Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study
Identifieur interne : 000F44 ( Ncbi/Merge ); précédent : 000F43; suivant : 000F45Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study
Auteurs : Bruno Frediani [Italie] ; Carmela Toscano [Italie] ; Paolo Falsetti [Italie] ; Antonella Nicosia [Italie] ; Serena Pierguidi [Italie] ; Alberto Migliore [Italie] ; Stefano Giannotti [Italie] ; Luca Cantarini [Italie] ; Edoardo Conticini [Italie]Source :
- Drugs in R&D [ 1174-5886 ] ; 2020.
Abstract
Clodronate is a nitrogen-free bisphosphonate that is widely and effectively used in the treatment of many osteo-metabolic disorders. The objective of our study was to evaluate the effectiveness of clodronate in reducing pain and bone marrow edema in knee osteoarthritis.
In total, 74 patients were included in the study. Group 1 received intramuscular clodronate 200 mg daily for 15 days and then once weekly for the next 11.5 months; group 2 received intramuscular clodronate 200 mg daily for 15 days and then once weekly for the next 2.5 months. Visual analog scale (VAS) scores were recorded at baseline (T0) and after 30 days (T1), 3 months (T2), 6 months (T3), 9 months (T4), and 12 months (end of study; T5). We also evaluated functional status and use of paracetamol (T0, T1, T2, T3, T4, and T5) and changes in Whole Organ Magnetic Resonance Imaging Score (WORMS; T0, T2, and T5).
Both groups had a statistically significant reduction in VAS score until 3 months. Group 1 then experienced further VAS reductions, whereas VAS scores for group 2 progressively increased. Pain, stiffness, and physical function also showed the same trend, as did bone marrow edema extension, which was evaluated with WORMS.
Our study indicates that intramuscular administration of a therapeutic dose of clodronate followed by a maintenance dose is effective in the management of symptomatic knee osteoarthritis, improving functional outcomes and reducing pain and bone marrow edema. Prolonged treatment increases the long-term efficacy of clodronate compared with the shorter schedule.
Url:
DOI: 10.1007/s40268-020-00294-4
PubMed: 32078147
PubMed Central: 7067729
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000095
- to stream Pmc, to step Curation: 000095
- to stream Pmc, to step Checkpoint: 000118
Links to Exploration step
PMC:7067729Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study</title><author><name sortKey="Frediani, Bruno" sort="Frediani, Bruno" uniqKey="Frediani B" first="Bruno" last="Frediani">Bruno Frediani</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Toscano, Carmela" sort="Toscano, Carmela" uniqKey="Toscano C" first="Carmela" last="Toscano">Carmela Toscano</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Falsetti, Paolo" sort="Falsetti, Paolo" uniqKey="Falsetti P" first="Paolo" last="Falsetti">Paolo Falsetti</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Nicosia, Antonella" sort="Nicosia, Antonella" uniqKey="Nicosia A" first="Antonella" last="Nicosia">Antonella Nicosia</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Pierguidi, Serena" sort="Pierguidi, Serena" uniqKey="Pierguidi S" first="Serena" last="Pierguidi">Serena Pierguidi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Migliore, Alberto" sort="Migliore, Alberto" uniqKey="Migliore A" first="Alberto" last="Migliore">Alberto Migliore</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.414765.5</institution-id><institution-id institution-id-type="ISNI">0000 0004 1763 7550</institution-id><institution>Unit of Rheumatology,</institution><institution>San Pietro Fatebenefratelli Hospital,</institution></institution-wrap>Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Rome</wicri:regionArea></affiliation></author><author><name sortKey="Giannotti, Stefano" sort="Giannotti, Stefano" uniqKey="Giannotti S" first="Stefano" last="Giannotti">Stefano Giannotti</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Orthopedics Unit,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Cantarini, Luca" sort="Cantarini, Luca" uniqKey="Cantarini L" first="Luca" last="Cantarini">Luca Cantarini</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Conticini, Edoardo" sort="Conticini, Edoardo" uniqKey="Conticini E" first="Edoardo" last="Conticini">Edoardo Conticini</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32078147</idno><idno type="pmc">7067729</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067729</idno><idno type="RBID">PMC:7067729</idno><idno type="doi">10.1007/s40268-020-00294-4</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000095</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000095</idno><idno type="wicri:Area/Pmc/Curation">000095</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000095</idno><idno type="wicri:Area/Pmc/Checkpoint">000118</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000118</idno><idno type="wicri:Area/Ncbi/Merge">000F44</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study</title><author><name sortKey="Frediani, Bruno" sort="Frediani, Bruno" uniqKey="Frediani B" first="Bruno" last="Frediani">Bruno Frediani</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Toscano, Carmela" sort="Toscano, Carmela" uniqKey="Toscano C" first="Carmela" last="Toscano">Carmela Toscano</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Falsetti, Paolo" sort="Falsetti, Paolo" uniqKey="Falsetti P" first="Paolo" last="Falsetti">Paolo Falsetti</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Nicosia, Antonella" sort="Nicosia, Antonella" uniqKey="Nicosia A" first="Antonella" last="Nicosia">Antonella Nicosia</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Pierguidi, Serena" sort="Pierguidi, Serena" uniqKey="Pierguidi S" first="Serena" last="Pierguidi">Serena Pierguidi</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Migliore, Alberto" sort="Migliore, Alberto" uniqKey="Migliore A" first="Alberto" last="Migliore">Alberto Migliore</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="GRID">grid.414765.5</institution-id><institution-id institution-id-type="ISNI">0000 0004 1763 7550</institution-id><institution>Unit of Rheumatology,</institution><institution>San Pietro Fatebenefratelli Hospital,</institution></institution-wrap>Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Rome</wicri:regionArea></affiliation></author><author><name sortKey="Giannotti, Stefano" sort="Giannotti, Stefano" uniqKey="Giannotti S" first="Stefano" last="Giannotti">Stefano Giannotti</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Orthopedics Unit,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Cantarini, Luca" sort="Cantarini, Luca" uniqKey="Cantarini L" first="Luca" last="Cantarini">Luca Cantarini</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author><author><name sortKey="Conticini, Edoardo" sort="Conticini, Edoardo" uniqKey="Conticini E" first="Edoardo" last="Conticini">Edoardo Conticini</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Siena</wicri:regionArea></affiliation></author></analytic><series><title level="j">Drugs in R&D</title><idno type="ISSN">1174-5886</idno><idno type="eISSN">1179-6901</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background and Objective</title><p id="Par1">Clodronate is a nitrogen-free bisphosphonate that is widely and effectively used in the treatment of many osteo-metabolic disorders. The objective of our study was to evaluate the effectiveness of clodronate in reducing pain and bone marrow edema in knee osteoarthritis.</p></sec><sec><title>Methods</title><p id="Par3">In total, 74 patients were included in the study. Group 1 received intramuscular clodronate 200 mg daily for 15 days and then once weekly for the next 11.5 months; group 2 received intramuscular clodronate 200 mg daily for 15 days and then once weekly for the next 2.5 months. Visual analog scale (VAS) scores were recorded at baseline (T0) and after 30 days (T1), 3 months (T2), 6 months (T3), 9 months (T4), and 12 months (end of study; T5). We also evaluated functional status and use of paracetamol (T0, T1, T2, T3, T4, and T5) and changes in Whole Organ Magnetic Resonance Imaging Score (WORMS; T0, T2, and T5).</p></sec><sec><title>Results</title><p id="Par4">Both groups had a statistically significant reduction in VAS score until 3 months. Group 1 then experienced further VAS reductions, whereas VAS scores for group 2 progressively increased. Pain, stiffness, and physical function also showed the same trend, as did bone marrow edema extension, which was evaluated with WORMS.</p></sec><sec><title>Conclusion</title><p id="Par5">Our study indicates that intramuscular administration of a therapeutic dose of clodronate followed by a maintenance dose is effective in the management of symptomatic knee osteoarthritis, improving functional outcomes and reducing pain and bone marrow edema. Prolonged treatment increases the long-term efficacy of clodronate compared with the shorter schedule.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lawrence, Rc" uniqKey="Lawrence R">RC Lawrence</name></author><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Helmick, Cg" uniqKey="Helmick C">CG Helmick</name></author><author><name sortKey="Arnold, Lm" uniqKey="Arnold L">LM Arnold</name></author><author><name sortKey="Choi, H" uniqKey="Choi H">H Choi</name></author><author><name sortKey="Deyo, Ra" uniqKey="Deyo R">RA Deyo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author><author><name sortKey="Chaisson, Ce" uniqKey="Chaisson C">CE Chaisson</name></author><author><name sortKey="Hill, Cl" uniqKey="Hill C">CL Hill</name></author><author><name sortKey="Totterman, Sm" uniqKey="Totterman S">SM Totterman</name></author><author><name sortKey="Gale, Me" uniqKey="Gale M">ME Gale</name></author><author><name sortKey="Skinner, Km" uniqKey="Skinner K">KM Skinner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dy" uniqKey="Felson D">DY Felson</name></author><author><name sortKey="Mclaughlin, S" uniqKey="Mclaughlin S">S McLaughlin</name></author><author><name sortKey="Goggins, J" uniqKey="Goggins J">J Goggins</name></author><author><name sortKey="Lavalley, Mp" uniqKey="Lavalley M">MP LaValley</name></author><author><name sortKey="Gale, Me" uniqKey="Gale M">ME Gale</name></author><author><name sortKey="Totterman, S" uniqKey="Totterman S">S Totterman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zanetti, M" uniqKey="Zanetti M">M Zanetti</name></author><author><name sortKey="Bruder, E" uniqKey="Bruder E">E Bruder</name></author><author><name sortKey="Romero, J" uniqKey="Romero J">J Romero</name></author><author><name sortKey="Hodler, J" uniqKey="Hodler J">J Hodler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saadat, E" uniqKey="Saadat E">E Saadat</name></author><author><name sortKey="Jobke, B" uniqKey="Jobke B">B Jobke</name></author><author><name sortKey="Chu, B" uniqKey="Chu B">B Chu</name></author><author><name sortKey="Lu, Y" uniqKey="Lu Y">Y Lu</name></author><author><name sortKey="Cheng, J" uniqKey="Cheng J">J Cheng</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kazakia, Gj" uniqKey="Kazakia G">GJ Kazakia</name></author><author><name sortKey="Kuo, D" uniqKey="Kuo D">D Kuo</name></author><author><name sortKey="Schooler, J" uniqKey="Schooler J">J Schooler</name></author><author><name sortKey="Siddiqui, S" uniqKey="Siddiqui S">S Siddiqui</name></author><author><name sortKey="Shanbhag, S" uniqKey="Shanbhag S">S Shanbhag</name></author><author><name sortKey="Bernstein, G" uniqKey="Bernstein G">G Bernstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yusuf, E" uniqKey="Yusuf E">E Yusuf</name></author><author><name sortKey="Kortekaas, Mc" uniqKey="Kortekaas M">MC Kortekaas</name></author><author><name sortKey="Watt, I" uniqKey="Watt I">I Watt</name></author><author><name sortKey="Huizinga, Tw" uniqKey="Huizinga T">TW Huizinga</name></author><author><name sortKey="Kloppenburg, M" uniqKey="Kloppenburg M">M Kloppenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Maksymowych, Wp" uniqKey="Maksymowych W">WP Maksymowych</name></author><author><name sortKey="Jhangri, Gs" uniqKey="Jhangri G">GS Jhangri</name></author><author><name sortKey="Fitzgerald, Aa" uniqKey="Fitzgerald A">AA Fitzgerald</name></author><author><name sortKey="Leclercq, S" uniqKey="Leclercq S">S LeClercq</name></author><author><name sortKey="Chiu, P" uniqKey="Chiu P">P Chiu</name></author><author><name sortKey="Yan, A" uniqKey="Yan A">A Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varenna, M" uniqKey="Varenna M">M Varenna</name></author><author><name sortKey="Zucchi, F" uniqKey="Zucchi F">F Zucchi</name></author><author><name sortKey="Binelli, L" uniqKey="Binelli L">L Binelli</name></author><author><name sortKey="Failoni, S" uniqKey="Failoni S">S Failoni</name></author><author><name sortKey="Gallazzi, M" uniqKey="Gallazzi M">M Gallazzi</name></author><author><name sortKey="Sinigaglia, L" uniqKey="Sinigaglia L">L Sinigaglia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tran, Dqh" uniqKey="Tran D">DQH Tran</name></author><author><name sortKey="Duong, S" uniqKey="Duong S">S Duong</name></author><author><name