Toxicities associated with checkpoint inhibitors—an overview
Identifieur interne : 000279 ( Pmc/Checkpoint ); précédent : 000278; suivant : 000280Toxicities associated with checkpoint inhibitors—an overview
Auteurs : Laura Spiers ; Nicholas Coupe ; Miranda PayneSource :
- Rheumatology (Oxford, England) [ 1462-0324 ] ; 2019.
Abstract
Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some time to emerge as some adverse events are rare, or can be subtle and potentially overlooked. Clinician awareness of these side effects can be particularly important in patients with pre-existing autoimmune conditions. Here we describe common symptoms and diagnostic strategies for organ-specific side effects of anti-CTLA-4 and anti-PD-1/PD-L1 immunotherapy agents.
Url:
DOI: 10.1093/rheumatology/kez418
PubMed: 31816085
PubMed Central: 6900917
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Toxicities associated with checkpoint inhibitors—an overview</title><author><name sortKey="Spiers, Laura" sort="Spiers, Laura" uniqKey="Spiers L" first="Laura" last="Spiers">Laura Spiers</name><affiliation><nlm:aff id="kez418-aff1"></nlm:aff></affiliation></author><author><name sortKey="Coupe, Nicholas" sort="Coupe, Nicholas" uniqKey="Coupe N" first="Nicholas" last="Coupe">Nicholas Coupe</name><affiliation><nlm:aff id="kez418-aff1"></nlm:aff></affiliation></author><author><name sortKey="Payne, Miranda" sort="Payne, Miranda" uniqKey="Payne M" first="Miranda" last="Payne">Miranda Payne</name><affiliation><nlm:aff id="kez418-aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31816085</idno><idno type="pmc">6900917</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6900917</idno><idno type="RBID">PMC:6900917</idno><idno type="doi">10.1093/rheumatology/kez418</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000805</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000805</idno><idno type="wicri:Area/Pmc/Curation">000805</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000805</idno><idno type="wicri:Area/Pmc/Checkpoint">000279</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000279</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Toxicities associated with checkpoint inhibitors—an overview</title><author><name sortKey="Spiers, Laura" sort="Spiers, Laura" uniqKey="Spiers L" first="Laura" last="Spiers">Laura Spiers</name><affiliation><nlm:aff id="kez418-aff1"></nlm:aff></affiliation></author><author><name sortKey="Coupe, Nicholas" sort="Coupe, Nicholas" uniqKey="Coupe N" first="Nicholas" last="Coupe">Nicholas Coupe</name><affiliation><nlm:aff id="kez418-aff1"></nlm:aff></affiliation></author><author><name sortKey="Payne, Miranda" sort="Payne, Miranda" uniqKey="Payne M" first="Miranda" last="Payne">Miranda Payne</name><affiliation><nlm:aff id="kez418-aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Rheumatology (Oxford, England)</title><idno type="ISSN">1462-0324</idno><idno type="eISSN">1462-0332</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some time to emerge as some adverse events are rare, or can be subtle and potentially overlooked. Clinician awareness of these side effects can be particularly important in patients with pre-existing autoimmune conditions. Here we describe common symptoms and diagnostic strategies for organ-specific side effects of anti-CTLA-4 and anti-PD-1/PD-L1 immunotherapy agents.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cousin, S" uniqKey="Cousin S">S Cousin</name></author><author><name sortKey="Seneschal, J" uniqKey="Seneschal J">J Seneschal</name></author><author><name sortKey="Italiano, A" uniqKey="Italiano A">A. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Rheumatology (Oxford)</journal-id><journal-id journal-id-type="iso-abbrev">Rheumatology (Oxford)</journal-id><journal-id journal-id-type="publisher-id">brheum</journal-id><journal-title-group><journal-title>Rheumatology (Oxford, England)</journal-title></journal-title-group><issn pub-type="ppub">1462-0324</issn><issn pub-type="epub">1462-0332</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31816085</article-id><article-id pub-id-type="pmc">6900917</article-id><article-id pub-id-type="doi">10.1093/rheumatology/kez418</article-id><article-id pub-id-type="publisher-id">kez418</article-id><article-categories><subj-group subj-group-type="heading"><subject>Supplement Articles</subject></subj-group></article-categories><title-group><article-title>Toxicities associated with checkpoint inhibitors—an overview</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Spiers</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="kez418-aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Coupe</surname><given-names>Nicholas</given-names></name><xref ref-type="aff" rid="kez418-aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Payne</surname><given-names>Miranda</given-names></name><xref ref-type="aff" rid="kez418-aff1"></xref><xref ref-type="corresp" rid="kez418-cor1"></xref><pmc-comment>Miranda.Payne@ouh.nhs.uk </pmc-comment>
</contrib></contrib-group><aff id="kez418-aff1"><institution>Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust</institution>, Oxford,<country country="GB">UK</country></aff><author-notes><corresp id="kez418-cor1">Correspondence to: Miranda J. Payne, Department of Oncology, Churchill Hospital, Oxford University Hospitals Foundation Trust, Oxford OX3 7LJ, UK. E-mail: <email>Miranda.Payne@ouh.nhs.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2019</year></pub-date><pub-date pub-type="epub" iso-8601-date="2019-12-09"><day>09</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="pmc-release"><day>09</day><month>12</month><year>2019</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>58</volume><issue>Suppl 7</issue><issue-title>The rheumatic side-effects of immuno-oncology treatment</issue-title><fpage>vii7</fpage><lpage>vii16</lpage><history><date date-type="received"><day>24</day><month>5</month><year>2019</year></date><date date-type="rev-recd"><day>30</day><month>7</month><year>2019</year></date></history><permissions><copyright-statement>© The Author(s) 2019. Published by Oxford University Press on behalf of the British Society for Rheumatology.</copyright-statement><copyright-year>2019</copyright-year><license license-type="cc-by-nc" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><self-uri xlink:href="kez418.pdf"></self-uri><abstract><title>Abstract</title><p>Immunotherapy has an increasing role in the management of cancer, both in metastatic disease and as an adjuvant therapy. However, sensitization of the immune system with checkpoint inhibitors comes with a unique side effect profile. Full appreciation of this can take some time to emerge as some adverse events are rare, or can be subtle and potentially overlooked. Clinician awareness of these side effects can be particularly important in patients with pre-existing autoimmune conditions. Here we describe common symptoms and diagnostic strategies for organ-specific side effects of anti-CTLA-4 and anti-PD-1/PD-L1 immunotherapy agents.</p></abstract><kwd-group><kwd>checkpoint inhibitor</kwd><kwd>adverse event</kwd></kwd-group><funding-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">National Institute for Health Research</named-content><named-content content-type="funder-identifier">10.13039/501100000272</named-content></funding-source></award-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">NIHR</named-content><named-content content-type="funder-identifier">10.13039/100006662</named-content></funding-source></award-group><award-group award-type="grant"><funding-source><named-content content-type="funder-name">BMS</named-content><named-content content-type="funder-identifier">10.13039/100002491</named-content></funding-source></award-group></funding-group><counts><page-count count="10"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Coupe, Nicholas" sort="Coupe, Nicholas" uniqKey="Coupe N" first="Nicholas" last="Coupe">Nicholas Coupe</name><name sortKey="Payne, Miranda" sort="Payne, Miranda" uniqKey="Payne M" first="Miranda" last="Payne">Miranda Payne</name><name sortKey="Spiers, Laura" sort="Spiers, Laura" uniqKey="Spiers L" first="Laura" last="Spiers">Laura Spiers</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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