Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
Identifieur interne : 000264 ( Pmc/Checkpoint ); précédent : 000263; suivant : 000265Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment
Auteurs : Xinyu Tian [République populaire de Chine] ; Han Shen [République populaire de Chine] ; Zhiyang Li [République populaire de Chine] ; Tingting Wang [République populaire de Chine] ; Shengjun Wang [République populaire de Chine]Source :
- Journal of Hematology & Oncology [ 1756-8722 ] ; 2019.
Abstract
Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor progression, in which myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells with immunosuppressive activity. Tumor cells and stromal cells facilitate the activation and expansion of MDSCs in TME via intercellular communication, and expanded MDSCs suppress anti-tumor immune responses through direct and indirect mechanisms. Currently, exosomes, which are a kind of extracellular vesicles (EVs) that can convey functional components, are demonstrated to participate in the local and distal intercellular communication between cells. Numerous studies have supposed that tumor-derived exosomes (TEXs), whose assembly and release can be modulated by TME, are capable of modulating the cell biology of MDSCs, including facilitating their activation, promoting the expansion, and enhancing the immunosuppressive function. Therefore, in this review, we mainly focus on the role of TEXs in the cell-cell communication between tumor cells and MDSCs, and discuss their clinical applications.
Url:
DOI: 10.1186/s13045-019-0772-z
PubMed: 31438991
PubMed Central: 6704713
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="Par1">Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor progression, in which myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells with immunosuppressive activity. Tumor cells and stromal cells facilitate the activation and expansion of MDSCs in TME via intercellular communication, and expanded MDSCs suppress anti-tumor immune responses through direct and indirect mechanisms. Currently, exosomes, which are a kind of extracellular vesicles (EVs) that can convey functional components, are demonstrated to participate in the local and distal intercellular communication between cells. Numerous studies have supposed that tumor-derived exosomes (TEXs), whose assembly and release can be modulated by TME, are capable of modulating the cell biology of MDSCs, including facilitating their activation, promoting the expansion, and enhancing the immunosuppressive function. Therefore, in this review, we mainly focus on the role of TEXs in the cell-cell communication between tumor cells and MDSCs, and discuss their clinical applications.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Hematol Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">J Hematol Oncol</journal-id>
<journal-title-group><journal-title>Journal of Hematology & Oncology</journal-title>
</journal-title-group>
<issn pub-type="epub">1756-8722</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31438991</article-id>
<article-id pub-id-type="pmc">6704713</article-id>
<article-id pub-id-type="publisher-id">772</article-id>
<article-id pub-id-type="doi">10.1186/s13045-019-0772-z</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Tumor-derived exosomes, myeloid-derived suppressor cells, and tumor microenvironment</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" equal-contrib="yes"><name><surname>Tian</surname>
<given-names>Xinyu</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" equal-contrib="yes"><name><surname>Shen</surname>
<given-names>Han</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Li</surname>
<given-names>Zhiyang</given-names>
</name>
<address><email>lizhiyangcn@qq.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname>
<given-names>Tingting</given-names>
</name>
<address><email>3288689388@qq.comand</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname>
<given-names>Shengjun</given-names>
</name>
<address><phone>86-511-8503-8301</phone>
<email>sjwjs@ujs.edu.cn</email>
</address>
<xref ref-type="aff" rid="Aff3">3</xref>
<xref ref-type="aff" rid="Aff4">4</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id>
<institution-id institution-id-type="GRID">grid.41156.37</institution-id>
<institution>Department of Laboratory Medicine, Nanjing Drum Tower Hospital,</institution>
<institution>Nanjing University Medical School,</institution>
</institution-wrap>
Nanjing, China</aff>
<aff id="Aff2"><label>2</label>
Department of Laboratory Medicine, Affiliated Wuxi People’s Hospital of Nanjing Medical University, Wuxi Children’s Hospital, Wuxi, China</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0743 511X</institution-id>
<institution-id institution-id-type="GRID">grid.440785.a</institution-id>
<institution>Department of Laboratory Medicine, The Affiliated People’s Hospital,</institution>
<institution>Jiangsu University,</institution>
</institution-wrap>
Zhenjiang, China</aff>
<aff id="Aff4"><label>4</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0743 511X</institution-id>
<institution-id institution-id-type="GRID">grid.440785.a</institution-id>
<institution>Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine,</institution>
<institution>Jiangsu University,</institution>
</institution-wrap>
Zhenjiang, China</aff>
</contrib-group>
<pub-date pub-type="epub"><day>22</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>22</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>12</volume>
<elocation-id>84</elocation-id>
<history><date date-type="received"><day>16</day>
<month>5</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>14</day>
<month>8</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2019</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><p id="Par1">Plenty of immune cells infiltrate into the tumor microenvironment (TME) during tumor progression, in which myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of immature myeloid cells with immunosuppressive activity. Tumor cells and stromal cells facilitate the activation and expansion of MDSCs in TME via intercellular communication, and expanded MDSCs suppress anti-tumor immune responses through direct and indirect mechanisms. Currently, exosomes, which are a kind of extracellular vesicles (EVs) that can convey functional components, are demonstrated to participate in the local and distal intercellular communication between cells. Numerous studies have supposed that tumor-derived exosomes (TEXs), whose assembly and release can be modulated by TME, are capable of modulating the cell biology of MDSCs, including facilitating their activation, promoting the expansion, and enhancing the immunosuppressive function. Therefore, in this review, we mainly focus on the role of TEXs in the cell-cell communication between tumor cells and MDSCs, and discuss their clinical applications.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Tumor-derived exosomes</kwd>
<kwd>Myeloid-derived suppressor cells</kwd>
<kwd>Tumor microenvironment</kwd>
<kwd>Immunosuppression</kwd>
<kwd>Intercellular communication</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution>National Natural Science Foundation of China </institution>
</funding-source>
<award-id>81802855</award-id>
<principal-award-recipient><name><surname>Tian</surname>
<given-names>Xinyu</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Tian, Xinyu" sort="Tian, Xinyu" uniqKey="Tian X" first="Xinyu" last="Tian">Xinyu Tian</name>
</noRegion>
<name sortKey="Li, Zhiyang" sort="Li, Zhiyang" uniqKey="Li Z" first="Zhiyang" last="Li">Zhiyang Li</name>
<name sortKey="Shen, Han" sort="Shen, Han" uniqKey="Shen H" first="Han" last="Shen">Han Shen</name>
<name sortKey="Wang, Shengjun" sort="Wang, Shengjun" uniqKey="Wang S" first="Shengjun" last="Wang">Shengjun Wang</name>
<name sortKey="Wang, Shengjun" sort="Wang, Shengjun" uniqKey="Wang S" first="Shengjun" last="Wang">Shengjun Wang</name>
<name sortKey="Wang, Tingting" sort="Wang, Tingting" uniqKey="Wang T" first="Tingting" last="Wang">Tingting Wang</name>
</country>
</tree>
</affiliations>
</record>
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