Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape
Identifieur interne : 000125 ( Pmc/Checkpoint ); précédent : 000124; suivant : 000126Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape
Auteurs : Sisi Xie ; Shu Li ; Jing Tian ; Fen LiSource :
- Frontiers in Pharmacology [ 1663-9812 ] ; 2020.
Abstract
Iguratimod (IGU) is a novel synthetic small molecule disease modified anti-rheumatic drug approved only in Japan and China up to date. IGU plays an important immunomodulatory role in the synovial tissue of rheumatoid arthritis by inhibiting the production of immunoglobulins and cytokines and regulating T lymphocyte subsets. IGU also regulates bone metabolism by stimulating bone formation while inhibiting osteoclast differentiation, migration, and bone resorption. In clinical trials, IGU was shown to be superior to placebo and not inferior to salazosulfapyridine. Combined therapy of IGU with other disease-modifying anti-rheumatic drugs showed significant improvements for disease activity. IGU has good efficacy and tolerance as an additional treatment for rheumatoid arthritis patients with inadequate response to methotrexate and biological disease-modifying anti-rheumatic drugs. In this review, we summarize current landscape on the mechanism of action of IGU and its clinical effectiveness and safety. It is expected that further translational studies on IGU will pave the road for wider application of IGU in the treatment of autoimmune diseases other than rheumatoid arthritis.
Url:
DOI: 10.3389/fphar.2020.00073
PubMed: 32174824
PubMed Central: 7054862
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape</title><author><name sortKey="Xie, Sisi" sort="Xie, Sisi" uniqKey="Xie S" first="Sisi" last="Xie">Sisi Xie</name></author><author><name sortKey="Li, Shu" sort="Li, Shu" uniqKey="Li S" first="Shu" last="Li">Shu Li</name></author><author><name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name></author><author><name sortKey="Li, Fen" sort="Li, Fen" uniqKey="Li F" first="Fen" last="Li">Fen Li</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32174824</idno><idno type="pmc">7054862</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7054862</idno><idno type="RBID">PMC:7054862</idno><idno type="doi">10.3389/fphar.2020.00073</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000997</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000997</idno><idno type="wicri:Area/Pmc/Curation">000997</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000997</idno><idno type="wicri:Area/Pmc/Checkpoint">000125</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000125</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape</title><author><name sortKey="Xie, Sisi" sort="Xie, Sisi" uniqKey="Xie S" first="Sisi" last="Xie">Sisi Xie</name></author><author><name sortKey="Li, Shu" sort="Li, Shu" uniqKey="Li S" first="Shu" last="Li">Shu Li</name></author><author><name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name></author><author><name sortKey="Li, Fen" sort="Li, Fen" uniqKey="Li F" first="Fen" last="Li">Fen Li</name></author></analytic><series><title level="j">Frontiers in Pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Iguratimod (IGU) is a novel synthetic small molecule disease modified anti-rheumatic drug approved only in Japan and China up to date. IGU plays an important immunomodulatory role in the synovial tissue of rheumatoid arthritis by inhibiting the production of immunoglobulins and cytokines and regulating T lymphocyte subsets. IGU also regulates bone metabolism by stimulating bone formation while inhibiting osteoclast differentiation, migration, and bone resorption. In clinical trials, IGU was shown to be superior to placebo and not inferior to salazosulfapyridine. Combined therapy of IGU with other disease-modifying anti-rheumatic drugs showed significant improvements for disease activity. IGU has good efficacy and tolerance as an additional treatment for rheumatoid arthritis patients with inadequate response to methotrexate and biological disease-modifying anti-rheumatic drugs. In this review, we summarize current landscape on the mechanism of action of IGU and its clinical effectiveness and safety. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Pharmacol</journal-id><journal-id journal-id-type="iso-abbrev">Front Pharmacol</journal-id><journal-id journal-id-type="publisher-id">Front. Pharmacol.</journal-id><journal-title-group><journal-title>Frontiers in Pharmacology</journal-title></journal-title-group><issn pub-type="epub">1663-9812</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32174824</article-id><article-id pub-id-type="pmc">7054862</article-id><article-id pub-id-type="doi">10.3389/fphar.2020.00073</article-id><article-categories><subj-group subj-group-type="heading"><subject>Pharmacology</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Iguratimod as a New Drug for Rheumatoid Arthritis: Current Landscape</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Xie</surname><given-names>Sisi</given-names></name><uri xlink:type="simple" xlink:href="https://loop.frontiersin.org/people/833916"></uri></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Shu</given-names></name></contrib><contrib contrib-type="author"><name><surname>Tian</surname><given-names>Jing</given-names></name></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Fen</given-names></name><xref ref-type="author-notes" rid="fn001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="https://loop.frontiersin.org/people/909355"></uri></contrib></contrib-group><aff id="aff1"><institution>Department of Internal Medicine, The 2nd Xiangya Hospital of Central South University</institution>,<addr-line>Changsha</addr-line>,<country>China</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Gerard Bannenberg, GOED, United States</p></fn><fn fn-type="edited-by"><p>Reviewed by: Helena Idborg, Karolinska Institutet (KI), Sweden; Yi Miao, Nanjing Medical University, China</p></fn><corresp id="fn001">*Correspondence: Fen Li, <email xlink:href="mailto:Lifen0731@csu.edu.cn" xlink:type="simple">Lifen0731@csu.edu.cn</email></corresp><fn fn-type="other" id="fn002"><p>This article was submitted to Inflammation Pharmacology, a section of the journal Frontiers in Pharmacology</p></fn></author-notes><pub-date pub-type="epub"><day>26</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="collection"><year>2020</year></pub-date><volume>11</volume><elocation-id>73</elocation-id><history><date date-type="received"><day>01</day><month>11</month><year>2019</year></date><date date-type="accepted"><day>24</day><month>1</month><year>2020</year></date></history><permissions><copyright-statement>Copyright © 2020 Xie, Li, Tian and Li</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Xie, Li, Tian and Li</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Iguratimod (IGU) is a novel synthetic small molecule disease modified anti-rheumatic drug approved only in Japan and China up to date. IGU plays an important immunomodulatory role in the synovial tissue of rheumatoid arthritis by inhibiting the production of immunoglobulins and cytokines and regulating T lymphocyte subsets. IGU also regulates bone metabolism by stimulating bone formation while inhibiting osteoclast differentiation, migration, and bone resorption. In clinical trials, IGU was shown to be superior to placebo and not inferior to salazosulfapyridine. Combined therapy of IGU with other disease-modifying anti-rheumatic drugs showed significant improvements for disease activity. IGU has good efficacy and tolerance as an additional treatment for rheumatoid arthritis patients with inadequate response to methotrexate and biological disease-modifying anti-rheumatic drugs. In this review, we summarize current landscape on the mechanism of action of IGU and its clinical effectiveness and safety. It is expected that further translational studies on IGU will pave the road for wider application of IGU in the treatment of autoimmune diseases other than rheumatoid arthritis.</p></abstract><kwd-group><kwd>iguratimod</kwd><kwd>rheumatoid arthritis</kwd><kwd>NF-kappa B</kwd><kwd>randomized controlled trial</kwd><kwd>pharmacology</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="2"></table-count><equation-count count="0"></equation-count><ref-count count="48"></ref-count><page-count count="9"></page-count><word-count count="4936"></word-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Li, Fen" sort="Li, Fen" uniqKey="Li F" first="Fen" last="Li">Fen Li</name><name sortKey="Li, Shu" sort="Li, Shu" uniqKey="Li S" first="Shu" last="Li">Shu Li</name><name sortKey="Tian, Jing" sort="Tian, Jing" uniqKey="Tian J" first="Jing" last="Tian">Jing Tian</name><name sortKey="Xie, Sisi" sort="Xie, Sisi" uniqKey="Xie S" first="Sisi" last="Xie">Sisi Xie</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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