LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT
Identifieur interne : 000116 ( Pmc/Checkpoint ); précédent : 000115; suivant : 000117LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT
Auteurs : Yi-Fang Dai [République populaire de Chine] ; Na Lin [République populaire de Chine] ; De-Qin He [République populaire de Chine] ; Mu Xu [République populaire de Chine] ; Li-Ying Zhong [République populaire de Chine] ; Shu-Qiong He [République populaire de Chine] ; Dan-Hua Guo [République populaire de Chine] ; Ying Li [République populaire de Chine] ; Hai-Long Huang [République populaire de Chine] ; Xiang-Qing Zheng [République populaire de Chine] ; Liang-Pu Xu [République populaire de Chine]Source :
- Journal of Cancer [ 1837-9664 ] ; 2020.
Abstract
Url:
DOI: 10.7150/jca.39359
PubMed: 32047568
PubMed Central: 6995386
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT</title><author><name sortKey="Dai, Yi Fang" sort="Dai, Yi Fang" uniqKey="Dai Y" first="Yi-Fang" last="Dai">Yi-Fang Dai</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Lin, Na" sort="Lin, Na" uniqKey="Lin N" first="Na" last="Lin">Na Lin</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="He, De Qin" sort="He, De Qin" uniqKey="He D" first="De-Qin" last="He">De-Qin He</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Xu, Mu" sort="Xu, Mu" uniqKey="Xu M" first="Mu" last="Xu">Mu Xu</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Zhong, Li Ying" sort="Zhong, Li Ying" uniqKey="Zhong L" first="Li-Ying" last="Zhong">Li-Ying Zhong</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="He, Shu Qiong" sort="He, Shu Qiong" uniqKey="He S" first="Shu-Qiong" last="He">Shu-Qiong He</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Guo, Dan Hua" sort="Guo, Dan Hua" uniqKey="Guo D" first="Dan-Hua" last="Guo">Dan-Hua Guo</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Li, Ying" sort="Li, Ying" uniqKey="Li Y" first="Ying" last="Li">Ying Li</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Huang, Hai Long" sort="Huang, Hai Long" uniqKey="Huang H" first="Hai-Long" last="Huang">Hai-Long Huang</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Zheng, Xiang Qing" sort="Zheng, Xiang Qing" uniqKey="Zheng X" first="Xiang-Qing" last="Zheng">Xiang-Qing Zheng</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Xu, Liang Pu" sort="Xu, Liang Pu" uniqKey="Xu L" first="Liang-Pu" last="Xu">Liang-Pu Xu</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32047568</idno><idno type="pmc">6995386</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6995386</idno><idno type="RBID">PMC:6995386</idno><idno type="doi">10.7150/jca.39359</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000649</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000649</idno><idno type="wicri:Area/Pmc/Curation">000649</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000649</idno><idno type="wicri:Area/Pmc/Checkpoint">000116</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000116</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT</title><author><name sortKey="Dai, Yi Fang" sort="Dai, Yi Fang" uniqKey="Dai Y" first="Yi-Fang" last="Dai">Yi-Fang Dai</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Lin, Na" sort="Lin, Na" uniqKey="Lin N" first="Na" last="Lin">Na Lin</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="He, De Qin" sort="He, De Qin" uniqKey="He D" first="De-Qin" last="He">De-Qin He</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Xu, Mu" sort="Xu, Mu" uniqKey="Xu M" first="Mu" last="Xu">Mu Xu</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Zhong, Li Ying" sort="Zhong, Li Ying" uniqKey="Zhong L" first="Li-Ying" last="Zhong">Li-Ying Zhong</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="He, Shu Qiong" sort="He, Shu Qiong" uniqKey="He S" first="Shu-Qiong" last="He">Shu-Qiong He</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Guo, Dan Hua" sort="Guo, Dan Hua" uniqKey="Guo D" first="Dan-Hua" last="Guo">Dan-Hua Guo</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Li, Ying" sort="Li, Ying" uniqKey="Li Y" first="Ying" last="Li">Ying Li</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Huang, Hai Long" sort="Huang, Hai Long" uniqKey="Huang H" first="Hai-Long" last="Huang">Hai-Long Huang</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Zheng, Xiang Qing" sort="Zheng, Xiang Qing" uniqKey="Zheng X" first="Xiang-Qing" last="Zheng">Xiang-Qing Zheng</name><affiliation wicri:level="1"><nlm:aff id="A3">Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author><author><name sortKey="Xu, Liang Pu" sort="Xu, Liang Pu" uniqKey="Xu L" first="Liang-Pu" last="Xu">Liang-Pu Xu</name><affiliation wicri:level="1"><nlm:aff id="A1">Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A2">Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001</wicri:regionArea><placeName><settlement type="city">Fuzhou</settlement><region type="province">Fujian</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Cancer</title><idno type="eISSN">1837-9664</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Objective</bold>: To explore the relationship and mechanism of LZAP in the occurrence and development of cervical cancer and to provide a new target and intervention method for the treatment of cervical cancer.</p><p><bold>Methods</bold>: Data mining and analysis of LZAP expression levels were performed using several online databases, including The Cancer Genome Atlas (TCGA). A cervical cancer cell line that stably overexpresses LZAP was established, and the effect of LZAP overexpression on cell proliferation, invasion, migration and tumor formation in vivo as well as its mechanism were explored.</p><p><bold>Results</bold>: Our study shows that the expression of LZAP is upregulated in cervical cancer. The overexpression of LZAP can significantly promote the proliferation, colony formation, and invasion and migration abilities of cervical cancer cells. The tumorigenesis test in nude mice showed that overexpression of LZAP could promote the tumorigenicity of cervical cancer cells in vivo. LZAP could also promote the phosphorylation of AKT at position 473 and the epithelial-mesenchymal transition (EMT).</p><p><bold>Conclusion</bold>: The expression of LAZP is increased in cervical cancer, which can enhance the invasion, metastasis, and EMT in cervical cancer cells by promoting AKT phosphorylation.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Soerjomataram, I" uniqKey="Soerjomataram I">I Soerjomataram</name></author><author><name sortKey="Dikshit, R" uniqKey="Dikshit R">R Dikshit</name></author><author><name sortKey="Eser, S" uniqKey="Eser S">S Eser</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Rebelo, M" uniqKey="Rebelo M">M Rebelo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peralta Zaragoza, O" uniqKey="Peralta Zaragoza O">O 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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">J Cancer</journal-id><journal-id journal-id-type="publisher-id">jca</journal-id><journal-title-group><journal-title>Journal of Cancer</journal-title></journal-title-group><issn pub-type="epub">1837-9664</issn><publisher><publisher-name>Ivyspring International Publisher</publisher-name><publisher-loc>Sydney</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32047568</article-id><article-id pub-id-type="pmc">6995386</article-id><article-id pub-id-type="doi">10.7150/jca.39359</article-id><article-id pub-id-type="publisher-id">jcav11p1625</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>LZAP promotes the proliferation and invasiveness of cervical carcinoma cells by targeting AKT and EMT</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Dai</surname><given-names>Yi-Fang</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Na</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>De-Qin</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Mu</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>Zhong</surname><given-names>Li-Ying</given-names></name><xref ref-type="aff" rid="A3">3</xref></contrib><contrib contrib-type="author"><name><surname>He</surname><given-names>Shu-Qiong</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Dan-Hua</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Ying</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Hai-Long</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Xiang-Qing</given-names></name><xref ref-type="aff" rid="A3">3</xref><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib><contrib