sortKey="Bertini, P" uniqKey="Bertini P">P Bertini</name></author><author><name sortKey="Finlayson, Rj" uniqKey="Finlayson R">RJ Finlayson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davis, Aj" uniqKey="Davis A">AJ Davis</name></author><author><name sortKey="Smith, To" uniqKey="Smith T">TO Smith</name></author><author><name sortKey="Hing, Cb" uniqKey="Hing C">CB Hing</name></author><author><name sortKey="Sofat, N" uniqKey="Sofat N">N Sofat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khan, Sa" uniqKey="Khan S">SA Khan</name></author><author><name sortKey="Mccloskey, Ev" uniqKey="Mccloskey E">EV McCloskey</name></author><author><name sortKey="Nakatsuka, K" uniqKey="Nakatsuka K">K Nakatsuka</name></author><author><name sortKey="Orgee, J" uniqKey="Orgee J">J Orgee</name></author><author><name sortKey="Coombes, Gm" uniqKey="Coombes G">GM Coombes</name></author><author><name sortKey="Kanis, Ja" uniqKey="Kanis J">JA Kanis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Body, Jj" uniqKey="Body J">JJ Body</name></author><author><name sortKey="Coleman, Re" uniqKey="Coleman R">RE Coleman</name></author><author><name sortKey="Piccart, M" uniqKey="Piccart M">M Piccart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adami, S" uniqKey="Adami S">S Adami</name></author><author><name sortKey="Bolzicco, Gp" uniqKey="Bolzicco G">GP Bolzicco</name></author><author><name sortKey="Rizzo, A" uniqKey="Rizzo A">A Rizzo</name></author><author><name sortKey="Salvagno, G" uniqKey="Salvagno G">G Salvagno</name></author><author><name sortKey="Bertoldo, F" uniqKey="Bertoldo F">F Bertoldo</name></author><author><name sortKey="Rossini, M" uniqKey="Rossini M">M Rossini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Douglas, Dl" uniqKey="Douglas D">DL Douglas</name></author><author><name sortKey="Kanis, Ja" uniqKey="Kanis J">JA Kanis</name></author><author><name sortKey="Paterson, Ad" uniqKey="Paterson A">AD Paterson</name></author><author><name sortKey="Beard, Dj" uniqKey="Beard D">DJ Beard</name></author><author><name sortKey="Cameron, Ec" uniqKey="Cameron E">EC Cameron</name></author><author><name sortKey="Watson, Me" uniqKey="Watson M">ME Watson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shane, E" uniqKey="Shane E">E Shane</name></author><author><name sortKey="Baquiran, Dc" uniqKey="Baquiran D">DC Baquiran</name></author><author><name sortKey="Bilezikian, Jp" uniqKey="Bilezikian J">JP Bilezikian</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Saviola, G" uniqKey="Saviola G">G Saviola</name></author><author><name sortKey="Abdi Ali, L" uniqKey="Abdi Ali L">L Abdi-Ali</name></author><author><name sortKey="Campostrini, L" uniqKey="Campostrini L">L Campostrini</name></author><author><name sortKey="Sacco, S" uniqKey="Sacco S">S Sacco</name></author><author><name sortKey="Baiardi, P" uniqKey="Baiardi P">P Baiardi</name></author><author><name sortKey="Manfredi, M" uniqKey="Manfredi M">M Manfredi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossini, M" uniqKey="Rossini M">M Rossini</name></author><author><name sortKey="Adami, S" uniqKey="Adami S">S Adami</name></author><author><name sortKey="Fracassi, E" uniqKey="Fracassi E">E Fracassi</name></author><author><name sortKey="Viapiana, O" uniqKey="Viapiana O">O Viapiana</name></author><author><name sortKey="Orsolini, G" uniqKey="Orsolini G">G Orsolini</name></author><author><name sortKey="Povino, Mr" uniqKey="Povino M">MR Povino</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frediani, B" uniqKey="Frediani B">B Frediani</name></author><author><name sortKey="Giusti, A" uniqKey="Giusti A">A Giusti</name></author><author><name sortKey="Bianchi, G" uniqKey="Bianchi G">G Bianchi</name></author><author><name sortKey="Dalle Carbonare, L" uniqKey="Dalle Carbonare L">L Dalle Carbonare</name></author><author><name sortKey="Malavolta, N" uniqKey="Malavolta N">N Malavolta</name></author><author><name sortKey="Cantarini, L" uniqKey="Cantarini L">L Cantarini</name></author><author><name sortKey="Saviola, G" uniqKey="Saviola G">G Saviola</name></author><author><name sortKey="Molfetta, L" uniqKey="Molfetta L">L Molfetta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Frediani, B" uniqKey="Frediani B">B Frediani</name></author><author><name sortKey="Bertoldi, I" uniqKey="Bertoldi I">I Bertoldi</name></author><author><name sortKey="Pierguidi, S" uniqKey="Pierguidi S">S Pierguidi</name></author><author><name sortKey="Nicosia, A" uniqKey="Nicosia A">A Nicosia</name></author><author><name sortKey="Picerno, V" uniqKey="Picerno V">V Picerno</name></author><author><name sortKey="Filippou, G" uniqKey="Filippou G">G Filippou</name></author><author><name sortKey="Cantarini, L" uniqKey="Cantarini L">L Cantarini</name></author><author><name sortKey="Galeazzi, M" uniqKey="Galeazzi M">M Galeazzi</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kellgren, Jh" uniqKey="Kellgren J">JH Kellgren</name></author><author><name sortKey="Lawrence, Js" uniqKey="Lawrence J">JS Lawrence</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peterfy, Cg" uniqKey="Peterfy C">CG Peterfy</name></author><author><name sortKey="Guermazi, A" uniqKey="Guermazi A">A Guermazi</name></author><author><name sortKey="Zaim, S" uniqKey="Zaim S">S Zaim</name></author><author><name sortKey="Tirman, Pf" uniqKey="Tirman P">PF Tirman</name></author><author><name sortKey="Miaux, Y" uniqKey="Miaux Y">Y Miaux</name></author><author><name sortKey="White, D" uniqKey="White D">D White</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Laslett, Ll" uniqKey="Laslett L">LL Laslett</name></author><author><name sortKey="Dore, Da" uniqKey="Dore D">DA Doré</name></author><author><name sortKey="Quinn, Sj" uniqKey="Quinn S">SJ Quinn</name></author><author><name sortKey="Boon, P" uniqKey="Boon P">P Boon</name></author><author><name sortKey="Ryan, E" uniqKey="Ryan E">E Ryan</name></author><author><name sortKey="Winzenberg, Tm" uniqKey="Winzenberg T">TM Winzenberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varenna, M" uniqKey="Varenna M">M Varenna</name></author><author><name sortKey="Zucchi, F" uniqKey="Zucchi F">F Zucchi</name></author><author><name sortKey="Failoni, S" uniqKey="Failoni S">S Failoni</name></author><author><name sortKey="Becciolini, A" uniqKey="Becciolini A">A Becciolini</name></author><author><name sortKey="Berruto, M" uniqKey="Berruto M">M Berruto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cassisi, G" uniqKey="Cassisi G">G Cassisi</name></author><author><name sortKey="Sartori, L" uniqKey="Sartori L">L Sartori</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varenna, M" uniqKey="Varenna M">M Varenna</name></author><author><name sortKey="Adami, S" uniqKey="Adami S">S Adami</name></author><author><name sortKey="Rossini, M" uniqKey="Rossini M">M Rossini</name></author><author><name sortKey="Gatti, D" uniqKey="Gatti D">D Gatti</name></author><author><name sortKey="Idolazzi, L" uniqKey="Idolazzi L">L Idolazzi</name></author><author><name sortKey="Zucchi, F" uniqKey="Zucchi F">F Zucchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Adami, S" uniqKey="Adami S">S Adami</name></author><author><name sortKey="Fossaluzza, V" uniqKey="Fossaluzza V">V Fossaluzza</name></author><author><name sortKey="Gatti, D" uniqKey="Gatti D">D Gatti</name></author><author><name sortKey="Fracassi, E" uniqKey="Fracassi E">E Fracassi</name></author><author><name sortKey="Braga, V" uniqKey="Braga V">V Braga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saviola, G" uniqKey="Saviola G">G Saviola</name></author><author><name sortKey="Abdi Ali, L" uniqKey="Abdi Ali L">L Abdi-Ali</name></author><author><name sortKey="Comini, L" uniqKey="Comini L">L Comini</name></author><author><name sortKey="Dalle Carbonare, Lg" uniqKey="Dalle Carbonare L">LG Dalle-Carbonare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Saviola, Gianantonio" uniqKey="Saviola G">Gianantonio Saviola</name></author><author><name sortKey="Abdi Ali, Lul" uniqKey="Abdi Ali L">Lul Abdi-Ali</name></author><author><name sortKey="Povino, Maria Rosaria" uniqKey="Povino M">Maria Rosaria Povino</name></author><author><name sortKey="Campostrini, Lorella" uniqKey="Campostrini L">Lorella Campostrini</name></author><author><name sortKey="Sacco, Silvano" uniqKey="Sacco S">Silvano Sacco</name></author><author><name sortKey="Carbonare, Luca Dalle" uniqKey="Carbonare L">Luca Dalle Carbonare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Valenti, Maria" uniqKey="Valenti M">Maria Valenti</name></author><author><name sortKey="Mottes, Monica" uniqKey="Mottes M">Monica Mottes</name></author><author><name sortKey="Biotti, Alessandro" uniqKey="Biotti A">Alessandro Biotti</name></author><author><name sortKey="Perduca, Massimiliano" uniqKey="Perduca M">Massimiliano Perduca</name></author><author><name sortKey="Pisani, Arianna" uniqKey="Pisani A">Arianna Pisani</name></author><author><name sortKey="Bovi, Michele" uniqKey="Bovi M">Michele Bovi</name></author><author><name sortKey="Deiana, Michela" uniqKey="Deiana M">Michela Deiana</name></author><author><name sortKey="Cheri, Samuele" uniqKey="Cheri S">Samuele Cheri</name></author><author><name sortKey="Dalle Carbonare, Luca" uniqKey="Dalle Carbonare L">Luca Dalle Carbonare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Felson, Dt" uniqKey="Felson D">DT Felson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Link, Tm" uniqKey="Link T">TM Link</name></author><author><name sortKey="Li, X" uniqKey="Li X">X Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taljanovic, Ms" uniqKey="Taljanovic M">MS Taljanovic</name></author><author><name sortKey="Graham, Ar" uniqKey="Graham A">AR Graham</name></author><author><name sortKey="Benjamin, Jb" uniqKey="Benjamin J">JB Benjamin</name></author><author><name sortKey="Gmitro, Af" uniqKey="Gmitro A">AF Gmitro</name></author><author><name sortKey="Krupinski, Ea" uniqKey="Krupinski E">EA Krupinski</name></author><author><name sortKey="Schwartz, Sa" uniqKey="Schwartz S">SA Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, L" uniqKey="Liu L">L Liu</name></author><author><name sortKey="Igarashi, K" uniqKey="Igarashi K">K Igarashi</name></author><author><name sortKey="Kanzaki, H" uniqKey="Kanzaki H">H Kanzaki</name></author><author><name sortKey="Chiba, M" uniqKey="Chiba M">M Chiba</name></author><author><name sortKey="Shinoda, H" uniqKey="Shinoda H">H Shinoda</name></author><author><name sortKey="Mitani, H" uniqKey="Mitani H">H Mitani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chiu, Yg" uniqKey="Chiu Y">YG Chiu</name></author><author><name sortKey="Ritchlin, Dt" uniqKey="Ritchlin D">DT Ritchlin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sims, Na" uniqKey="Sims N">NA Sims</name></author><author><name sortKey="Green, Jr" uniqKey="Green J">JR Green</name></author><author><name sortKey="Glatt, M" uniqKey="Glatt M">M Glatt</name></author><author><name sortKey="Schlict, S" uniqKey="Schlict S">S Schlict</name></author><author><name sortKey="Martin, Tj" uniqKey="Martin T">TJ Martin</name></author><author><name sortKey="Gillespie, Mt" uniqKey="Gillespie M">MT Gillespie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oelzner, P" uniqKey="Oelzner P">P Oelzner</name></author><author><name sortKey="Kunze, A" uniqKey="Kunze A">A Kunze</name></author><author><name sortKey="Henzgen, S" uniqKey="Henzgen S">S Henzgen</name></author><author><name sortKey="Thoss, K" uniqKey="Thoss K">K Thoss</name></author><author><name sortKey="Hein, G" uniqKey="Hein G">G Hein</name></author><author><name sortKey="Stein, G" uniqKey="Stein G">G Stein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osterman, T" uniqKey="Osterman T">T Osterman</name></author><author><name sortKey="Kippo, K" uniqKey="Kippo K">K Kippo</name></author><author><name sortKey="Lauren, L" uniqKey="Lauren L">L Laurén</name></author><author><name sortKey="Hannuniemi, R" uniqKey="Hannuniemi R">R Hannuniemi</name></author><author><name sortKey="Sellman, R" uniqKey="Sellman R">R Sellman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonabello, A" uniqKey="Bonabello A">A Bonabello</name></author><author><name sortKey="Galmozzi, Mr" uniqKey="Galmozzi M">MR Galmozzi</name></author><author><name sortKey="Bruzzese, T" uniqKey="Bruzzese T">T Bruzzese</name></author><author><name sortKey="Zara, Gp" uniqKey="Zara G">GP Zara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonabello, A" uniqKey="Bonabello A">A Bonabello</name></author><author><name sortKey="Galmozzi, Mr" uniqKey="Galmozzi M">MR Galmozzi</name></author><author><name sortKey="Canaparo, R" uniqKey="Canaparo R">R Canaparo</name></author><author><name sortKey="Serpe, L" uniqKey="Serpe L">L Serpe</name></author><author><name sortKey="Zara, Gp" uniqKey="Zara G">GP Zara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muratore, M" uniqKey="Muratore M">M Muratore</name></author><author><name sortKey="Calcagnile, F" uniqKey="Calcagnile F">F Calcagnile</name></author><author><name sortKey="Quarta, E" uniqKey="Quarta E">E Quarta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rovetta, G" uniqKey="Rovetta G">G Rovetta</name></author><author><name sortKey="Maggiani, G" uniqKey="Maggiani G">G Maggiani</name></author><author><name sortKey="Molfetta, L" uniqKey="Molfetta L">L Molfetta</name></author><author><name sortKey="Monteforte, P" uniqKey="Monteforte P">P Monteforte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rovetta, G" uniqKey="Rovetta G">G Rovetta</name></author><author><name sortKey="Monteforte, P" uniqKey="Monteforte P">P Monteforte</name></author><author><name sortKey="Balestra, V" uniqKey="Balestra V">V Balestra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muratore, M" uniqKey="Muratore M">M Muratore</name></author><author><name sortKey="Canaparo, R" uniqKey="Canaparo R">R Canaparo</name></author><author><name sortKey="Della Pepa, C" uniqKey="Della Pepa C">C Della Pepa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ernst, Ds" uniqKey="Ernst D">DS Ernst</name></author><author><name sortKey="Brasher, P" uniqKey="Brasher P">P Brasher</name></author><author><name sortKey="Hagen, N" uniqKey="Hagen N">N Hagen</name></author><author><name sortKey="Paterson, Ah" uniqKey="Paterson A">AH Paterson</name></author><author><name sortKey="Macdonald, Rn" uniqKey="Macdonald R">RN MacDonald</name></author><author><name sortKey="Bruera, E" uniqKey="Bruera E">E Bruera</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tubiana Hulin, M" uniqKey="Tubiana Hulin M">M Tubiana-Hulin</name></author><author><name sortKey="Beuzeboc, P" uniqKey="Beuzeboc P">P Beuzeboc</name></author><author><name sortKey="Mauriac, L" uniqKey="Mauriac L">L Mauriac</name></author><author><name sortKey="Barbet, N" uniqKey="Barbet N">N Barbet</name></author><author><name sortKey="Frenay, M" uniqKey="Frenay M">M Frenay</name></author><author><name sortKey="Monnier, A" uniqKey="Monnier A">A Monnier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rossini, M" uniqKey="Rossini M">M Rossini</name></author><author><name sortKey="Viapiana, O" uniqKey="Viapiana O">O Viapiana</name></author><author><name sortKey="Ramonda, R" uniqKey="Ramonda R">R Ramonda</name></author><author><name sortKey="Bianchi, G" uniqKey="Bianchi G">G Bianchi</name></author><author><name sortKey="Olivieri, I" uniqKey="Olivieri I">I Olivieri</name></author><author><name sortKey="Lapadula, G" uniqKey="Lapadula G">G Lapadula</name></author><author><name sortKey="Adami, S" uniqKey="Adami S">S Adami</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Drugs R D</journal-id><journal-id journal-id-type="iso-abbrev">Drugs R D</journal-id><journal-title-group><journal-title>Drugs in R&D</journal-title></journal-title-group><issn pub-type="ppub">1174-5886</issn><issn pub-type="epub">1179-6901</issn><publisher><publisher-name>Springer International Publishing</publisher-name><publisher-loc>Cham</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">32078147</article-id><article-id pub-id-type="pmc">7067729</article-id><article-id pub-id-type="publisher-id">294</article-id><article-id pub-id-type="doi">10.1007/s40268-020-00294-4</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research Article</subject></subj-group></article-categories><title-group><article-title>Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Frediani</surname><given-names>Bruno</given-names></name><address><email>fredianibruno60@gmail.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Toscano</surname><given-names>Carmela</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Falsetti</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nicosia</surname><given-names>Antonella</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pierguidi</surname><given-names>Serena</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Migliore</surname><given-names>Alberto</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Giannotti</surname><given-names>Stefano</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Cantarini</surname><given-names>Luca</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Conticini</surname><given-names>Edoardo</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Institute of Rheumatology,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="GRID">grid.414765.5</institution-id><institution-id institution-id-type="ISNI">0000 0004 1763 7550</institution-id><institution>Unit of Rheumatology,</institution><institution>San Pietro Fatebenefratelli Hospital,</institution></institution-wrap>Rome, Italy</aff><aff id="Aff3"><label>3</label><institution-wrap><institution-id institution-id-type="GRID">grid.9024.f</institution-id><institution-id institution-id-type="ISNI">0000 0004 1757 4641</institution-id><institution>Orthopedics Unit,</institution><institution>University of Siena,</institution></institution-wrap>Siena, Italy</aff></contrib-group><pub-date pub-type="epub"><day>20</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="pmc-release"><day>20</day><month>2</month><year>2020</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2020</year></pub-date><volume>20</volume><issue>1</issue><fpage>39</fpage><lpage>45</lpage><permissions><copyright-statement>© The Author(s) 2020</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold>This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.To view a copy of this licence, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><sec><title>Background and Objective</title><p id="Par1">Clodronate is a nitrogen-free bisphosphonate that is widely and effectively used in the treatment of many osteo-metabolic disorders. The objective of our study was to evaluate the effectiveness of clodronate in reducing pain and bone marrow edema in knee osteoarthritis.</p></sec><sec><title>Methods</title><p id="Par3">In total, 74 patients were included in the study. Group 1 received intramuscular clodronate 200 mg daily for 15 days and then once weekly for the next 11.5 months; group 2 received intramuscular clodronate 200 mg daily for 15 days and then once weekly for the next 2.5 months. Visual analog scale (VAS) scores were recorded at baseline (T0) and after 30 days (T1), 3 months (T2), 6 months (T3), 9 months (T4), and 12 months (end of study; T5). We also evaluated functional status and use of paracetamol (T0, T1, T2, T3, T4, and T5) and changes in Whole Organ Magnetic Resonance Imaging Score (WORMS; T0, T2, and T5).</p></sec><sec><title>Results</title><p id="Par4">Both groups had a statistically significant reduction in VAS score until 3 months. Group 1 then experienced further VAS reductions, whereas VAS scores for group 2 progressively increased. Pain, stiffness, and physical function also showed the same trend, as did bone marrow edema extension, which was evaluated with WORMS.</p></sec><sec><title>Conclusion</title><p id="Par5">Our study indicates that intramuscular administration of a therapeutic dose of clodronate followed by a maintenance dose is effective in the management of symptomatic knee osteoarthritis, improving functional outcomes and reducing pain and bone marrow edema. Prolonged treatment increases the long-term efficacy of clodronate compared with the shorter schedule.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2020</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Frediani, Bruno" sort="Frediani, Bruno" uniqKey="Frediani B" first="Bruno" last="Frediani">Bruno Frediani</name></noRegion><name sortKey="Cantarini, Luca" sort="Cantarini, Luca" uniqKey="Cantarini L" first="Luca" last="Cantarini">Luca Cantarini</name><name sortKey="Conticini, Edoardo" sort="Conticini, Edoardo" uniqKey="Conticini E" first="Edoardo" last="Conticini">Edoardo Conticini</name><name sortKey="Falsetti, Paolo" sort="Falsetti, Paolo" uniqKey="Falsetti P" first="Paolo" last="Falsetti">Paolo Falsetti</name><name sortKey="Giannotti, Stefano" sort="Giannotti, Stefano" uniqKey="Giannotti S" first="Stefano" last="Giannotti">Stefano Giannotti</name><name sortKey="Migliore, Alberto" sort="Migliore, Alberto" uniqKey="Migliore A" first="Alberto" last="Migliore">Alberto Migliore</name><name sortKey="Nicosia, Antonella" sort="Nicosia, Antonella" uniqKey="Nicosia A" first="Antonella" last="Nicosia">Antonella Nicosia</name><name sortKey="Pierguidi, Serena" sort="Pierguidi, Serena" uniqKey="Pierguidi S" first="Serena" last="Pierguidi">Serena Pierguidi</name><name sortKey="Toscano, Carmela" sort="Toscano, Carmela" uniqKey="Toscano C" first="Carmela" last="Toscano">Carmela Toscano</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F44 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000F44 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:7067729
|texte= Intramuscular Clodronate in Long-Term Treatment of Symptomatic Knee Osteoarthritis: A Randomized Controlled Study
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:32078147" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |