A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer
Identifieur interne : 000213 ( Pmc/Checkpoint ); précédent : 000212; suivant : 000214A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer
Auteurs : Tuo Ruan [République populaire de Chine] ; Weizhen Liu [République populaire de Chine] ; Kaixiong Tao [République populaire de Chine] ; Chuanqing Wu [République populaire de Chine]Source :
- OncoTargets and therapy [ 1178-6930 ] ; 2020.
Abstract
Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.
Url:
DOI: 10.2147/OTT.S239336
PubMed: 32184615
PubMed Central: 7053652
Affiliations:
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<p>Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Onco Targets Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">Onco Targets Ther</journal-id>
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<article-id pub-id-type="doi">10.2147/OTT.S239336</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>A Review of Research Progress in Multidrug-Resistance Mechanisms in Gastric Cancer</article-title>
<alt-title alt-title-type="running-authors">Ruan et al</alt-title>
<alt-title alt-title-type="running-title">Ruan et al</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ruan</surname>
<given-names>Tuo</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
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<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Weizhen</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
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<contrib contrib-type="author"><name><surname>Tao</surname>
<given-names>Kaixiong</given-names>
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<xref ref-type="corresp" rid="AN0001"></xref>
<xref ref-type="aff" rid="AFF0001">1</xref>
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<contrib contrib-type="author"><name><surname>Wu</surname>
<given-names>Chuanqing</given-names>
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<xref ref-type="aff" rid="AFF0001">1</xref>
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<aff id="AFF0001"><label>1</label>
<institution>Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology</institution>
,<addr-line>Wuhan</addr-line>
<addr-line>430022</addr-line>
,<country>China</country>
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</contrib-group>
<author-notes><corresp id="AN0001">Correspondence: Kaixiong Tao; Chuanqing Wu <institution>Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology</institution>
, <addr-line>Wuhan</addr-line>
<addr-line>430022</addr-line>
, <country>China</country>
Email tao_kaixiong@163.com; wucq2014@hust.edu.cn</corresp>
</author-notes>
<pub-date pub-type="epub"><day>28</day>
<month>2</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><year>2020</year>
</pub-date>
<volume>13</volume>
<fpage>1797</fpage>
<lpage>1807</lpage>
<history><date date-type="received"><day>20</day>
<month>11</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>15</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>© 2020 Ruan et al.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>Ruan et al.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
).</license-p>
</license>
</permissions>
<abstract><title>Abstract</title>
<p>Gastric cancer is one of the most common malignant tumors, and it is also one of the leading causes of cancer death worldwide. Because of its insidious symptoms and lack of early dictation screening, many cases of gastric cancer are at late stages which make it more complicated to cure. For these advanced-stage gastric cancers, combination therapy of surgery, chemotherapy, radiotherapy and target therapy would bring more benefit to the patients. However, the drug-resistance to the chemotherapy restricts its effect and might lead to treatment failure. In this review article, we discuss the mechanisms which have been found in recent years of drug resistance in gastric cancer. And we also want to find new approaches to counteract chemotherapy resistance and bring more benefits to the patients.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>gastric cancer</kwd>
<kwd>chemotherapy</kwd>
<kwd>resistance</kwd>
</kwd-group>
<counts><fig-count count="1"></fig-count>
<ref-count count="141"></ref-count>
<page-count count="11"></page-count>
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