contrib-type="author"><name><surname>Xu</surname><given-names>Liang-Pu</given-names></name><xref ref-type="aff" rid="A1">1</xref><xref ref-type="aff" rid="A2">2</xref><xref ref-type="corresp" rid="FNA_envelop">✉</xref></contrib></contrib-group><aff id="A1"><label>1</label>Center of Prenatal Diagnosis, Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China</aff><aff id="A2"><label>2</label>Fujian Provincial Key Laboratory for Prenatal diagnosis and Birth Defect, Fuzhou 350001, China</aff><aff id="A3"><label>3</label>Department of Gynecology, Fujian Provincial Maternity and Children's Hospital, Fuzhou 350001, China</aff><author-notes><corresp id="FNA_envelop">✉ Corresponding authors: Xiang-Qing Zheng, Department of Gynecology, E-mail: <email>zhengxq1215@163.com</email>; Liang-Pu Xu, Center of Prenatal Diagnosis, E-mail: <email>ipxiu304@126.com</email>. Fujian Provincial Maternity and Children's Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou 350001, China.</corresp><fn fn-type="COI-statement"><p>Competing Interests: The authors have declared that no competing interest exists.</p></fn></author-notes><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>14</day><month>1</month><year>2020</year></pub-date><volume>11</volume><issue>6</issue><fpage>1625</fpage><lpage>1633</lpage><history><date date-type="received"><day>15</day><month>8</month><year>2019</year></date><date date-type="accepted"><day>1</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>© The author(s)</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</ext-link>). See <ext-link ext-link-type="uri" xlink:href="http://ivyspring.com/terms">http://ivyspring.com/terms</ext-link> for full terms and conditions.</license-p></license></permissions><abstract><p><bold>Objective</bold>: To explore the relationship and mechanism of LZAP in the occurrence and development of cervical cancer and to provide a new target and intervention method for the treatment of cervical cancer.</p><p><bold>Methods</bold>: Data mining and analysis of LZAP expression levels were performed using several online databases, including The Cancer Genome Atlas (TCGA). A cervical cancer cell line that stably overexpresses LZAP was established, and the effect of LZAP overexpression on cell proliferation, invasion, migration and tumor formation in vivo as well as its mechanism were explored.</p><p><bold>Results</bold>: Our study shows that the expression of LZAP is upregulated in cervical cancer. The overexpression of LZAP can significantly promote the proliferation, colony formation, and invasion and migration abilities of cervical cancer cells. The tumorigenesis test in nude mice showed that overexpression of LZAP could promote the tumorigenicity of cervical cancer cells in vivo. LZAP could also promote the phosphorylation of AKT at position 473 and the epithelial-mesenchymal transition (EMT).</p><p><bold>Conclusion</bold>: The expression of LAZP is increased in cervical cancer, which can enhance the invasion, metastasis, and EMT in cervical cancer cells by promoting AKT phosphorylation.</p></abstract><kwd-group><kwd>LZAP</kwd><kwd>EMT</kwd><kwd>Cervical Carcinoma</kwd><kwd>Metastasis</kwd></kwd-group></article-meta></front><floats-group><fig id="F1" position="float"><label>Figure 1</label><caption><p>Expression levels of LZAP in cervical carcinoma tissue. (A, B) Oncomine data mining analysis of LZAP levels in the Scotto and Biewenga datasets between normal tissues and cervical carcinoma tissues. (C) Expression of LZAP in cervical squamous cell carcinoma (CESC) according to the TCGA data. (D) The expression of LZAP was significantly elevated in cervical carcinoma tissues compared with adjacent normal tissues. (E) The expression of LZAP protein in cervical carcinoma tissues and corresponding adjacent tissues was analyzed using IHC. (*P < 0.05; **p< 0.01)</p></caption><graphic xlink:href="jcav11p1625g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2</label><caption><p>Construction of the overexpressing stable cell line. (A) The overexpression efficiencies of HeLa cells and HCC94 cells after transfection of LZAP. (B) Cell lysates were extracted from HeLa and HCC94 cell lines that stably expressed LZAP protein, which along with GAPDH, was detected by Western blot, scale bar, 50 µm.</p></caption><graphic xlink:href="jcav11p1625g002"></graphic></fig><fig id="F3" position="float"><label>Figure 3</label><caption><p>CCK8 and colony-formation assays were used to verify the function of the stably transfected cells. (A) Proliferation of HeLa and HCC94 cell lines stably expressing LZAP was assessed by CCK8 assay. (B) Colony-forming ability of HeLa and HCC94 cell lines stably expressing LZAP was investigated by colony formation assay. (*P < 0.05; **p< 0.01)</p></caption><graphic xlink:href="jcav11p1625g003"></graphic></fig><fig id="F4" position="float"><label>Figure 4</label><caption><p>Transwell assay was used to verify the function of the stably transfected cells. (A, B) The migration and invasion abilities of HeLa and HCC94 cell lines stably expressing LZAP was examined using a Transwell assay, scale bar, 50 µm. (*P < 0.05; **p< 0.01)</p></caption><graphic xlink:href="jcav11p1625g004"></graphic></fig><fig id="F5" position="float"><label>Figure 5</label><caption><p>Xenograft models in nude mice. Xenograft models using three sets of stable HeLa cells were established, and the tumors were allowed to grow for 35 days. (A) The size of the xenografts was measured every seven days until the mice were sacrificed. (B) Representative images of the effect of LZAP overexpression are presented. (C) The average tumor weights of the three different groups were compared. (D) The localization and expression of LZAP in xenografts were detected by IHC. (*P < 0.05; **p< 0.01)</p></caption><graphic xlink:href="jcav11p1625g005"></graphic></fig><fig id="F6" position="float"><label>Figure 6</label><caption><p>The expression levels of EMT-related proteins indicated by Western blotting in control (NC) and LZAP overexpression groups of HeLa and HCC94 cells. (*P < 0.05; **p< 0.01)</p></caption><graphic xlink:href="jcav11p1625g006"></graphic></fig></floats-group></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Fujian</li></region><settlement><li>Fuzhou</li></settlement></list><tree><country name="République populaire de Chine"><region name="Fujian"><name sortKey="Dai, Yi Fang" sort="Dai, Yi Fang" uniqKey="Dai Y" first="Yi-Fang" last="Dai">Yi-Fang Dai</name></region><name sortKey="Dai, Yi Fang" sort="Dai, Yi Fang" uniqKey="Dai Y" first="Yi-Fang" last="Dai">Yi-Fang Dai</name><name sortKey="Guo, Dan Hua" sort="Guo, Dan Hua" uniqKey="Guo D" first="Dan-Hua" last="Guo">Dan-Hua Guo</name><name sortKey="Guo, Dan Hua" sort="Guo, Dan Hua" uniqKey="Guo D" first="Dan-Hua" last="Guo">Dan-Hua Guo</name><name sortKey="He, De Qin" sort="He, De Qin" uniqKey="He D" first="De-Qin" last="He">De-Qin He</name><name sortKey="He, De Qin" sort="He, De Qin" uniqKey="He D" first="De-Qin" last="He">De-Qin He</name><name sortKey="He, Shu Qiong" sort="He, Shu Qiong" uniqKey="He S" first="Shu-Qiong" last="He">Shu-Qiong He</name><name sortKey="He, Shu Qiong" sort="He, Shu Qiong" uniqKey="He S" first="Shu-Qiong" last="He">Shu-Qiong He</name><name sortKey="Huang, Hai Long" sort="Huang, Hai Long" uniqKey="Huang H" first="Hai-Long" last="Huang">Hai-Long Huang</name><name sortKey="Huang, Hai Long" sort="Huang, Hai Long" uniqKey="Huang H" first="Hai-Long" last="Huang">Hai-Long Huang</name><name sortKey="Li, Ying" sort="Li, Ying" uniqKey="Li Y" first="Ying" last="Li">Ying Li</name><name sortKey="Li, Ying" sort="Li, Ying" uniqKey="Li Y" first="Ying" last="Li">Ying Li</name><name sortKey="Lin, Na" sort="Lin, Na" uniqKey="Lin N" first="Na" last="Lin">Na Lin</name><name sortKey="Lin, Na" sort="Lin, Na" uniqKey="Lin N" first="Na" last="Lin">Na Lin</name><name sortKey="Xu, Liang Pu" sort="Xu, Liang Pu" uniqKey="Xu L" first="Liang-Pu" last="Xu">Liang-Pu Xu</name><name sortKey="Xu, Liang Pu" sort="Xu, Liang Pu" uniqKey="Xu L" first="Liang-Pu" last="Xu">Liang-Pu Xu</name><name sortKey="Xu, Mu" sort="Xu, Mu" uniqKey="Xu M" first="Mu" last="Xu">Mu Xu</name><name sortKey="Zheng, Xiang Qing" sort="Zheng, Xiang Qing" uniqKey="Zheng X" first="Xiang-Qing" last="Zheng">Xiang-Qing Zheng</name><name sortKey="Zhong, Li Ying" sort="Zhong, Li Ying" uniqKey="Zhong L" first="Li-Ying" last="Zhong">Li-Ying Zhong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |