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Influence of chloroquine and lidocaine on retention and cytotoxic effects of [131I]EGG : studies on cultured glioma cells

Identifieur interne : 000071 ( PascalFrancis/Curation ); précédent : 000070; suivant : 000072

Influence of chloroquine and lidocaine on retention and cytotoxic effects of [131I]EGG : studies on cultured glioma cells

Auteurs : J. Capala [Suède] ; J. Carlsson

Source :

RBID : Pascal:92-0245450

Descripteurs français

English descriptors

Abstract

Targeting of toxic substances to the epidermal growth factor, EGF, receptor might be an attractive therapeutic approach because of the increased receptor-expression in some human tumours such as, for example, malignant gliomas and squamous lung carcinomas. Radiation effects of [131I]EGF on human malignant glioma cells growing as monolayers were analysed in this study. The cells were, in all cases, incubated for 25 min with about 350 kBq/ml [131I]EGF, which gave a total binding of 3-2-3-5 kBq/105 cells
pA  
A01 01  1    @0 0955-3002
A03   1    @0 Int. j. radiat. biol.
A05       @2 60
A06       @2 3
A08 01  1  ENG  @1 Influence of chloroquine and lidocaine on retention and cytotoxic effects of [131I]EGG : studies on cultured glioma cells
A11 01  1    @1 CAPALA (J.)
A11 02  1    @1 CARLSSON (J.)
A14 01      @1 Uppsala univ., dep. radiation sci. @2 Uppsala 751 21 @3 SWE
A20       @1 497-510
A21       @1 1991
A23 01      @0 ENG
A24 01      @0 eng
A43 01      @1 INIST @2 9269 @5 354000010084170070
A44       @0 0000
A45       @0 2 p.
A47 01  1    @0 92-0245450
A60       @1 P
A61       @0 A
A64   1    @0 International journal of radiation biology
A66 01      @0 GBR
C01 01    ENG  @0 Targeting of toxic substances to the epidermal growth factor, EGF, receptor might be an attractive therapeutic approach because of the increased receptor-expression in some human tumours such as, for example, malignant gliomas and squamous lung carcinomas. Radiation effects of [131I]EGF on human malignant glioma cells growing as monolayers were analysed in this study. The cells were, in all cases, incubated for 25 min with about 350 kBq/ml [131I]EGF, which gave a total binding of 3-2-3-5 kBq/105 cells
C02 01  X    @0 002B04H02A
C03 01  X  FRE  @0 Irradiation ionisante
C03 01  X  ENG  @0 Ionizing irradiation
C03 01  X  SPA  @0 Irradiación ionizante
C03 02  X  FRE  @0 Facteur croissance épiderme
C03 02  X  ENG  @0 Epidermal growth factor
C03 02  X  SPA  @0 Factor crecimiento epidermi
C03 03  X  FRE  @0 Récepteur biologique
C03 03  X  ENG  @0 Biological receptor
C03 03  X  SPA  @0 Receptor biológico
C03 04  X  FRE  @0 Culture monocouche
C03 04  X  ENG  @0 Monolayer culture
C03 04  X  SPA  @0 Cultivo monocapa
C03 05  X  FRE  @0 Cellule tumorale
C03 05  X  ENG  @0 Tumor cell
C03 05  X  SPA  @0 Célula tumoral
C03 06  X  FRE  @0 Gliome
C03 06  X  ENG  @0 Glioma
C03 06  X  SPA  @0 Glioma
C03 07  X  FRE  @0 Chloroquine @2 NK @2 FR
C03 08  X  FRE  @0 Lidocaïne @2 NK @2 FR
C03 09  X  FRE  @0 Radiothérapie
C03 09  X  ENG  @0 Radiotherapy
C03 09  X  SPA  @0 Radioterapia
C03 10  X  FRE  @0 Radioisotope
C03 10  X  ENG  @0 Radioisotope
C03 10  X  SPA  @0 Radionúclido
C03 11  X  FRE  @0 Iode Complexe @2 NC @2 NA
C03 11  X  ENG  @0 Iodine Complexes @2 NC @2 NA
C03 11  X  SPA  @0 Iodo Complejo @2 NC @2 NA
C03 12  X  FRE  @0 Radiobiologie
C03 12  X  ENG  @0 Radiobiology
C03 12  X  SPA  @0 Radiobiología
C03 13  X  FRE  @0 Biophysique
C03 13  X  ENG  @0 Biophysics
C03 13  X  SPA  @0 Biofísica
C03 14  X  FRE  @0 Ciblage @4 INC
C03 15  X  FRE  @0 Iode 131 @4 INC
N21       @1 180

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Pascal:92-0245450

Le document en format XML

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   |texte=   Influence of chloroquine and lidocaine on retention and cytotoxic effects of [131I]EGG : studies on cultured glioma cells
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