Oral Microbiota Perturbations Are Linked to High Risk for Rheumatoid Arthritis
Identifieur interne : 000F09 ( Ncbi/Merge ); précédent : 000F08; suivant : 000F10Oral Microbiota Perturbations Are Linked to High Risk for Rheumatoid Arthritis
Auteurs : Yanli Tong [République populaire de Chine] ; Linlin Zheng [République populaire de Chine] ; Pingying Qing [République populaire de Chine] ; Hua Zhao [République populaire de Chine] ; Yanhong Li [République populaire de Chine] ; Linchong Su [République populaire de Chine] ; Qiuping Zhang [République populaire de Chine] ; Yi Zhao [République populaire de Chine] ; Yubin Luo [République populaire de Chine] ; Yi Liu [République populaire de Chine]Source :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2020.
Abstract
Oral microbial dysbiosis is known to increase susceptibility of an individual to develop rheumatoid arthritis (RA). Individuals at-risk of RA may undergo different phases of disease progression. In this study, we aim to investigate whether and whereby the oral microbiome communities alter prior to symptoms of RA. Seventy-nine saliva samples were collected from 29 high-risk individuals, who were positive for anti-citrullinated protein antibodies (ACPA) and have no clinical arthritis, 27 RA patients and 23 healthy controls (HCs). The salivary microbiome was examined using 16S ribosomal RNA gene sequencing. Alpha and beta diversity analysis and the linear discriminant analysis were applied to examine the bacterial diversity, community structure and discriminatory taxa between three groups, respectively. The correlation between salivary bacteria and autoantibodies were analyzed. In the “pre-clinical” stages, salivary microbial diversity was significantly reduced comparing to RA patients and HCs. In contrast to HCs, like RA patients, individuals at high-risk for RA showed a reduction in the abundance of genus
Url:
DOI: 10.3389/fcimb.2019.00475
PubMed: 32039051
PubMed Central: 6987375
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<front><div type="abstract" xml:lang="en"><p>Oral microbial dysbiosis is known to increase susceptibility of an individual to develop rheumatoid arthritis (RA). Individuals at-risk of RA may undergo different phases of disease progression. In this study, we aim to investigate whether and whereby the oral microbiome communities alter prior to symptoms of RA. Seventy-nine saliva samples were collected from 29 high-risk individuals, who were positive for anti-citrullinated protein antibodies (ACPA) and have no clinical arthritis, 27 RA patients and 23 healthy controls (HCs). The salivary microbiome was examined using 16S ribosomal RNA gene sequencing. Alpha and beta diversity analysis and the linear discriminant analysis were applied to examine the bacterial diversity, community structure and discriminatory taxa between three groups, respectively. The correlation between salivary bacteria and autoantibodies were analyzed. In the “pre-clinical” stages, salivary microbial diversity was significantly reduced comparing to RA patients and HCs. In contrast to HCs, like RA patients, individuals at high-risk for RA showed a reduction in the abundance of genus <italic>Defluviitaleaceae_UCG-011</italic>
and the species <italic>Neisseria oralis</italic>
, but an expansion of <italic>Prevotella</italic>
_6. Unexpectedly, the relative abundance of <italic>Porphyromonas gingivalis</italic>
, reported as opportunistic pathogens for RA development, was significantly decreased in high-risk individuals. Additionally, we identified four genera in the saliva from high-risk individuals positively correlated with serum ACPA titers, and the other two genera inversely displayed. In summary, we observed a characteristic compositional change of salivary microbes in individuals at high-risk for RA, suggesting that oral microbiota dysbiosis occurs in the “pre-clinical” stage of RA and are correlated with systemic autoimmune features.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alpizar Rodriguez, D" uniqKey="Alpizar Rodriguez D">D. Alpizar-Rodriguez</name>
</author>
<author><name sortKey="Lesker, T R" uniqKey="Lesker T">T. R. Lesker</name>
</author>
<author><name sortKey="Gronow, A" uniqKey="Gronow A">A. Gronow</name>
</author>
<author><name sortKey="Gilbert, B" uniqKey="Gilbert B">B. Gilbert</name>
</author>
<author><name sortKey="Raemy, E" uniqKey="Raemy E">E. Raemy</name>
</author>
<author><name sortKey="Lamacchia, C" uniqKey="Lamacchia C">C. Lamacchia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berglin, E" uniqKey="Berglin E">E. Berglin</name>
</author>
<author><name sortKey="Padyukov, L" uniqKey="Padyukov L">L. Padyukov</name>
</author>
<author><name sortKey="Sundin, U" uniqKey="Sundin U">U. Sundin</name>
</author>
<author><name sortKey="Hallmans, G" uniqKey="Hallmans G">G. Hallmans</name>
</author>
<author><name sortKey="Stenlund, H" uniqKey="Stenlund H">H. Stenlund</name>
</author>
<author><name sortKey="Van Venrooij, W J" uniqKey="Van Venrooij W">W. J. Van Venrooij</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boudewijns, M" uniqKey="Boudewijns M">M. Boudewijns</name>
</author>
<author><name sortKey="Magerman, K" uniqKey="Magerman K">K. Magerman</name>
</author>
<author><name sortKey="Verhaegen, J" uniqKey="Verhaegen J">J. Verhaegen</name>
</author>
<author><name sortKey="Debrock, G" uniqKey="Debrock G">G. Debrock</name>
</author>
<author><name sortKey="Peetermans, W E" uniqKey="Peetermans W">W. E. Peetermans</name>
</author>
<author><name sortKey="Donkersloot, P" uniqKey="Donkersloot P">P. Donkersloot</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breiman, L" uniqKey="Breiman L">L. Breiman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Aquino, S G" uniqKey="De Aquino S">S. G. de Aquino</name>
</author>
<author><name sortKey="Abdollahi Roodsaz, S" uniqKey="Abdollahi Roodsaz S">S. Abdollahi-Roodsaz</name>
</author>
<author><name sortKey="Koenders, M I" uniqKey="Koenders M">M. I. Koenders</name>
</author>
<author><name sortKey="Van De Loo, F A" uniqKey="Van De Loo F">F. A. van de Loo</name>
</author>
<author><name sortKey="Pruijn, G J" uniqKey="Pruijn G">G. J. Pruijn</name>
</author>
<author><name sortKey="Marijnissen, R J" uniqKey="Marijnissen R">R. J. Marijnissen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Steenhuijsen Piters, W A" uniqKey="De Steenhuijsen Piters W">W. A. de Steenhuijsen Piters</name>
</author>
<author><name sortKey="Huijskens, E G" uniqKey="Huijskens E">E. G. Huijskens</name>
</author>
<author><name sortKey="Wyllie, A L" uniqKey="Wyllie A">A. L. Wyllie</name>
</author>
<author><name sortKey="Biesbroek, G" uniqKey="Biesbroek G">G. Biesbroek</name>
</author>
<author><name sortKey="Van Den Bergh, M R" uniqKey="Van Den Bergh M">M. R. van den Bergh</name>
</author>
<author><name sortKey="Veenhoven, R H" uniqKey="Veenhoven R">R. H. Veenhoven</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hirschfeld, J" uniqKey="Hirschfeld J">J. Hirschfeld</name>
</author>
<author><name sortKey="Roberts, H M" uniqKey="Roberts H">H. M. Roberts</name>
</author>
<author><name sortKey="Chapple, I L" uniqKey="Chapple I">I. L. Chapple</name>
</author>
<author><name sortKey="Parcina, M" uniqKey="Parcina M">M. Parcina</name>
</author>
<author><name sortKey="Jepsen, S" uniqKey="Jepsen S">S. Jepsen</name>
</author>
<author><name sortKey="Johansson, A" uniqKey="Johansson A">A. Johansson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Johansson, L" uniqKey="Johansson L">L. Johansson</name>
</author>
<author><name sortKey="Sherina, N" uniqKey="Sherina N">N. Sherina</name>
</author>
<author><name sortKey="Kharlamova, N" uniqKey="Kharlamova N">N. Kharlamova</name>
</author>
<author><name sortKey="Potempa, B" uniqKey="Potempa B">B. Potempa</name>
</author>
<author><name sortKey="Larsson, B" uniqKey="Larsson B">B. Larsson</name>
</author>
<author><name sortKey="Israelsson, L" uniqKey="Israelsson L">L. Israelsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jorgensen, K T" uniqKey="Jorgensen K">K. T. Jorgensen</name>
</author>
<author><name sortKey="Wiik, A" uniqKey="Wiik A">A. Wiik</name>
</author>
<author><name sortKey="Pedersen, M" uniqKey="Pedersen M">M. Pedersen</name>
</author>
<author><name sortKey="Hedegaard, C J" uniqKey="Hedegaard C">C. J. Hedegaard</name>
</author>
<author><name sortKey="Vestergaard, B F" uniqKey="Vestergaard B">B. F. Vestergaard</name>
</author>
<author><name sortKey="Gislefoss, R E" uniqKey="Gislefoss R">R. E. Gislefoss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konig, M F" uniqKey="Konig M">M. F. Konig</name>
</author>
<author><name sortKey="Abusleme, L" uniqKey="Abusleme L">L. Abusleme</name>
</author>
<author><name sortKey="Reinholdt, J" uniqKey="Reinholdt J">J. Reinholdt</name>
</author>
<author><name sortKey="Palmer, R J" uniqKey="Palmer R">R. J. Palmer</name>
</author>
<author><name sortKey="Teles, R P" uniqKey="Teles R">R. P. Teles</name>
</author>
<author><name sortKey="Sampson, K" uniqKey="Sampson K">K. Sampson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Konig, M F" uniqKey="Konig M">M. F. Konig</name>
</author>
<author><name sortKey="Paracha, A S" uniqKey="Paracha A">A. S. Paracha</name>
</author>
<author><name sortKey="Moni, M" uniqKey="Moni M">M. Moni</name>
</author>
<author><name sortKey="Bingham, C O" uniqKey="Bingham C">C. O. Bingham</name>
</author>
<author><name sortKey="Andrade, F" uniqKey="Andrade F">F. Andrade</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Langille, M G" uniqKey="Langille M">M. G. Langille</name>
</author>
<author><name sortKey="Zaneveld, J" uniqKey="Zaneveld J">J. Zaneveld</name>
</author>
<author><name sortKey="Caporaso, J G" uniqKey="Caporaso J">J. G. Caporaso</name>
</author>
<author><name sortKey="Mcdonald, D" uniqKey="Mcdonald D">D. McDonald</name>
</author>
<author><name sortKey="Knights, D" uniqKey="Knights D">D. Knights</name>
</author>
<author><name sortKey="Reyes, J A" uniqKey="Reyes J">J. A. Reyes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lappin, D F" uniqKey="Lappin D">D. F. Lappin</name>
</author>
<author><name sortKey="Apatzidou, D" uniqKey="Apatzidou D">D. Apatzidou</name>
</author>
<author><name sortKey="Quirke, A M" uniqKey="Quirke A">A. M. Quirke</name>
</author>
<author><name sortKey="Oliver Bell, J" uniqKey="Oliver Bell J">J. Oliver-Bell</name>
</author>
<author><name sortKey="Butcher, J P" uniqKey="Butcher J">J. P. Butcher</name>
</author>
<author><name sortKey="Kinane, D F" uniqKey="Kinane D">D. F. Kinane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mascitti, M" uniqKey="Mascitti M">M. Mascitti</name>
</author>
<author><name sortKey="Togni, L" uniqKey="Togni L">L. Togni</name>
</author>
<author><name sortKey="Troiano, G" uniqKey="Troiano G">G. Troiano</name>
</author>
<author><name sortKey="Caponio, V C A" uniqKey="Caponio V">V. C. A. Caponio</name>
</author>
<author><name sortKey="Gissi, D B" uniqKey="Gissi D">D. B. Gissi</name>
</author>
<author><name sortKey="Montebugnoli, L" uniqKey="Montebugnoli L">L. Montebugnoli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mikuls, T R" uniqKey="Mikuls T">T. R. Mikuls</name>
</author>
<author><name sortKey="Thiele, G M" uniqKey="Thiele G">G. M. Thiele</name>
</author>
<author><name sortKey="Deane, K D" uniqKey="Deane K">K. D. Deane</name>
</author>
<author><name sortKey="Payne, J B" uniqKey="Payne J">J. B. Payne</name>
</author>
<author><name sortKey="O Dell, J R" uniqKey="O Dell J">J. R. O'Dell</name>
</author>
<author><name sortKey="Yu, F" uniqKey="Yu F">F. Yu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nielen, M M" uniqKey="Nielen M">M. M. Nielen</name>
</author>
<author><name sortKey="Van Schaardenburg, D" uniqKey="Van Schaardenburg D">D. van Schaardenburg</name>
</author>
<author><name sortKey="Reesink, H W" uniqKey="Reesink H">H. W. Reesink</name>
</author>
<author><name sortKey="Van De Stadt, R J" uniqKey="Van De Stadt R">R. J. van de Stadt</name>
</author>
<author><name sortKey="Van Der Horst Bruinsma, I E" uniqKey="Van Der Horst Bruinsma I">I. E. van der Horst-Bruinsma</name>
</author>
<author><name sortKey="De Koning, M H" uniqKey="De Koning M">M. H. de Koning</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ramanan, P" uniqKey="Ramanan P">P. Ramanan</name>
</author>
<author><name sortKey="Barreto, J N" uniqKey="Barreto J">J. N. Barreto</name>
</author>
<author><name sortKey="Osmon, D R" uniqKey="Osmon D">D. R. Osmon</name>
</author>
<author><name sortKey="Tosh, P K" uniqKey="Tosh P">P. K. Tosh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rantapaa Dahlqvist, S" uniqKey="Rantapaa Dahlqvist S">S. Rantapaa-Dahlqvist</name>
</author>
<author><name sortKey="De Jong, B A" uniqKey="De Jong B">B. A. de Jong</name>
</author>
<author><name sortKey="Berglin, E" uniqKey="Berglin E">E. Berglin</name>
</author>
<author><name sortKey="Hallmans, G" uniqKey="Hallmans G">G. Hallmans</name>
</author>
<author><name sortKey="Wadell, G" uniqKey="Wadell G">G. Wadell</name>
</author>
<author><name sortKey="Stenlund, H" uniqKey="Stenlund H">H. Stenlund</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rombouts, Y" uniqKey="Rombouts Y">Y. Rombouts</name>
</author>
<author><name sortKey="Ewing, E" uniqKey="Ewing E">E. Ewing</name>
</author>
<author><name sortKey="Van De Stadt, L A" uniqKey="Van De Stadt L">L. A. van de Stadt</name>
</author>
<author><name sortKey="Selman, M H" uniqKey="Selman M">M. H. Selman</name>
</author>
<author><name sortKey="Trouw, L A" uniqKey="Trouw L">L. A. Trouw</name>
</author>
<author><name sortKey="Deelder, A M" uniqKey="Deelder A">A. M. Deelder</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ronnelid, J" uniqKey="Ronnelid J">J. Ronnelid</name>
</author>
<author><name sortKey="Wick, M C" uniqKey="Wick M">M. C. Wick</name>
</author>
<author><name sortKey="Lampa, J" uniqKey="Lampa J">J. Lampa</name>
</author>
<author><name sortKey="Lindblad, S" uniqKey="Lindblad S">S. Lindblad</name>
</author>
<author><name sortKey="Nordmark, B" uniqKey="Nordmark B">B. Nordmark</name>
</author>
<author><name sortKey="Klareskog, L" uniqKey="Klareskog L">L. Klareskog</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schellekens, G A" uniqKey="Schellekens G">G. A. Schellekens</name>
</author>
<author><name sortKey="Visser, H" uniqKey="Visser H">H. Visser</name>
</author>
<author><name sortKey="De Jong, B A" uniqKey="De Jong B">B. A. de Jong</name>
</author>
<author><name sortKey="Van Den Hoogen, F H" uniqKey="Van Den Hoogen F">F. H. van den Hoogen</name>
</author>
<author><name sortKey="Hazes, J M" uniqKey="Hazes J">J. M. Hazes</name>
</author>
<author><name sortKey="Breedveld, F C" uniqKey="Breedveld F">F. C. Breedveld</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scher, J U" uniqKey="Scher J">J. U. Scher</name>
</author>
<author><name sortKey="Joshua, V" uniqKey="Joshua V">V. Joshua</name>
</author>
<author><name sortKey="Artacho, A" uniqKey="Artacho A">A. Artacho</name>
</author>
<author><name sortKey="Abdollahi Roodsaz, S" uniqKey="Abdollahi Roodsaz S">S. Abdollahi-Roodsaz</name>
</author>
<author><name sortKey="Ockinger, J" uniqKey="Ockinger J">J. Ockinger</name>
</author>
<author><name sortKey="Kullberg, S" uniqKey="Kullberg S">S. Kullberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scher, J U" uniqKey="Scher J">J. U. Scher</name>
</author>
<author><name sortKey="Sczesnak, A" uniqKey="Sczesnak A">A. Sczesnak</name>
</author>
<author><name sortKey="Longman, R S" uniqKey="Longman R">R. S. Longman</name>
</author>
<author><name sortKey="Segata, N" uniqKey="Segata N">N. Segata</name>
</author>
<author><name sortKey="Ubeda, C" uniqKey="Ubeda C">C. Ubeda</name>
</author>
<author><name sortKey="Bielski, C" uniqKey="Bielski C">C. Bielski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scher, J U" uniqKey="Scher J">J. U. Scher</name>
</author>
<author><name sortKey="Ubeda, C" uniqKey="Ubeda C">C. Ubeda</name>
</author>
<author><name sortKey="Equinda, M" uniqKey="Equinda M">M. Equinda</name>
</author>
<author><name sortKey="Khanin, R" uniqKey="Khanin R">R. Khanin</name>
</author>
<author><name sortKey="Buischi, Y" uniqKey="Buischi Y">Y. Buischi</name>
</author>
<author><name sortKey="Viale, A" uniqKey="Viale A">A. Viale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sokolove, J" uniqKey="Sokolove J">J. Sokolove</name>
</author>
<author><name sortKey="Bromberg, R" uniqKey="Bromberg R">R. Bromberg</name>
</author>
<author><name sortKey="Deane, K D" uniqKey="Deane K">K. D. Deane</name>
</author>
<author><name sortKey="Lahey, L J" uniqKey="Lahey L">L. J. Lahey</name>
</author>
<author><name sortKey="Derber, L A" uniqKey="Derber L">L. A. Derber</name>
</author>
<author><name sortKey="Chandra, P E" uniqKey="Chandra P">P. E. Chandra</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Syversen, S W" uniqKey="Syversen S">S. W. Syversen</name>
</author>
<author><name sortKey="Gaarder, P I" uniqKey="Gaarder P">P. I. Gaarder</name>
</author>
<author><name sortKey="Goll, G L" uniqKey="Goll G">G. L. Goll</name>
</author>
<author><name sortKey="Odegard, S" uniqKey="Odegard S">S. Odegard</name>
</author>
<author><name sortKey="Haavardsholm, E A" uniqKey="Haavardsholm E">E. A. Haavardsholm</name>
</author>
<author><name sortKey="Mowinckel, P" uniqKey="Mowinckel P">P. Mowinckel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van De Stadt, L A" uniqKey="Van De Stadt L">L. A. van de Stadt</name>
</author>
<author><name sortKey="Van Der Horst, A R" uniqKey="Van Der Horst A">A. R. van der Horst</name>
</author>
<author><name sortKey="De Koning, M H" uniqKey="De Koning M">M. H. de Koning</name>
</author>
<author><name sortKey="Bos, W H" uniqKey="Bos W">W. H. Bos</name>
</author>
<author><name sortKey="Wolbink, G J" uniqKey="Wolbink G">G. J. Wolbink</name>
</author>
<author><name sortKey="Van De Stadt, R J" uniqKey="Van De Stadt R">R. J. van de Stadt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Verrall, A J" uniqKey="Verrall A">A. J. Verrall</name>
</author>
<author><name sortKey="Robinson, P C" uniqKey="Robinson P">P. C. Robinson</name>
</author>
<author><name sortKey="Tan, C E" uniqKey="Tan C">C. E. Tan</name>
</author>
<author><name sortKey="Mackie, W G" uniqKey="Mackie W">W. G. Mackie</name>
</author>
<author><name sortKey="Blackmore, T K" uniqKey="Blackmore T">T. K. Blackmore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name>
</author>
<author><name sortKey="Jia, H" uniqKey="Jia H">H. Jia</name>
</author>
<author><name sortKey="Feng, Q" uniqKey="Feng Q">Q. Feng</name>
</author>
<author><name sortKey="Wang, D" uniqKey="Wang D">D. Wang</name>
</author>
<author><name sortKey="Liang, D" uniqKey="Liang D">D. Liang</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Cell Infect Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Cell Infect Microbiol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Cell. Infect. Microbiol.</journal-id>
<journal-title-group><journal-title>Frontiers in Cellular and Infection Microbiology</journal-title>
</journal-title-group>
<issn pub-type="epub">2235-2988</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">32039051</article-id>
<article-id pub-id-type="pmc">6987375</article-id>
<article-id pub-id-type="doi">10.3389/fcimb.2019.00475</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Cellular and Infection Microbiology</subject>
<subj-group><subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Oral Microbiota Perturbations Are Linked to High Risk for Rheumatoid Arthritis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tong</surname>
<given-names>Yanli</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/880261/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Zheng</surname>
<given-names>Linlin</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Qing</surname>
<given-names>Pingying</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Hua</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Yanhong</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/581991/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Su</surname>
<given-names>Linchong</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhang</surname>
<given-names>Qiuping</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhao</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/193477/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Luo</surname>
<given-names>Yubin</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/853718/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Yi</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/346118/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Department of Rheumatology and Immunology, West China Hospital, Sichuan University</institution>
,<addr-line>Chengdu</addr-line>
,<country>China</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases</institution>
,<addr-line>Enshi</addr-line>
,<country>China</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Lorenzo Lo Muzio, University of Foggia, Italy</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Marco Mascitti, Marche Polytechnic University, Italy; J. Christopher Fenno, University of Michigan, United States</p>
</fn>
<corresp id="c001">*Correspondence: Yubin Luo <email>luoyubin2016@163.com</email>
</corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>22</day>
<month>1</month>
<year>2020</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>9</volume>
<elocation-id>475</elocation-id>
<history><date date-type="received"><day>24</day>
<month>11</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>24</day>
<month>12</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2020 Tong, Zheng, Qing, Zhao, Li, Su, Zhang, Zhao, Luo and Liu.</copyright-statement>
<copyright-year>2020</copyright-year>
<copyright-holder>Tong, Zheng, Qing, Zhao, Li, Su, Zhang, Zhao, Luo and Liu</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Oral microbial dysbiosis is known to increase susceptibility of an individual to develop rheumatoid arthritis (RA). Individuals at-risk of RA may undergo different phases of disease progression. In this study, we aim to investigate whether and whereby the oral microbiome communities alter prior to symptoms of RA. Seventy-nine saliva samples were collected from 29 high-risk individuals, who were positive for anti-citrullinated protein antibodies (ACPA) and have no clinical arthritis, 27 RA patients and 23 healthy controls (HCs). The salivary microbiome was examined using 16S ribosomal RNA gene sequencing. Alpha and beta diversity analysis and the linear discriminant analysis were applied to examine the bacterial diversity, community structure and discriminatory taxa between three groups, respectively. The correlation between salivary bacteria and autoantibodies were analyzed. In the “pre-clinical” stages, salivary microbial diversity was significantly reduced comparing to RA patients and HCs. In contrast to HCs, like RA patients, individuals at high-risk for RA showed a reduction in the abundance of genus <italic>Defluviitaleaceae_UCG-011</italic>
and the species <italic>Neisseria oralis</italic>
, but an expansion of <italic>Prevotella</italic>
_6. Unexpectedly, the relative abundance of <italic>Porphyromonas gingivalis</italic>
, reported as opportunistic pathogens for RA development, was significantly decreased in high-risk individuals. Additionally, we identified four genera in the saliva from high-risk individuals positively correlated with serum ACPA titers, and the other two genera inversely displayed. In summary, we observed a characteristic compositional change of salivary microbes in individuals at high-risk for RA, suggesting that oral microbiota dysbiosis occurs in the “pre-clinical” stage of RA and are correlated with systemic autoimmune features.</p>
</abstract>
<kwd-group><kwd>oral microbiome</kwd>
<kwd>rheumatoid arthritis</kwd>
<kwd>high risk</kwd>
<kwd>anti-citrullinated protein autoantibodies</kwd>
<kwd>dysbiosis</kwd>
</kwd-group>
<funding-group><award-group><funding-source id="cn001">National Natural Science Foundation of China<named-content content-type="fundref-id">10.13039/501100001809</named-content>
</funding-source>
<award-id rid="cn001">81403041</award-id>
<award-id rid="cn001">81770101</award-id>
</award-group>
<award-group><funding-source id="cn002">West China Hospital, Sichuan University<named-content content-type="fundref-id">10.13039/501100013365</named-content>
</funding-source>
<award-id rid="cn002">2019HXBH037</award-id>
<award-id rid="cn002">ZYJC18024</award-id>
</award-group>
</funding-group>
<counts><fig-count count="5"></fig-count>
<table-count count="1"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="29"></ref-count>
<page-count count="10"></page-count>
<word-count count="6446"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>République populaire de Chine</li>
</country>
</list>
<tree><country name="République populaire de Chine"><noRegion><name sortKey="Tong, Yanli" sort="Tong, Yanli" uniqKey="Tong Y" first="Yanli" last="Tong">Yanli Tong</name>
</noRegion>
<name sortKey="Li, Yanhong" sort="Li, Yanhong" uniqKey="Li Y" first="Yanhong" last="Li">Yanhong Li</name>
<name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name>
<name sortKey="Luo, Yubin" sort="Luo, Yubin" uniqKey="Luo Y" first="Yubin" last="Luo">Yubin Luo</name>
<name sortKey="Qing, Pingying" sort="Qing, Pingying" uniqKey="Qing P" first="Pingying" last="Qing">Pingying Qing</name>
<name sortKey="Su, Linchong" sort="Su, Linchong" uniqKey="Su L" first="Linchong" last="Su">Linchong Su</name>
<name sortKey="Su, Linchong" sort="Su, Linchong" uniqKey="Su L" first="Linchong" last="Su">Linchong Su</name>
<name sortKey="Zhang, Qiuping" sort="Zhang, Qiuping" uniqKey="Zhang Q" first="Qiuping" last="Zhang">Qiuping Zhang</name>
<name sortKey="Zhao, Hua" sort="Zhao, Hua" uniqKey="Zhao H" first="Hua" last="Zhao">Hua Zhao</name>
<name sortKey="Zhao, Yi" sort="Zhao, Yi" uniqKey="Zhao Y" first="Yi" last="Zhao">Yi Zhao</name>
<name sortKey="Zheng, Linlin" sort="Zheng, Linlin" uniqKey="Zheng L" first="Linlin" last="Zheng">Linlin Zheng</name>
</country>
</tree>
</affiliations>
</record>
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