Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)
Identifieur interne : 000162 ( Pmc/Checkpoint ); précédent : 000161; suivant : 000163Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae)
Auteurs : Romeol Romain Koagne [Cameroun, Espagne] ; Frederick Annang [Espagne] ; Bastien Cautain [Espagne] ; Jesús Martín [Espagne] ; Guiomar Pérez-Moreno [Espagne] ; Gabin Thierry M. Bitchagno [Cameroun] ; Dolores González-Pacanowska [Espagne] ; Francisca Vicente [Espagne] ; Ingrid Konga Simo [Cameroun] ; Fernando Reyes [Espagne] ; Pierre Tane [Cameroun]Source :
- BMC Complementary Medicine and Therapies [ 2662-7671 ] ; 2020.
Abstract
The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of
The plant extract was prepared by maceration in methanol. Standard chromatographic, HPLC and spectroscopic methods were used to isolate and identify six compounds (
In general, compounds showed moderate activity against the human pancreatic carcinoma cell line MiaPaca-2 (10 < IC50 < 20 μM) and weak activity against other tumor cell lines such as lung (A-549), hepatocarcinoma (HepG2) and human breast adenocarcinoma (MCF-7and A2058) (IC50 > 20 μM). Additionally, the two semi-synthetic derivatives of quercetin 3-
The results of this study clearly suggest that, the appropriate introduction of acetyl groups into some flavonoids could lead to more useful derivatives for the development of an antiplasmodial agent.
Url:
DOI: 10.1186/s12906-019-2792-1
PubMed: 32020891
PubMed Central: 7076739
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:7076739Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Cytotoxycity and antiplasmodial activity of phenolic derivatives from <italic>Albizia zygia</italic>
(DC.) J.F. Macbr. (Mimosaceae)</title>
<author><name sortKey="Koagne, Romeol Romain" sort="Koagne, Romeol Romain" uniqKey="Koagne R" first="Romeol Romain" last="Koagne">Romeol Romain Koagne</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cautain, Bastien" sort="Cautain, Bastien" uniqKey="Cautain B" first="Bastien" last="Cautain">Bastien Cautain</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Jesus" sort="Martin, Jesus" uniqKey="Martin J" first="Jesús" last="Martín">Jesús Martín</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2183 4846</institution-id>
<institution-id institution-id-type="GRID">grid.4711.3</institution-id>
<institution>Instituto de Parasitología y Biomedicina “López-Neyra”,</institution>
<institution>Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento s/n,</institution>
</institution-wrap>
18016, Armilla, Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>18016, Armilla, Granada</wicri:regionArea>
<wicri:noRegion>Granada</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bitchagno, Gabin Thierry M" sort="Bitchagno, Gabin Thierry M" uniqKey="Bitchagno G" first="Gabin Thierry M." last="Bitchagno">Gabin Thierry M. Bitchagno</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Pacanowska, Dolores" sort="Gonzalez Pacanowska, Dolores" uniqKey="Gonzalez Pacanowska D" first="Dolores" last="González-Pacanowska">Dolores González-Pacanowska</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2183 4846</institution-id>
<institution-id institution-id-type="GRID">grid.4711.3</institution-id>
<institution>Instituto de Parasitología y Biomedicina “López-Neyra”,</institution>
<institution>Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento s/n,</institution>
</institution-wrap>
18016, Armilla, Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>18016, Armilla, Granada</wicri:regionArea>
<wicri:noRegion>Granada</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vicente, Francisca" sort="Vicente, Francisca" uniqKey="Vicente F" first="Francisca" last="Vicente">Francisca Vicente</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simo, Ingrid Konga" sort="Simo, Ingrid Konga" uniqKey="Simo I" first="Ingrid Konga" last="Simo">Ingrid Konga Simo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tane, Pierre" sort="Tane, Pierre" uniqKey="Tane P" first="Pierre" last="Tane">Pierre Tane</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32020891</idno>
<idno type="pmc">7076739</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7076739</idno>
<idno type="RBID">PMC:7076739</idno>
<idno type="doi">10.1186/s12906-019-2792-1</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000040</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000040</idno>
<idno type="wicri:Area/Pmc/Curation">000040</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000040</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000162</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000162</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cytotoxycity and antiplasmodial activity of phenolic derivatives from <italic>Albizia zygia</italic>
(DC.) J.F. Macbr. (Mimosaceae)</title>
<author><name sortKey="Koagne, Romeol Romain" sort="Koagne, Romeol Romain" uniqKey="Koagne R" first="Romeol Romain" last="Koagne">Romeol Romain Koagne</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cautain, Bastien" sort="Cautain, Bastien" uniqKey="Cautain B" first="Bastien" last="Cautain">Bastien Cautain</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Martin, Jesus" sort="Martin, Jesus" uniqKey="Martin J" first="Jesús" last="Martín">Jesús Martín</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2183 4846</institution-id>
<institution-id institution-id-type="GRID">grid.4711.3</institution-id>
<institution>Instituto de Parasitología y Biomedicina “López-Neyra”,</institution>
<institution>Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento s/n,</institution>
</institution-wrap>
18016, Armilla, Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>18016, Armilla, Granada</wicri:regionArea>
<wicri:noRegion>Granada</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bitchagno, Gabin Thierry M" sort="Bitchagno, Gabin Thierry M" uniqKey="Bitchagno G" first="Gabin Thierry M." last="Bitchagno">Gabin Thierry M. Bitchagno</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gonzalez Pacanowska, Dolores" sort="Gonzalez Pacanowska, Dolores" uniqKey="Gonzalez Pacanowska D" first="Dolores" last="González-Pacanowska">Dolores González-Pacanowska</name>
<affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2183 4846</institution-id>
<institution-id institution-id-type="GRID">grid.4711.3</institution-id>
<institution>Instituto de Parasitología y Biomedicina “López-Neyra”,</institution>
<institution>Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento s/n,</institution>
</institution-wrap>
18016, Armilla, Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>18016, Armilla, Granada</wicri:regionArea>
<wicri:noRegion>Granada</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vicente, Francisca" sort="Vicente, Francisca" uniqKey="Vicente F" first="Francisca" last="Vicente">Francisca Vicente</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Simo, Ingrid Konga" sort="Simo, Ingrid Konga" uniqKey="Simo I" first="Ingrid Konga" last="Simo">Ingrid Konga Simo</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name>
<affiliation wicri:level="2"><nlm:aff id="Aff2">Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada</wicri:regionArea>
<placeName><region nuts="2" type="communauté">Andalousie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tane, Pierre" sort="Tane, Pierre" uniqKey="Tane P" first="Pierre" last="Tane">Pierre Tane</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</nlm:aff>
<country xml:lang="fr">Cameroun</country>
<wicri:regionArea>P.O. Box 67, Dschang</wicri:regionArea>
<wicri:noRegion>Dschang</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">BMC Complementary Medicine and Therapies</title>
<idno type="eISSN">2662-7671</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p id="Par1">The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of <italic>Albizia zygia</italic>
(Mimosaseae).</p>
</sec>
<sec><title>Material</title>
<p id="Par2">The plant extract was prepared by maceration in methanol. Standard chromatographic, HPLC and spectroscopic methods were used to isolate and identify six compounds (<bold>1–6</bold>
). The acetylated derivatives (<bold>7–10</bold>
) were prepared by modifying 2-<italic>O</italic>
-<italic>β</italic>
-D-glucopyranosyl-4-hydroxyphenylacetic acid and quercetin 3-<italic>O</italic>
-<italic>α</italic>
-L-rhamnopyranoside, previously isolated from <italic>A. zygia</italic>
(Mimosaceae). A two-fold serial micro-dilution method was used to determine the IC<sub>50s</sub>
against five tumor cell lines and <italic>Plasmodium falciparum</italic>
.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">In general, compounds showed moderate activity against the human pancreatic carcinoma cell line MiaPaca-2 (10 < IC<sub>50</sub>
< 20 μM) and weak activity against other tumor cell lines such as lung (A-549), hepatocarcinoma (HepG2) and human breast adenocarcinoma (MCF-7and A2058) (IC<sub>50</sub>
> 20 μM). Additionally, the two semi-synthetic derivatives of quercetin 3-<italic>O</italic>
-<italic>α</italic>
-L-rhamnopyranoside exhibited significant activity against <italic>P. falciparum</italic>
with IC<sub>50</sub>
of 7.47 ± 0.25 μM for compound <bold>9</bold>
and 6.77 ± 0.25 μM for compound <bold>10</bold>
, higher than that of their natural precursor (IC<sub>50</sub>
25.1 ± 0.25 μM).</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The results of this study clearly suggest that, the appropriate introduction of acetyl groups into some flavonoids could lead to more useful derivatives for the development of an antiplasmodial agent.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Karuppannan, K" uniqKey="Karuppannan K">K Karuppannan</name>
</author>
<author><name sortKey="Subramanian, Dp" uniqKey="Subramanian D">DP Subramanian</name>
</author>
<author><name sortKey="Venugopal, S" uniqKey="Venugopal S">S Venugopal</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Note, Op" uniqKey="Note O">OP Note</name>
</author>
<author><name sortKey="Chabert, P" uniqKey="Chabert P">P Chabert</name>
</author>
<author><name sortKey="Pegnyem, De" uniqKey="Pegnyem D">DE Pegnyem</name>
</author>
<author><name sortKey="Weniger, B" uniqKey="Weniger B">B Weniger</name>
</author>
<author><name sortKey="Dubois, Ml" uniqKey="Dubois M">ML Dubois</name>
</author>
<author><name sortKey="Lobstei, A" uniqKey="Lobstei A">A Lobstei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kigondu, Evm" uniqKey="Kigondu E">EVM Kigondu</name>
</author>
<author><name sortKey="Rukunga, Gm" uniqKey="Rukunga G">GM Rukunga</name>
</author>
<author><name sortKey="Keriko, Jm" uniqKey="Keriko J">JM Keriko</name>
</author>
<author><name sortKey="Tonui, Wk" uniqKey="Tonui W">WK Tonui</name>
</author>
<author><name sortKey="Gathirwa, Jw" uniqKey="Gathirwa J">JW Gathirwa</name>
</author>
<author><name sortKey="Kirira, Pg" uniqKey="Kirira P">PG Kirira</name>
</author>
<author><name sortKey="Irungu, B" uniqKey="Irungu B">B Irungu</name>
</author>
<author><name sortKey="Ingonga, Jm" uniqKey="Ingonga J">JM Ingonga</name>
</author>
<author><name sortKey="Ndiegei, O" uniqKey="Ndiegei O">O NdiegeI</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wanyama, Pag" uniqKey="Wanyama P">PAG Wanyama</name>
</author>
<author><name sortKey="Kiremire, Bt" uniqKey="Kiremire B">BT Kiremire</name>
</author>
<author><name sortKey="Murumu, Jes" uniqKey="Murumu J">JES Murumu</name>
</author>
<author><name sortKey="Kamoga, O" uniqKey="Kamoga O">O Kamoga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lenta, Bn" uniqKey="Lenta B">BN Lenta</name>
</author>
<author><name sortKey="Vonthron Senecheau, C" uniqKey="Vonthron Senecheau C">C Vonthron-Sénécheau</name>
</author>
<author><name sortKey="Soh, Rf" uniqKey="Soh R">RF Soh</name>
</author>
<author><name sortKey="Tantangmo, F" uniqKey="Tantangmo F">F Tantangmo</name>
</author>
<author><name sortKey="Ngouela, S" uniqKey="Ngouela S">S Ngouela</name>
</author>
<author><name sortKey="Kaiser, M" uniqKey="Kaiser M">M Kaiser</name>
</author>
<author><name sortKey="Tsamo, E" uniqKey="Tsamo E">E Tsamo</name>
</author>
<author><name sortKey="Anton, R" uniqKey="Anton R">R Anton</name>
</author>
<author><name sortKey="Weniger, B" uniqKey="Weniger B">B Weniger</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cheng, Zq" uniqKey="Cheng Z">ZQ Cheng</name>
</author>
<author><name sortKey="Yang, D" uniqKey="Yang D">D Yang</name>
</author>
<author><name sortKey="Ma, Qy" uniqKey="Ma Q">QY Ma</name>
</author>
<author><name sortKey="Yi, Xh" uniqKey="Yi X">XH Yi</name>
</author>
<author><name sortKey="Zhang, Nl" uniqKey="Zhang N">NL Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Singab, An" uniqKey="Singab A">AN Singab</name>
</author>
<author><name sortKey="Bahgat, D" uniqKey="Bahgat D">D Bahgat</name>
</author>
<author><name sortKey="Al Sayed, E" uniqKey="Al Sayed E">E Al-Sayed</name>
</author>
<author><name sortKey="Eldahshan, O" uniqKey="Eldahshan O">O Eldahshan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gupta, Rs" uniqKey="Gupta R">RS Gupta</name>
</author>
<author><name sortKey="Chaudhary, R" uniqKey="Chaudhary R">R Chaudhary</name>
</author>
<author><name sortKey="Yadav, Rk" uniqKey="Yadav R">RK Yadav</name>
</author>
<author><name sortKey="Verma, Sk" uniqKey="Verma S">SK Verma</name>
</author>
<author><name sortKey="Dobhal, Mp" uniqKey="Dobhal M">MP Dobhal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Abdel Kader, M" uniqKey="Abdel Kader M">M Abdel-Kader</name>
</author>
<author><name sortKey="Hoch, J" uniqKey="Hoch J">J Hoch</name>
</author>
<author><name sortKey="Berger, Jm" uniqKey="Berger J">JM Berger</name>
</author>
<author><name sortKey="Evans, R" uniqKey="Evans R">R Evans</name>
</author>
<author><name sortKey="Miller, Js" uniqKey="Miller J">JS Miller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Debella, A" uniqKey="Debella A">A Debella</name>
</author>
<author><name sortKey="Haslinger, E" uniqKey="Haslinger E">E Haslinger</name>
</author>
<author><name sortKey="Schmid, Mg" uniqKey="Schmid M">MG Schmid</name>
</author>
<author><name sortKey="Bucar, F" uniqKey="Bucar F">F Bucar</name>
</author>
<author><name sortKey="Michl, G" uniqKey="Michl G">G Michl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martin, J" uniqKey="Martin J">J Martín</name>
</author>
<author><name sortKey="Crespo, G" uniqKey="Crespo G">G Crespo</name>
</author>
<author><name sortKey="Gonzalez Menendez, V" uniqKey="Gonzalez Menendez V">V González-Menéndez</name>
</author>
<author><name sortKey="Perez Moreno, G" uniqKey="Perez Moreno G">G Pérez-Moreno</name>
</author>
<author><name sortKey="Sanchez Carrasco, P" uniqKey="Sanchez Carrasco P">P Sánchez-Carrasco</name>
</author>
<author><name sortKey="Perez Victoria, I" uniqKey="Perez Victoria I">I Pérez-Victoria</name>
</author>
<author><name sortKey="Ruiz Perez, Lm" uniqKey="Ruiz Perez L">LM Ruiz-Pérez</name>
</author>
<author><name sortKey="Gonzalez Packanowska, D" uniqKey="Gonzalez Packanowska D">D González-Packanowska</name>
</author>
<author><name sortKey="Vicente, F" uniqKey="Vicente F">F Vicente</name>
</author>
<author><name sortKey="Genilloud, O" uniqKey="Genilloud O">O Genilloud</name>
</author>
<author><name sortKey="Bills, Gf" uniqKey="Bills G">GF Bills</name>
</author>
<author><name sortKey="Reyes, F" uniqKey="Reyes F">F Reyes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Perez Moreno, G" uniqKey="Perez Moreno G">G Pérez-Moreno</name>
</author>
<author><name sortKey="Cantizani, J" uniqKey="Cantizani J">J Cantizani</name>
</author>
<author><name sortKey="Sanchez Carrasco, P" uniqKey="Sanchez Carrasco P">P Sánchez-Carrasco</name>
</author>
<author><name sortKey="Ruiz Perez, Lm" uniqKey="Ruiz Perez L">LM Ruiz-Pérez</name>
</author>
<author><name sortKey="Martin, J" uniqKey="Martin J">J Martín</name>
</author>
<author><name sortKey="El Aouad, N" uniqKey="El Aouad N">N El Aouad</name>
</author>
<author><name sortKey="Perez Victoria, I" uniqKey="Perez Victoria I">I Pérez-Victoria</name>
</author>
<author><name sortKey="Tormo, Jr" uniqKey="Tormo J">JR Tormo</name>
</author>
<author><name sortKey="Gonzalez Menendez, V" uniqKey="Gonzalez Menendez V">V González-Menendez</name>
</author>
<author><name sortKey="Gonzalez, I" uniqKey="Gonzalez I">I González</name>
</author>
<author><name sortKey="De Pedro, N" uniqKey="De Pedro N">N de Pedro</name>
</author>
<author><name sortKey="Reyes, F" uniqKey="Reyes F">F Reyes</name>
</author>
<author><name sortKey="Genilloud, O" uniqKey="Genilloud O">O Genilloud</name>
</author>
<author><name sortKey="Vicente, F" uniqKey="Vicente F">F Vicente</name>
</author>
<author><name sortKey="Gonzalez Pacanowska, D" uniqKey="Gonzalez Pacanowska D">D González-Pacanowska</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weinhold, A" uniqKey="Weinhold A">A Weinhold</name>
</author>
<author><name sortKey="Wenzler, M" uniqKey="Wenzler M">M Wenzler</name>
</author>
<author><name sortKey="Schneider, B" uniqKey="Schneider B">B Schneider</name>
</author>
<author><name sortKey="Baldwin, It" uniqKey="Baldwin I">IT Baldwin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marzouk, Ms" uniqKey="Marzouk M">MS Marzouk</name>
</author>
<author><name sortKey="El Toumy, Saa" uniqKey="El Toumy S">SAA El-Toumy</name>
</author>
<author><name sortKey="Merfort, I" uniqKey="Merfort I">I Merfort</name>
</author>
<author><name sortKey="Nawwar, Mam" uniqKey="Nawwar M">MAM Nawwar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shaheen, F" uniqKey="Shaheen F">F Shaheen</name>
</author>
<author><name sortKey="Ali, L" uniqKey="Ali L">L Ali</name>
</author>
<author><name sortKey="Ali, S" uniqKey="Ali S">S Ali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ardhaoui, M" uniqKey="Ardhaoui M">M Ardhaoui</name>
</author>
<author><name sortKey="Falcimaigne, A" uniqKey="Falcimaigne A">A Falcimaigne</name>
</author>
<author><name sortKey="Engasser, Jm" uniqKey="Engasser J">JM Engasser</name>
</author>
<author><name sortKey="Moussou, P" uniqKey="Moussou P">P Moussou</name>
</author>
<author><name sortKey="Pauly, G" uniqKey="Pauly G">G Pauly</name>
</author>
<author><name sortKey="Ghoul, M" uniqKey="Ghoul M">M Ghoul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chebil, L" uniqKey="Chebil L">L Chebil</name>
</author>
<author><name sortKey="Anthoni, J" uniqKey="Anthoni J">J Anthoni</name>
</author>
<author><name sortKey="Humeau, C" uniqKey="Humeau C">C Humeau</name>
</author>
<author><name sortKey="Gerardin, C" uniqKey="Gerardin C">C Gerardin</name>
</author>
<author><name sortKey="Engasser, Jm" uniqKey="Engasser J">JM Engasser</name>
</author>
<author><name sortKey="Ghoul, M" uniqKey="Ghoul M">M Ghoul</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Brahemi, G" uniqKey="Brahemi G">G Brahemi</name>
</author>
<author><name sortKey="Kona, Fr" uniqKey="Kona F">FR Kona</name>
</author>
<author><name sortKey="Fiasella, A" uniqKey="Fiasella A">A Fiasella</name>
</author>
<author><name sortKey="Buac, D" uniqKey="Buac D">D Buac</name>
</author>
<author><name sortKey="Soukupova, J" uniqKey="Soukupova J">J Soukupova</name>
</author>
<author><name sortKey="Brancale, A" uniqKey="Brancale A">A Brancale</name>
</author>
<author><name sortKey="Burger, Am" uniqKey="Burger A">AM Burger</name>
</author>
<author><name sortKey="Westwell, Ad" uniqKey="Westwell A">AD Westwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rukunga, Gm" uniqKey="Rukunga G">GM Rukunga</name>
</author>
<author><name sortKey="Waterman, Pg" uniqKey="Waterman P">PG Waterman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, Cs" uniqKey="Lau C">CS Lau</name>
</author>
<author><name sortKey="Carrier, Dj" uniqKey="Carrier D">DJ Carrier</name>
</author>
<author><name sortKey="Beitle, Rr" uniqKey="Beitle R">RR Beitle</name>
</author>
<author><name sortKey="Bransby, Di" uniqKey="Bransby D">DI Bransby</name>
</author>
<author><name sortKey="Howard, Lr" uniqKey="Howard L">LR Howard</name>
</author>
<author><name sortKey="Lay, Jjo" uniqKey="Lay J">JJO Lay</name>
</author>
<author><name sortKey="Liyanage, R" uniqKey="Liyanage R">R Liyanage</name>
</author>
<author><name sortKey="Clausen, Ec" uniqKey="Clausen E">EC Clausen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gopiesh, Kv" uniqKey="Gopiesh K">KV Gopiesh</name>
</author>
<author><name sortKey="Kannabiran, K" uniqKey="Kannabiran K">K Kannabiran</name>
</author>
<author><name sortKey="Rajakumar, G" uniqKey="Rajakumar G">G Rajakumar</name>
</author>
<author><name sortKey="Rahuman, Aa" uniqKey="Rahuman A">AA Rahuman</name>
</author>
<author><name sortKey="Santhoshkumar, T" uniqKey="Santhoshkumar T">T Santhoshkumar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kraft, C" uniqKey="Kraft C">C Kraft</name>
</author>
<author><name sortKey="Jenett Siems, K" uniqKey="Jenett Siems K">K Jenett-Siems</name>
</author>
<author><name sortKey="Siems, K" uniqKey="Siems K">K Siems</name>
</author>
<author><name sortKey="Gupta, Mp" uniqKey="Gupta M">MP Gupta</name>
</author>
<author><name sortKey="Bienzle, U" uniqKey="Bienzle U">U Bienzle</name>
</author>
<author><name sortKey="Eich, E" uniqKey="Eich E">E Eich</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lehane, Am" uniqKey="Lehane A">AM Lehane</name>
</author>
<author><name sortKey="Saliba, Kj" uniqKey="Saliba K">KJ Saliba</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kuete, V" uniqKey="Kuete V">V Kuete</name>
</author>
<author><name sortKey="Sandjo, Lp" uniqKey="Sandjo L">LP Sandjo</name>
</author>
<author><name sortKey="Kwamou, Gmn" uniqKey="Kwamou G">GMN Kwamou</name>
</author>
<author><name sortKey="Wiench, B" uniqKey="Wiench B">B Wiench</name>
</author>
<author><name sortKey="Nkengfack, Ae" uniqKey="Nkengfack A">AE Nkengfack</name>
</author>
<author><name sortKey="Efferth, T" uniqKey="Efferth T">T Efferth</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name>
</author>
<author><name sortKey="Zhang, X" uniqKey="Zhang X">X Zhang</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W Wang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Complement Med Ther</journal-id>
<journal-id journal-id-type="iso-abbrev">BMC Complement Med Ther</journal-id>
<journal-title-group><journal-title>BMC Complementary Medicine and Therapies</journal-title>
</journal-title-group>
<issn pub-type="epub">2662-7671</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
<publisher-loc>London</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32020891</article-id>
<article-id pub-id-type="pmc">7076739</article-id>
<article-id pub-id-type="publisher-id">2792</article-id>
<article-id pub-id-type="doi">10.1186/s12906-019-2792-1</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Cytotoxycity and antiplasmodial activity of phenolic derivatives from <italic>Albizia zygia</italic>
(DC.) J.F. Macbr. (Mimosaceae)</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Koagne</surname>
<given-names>Romeol Romain</given-names>
</name>
<address><email>romykoagne@yahoo.fr</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Annang</surname>
<given-names>Frederick</given-names>
</name>
<address><email>freddie.annang@medinaandalucia.es</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cautain</surname>
<given-names>Bastien</given-names>
</name>
<address><email>bastien.cautain@medinaandalucia.es</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Martín</surname>
<given-names>Jesús</given-names>
</name>
<address><email>jesus.martin@medinaandalucia.es</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pérez-Moreno</surname>
<given-names>Guiomar</given-names>
</name>
<address><email>guiomar@ipb.csic.es</email>
</address>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bitchagno</surname>
<given-names>Gabin Thierry M.</given-names>
</name>
