Anti-Tumor Activities of Bioactive Phytochemicals in Sophora flavescens for Breast Cancer
Identifieur interne : 001011 ( Ncbi/Merge ); précédent : 001010; suivant : 001012Anti-Tumor Activities of Bioactive Phytochemicals in Sophora flavescens for Breast Cancer
Auteurs : Xianjiao Cao [République populaire de Chine] ; Qingqing He [République populaire de Chine]Source :
- Cancer Management and Research [ 1179-1322 ] ; 2020.
Abstract
Patients with breast cancer and breast cancer survivors are frequent users of botanicals and their bioactive phytochemicals. In China, active ingredients in
Url:
DOI: 10.2147/CMAR.S243127
PubMed: 32161498
PubMed Central: 7051174
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-Tumor Activities of Bioactive Phytochemicals in <italic>Sophora flavescens</italic> for Breast Cancer</title><author><name sortKey="Cao, Xianjiao" sort="Cao, Xianjiao" uniqKey="Cao X" first="Xianjiao" last="Cao">Xianjiao Cao</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine</institution>,<addr-line>Jinan</addr-line>,<addr-line>Shandong</addr-line><addr-line>250011</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="He, Qingqing" sort="He, Qingqing" uniqKey="He Q" first="Qingqing" last="He">Qingqing He</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force</institution>,<addr-line>Jinan</addr-line>,<addr-line>Shandong</addr-line><addr-line>250031</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32161498</idno><idno type="pmc">7051174</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7051174</idno><idno type="RBID">PMC:7051174</idno><idno type="doi">10.2147/CMAR.S243127</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000883</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000883</idno><idno type="wicri:Area/Pmc/Curation">000883</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000883</idno><idno type="wicri:Area/Pmc/Checkpoint">000201</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000201</idno><idno type="wicri:Area/Ncbi/Merge">001011</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-Tumor Activities of Bioactive Phytochemicals in <italic>Sophora flavescens</italic> for Breast Cancer</title><author><name sortKey="Cao, Xianjiao" sort="Cao, Xianjiao" uniqKey="Cao X" first="Xianjiao" last="Cao">Xianjiao Cao</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine</institution>,<addr-line>Jinan</addr-line>,<addr-line>Shandong</addr-line><addr-line>250011</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="He, Qingqing" sort="He, Qingqing" uniqKey="He Q" first="Qingqing" last="He">Qingqing He</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force</institution>,<addr-line>Jinan</addr-line>,<addr-line>Shandong</addr-line><addr-line>250031</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cancer Management and Research</title><idno type="eISSN">1179-1322</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Patients with breast cancer and breast cancer survivors are frequent users of botanicals and their bioactive phytochemicals. In China, active ingredients in <italic>Sophora flavescens</italic> like matrine (MT), oxymatrine (OMT), other <italic>Sophora flavescens</italic> alkaloids and Compound Kushen Injection (CKI) are extensively used for multiple malignant tumors. In vivo and in vitro studies have confirmed that these activities or injection have significant effects on relieving symptoms, alleviating side effects after chemotherapy and improving the quality of life of breast cancer patients, where there is evidence for efficacy. A large number of experimental studies have also revealed that they can inhibit the proliferation, invasion and migration of breast cancer cells according to different mechanisms. This provides promising valuable supportive therapies for prevention, treatment and postoperative recovery of breast cancer. Rigorous clinical research and experimental studies reflect integrative care as it is used in hospital is needed to responsibly move this field forward. This review summarizes an up to date knowledge of the available bioactive phytochemicals, their discovery, current clinical and experimental status.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cancer Manag Res</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Manag Res</journal-id><journal-id journal-id-type="publisher-id">CMAR</journal-id><journal-id journal-id-type="pmc">cancmanres</journal-id><journal-title-group><journal-title>Cancer Management and Research</journal-title></journal-title-group><issn pub-type="epub">1179-1322</issn><publisher><publisher-name>Dove</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32161498</article-id><article-id pub-id-type="pmc">7051174</article-id><article-id pub-id-type="publisher-id">243127</article-id><article-id pub-id-type="doi">10.2147/CMAR.S243127</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Anti-Tumor Activities of Bioactive Phytochemicals in <italic>Sophora flavescens</italic> for Breast Cancer</article-title><alt-title alt-title-type="running-authors">Cao and He</alt-title><alt-title alt-title-type="running-title">Cao and He</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cao</surname><given-names>Xianjiao</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2159-1976</contrib-id><name><surname>He</surname><given-names>Qingqing</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0002">2</xref></contrib><aff id="AFF0001"><label>1</label><institution>The First School of Clinical Medicine, Shandong University of Traditional Chinese Medicine</institution>,<addr-line>Jinan</addr-line>,<addr-line>Shandong</addr-line><addr-line>250011</addr-line>,<country>People’s Republic of China</country></aff><aff id="AFF0002"><label>2</label><institution>Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force</institution>,<addr-line>Jinan</addr-line>,<addr-line>Shandong</addr-line><addr-line>250031</addr-line>,<country>People’s Republic of China</country></aff></contrib-group><author-notes><corresp id="AN0001">Correspondence: Qingqing He <institution>Department of Thyroid and Breast Surgery, The 960th Hospital of the PLA Joint Logistics Support Force</institution>, <addr-line>No. 25 Shifan Road</addr-line>, <addr-line>Jinan</addr-line>, <addr-line>Shandong</addr-line><addr-line>250031</addr-line>, <country>People’s Republic of China</country><phone>Tel +86 13789828035</phone><fax>Fax +86 531666673</fax> Email heqingqing@yeah.net</corresp></author-notes><pub-date pub-type="epub"><day>27</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="collection"><year>2020</year></pub-date><volume>12</volume><fpage>1457</fpage><lpage>1467</lpage><history><date date-type="received"><day>20</day><month>12</month><year>2019</year></date><date date-type="accepted"><day>05</day><month>2</month><year>2020</year></date></history><permissions><copyright-statement>© 2020 Cao and He.</copyright-statement><copyright-year>2020</copyright-year><copyright-holder>Cao and He.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>).</license-p></license></permissions><abstract><title>Abstract</title><p>Patients with breast cancer and breast cancer survivors are frequent users of botanicals and their bioactive phytochemicals. In China, active ingredients in <italic>Sophora flavescens</italic> like matrine (MT), oxymatrine (OMT), other <italic>Sophora flavescens</italic> alkaloids and Compound Kushen Injection (CKI) are extensively used for multiple malignant tumors. In vivo and in vitro studies have confirmed that these activities or injection have significant effects on relieving symptoms, alleviating side effects after chemotherapy and improving the quality of life of breast cancer patients, where there is evidence for efficacy. A large number of experimental studies have also revealed that they can inhibit the proliferation, invasion and migration of breast cancer cells according to different mechanisms. This provides promising valuable supportive therapies for prevention, treatment and postoperative recovery of breast cancer. Rigorous clinical research and experimental studies reflect integrative care as it is used in hospital is needed to responsibly move this field forward. This review summarizes an up to date knowledge of the available bioactive phytochemicals, their discovery, current clinical and experimental status.</p></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>breast cancer</kwd><kwd><italic>Sophora flavescens</italic></kwd><kwd>CKI</kwd><kwd>matrine</kwd><kwd>oxymatrine</kwd></kwd-group><funding-group><funding-statement>This work was supported by grants from the President Funding of Jinan Military General Hospital of PLA (Grants 2016ZD02 and 2018ZX01).</funding-statement></funding-group><counts><table-count count="1"></table-count><ref-count count="108"></ref-count><page-count count="11"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cao, Xianjiao" sort="Cao, Xianjiao" uniqKey="Cao X" first="Xianjiao" last="Cao">Xianjiao Cao</name></noRegion><name sortKey="He, Qingqing" sort="He, Qingqing" uniqKey="He Q" first="Qingqing" last="He">Qingqing He</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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