Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling
Identifieur interne : 000E09 ( Ncbi/Merge ); précédent : 000E08; suivant : 000E10Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling
Auteurs : Fubiao Ni [République populaire de Chine] ; Hengjie Tang [République populaire de Chine] ; Cheng Wang [République populaire de Chine] ; Hewei Zhang [République populaire de Chine] ; Chenlei Zheng [République populaire de Chine] ; Ning Zhang [République populaire de Chine] ; Bicheng Chen [République populaire de Chine] ; Linxiao Sun [République populaire de Chine]Source :
- Cancer Management and Research [ 1179-1322 ] ; 2019.
Abstract
Although the incidence of pancreatic cancer has increased markedly, the 5-year survival rate for this disease is considerably low compared with other types of cancer. Moreover, the mortality rate of pancreatic cancer is similar to its incidence rate. Current therapeutic agents exhibit a lack of specificity for pancreatic cancer. Baohuoside I is traditionally used to treat orgasmic disorder and inflammation. However, its role in pancreatic cancer is unknown.
To explore the effects of Baohuoside I on pancreatic cancer and to study the potential-related molecular mechanism.
In the present study, the antineoplastic effect of Baohuoside I was investigated with regard to pancreatic cancer via colony formation, transwell and migration assay. The energy metabolism changes of pancreatic cancer were tested by flow cytometry analysis and oxidative phosphorylation and glycolysis assay. The target signaling members were analyzed by Western blot.
Baohuoside I inhibited the cell growth of pancreatic cancer cells. In addition, it affected intracellular energy metabolism to induce cancer cell apoptosis via the mTOR/S6K1 and the caspase/Bcl2/Bax signaling pathways.
The present data provide further insight into the development of novel drugs against pancreatic cancer.
Url:
DOI: 10.2147/CMAR.S228926
PubMed: 31908533
PubMed Central: 6927568
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Tang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical 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strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Linxiao" sort="Sun, Linxiao" uniqKey="Sun L" first="Linxiao" last="Sun">Linxiao Sun</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31908533</idno><idno type="pmc">6927568</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6927568</idno><idno type="RBID">PMC:6927568</idno><idno 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Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tang, Hengjie" sort="Tang, Hengjie" uniqKey="Tang H" first="Hengjie" last="Tang">Hengjie Tang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Hewei" sort="Zhang, Hewei" uniqKey="Zhang H" first="Hewei" last="Zhang">Hewei Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zheng, Chenlei" sort="Zheng, Chenlei" uniqKey="Zheng C" first="Chenlei" last="Zheng">Chenlei Zheng</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name><affiliation wicri:level="1"><nlm:aff id="AFF0002"><institution>First School of Clinical Medicine, Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Bicheng" sort="Chen, Bicheng" uniqKey="Chen B" first="Bicheng" last="Chen">Bicheng Chen</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Linxiao" sort="Sun, Linxiao" uniqKey="Sun L" first="Linxiao" last="Sun">Linxiao Sun</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Cancer Management and Research</title><idno type="eISSN">1179-1322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S2001"><title>Background</title><p>Although the incidence of pancreatic cancer has increased markedly, the 5-year survival rate for this disease is considerably low compared with other types of cancer. Moreover, the mortality rate of pancreatic cancer is similar to its incidence rate. Current therapeutic agents exhibit a lack of specificity for pancreatic cancer. Baohuoside I is traditionally used to treat orgasmic disorder and inflammation. However, its role in pancreatic cancer is unknown.</p></sec><sec id="S2002"><title>Objective</title><p>To explore the effects of Baohuoside I on pancreatic cancer and to study the potential-related molecular mechanism.</p></sec><sec id="S2003"><title>Materials and methods</title><p>In the present study, the antineoplastic effect of Baohuoside I was investigated with regard to pancreatic cancer via colony formation, transwell and migration assay. The energy metabolism changes of pancreatic cancer were tested by flow cytometry analysis and oxidative phosphorylation and glycolysis assay. The target signaling members were analyzed by Western blot.</p></sec><sec id="S2004"><title>Results</title><p>Baohuoside I inhibited the cell growth of pancreatic cancer cells. In addition, it affected intracellular energy metabolism to induce cancer cell apoptosis via the mTOR/S6K1 and the caspase/Bcl2/Bax signaling pathways.</p></sec><sec id="S2005"><title>Conclusion</title><p>The present data provide further insight into the development of novel drugs against pancreatic cancer.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cancer Manag Res</journal-id><journal-id journal-id-type="iso-abbrev">Cancer Manag Res</journal-id><journal-id journal-id-type="publisher-id">CMAR</journal-id><journal-id journal-id-type="pmc">cancmanres</journal-id><journal-title-group><journal-title>Cancer Management and Research</journal-title></journal-title-group><issn pub-type="epub">1179-1322</issn><publisher><publisher-name>Dove</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31908533</article-id><article-id pub-id-type="pmc">6927568</article-id><article-id pub-id-type="publisher-id">228926</article-id><article-id pub-id-type="doi">10.2147/CMAR.S228926</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Baohuoside I Inhibits the Proliferation of Pancreatic Cancer Cells via mTOR/S6K1-Caspases/Bcl2/Bax Apoptotic Signaling</article-title><alt-title alt-title-type="running-authors">Ni et al</alt-title><alt-title alt-title-type="running-title">Ni et al</alt-title></title-group><contrib-group><contrib contrib-type="author" equal-contrib="yes"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-2698-9705</contrib-id><name><surname>Ni</surname><given-names>Fubiao</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref><xref ref-type="author-notes" rid="FT0001"></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Tang</surname><given-names>Hengjie</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref><xref ref-type="author-notes" rid="FT0001"></xref></contrib><contrib contrib-type="author" equal-contrib="yes"><name><surname>Wang</surname><given-names>Cheng</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref><xref ref-type="author-notes" rid="FT0001"></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0003-1784-4026</contrib-id><name><surname>Zhang</surname><given-names>Hewei</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Zheng</surname><given-names>Chenlei</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Ning</given-names></name><xref ref-type="aff" rid="AFF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Bicheng</given-names></name><xref ref-type="aff" rid="AFF0001">1</xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-5849-4881</contrib-id><name><surname>Sun</surname><given-names>Linxiao</given-names></name><xref ref-type="corresp" rid="AN0001"></xref><xref ref-type="aff" rid="AFF0001">1</xref></contrib><aff id="AFF0001"><label>1</label><institution>Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province, Zhejiang Provincial Top Key Discipline in Surgery, First Affiliated Hospital of Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></aff><aff id="AFF0002"><label>2</label><institution>First School of Clinical Medicine, Wenzhou Medical University</institution>,<addr-line>Wenzhou</addr-line>,<addr-line>Zhejiang</addr-line><addr-line>325000</addr-line>,<country>People’s Republic of China</country></aff></contrib-group><author-notes><corresp id="AN0001">Correspondence: Linxiao Sun; Bicheng Chen Email sunlinxiao@wmu.edu.cn; bichengchen@hotmail.com</corresp><fn id="FT0001"><label>*</label><p>These authors contributed equally to this work</p></fn></author-notes><pub-date pub-type="epub"><day>19</day><month>12</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>11</volume><fpage>10609</fpage><lpage>10621</lpage><history><date date-type="received"><day>27</day><month>8</month><year>2019</year></date><date date-type="accepted"><day>06</day><month>12</month><year>2019</year></date></history><permissions><copyright-statement>© 2019 Ni et al.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Ni et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>).</license-p></license></permissions><abstract><sec id="S2001"><title>Background</title><p>Although the incidence of pancreatic cancer has increased markedly, the 5-year survival rate for this disease is considerably low compared with other types of cancer. Moreover, the mortality rate of pancreatic cancer is similar to its incidence rate. Current therapeutic agents exhibit a lack of specificity for pancreatic cancer. Baohuoside I is traditionally used to treat orgasmic disorder and inflammation. However, its role in pancreatic cancer is unknown.</p></sec><sec id="S2002"><title>Objective</title><p>To explore the effects of Baohuoside I on pancreatic cancer and to study the potential-related molecular mechanism.</p></sec><sec id="S2003"><title>Materials and methods</title><p>In the present study, the antineoplastic effect of Baohuoside I was investigated with regard to pancreatic cancer via colony formation, transwell and migration assay. The energy metabolism changes of pancreatic cancer were tested by flow cytometry analysis and oxidative phosphorylation and glycolysis assay. The target signaling members were analyzed by Western blot.</p></sec><sec id="S2004"><title>Results</title><p>Baohuoside I inhibited the cell growth of pancreatic cancer cells. In addition, it affected intracellular energy metabolism to induce cancer cell apoptosis via the mTOR/S6K1 and the caspase/Bcl2/Bax signaling pathways.</p></sec><sec id="S2005"><title>Conclusion</title><p>The present data provide further insight into the development of novel drugs against pancreatic cancer.</p></sec></abstract><kwd-group kwd-group-type="author"><title>Keywords</title><kwd>Baohuoside I</kwd><kwd>pancreatic cancer</kwd><kwd>apoptosis</kwd></kwd-group><funding-group><funding-statement>This study was supported by Natural Science Foundation of Zhejiang Province (LQ20H030004) and Wenzhou Science and Technology Bureau (Y20190073).</funding-statement></funding-group><counts><fig-count count="7"></fig-count><ref-count count="34"></ref-count><page-count count="13"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Ni, Fubiao" sort="Ni, Fubiao" uniqKey="Ni F" first="Fubiao" last="Ni">Fubiao Ni</name></noRegion><name sortKey="Chen, Bicheng" sort="Chen, Bicheng" uniqKey="Chen B" first="Bicheng" last="Chen">Bicheng Chen</name><name sortKey="Sun, Linxiao" sort="Sun, Linxiao" uniqKey="Sun L" first="Linxiao" last="Sun">Linxiao Sun</name><name sortKey="Tang, Hengjie" sort="Tang, Hengjie" uniqKey="Tang H" first="Hengjie" last="Tang">Hengjie Tang</name><name sortKey="Wang, Cheng" sort="Wang, Cheng" uniqKey="Wang C" first="Cheng" last="Wang">Cheng Wang</name><name sortKey="Zhang, Hewei" sort="Zhang, Hewei" uniqKey="Zhang H" first="Hewei" last="Zhang">Hewei Zhang</name><name sortKey="Zhang, Ning" sort="Zhang, Ning" uniqKey="Zhang N" first="Ning" last="Zhang">Ning Zhang</name><name sortKey="Zheng, Chenlei" sort="Zheng, Chenlei" uniqKey="Zheng C" first="Chenlei" last="Zheng">Chenlei Zheng</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:31908533" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |