Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells
Identifieur interne : 000044 ( PascalFrancis/Checkpoint ); précédent : 000043; suivant : 000045Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells
Auteurs : Elizabeth A. Perkett [États-Unis] ; Wojclech Ornatowski [États-Unis] ; Jens F. Poschet [États-Unis] ; Vojo Deretic [États-Unis]Source :
- Pediatric pulmonology [ 8755-6863 ] ; 2006.
Descripteurs français
- Pascal (Inist)
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- topic : Pédiatrie.
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Abstract
Cystic fibrosis (CF) remains a fatal progressive disease in spite of the discovery and characterization of the CFTR gene. Transforming growth factor beta (TGF-p) has been implicated in pathophysiology of CF Previous reports have shown the trans-Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF-p produced by CF and normal cells was measured using a reporter cell line with a TGF-p responsive promoter linked to luciferase. Increased levels of TGF-β were detected in the conditioned media from CF epithelial cells compared to their matched controls-(IB3-1 vs. S9; pCEP-R vs. pCEP, CuFi-4 vs. NuLi-1). Levels of TGF-β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF-p levels.
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Perkett</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Ornatowski, Wojclech" sort="Ornatowski, Wojclech" uniqKey="Ornatowski W" first="Wojclech" last="Ornatowski">Wojclech Ornatowski</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Poschet, Jens F" sort="Poschet, Jens F" uniqKey="Poschet J" first="Jens F." last="Poschet">Jens F. Poschet</name><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author><author><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation><affiliation wicri:level="2"><inist:fA14 i1="02"><s1>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Nouveau-Mexique</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Pediatric pulmonology</title><title level="j" type="abbreviated">Pediatr. pulmonol.</title><idno type="ISSN">8755-6863</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Pediatric pulmonology</title><title level="j" type="abbreviated">Pediatr. pulmonol.</title><idno type="ISSN">8755-6863</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Activity</term><term>Anomaly</term><term>Antimalarial</term><term>Bronchus</term><term>Chloroquine</term><term>Chronic</term><term>Cystic fibrosis</term><term>Epithelial cell</term><term>Fibrosis</term><term>Furin</term><term>Golgi apparatus</term><term>Inflammation</term><term>Lung</term><term>Parasiticide</term><term>Pediatrics</term><term>Respiratory disease</term><term>Transforming growth factor β</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Mucoviscidose</term><term>Appareil respiratoire pathologie</term><term>Chloroquine</term><term>Anomalie</term><term>Facteur croissance transformant β</term><term>Activité</term><term>Bronche</term><term>Cellule épithéliale</term><term>Poumon</term><term>Fibrose</term><term>Chronique</term><term>Inflammation</term><term>Furin</term><term>Appareil Golgi</term><term>Pédiatrie</term><term>Antipaludique</term><term>Antiparasitaire</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Pédiatrie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cystic fibrosis (CF) remains a fatal progressive disease in spite of the discovery and characterization of the CFTR gene. Transforming growth factor beta (TGF-p) has been implicated in pathophysiology of CF Previous reports have shown the trans-Golgi network (TGN) is hyperacdified in CF epithelial cells in culture and that this hyperacidification can be corrected with the membrane permeant weak base, chloroquine. In this study bioactive TGF-p produced by CF and normal cells was measured using a reporter cell line with a TGF-p responsive promoter linked to luciferase. Increased levels of TGF-β were detected in the conditioned media from CF epithelial cells compared to their matched controls-(IB3-1 vs. S9; pCEP-R vs. pCEP, CuFi-4 vs. NuLi-1). Levels of TGF-β were normalized with chloroquine indicating that the hyperacidification of the TGN of CF cells is responsible for the altered TGF-p levels.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>8755-6863</s0></fA01><fA02 i1="01"><s0>PEPUES</s0></fA02><fA03 i2="1"><s0>Pediatr. pulmonol.</s0></fA03><fA05><s2>41</s2></fA05><fA06><s2>8</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Chloroquine normalizes aberrant transforming growth factor beta activity in cystic fibrosis bronchial epithelial cells</s1></fA08><fA11 i1="01" i2="1"><s1>PERKETT (Elizabeth A.)</s1></fA11><fA11 i1="02" i2="1"><s1>ORNATOWSKI (Wojclech)</s1></fA11><fA11 i1="03" i2="1"><s1>POSCHET (Jens F.)</s1></fA11><fA11 i1="04" i2="1"><s1>DERETIC (Vojo)</s1></fA11><fA14 i1="01"><s1>Department of Cell Biology and Physiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center</s1><s2>Albuquerque, New Mexico</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ></fA14><fA20><s1>771-778</s1></fA20><fA21><s1>2006</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>21407</s2><s5>354000157074260110</s5></fA43><fA44><s0>0000</s0><s1>© 2006 INIST-CNRS. 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Increased levels of TGF-β were detected in the conditioned media from CF epithelial cells compared to their matched controls-(IB3-1 vs. S9; pCEP-R vs. pCEP, CuFi-4 vs. NuLi-1). 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sortKey="Perkett, Elizabeth A" sort="Perkett, Elizabeth A" uniqKey="Perkett E" first="Elizabeth A." last="Perkett">Elizabeth A. Perkett</name></region><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><name sortKey="Deretic, Vojo" sort="Deretic, Vojo" uniqKey="Deretic V" first="Vojo" last="Deretic">Vojo Deretic</name><name sortKey="Ornatowski, Wojclech" sort="Ornatowski, Wojclech" uniqKey="Ornatowski W" first="Wojclech" last="Ornatowski">Wojclech Ornatowski</name><name sortKey="Poschet, Jens F" sort="Poschet, Jens F" uniqKey="Poschet J" first="Jens F." last="Poschet">Jens F. Poschet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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