sort="Wei, Jie" uniqKey="Wei J" first="Jie" last="Wei">Jie Wei</name>
<name sortKey="Xu, Zhijie" sort="Xu, Zhijie" uniqKey="Xu Z" first="Zhijie" last="Xu">Zhijie Xu</name>
<name sortKey="Yan, Yuanliang" sort="Yan, Yuanliang" uniqKey="Yan Y" first="Yuanliang" last="Yan">Yuanliang Yan</name>
<name sortKey="Yang, Xue" sort="Yang, Xue" uniqKey="Yang X" first="Xue" last="Yang">Xue Yang</name>
<name sortKey="Zeng, Shuangshuang" sort="Zeng, Shuangshuang" uniqKey="Zeng S" first="Shuangshuang" last="Zeng">Shuangshuang Zeng</name>
<name sortKey="Zhao, Zijin" sort="Zhao, Zijin" uniqKey="Zhao Z" first="Zijin" last="Zhao">Zijin Zhao</name>
<name sortKey="Zhou, Shuyi" sort="Zhou, Shuyi" uniqKey="Zhou S" first="Shuyi" last="Zhou">Shuyi Zhou</name>
</noCountry>
</tree>
</affiliations>
</record>
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