Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicanaIn Vitro
Identifieur interne : 000207 ( Pmc/Checkpoint ); précédent : 000206; suivant : 000208Activity of Chitosan and Its Derivatives against Leishmania major and Leishmania mexicanaIn Vitro
Auteurs : Alaa Riezk [Royaume-Uni] ; John G. Raynes [Royaume-Uni] ; Vanessa Yardley [Royaume-Uni] ; Sudaxshina Murdan [Royaume-Uni] ; Simon L. Croft [Royaume-Uni]Source :
- Antimicrobial Agents and Chemotherapy [ 0066-4804 ] ; 2020.
Abstract
There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities.
Url:
DOI: 10.1128/AAC.01772-19
PubMed: 31871082
PubMed Central: 7038302
Affiliations:
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PMC:7038302Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Activity of Chitosan and Its Derivatives against <named-content content-type="genus-species">Leishmania major</named-content> and <named-content content-type="genus-species">Leishmania mexicana</named-content><italic>In Vitro</italic></title><author><name sortKey="Riezk, Alaa" sort="Riezk, Alaa" uniqKey="Riezk A" first="Alaa" last="Riezk">Alaa Riezk</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Raynes, John G" sort="Raynes, John G" uniqKey="Raynes J" first="John G." last="Raynes">John G. Raynes</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yardley, Vanessa" sort="Yardley, Vanessa" uniqKey="Yardley V" first="Vanessa" last="Yardley">Vanessa Yardley</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Murdan, Sudaxshina" sort="Murdan, Sudaxshina" uniqKey="Murdan S" first="Sudaxshina" last="Murdan">Sudaxshina Murdan</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmaceutics, UCL School of Pharmacy, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Croft, Simon L" sort="Croft, Simon L" uniqKey="Croft S" first="Simon L." last="Croft">Simon L. 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Raynes</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Yardley, Vanessa" sort="Yardley, Vanessa" uniqKey="Yardley V" first="Vanessa" last="Yardley">Vanessa Yardley</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Murdan, Sudaxshina" sort="Murdan, Sudaxshina" uniqKey="Murdan S" first="Sudaxshina" last="Murdan">Sudaxshina Murdan</name><affiliation wicri:level="4"><nlm:aff id="aff2"><addr-line>Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Pharmaceutics, UCL School of Pharmacy, University College London, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName><orgName type="university">University College de Londres</orgName></affiliation></author><author><name sortKey="Croft, Simon L" sort="Croft, Simon L" uniqKey="Croft S" first="Simon L." last="Croft">Simon L. Croft</name><affiliation wicri:level="3"><nlm:aff id="aff1"><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Antimicrobial Agents and Chemotherapy</title><idno type="ISSN">0066-4804</idno><idno type="eISSN">1098-6596</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. 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article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Antimicrob Agents Chemother</journal-id><journal-id journal-id-type="iso-abbrev">Antimicrob. Agents Chemother</journal-id><journal-id journal-id-type="hwp">aac</journal-id><journal-id journal-id-type="pmc">aac</journal-id><journal-id journal-id-type="publisher-id">AAC</journal-id><journal-title-group><journal-title>Antimicrobial Agents and Chemotherapy</journal-title></journal-title-group><issn pub-type="ppub">0066-4804</issn><issn pub-type="epub">1098-6596</issn><publisher><publisher-name>American Society for Microbiology</publisher-name><publisher-loc>1752 N St., N.W., Washington, DC</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31871082</article-id><article-id pub-id-type="pmc">7038302</article-id><article-id pub-id-type="publisher-id">01772-19</article-id><article-id pub-id-type="doi">10.1128/AAC.01772-19</article-id><article-categories><subj-group subj-group-type="heading"><subject>Experimental Therapeutics</subject></subj-group></article-categories><title-group><article-title>Activity of Chitosan and Its Derivatives against <named-content content-type="genus-species">Leishmania major</named-content> and <named-content content-type="genus-species">Leishmania mexicana</named-content><italic>In Vitro</italic></article-title><alt-title alt-title-type="running-head">Antileishmanial Activity of Chitosan</alt-title><alt-title alt-title-type="short-authors">Riezk et al.</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Riezk</surname><given-names>Alaa</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Raynes</surname><given-names>John G.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yardley</surname><given-names>Vanessa</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><contrib contrib-type="author"><name><surname>Murdan</surname><given-names>Sudaxshina</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Croft</surname><given-names>Simon L.</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref></contrib><aff id="aff1"><label>a</label><addr-line>Department of Infection Biology, London School of Hygiene and Tropical Medicine, London, United Kingdom</addr-line></aff><aff id="aff2"><label>b</label><addr-line>Department of Pharmaceutics, UCL School of Pharmacy, University College London, London, United Kingdom</addr-line></aff></contrib-group><author-notes><corresp id="cor1">Address correspondence to Simon L. Croft, <email>simon.croft@lshtm.ac.uk</email>.</corresp><fn fn-type="other"><p><bold>Citation</bold> Riezk A, Raynes JG, Yardley V, Murdan S, Croft SL. 2020. Activity of chitosan and its derivatives against <italic>Leishmania major</italic> and <italic>Leishmania mexicana in vitro</italic>. Antimicrob Agents Chemother 64:e01772-19. <ext-link ext-link-type="uri" xlink:href="https://doi.org/10.1128/AAC.01772-19">https://doi.org/10.1128/AAC.01772-19</ext-link>.</p></fn></author-notes><pub-date pub-type="epreprint"><day>23</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>21</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="collection"><month>3</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>21</day><month>2</month><year>2020</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>64</volume><issue>3</issue><elocation-id>e01772-19</elocation-id><history><date date-type="received"><day>3</day><month>9</month><year>2019</year></date><date date-type="rev-request"><day>10</day><month>10</month><year>2019</year></date><date date-type="accepted"><day>8</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2020 Riezk et al.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Riezk et al.</copyright-holder><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution 4.0 International license</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="AAC.01772-19.pdf"></self-uri><abstract abstract-type="precis"><p>There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities.</p></abstract><abstract><title>ABSTRACT</title><p>There is an urgent need for safe, efficacious, affordable, and field-adapted drugs for the treatment of cutaneous leishmaniasis, which newly affects around 1.5 million people worldwide annually. Chitosan, a biodegradable cationic polysaccharide, has previously been reported to have antimicrobial, antileishmanial, and immunostimulatory activities. We investigated the <italic>in vitro</italic> activity of chitosan and several of its derivatives and showed that the pH of the culture medium plays a critical role in antileishmanial activity of chitosan against both extracellular promastigotes and intracellular amastigotes of <named-content content-type="genus-species">Leishmania major</named-content> and <named-content content-type="genus-species">Leishmania mexicana</named-content>. Chitosan and its derivatives were approximately 7 to 20 times more active at pH 6.5 than at pH 7.5, with high-molecular-weight chitosan being the most potent. High-molecular-weight chitosan stimulated the production of nitric oxide and reactive oxygen species by uninfected and <italic>Leishmania</italic>-infected macrophages in a time- and dose-dependent manner at pH 6.5. Despite the <italic>in vitro</italic> activation of bone marrow macrophages by chitosan to produce nitric oxide and reactive oxygen species, we showed that the antileishmanial activity of chitosan was not mediated by these metabolites. Finally, we showed that rhodamine-labeled chitosan is taken up by pinocytosis and accumulates in the parasitophorous vacuole of <italic>Leishmania</italic>-infected macrophages.</p></abstract><kwd-group><title>KEYWORDS</title><kwd>cutaneous leishmaniasis</kwd><kwd><italic>Leishmania major</italic></kwd><kwd><italic>Leishmania mexicana</italic></kwd><kwd>chitosan</kwd><kwd>macrophage uptake</kwd></kwd-group><funding-group><award-group id="award1"><funding-source><institution-wrap><institution>Council for At-Risk Academics (CARA) UK</institution></institution-wrap></funding-source><principal-award-recipient><name><surname>Riezk</surname><given-names>Alaa</given-names></name></principal-award-recipient></award-group><award-group id="award2"><funding-source><institution-wrap><institution>London School of Hygiene and Tropical Medicine (LSHTM)</institution><institution-id>https://doi.org/10.13039/100009660</institution-id></institution-wrap></funding-source><principal-award-recipient><name><surname>Riezk</surname><given-names>Alaa</given-names></name></principal-award-recipient></award-group></funding-group><counts><count count="1" count-type="supplementary-material"></count><fig-count count="8"></fig-count><table-count count="4"></table-count><equation-count count="0"></equation-count><ref-count count="74"></ref-count><page-count count="17"></page-count><word-count count="11797"></word-count></counts><custom-meta-group><custom-meta><meta-name>cover-date</meta-name><meta-value>March 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement><orgName><li>University College de Londres</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Riezk, Alaa" sort="Riezk, Alaa" uniqKey="Riezk A" first="Alaa" last="Riezk">Alaa Riezk</name></region><name sortKey="Croft, Simon L" sort="Croft, Simon L" uniqKey="Croft S" first="Simon L." last="Croft">Simon L. Croft</name><name sortKey="Murdan, Sudaxshina" sort="Murdan, Sudaxshina" uniqKey="Murdan S" first="Sudaxshina" last="Murdan">Sudaxshina Murdan</name><name sortKey="Raynes, John G" sort="Raynes, John G" uniqKey="Raynes J" first="John G." last="Raynes">John G. Raynes</name><name sortKey="Yardley, Vanessa" sort="Yardley, Vanessa" uniqKey="Yardley V" first="Vanessa" last="Yardley">Vanessa Yardley</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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