<address><email>bmgt198716@ymail.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>González-Pacanowska</surname>
<given-names>Dolores</given-names>
</name>
<address><email>dgonzalez@ipb.csic.es</email>
</address>
<xref ref-type="aff" rid="Aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vicente</surname>
<given-names>Francisca</given-names>
</name>
<address><email>francisca.vicente@medinaandalucia.es</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Simo</surname>
<given-names>Ingrid Konga</given-names>
</name>
<address><email>simoingrid@yahoo.fr</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Reyes</surname>
<given-names>Fernando</given-names>
</name>
<address><email>Fernando.reyes@medinaandalucia.es</email>
</address>
<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes" deceased="yes"><name><surname>Tane</surname>
<given-names>Pierre</given-names>
</name>
<address><email>ptane@yahoo.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<aff id="Aff1"><label>1</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 0657 2358</institution-id>
<institution-id institution-id-type="GRID">grid.8201.b</institution-id>
<institution>Department of Chemistry, Faculty of Science,</institution>
<institution>University of Dschang,</institution>
</institution-wrap>
P.O. Box 67, Dschang, Cameroon</aff>
<aff id="Aff2"><label>2</label>
Fundación MEDINA, Centro de Excelencia en Investigación de MedicamentosInnovadores en Andalucía, Avda. delConocimiento 34, Parque Tecnológico de Ciencias de la Salud, E-18016 Granada, Spain</aff>
<aff id="Aff3"><label>3</label>
<institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2183 4846</institution-id>
<institution-id institution-id-type="GRID">grid.4711.3</institution-id>
<institution>Instituto de Parasitología y Biomedicina “López-Neyra”,</institution>
<institution>Consejo Superior de Investigaciones Científicas (CSIC) Avda. del Conocimiento s/n,</institution>
</institution-wrap>
18016, Armilla, Granada, Spain</aff>
</contrib-group>
<pub-date pub-type="epub"><day>15</day>
<month>1</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>15</day>
<month>1</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><year>2020</year>
</pub-date>
<volume>20</volume>
<elocation-id>8</elocation-id>
<history><date date-type="received"><day>5</day>
<month>12</month>
<year>2018</year>
</date>
<date date-type="accepted"><day>9</day>
<month>12</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s). 2020</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>
) applies to the data made available in this article, unless otherwise stated.</license-p>
</license>
</permissions>
<abstract id="Abs1"><sec><title>Background</title>
<p id="Par1">The proliferation and resistance of microorganisms area serious threat against humankind and the search for new therapeutics is needed. The present report describes the antiplasmodial and anticancer activities of samples isolated from the methanol extract of <italic>Albizia zygia</italic>
(Mimosaseae).</p>
</sec>
<sec><title>Material</title>
<p id="Par2">The plant extract was prepared by maceration in methanol. Standard chromatographic, HPLC and spectroscopic methods were used to isolate and identify six compounds (<bold>1–6</bold>
). The acetylated derivatives (<bold>7–10</bold>
) were prepared by modifying 2-<italic>O</italic>
-<italic>β</italic>
-D-glucopyranosyl-4-hydroxyphenylacetic acid and quercetin 3-<italic>O</italic>
-<italic>α</italic>
-L-rhamnopyranoside, previously isolated from <italic>A. zygia</italic>
(Mimosaceae). A two-fold serial micro-dilution method was used to determine the IC<sub>50s</sub>
against five tumor cell lines and <italic>Plasmodium falciparum</italic>
.</p>
</sec>
<sec><title>Results</title>
<p id="Par3">In general, compounds showed moderate activity against the human pancreatic carcinoma cell line MiaPaca-2 (10 < IC<sub>50</sub>
< 20 μM) and weak activity against other tumor cell lines such as lung (A-549), hepatocarcinoma (HepG2) and human breast adenocarcinoma (MCF-7and A2058) (IC<sub>50</sub>
> 20 μM). Additionally, the two semi-synthetic derivatives of quercetin 3-<italic>O</italic>
-<italic>α</italic>
-L-rhamnopyranoside exhibited significant activity against <italic>P. falciparum</italic>
with IC<sub>50</sub>
of 7.47 ± 0.25 μM for compound <bold>9</bold>
and 6.77 ± 0.25 μM for compound <bold>10</bold>
, higher than that of their natural precursor (IC<sub>50</sub>
25.1 ± 0.25 μM).</p>
</sec>
<sec><title>Conclusion</title>
<p id="Par4">The results of this study clearly suggest that, the appropriate introduction of acetyl groups into some flavonoids could lead to more useful derivatives for the development of an antiplasmodial agent.</p>
</sec>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Phenolic compounds</kwd>
<kwd>Anticancer activity</kwd>
<kwd><italic>Plasmodium falciparum</italic>
</kwd>
<kwd><italic>Albizia zygia</italic>
</kwd>
</kwd-group>
<funding-group><award-group><funding-source><institution-wrap><institution-id institution-id-type="FundRef">http://dx.doi.org/10.13039/501100004766</institution-id>
<institution>Organisation for the Prohibition of Chemical Weapons</institution>
</institution-wrap>
</funding-source>
<award-id>L/ICA/ICB/201822/17</award-id>
<principal-award-recipient><name><surname>Koagne</surname>
<given-names>Romeol Romain</given-names>
</name>
</principal-award-recipient>
</award-group>
</funding-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© The Author(s) 2020</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Cameroun</li>
<li>Espagne</li>
</country>
<region><li>Andalousie</li>
</region>
</list>
<tree><country name="Cameroun"><noRegion><name sortKey="Koagne, Romeol Romain" sort="Koagne, Romeol Romain" uniqKey="Koagne R" first="Romeol Romain" last="Koagne">Romeol Romain Koagne</name>
</noRegion>
<name sortKey="Bitchagno, Gabin Thierry M" sort="Bitchagno, Gabin Thierry M" uniqKey="Bitchagno G" first="Gabin Thierry M." last="Bitchagno">Gabin Thierry M. Bitchagno</name>
<name sortKey="Simo, Ingrid Konga" sort="Simo, Ingrid Konga" uniqKey="Simo I" first="Ingrid Konga" last="Simo">Ingrid Konga Simo</name>
<name sortKey="Tane, Pierre" sort="Tane, Pierre" uniqKey="Tane P" first="Pierre" last="Tane">Pierre Tane</name>
</country>
<country name="Espagne"><region name="Andalousie"><name sortKey="Koagne, Romeol Romain" sort="Koagne, Romeol Romain" uniqKey="Koagne R" first="Romeol Romain" last="Koagne">Romeol Romain Koagne</name>
</region>
<name sortKey="Annang, Frederick" sort="Annang, Frederick" uniqKey="Annang F" first="Frederick" last="Annang">Frederick Annang</name>
<name sortKey="Cautain, Bastien" sort="Cautain, Bastien" uniqKey="Cautain B" first="Bastien" last="Cautain">Bastien Cautain</name>
<name sortKey="Gonzalez Pacanowska, Dolores" sort="Gonzalez Pacanowska, Dolores" uniqKey="Gonzalez Pacanowska D" first="Dolores" last="González-Pacanowska">Dolores González-Pacanowska</name>
<name sortKey="Martin, Jesus" sort="Martin, Jesus" uniqKey="Martin J" first="Jesús" last="Martín">Jesús Martín</name>
<name sortKey="Perez Moreno, Guiomar" sort="Perez Moreno, Guiomar" uniqKey="Perez Moreno G" first="Guiomar" last="Pérez-Moreno">Guiomar Pérez-Moreno</name>
<name sortKey="Reyes, Fernando" sort="Reyes, Fernando" uniqKey="Reyes F" first="Fernando" last="Reyes">Fernando Reyes</name>
<name sortKey="Vicente, Francisca" sort="Vicente, Francisca" uniqKey="Vicente F" first="Francisca" last="Vicente">Francisca Vicente</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000162 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 000162 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Pmc |étape= Checkpoint |type= RBID |clé= PMC:7076739 |texte= Cytotoxycity and antiplasmodial activity of phenolic derivatives from Albizia zygia (DC.) J.F. Macbr. (Mimosaceae) }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:32020891" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |