Fatal Disseminated Aspergillosis in a Patient with Systemic Lupus Erythematosus
Identifieur interne : 000143 ( Pmc/Checkpoint ); précédent : 000142; suivant : 000144Fatal Disseminated Aspergillosis in a Patient with Systemic Lupus Erythematosus
Auteurs : Rochelle Hardie [États-Unis] ; Tracian James-Goulbourne [États-Unis] ; Monsoon Rashid [États-Unis] ; Jeremy Sullivan [États-Unis] ; Yamen Homsi [États-Unis]Source :
- Case Reports in Infectious Diseases [ 2090-6625 ] ; 2020.
Abstract
Patients with systemic lupus erythematosus (SLE) are at increased risk for infection including opportunistic infections. Fungal infection in particular can be difficult to diagnose and treat and often can be life-threatening in the immunocompromised patient. We present a case in which a patient with SLE presented to the hospital with shortness of breath and cough. Throughout the hospital course, the patient's condition continued to decline leading to acute respiratory failure, and eventually, the patient expired. Postmortem autopsy revealed invasive fungal aspergillosis infection involving the heart, lungs, and brain. Earlier diagnosis and treatment with empiric antifungals may improve survival in these patients.
Url:
DOI: 10.1155/2020/9623198
PubMed: 32181030
PubMed Central: 7066410
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Fatal Disseminated Aspergillosis in a Patient with Systemic Lupus Erythematosus</title>
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<author><name sortKey="James Goulbourne, Tracian" sort="James Goulbourne, Tracian" uniqKey="James Goulbourne T" first="Tracian" last="James-Goulbourne">Tracian James-Goulbourne</name>
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<author><name sortKey="Homsi, Yamen" sort="Homsi, Yamen" uniqKey="Homsi Y" first="Yamen" last="Homsi">Yamen Homsi</name>
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<front><div type="abstract" xml:lang="en"><p>Patients with systemic lupus erythematosus (SLE) are at increased risk for infection including opportunistic infections. Fungal infection in particular can be difficult to diagnose and treat and often can be life-threatening in the immunocompromised patient. We present a case in which a patient with SLE presented to the hospital with shortness of breath and cough. Throughout the hospital course, the patient's condition continued to decline leading to acute respiratory failure, and eventually, the patient expired. Postmortem autopsy revealed invasive fungal aspergillosis infection involving the heart, lungs, and brain. Earlier diagnosis and treatment with empiric antifungals may improve survival in these patients.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Barber, C" uniqKey="Barber C">C. Barber</name>
</author>
<author><name sortKey="Gold, W L" uniqKey="Gold W">W. L. Gold</name>
</author>
<author><name sortKey="Fortin, P R" uniqKey="Fortin P">P. R. Fortin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tektonidou, M G" uniqKey="Tektonidou M">M. G. Tektonidou</name>
</author>
<author><name sortKey="Wang, Z" uniqKey="Wang Z">Z. Wang</name>
</author>
<author><name sortKey="Dasgupta, A" uniqKey="Dasgupta A">A. Dasgupta</name>
</author>
<author><name sortKey="Ward, M M" uniqKey="Ward M">M. M. Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weng, C T" uniqKey="Weng C">C.-T. Weng</name>
</author>
<author><name sortKey="Lee, N Y" uniqKey="Lee N">N.-Y. Lee</name>
</author>
<author><name sortKey="Liu, M F" uniqKey="Liu M">M.-F. Liu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, G L" uniqKey="Chen G">G.-L. Chen</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
<author><name sortKey="Zhu, C Q" uniqKey="Zhu C">C.-Q. Zhu</name>
</author>
<author><name sortKey="Yang, C D" uniqKey="Yang C">C.-D. Yang</name>
</author>
<author><name sortKey="Ye, S" uniqKey="Ye S">S. Ye</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silva, M F" uniqKey="Silva M">M. F. Silva</name>
</author>
<author><name sortKey="Ferriani, M P" uniqKey="Ferriani M">M. P. Ferriani</name>
</author>
<author><name sortKey="Terreri, M T" uniqKey="Terreri M">M. T. Terreri</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hung, M" uniqKey="Hung M">M. Hung</name>
</author>
<author><name sortKey="Liao, H" uniqKey="Liao H">H. Liao</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Martinez Martinez, M U" uniqKey="Martinez Martinez M">M. U. Martínez-martínez</name>
</author>
<author><name sortKey="Herrera Van Oostdam, D" uniqKey="Herrera Van Oostdam D">D. Herrera-van Oostdam</name>
</author>
<author><name sortKey="Roman Acosta, S" uniqKey="Roman Acosta S">S. Román-acosta</name>
</author>
<author><name sortKey="Maga A Aquino, M" uniqKey="Maga A Aquino M">M. Magaña-aquino</name>
</author>
<author><name sortKey="Baranda Candido, L" uniqKey="Baranda Candido L">L. Baranda-cándido</name>
</author>
<author><name sortKey="Abud Mendoza, C" uniqKey="Abud Mendoza C">C. Abud-mendoza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hites, M" uniqKey="Hites M">M. Hites</name>
</author>
<author><name sortKey="Goicoechea Turcott, E W" uniqKey="Goicoechea Turcott E">E. W. Goicoechea Turcott</name>
</author>
<author><name sortKey="Taccone, F S" uniqKey="Taccone F">F. S. Taccone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Meersseman, W" uniqKey="Meersseman W">W. Meersseman</name>
</author>
<author><name sortKey="Vandecasteele, S J" uniqKey="Vandecasteele S">S. J. Vandecasteele</name>
</author>
<author><name sortKey="Wilmer, A" uniqKey="Wilmer A">A. Wilmer</name>
</author>
<author><name sortKey="Verbeken, E" uniqKey="Verbeken E">E. Verbeken</name>
</author>
<author><name sortKey="Peetermans, W E" uniqKey="Peetermans W">W. E. Peetermans</name>
</author>
<author><name sortKey="Van Wijngaerden, E" uniqKey="Van Wijngaerden E">E. Van Wijngaerden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azoulay, E" uniqKey="Azoulay E">E. Azoulay</name>
</author>
<author><name sortKey="Mokart, D" uniqKey="Mokart D">D. Mokart</name>
</author>
<author><name sortKey="Kouatchet, A" uniqKey="Kouatchet A">A. Kouatchet</name>
</author>
<author><name sortKey="Demoule, A" uniqKey="Demoule A">A. Demoule</name>
</author>
<author><name sortKey="Lemiale, V" uniqKey="Lemiale V">V. Lemiale</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Case Rep Infect Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Case Rep Infect Dis</journal-id>
<journal-id journal-id-type="publisher-id">CRIID</journal-id>
<journal-title-group><journal-title>Case Reports in Infectious Diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">2090-6625</issn>
<issn pub-type="epub">2090-6633</issn>
<publisher><publisher-name>Hindawi</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32181030</article-id>
<article-id pub-id-type="pmc">7066410</article-id>
<article-id pub-id-type="doi">10.1155/2020/9623198</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Fatal Disseminated Aspergillosis in a Patient with Systemic Lupus Erythematosus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hardie</surname>
<given-names>Rochelle</given-names>
</name>
<xref ref-type="aff" rid="I1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>James-Goulbourne</surname>
<given-names>Tracian</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rashid</surname>
<given-names>Monsoon</given-names>
</name>
<xref ref-type="aff" rid="I2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sullivan</surname>
<given-names>Jeremy</given-names>
</name>
<xref ref-type="aff" rid="I3"><sup>3</sup>
</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-4195-2281</contrib-id>
<name><surname>Homsi</surname>
<given-names>Yamen</given-names>
</name>
<email>yamenhomsi@yahoo.com</email>
<xref ref-type="aff" rid="I4"><sup>4</sup>
</xref>
</contrib>
</contrib-group>
<aff id="I1"><sup>1</sup>
Division of Infection Disease, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA</aff>
<aff id="I2"><sup>2</sup>
Division of Internal Medicine, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA</aff>
<aff id="I3"><sup>3</sup>
Division of Internal Medicine, NYU Langone Hospital-Brooklyn, 150 55th St, Brooklyn, NY 11220, USA</aff>
<aff id="I4"><sup>4</sup>
Division of Rheumatology, NYU Langone Hospital-Brooklyn, 150 55th St, Brooklyn, NY 11220, USA</aff>
<author-notes><fn fn-type="other"><p>Academic Editor: Larry M. Bush</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2020</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>2</month>
<year>2020</year>
</pub-date>
<volume>2020</volume>
<elocation-id>9623198</elocation-id>
<history><date date-type="received"><day>6</day>
<month>10</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>1</month>
<year>2020</year>
</date>
<date date-type="accepted"><day>5</day>
<month>2</month>
<year>2020</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2020 Rochelle Hardie et al.</copyright-statement>
<copyright-year>2020</copyright-year>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><p>Patients with systemic lupus erythematosus (SLE) are at increased risk for infection including opportunistic infections. Fungal infection in particular can be difficult to diagnose and treat and often can be life-threatening in the immunocompromised patient. We present a case in which a patient with SLE presented to the hospital with shortness of breath and cough. Throughout the hospital course, the patient's condition continued to decline leading to acute respiratory failure, and eventually, the patient expired. Postmortem autopsy revealed invasive fungal aspergillosis infection involving the heart, lungs, and brain. Earlier diagnosis and treatment with empiric antifungals may improve survival in these patients.</p>
</abstract>
</article-meta>
</front>
<floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>CT chest without contrast showed multifocal consolidations bilaterally with bibasilar predominance.</p>
</caption>
<graphic xlink:href="CRIID2020-9623198.001"></graphic>
</fig>
<fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Image of MRI brain showing multifocal areas of diffusion restriction suggestive of vasculitis versus acute infarcts.</p>
</caption>
<graphic xlink:href="CRIID2020-9623198.002"></graphic>
</fig>
<fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Histopathological slide showing a section from the Heart.</p>
</caption>
<graphic xlink:href="CRIID2020-9623198.003"></graphic>
</fig>
<fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Histopathological slide showing a section from the Lung.</p>
</caption>
<graphic xlink:href="CRIID2020-9623198.004"></graphic>
</fig>
<fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label>
<caption><p>Histopathological slide showing a section from the Brain.</p>
</caption>
<graphic xlink:href="CRIID2020-9623198.005"></graphic>
</fig>
<table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label>
<caption><p>Blood and urine studies.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Complete blood count</th>
<th align="center" rowspan="1" colspan="1">Current visit</th>
<th align="center" rowspan="1" colspan="1">Four months prior</th>
<th align="center" rowspan="1" colspan="1">Reference range</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">White blood cells</td>
<td align="center" rowspan="1" colspan="1">11.07</td>
<td align="center" rowspan="1" colspan="1">4.75</td>
<td align="center" rowspan="1" colspan="1">(4.5–10.9) K/uL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Neutrophils</td>
<td align="center" rowspan="1" colspan="1">84.0</td>
<td align="center" rowspan="1" colspan="1">59.7</td>
<td align="center" rowspan="1" colspan="1">(38.7–60.3) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Bands</td>
<td align="center" rowspan="1" colspan="1">12.0</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">(0.0–10.0) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Lymphocytes</td>
<td align="center" rowspan="1" colspan="1">2.0</td>
<td align="center" rowspan="1" colspan="1">26.5</td>
<td align="center" rowspan="1" colspan="1">(22.4–49.0) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Monocytes</td>
<td align="center" rowspan="1" colspan="1">2.0</td>
<td align="center" rowspan="1" colspan="1">8.7</td>
<td align="center" rowspan="1" colspan="1">(2.4–9.2) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Eosinophils</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">1.3</td>
<td align="center" rowspan="1" colspan="1">(0–8.6) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Basophils</td>
<td align="center" rowspan="1" colspan="1">0</td>
<td align="center" rowspan="1" colspan="1">1.3</td>
<td align="center" rowspan="1" colspan="1">(0–1.0) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Hgb</td>
<td align="center" rowspan="1" colspan="1">6.7</td>
<td align="center" rowspan="1" colspan="1">8.1</td>
<td align="center" rowspan="1" colspan="1">(12.0–16.0) g/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Hct</td>
<td align="center" rowspan="1" colspan="1">22.3</td>
<td align="center" rowspan="1" colspan="1">26.6</td>
<td align="center" rowspan="1" colspan="1">(37.0–47.0) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">RDW</td>
<td align="center" rowspan="1" colspan="1">19.8</td>
<td align="center" rowspan="1" colspan="1">19.4</td>
<td align="center" rowspan="1" colspan="1">(11.5–15.1) %</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Platelets</td>
<td align="center" rowspan="1" colspan="1">111</td>
<td align="center" rowspan="1" colspan="1">210</td>
<td align="center" rowspan="1" colspan="1">(130–400) K/uL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Metabolic panel</td>
<td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Sodium</td>
<td align="center" rowspan="1" colspan="1">139</td>
<td align="center" rowspan="1" colspan="1">141</td>
<td align="center" rowspan="1" colspan="1">(136–141) mmol/L</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Potassium</td>
<td align="center" rowspan="1" colspan="1">4.7</td>
<td align="center" rowspan="1" colspan="1">4.1</td>
<td align="center" rowspan="1" colspan="1">(3.5–5) mmol/L</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Chloride</td>
<td align="center" rowspan="1" colspan="1">99</td>
<td align="center" rowspan="1" colspan="1">105</td>
<td align="center" rowspan="1" colspan="1">(98–106) mmol/L</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> CO<sub>2</sub>
</td>
<td align="center" rowspan="1" colspan="1">21</td>
<td align="center" rowspan="1" colspan="1">20</td>
<td align="center" rowspan="1" colspan="1">(24–31) mmol/L</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Plasma urea nitrogen (BUN)</td>
<td align="center" rowspan="1" colspan="1">70</td>
<td align="center" rowspan="1" colspan="1">43</td>
<td align="center" rowspan="1" colspan="1">(6–20) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Creatinine</td>
<td align="center" rowspan="1" colspan="1">2.88</td>
<td align="center" rowspan="1" colspan="1">2.35</td>
<td align="center" rowspan="1" colspan="1">(0.4–1.2) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Glucose</td>
<td align="center" rowspan="1" colspan="1">117</td>
<td align="center" rowspan="1" colspan="1">79</td>
<td align="center" rowspan="1" colspan="1">(70–99) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Calcium</td>
<td align="center" rowspan="1" colspan="1">8.2</td>
<td align="center" rowspan="1" colspan="1">8.6</td>
<td align="center" rowspan="1" colspan="1">(8.4–10.3) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Total protein</td>
<td align="center" rowspan="1" colspan="1">4.6</td>
<td align="center" rowspan="1" colspan="1">6.2</td>
<td align="center" rowspan="1" colspan="1">(6.0–8.5) g/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Albumin</td>
<td align="center" rowspan="1" colspan="1">2.5</td>
<td align="center" rowspan="1" colspan="1">3.2</td>
<td align="center" rowspan="1" colspan="1">(2.8–5.7) g/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Aspartate amino transferase</td>
<td align="center" rowspan="1" colspan="1">20</td>
<td align="center" rowspan="1" colspan="1">28</td>
<td align="center" rowspan="1" colspan="1">(10–35) u/l</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Alanine aminotransferase</td>
<td align="center" rowspan="1" colspan="1">29</td>
<td align="center" rowspan="1" colspan="1">23</td>
<td align="center" rowspan="1" colspan="1">(0–31) u/l</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Alkaline phosphatase</td>
<td align="center" rowspan="1" colspan="1">143</td>
<td align="center" rowspan="1" colspan="1">69</td>
<td align="center" rowspan="1" colspan="1">(25–125) u/l</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Total bilirubin</td>
<td align="center" rowspan="1" colspan="1">1.49</td>
<td align="center" rowspan="1" colspan="1">0.39</td>
<td align="center" rowspan="1" colspan="1">(0.0–1.2) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> LDH</td>
<td align="center" rowspan="1" colspan="1">222</td>
<td align="center" rowspan="1" colspan="1">n/a</td>
<td align="center" rowspan="1" colspan="1">(140–280) u/l</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Rheumatology workup:</td>
<td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> ANA</td>
<td align="center" rowspan="1" colspan="1">1 : 640 homogenous pattern</td>
<td align="center" rowspan="1" colspan="1">1 : 640 speckled pattern</td>
<td align="center" rowspan="1" colspan="1"><1 : 40</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Anti-SSA</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Anti-SSB</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Anti-Smith</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Anti-ds DNA</td>
<td align="center" rowspan="1" colspan="1">130</td>
<td align="center" rowspan="1" colspan="1">65</td>
<td align="center" rowspan="1" colspan="1">(<100) U/mL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Rheumatoid factor</td>
<td align="center" rowspan="1" colspan="1"><7</td>
<td align="center" rowspan="1" colspan="1"><7</td>
<td align="center" rowspan="1" colspan="1">(<14) IU/mL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Anticyclic citrullinated peptide antibodies</td>
<td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">(0–19) units</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Anti-RNP</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Creatine Kinase</td>
<td align="center" rowspan="1" colspan="1">32</td>
<td align="center" rowspan="1" colspan="1">30</td>
<td align="center" rowspan="1" colspan="1">(24–195) u/l</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> ESR</td>
<td align="center" rowspan="1" colspan="1">76</td>
<td align="center" rowspan="1" colspan="1">38</td>
<td align="center" rowspan="1" colspan="1">(0–20) mm/hr</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> hsCRP</td>
<td align="center" rowspan="1" colspan="1">>300</td>
<td align="center" rowspan="1" colspan="1">38.59</td>
<td align="center" rowspan="1" colspan="1">(1.0–4.0) mg/L</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> C3</td>
<td align="center" rowspan="1" colspan="1">87</td>
<td align="center" rowspan="1" colspan="1">45</td>
<td align="center" rowspan="1" colspan="1">(86–184) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> C4</td>
<td align="center" rowspan="1" colspan="1">26</td>
<td align="center" rowspan="1" colspan="1">22</td>
<td align="center" rowspan="1" colspan="1">(20–58) mg/dL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Total complement CH50</td>
<td align="center" rowspan="1" colspan="1">52</td>
<td align="center" rowspan="1" colspan="1">50</td>
<td align="center" rowspan="1" colspan="1">(42–60) U/mL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> c-ANCA (PR3)</td>
<td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">8</td>
<td align="center" rowspan="1" colspan="1">AU/mL<break></break>
<100—neg<break></break>
100–120—equivocal<break></break>
>100—pos</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> p-ANCA (MPO)</td>
<td align="center" rowspan="1" colspan="1">5</td>
<td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">AU/mL<break></break>
<100—neg<break></break>
100–120—equivocal<break></break>
>100—pos</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">Others blood tests:</td>
<td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1"> </td>
<td align="left" rowspan="1" colspan="1"> </td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Hep B Surface antibody</td>
<td align="center" rowspan="1" colspan="1"><3.5</td>
<td align="center" rowspan="1" colspan="1"><3.5</td>
<td align="center" rowspan="1" colspan="1"><8.499 mIU/mL</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Hepatitis B Surface Ag</td>
<td align="center" rowspan="1" colspan="1">Nonreactive</td>
<td align="center" rowspan="1" colspan="1">Nonreactive</td>
<td align="center" rowspan="1" colspan="1">Nonreactive</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Hep C antibody</td>
<td align="center" rowspan="1" colspan="1">Nonreactive</td>
<td align="center" rowspan="1" colspan="1">Nonreactive</td>
<td align="center" rowspan="1" colspan="1">Nonreactive</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Quantiferon</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Pro-BNP</td>
<td align="center" rowspan="1" colspan="1">>7000</td>
<td align="center" rowspan="1" colspan="1">110</td>
<td align="center" rowspan="1" colspan="1">( = 125) pg/ml</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1"> Urine protein/creatinine ratio</td>
<td align="center" rowspan="1" colspan="1">6.3</td>
<td align="center" rowspan="1" colspan="1">3.7</td>
<td align="center" rowspan="1" colspan="1">0.5 mg/g</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label>
<caption><p>CSF analysis.</p>
</caption>
<table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Variable</th>
<th align="center" rowspan="1" colspan="1">Result</th>
<th align="center" rowspan="1" colspan="1">Reference range</th>
</tr>
</thead>
<tbody><tr><td align="left" rowspan="1" colspan="1">CSF appearance</td>
<td align="center" rowspan="1" colspan="1">Clear-colorless</td>
<td align="center" rowspan="1" colspan="1">Clear-colorless</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF WBC</td>
<td align="center" rowspan="1" colspan="1">1</td>
<td align="center" rowspan="1" colspan="1">0–5 ul</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF RBC</td>
<td align="center" rowspan="1" colspan="1">6–10</td>
<td align="center" rowspan="1" colspan="1">0 ul</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF glucose</td>
<td align="center" rowspan="1" colspan="1">60</td>
<td align="center" rowspan="1" colspan="1">40–70 mg/dl</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF total protein</td>
<td align="center" rowspan="1" colspan="1">95</td>
<td align="center" rowspan="1" colspan="1">15–45 mg/dl</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF cryptococcal antigen</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF CMV PCR</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF EBV PCR</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF HSV PCR</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
<td align="center" rowspan="1" colspan="1">Negative</td>
</tr>
<tr><td align="left" rowspan="1" colspan="1">CSF culture</td>
<td align="center" rowspan="1" colspan="1">No growth after 72 hrs</td>
<td align="center" rowspan="1" colspan="1">No growth</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Hardie, Rochelle" sort="Hardie, Rochelle" uniqKey="Hardie R" first="Rochelle" last="Hardie">Rochelle Hardie</name>
</noRegion>
<name sortKey="Homsi, Yamen" sort="Homsi, Yamen" uniqKey="Homsi Y" first="Yamen" last="Homsi">Yamen Homsi</name>
<name sortKey="James Goulbourne, Tracian" sort="James Goulbourne, Tracian" uniqKey="James Goulbourne T" first="Tracian" last="James-Goulbourne">Tracian James-Goulbourne</name>
<name sortKey="Rashid, Monsoon" sort="Rashid, Monsoon" uniqKey="Rashid M" first="Monsoon" last="Rashid">Monsoon Rashid</name>
<name sortKey="Sullivan, Jeremy" sort="Sullivan, Jeremy" uniqKey="Sullivan J" first="Jeremy" last="Sullivan">Jeremy Sullivan</name>
</country>
</tree>
</affiliations>
</record>
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