《胸部恶性肿瘤围术期静脉血栓栓塞症预防中国专家共识（2018版）》解读之围术期高凝状态篇
Identifieur interne : 000D70 ( Ncbi/Merge ); précédent : 000D69; suivant : 000D71《胸部恶性肿瘤围术期静脉血栓栓塞症预防中国专家共识（2018版）》解读之围术期高凝状态篇
Auteurs :Source :
- Chinese Journal of Lung Cancer [ 1009-3419 ] ; 2019.
Abstract
静脉血栓栓塞症（venous thromboembolism, VTE）是肺癌围术期常见的并发症，也是导致院内非预期死亡的重要原因。VTE临床相关的高危因素包括：患者自身的因素（高龄、肥胖等）、肿瘤相关因素（分型、分期等）、治疗相关因素（化疗、手术等）。除此之外，肿瘤细胞会表达癌性促凝因子（cancer procoagulant, CP）、组织因子（tissue factor, TF）、炎症因子等，或是激活血小板、炎性细胞等相关细胞，直接或间接地活化凝血过程，引起血液高凝状态，从而促进VTE的发生。同时，相关的生物标记物也可反映肺癌患者围术期的凝血状态，这有助于更准确地筛选VTE高危患者，更精准地予以预防策略。
Url:
DOI: 10.3779/j.issn.1009-3419.2019.12.03
PubMed: 31874669
PubMed Central: 6935033
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">《胸部恶性肿瘤围术期静脉血栓栓塞症预防中国专家共识（2018版）》解读之围术期高凝状态篇</title></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31874669</idno><idno type="pmc">6935033</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935033</idno><idno type="RBID">PMC:6935033</idno><idno type="doi">10.3779/j.issn.1009-3419.2019.12.03</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000342</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000342</idno><idno type="wicri:Area/Pmc/Curation">000342</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000342</idno><idno type="wicri:Area/Pmc/Checkpoint">000221</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000221</idno><idno type="wicri:Area/Ncbi/Merge">000D70</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">《胸部恶性肿瘤围术期静脉血栓栓塞症预防中国专家共识（2018版）》解读之围术期高凝状态篇</title></analytic><series><title level="j">Chinese Journal of Lung Cancer</title><idno type="ISSN">1009-3419</idno><idno type="eISSN">1999-6187</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>静脉血栓栓塞症（venous thromboembolism, VTE）是肺癌围术期常见的并发症，也是导致院内非预期死亡的重要原因。VTE临床相关的高危因素包括：患者自身的因素（高龄、肥胖等）、肿瘤相关因素（分型、分期等）、治疗相关因素（化疗、手术等）。除此之外，肿瘤细胞会表达癌性促凝因子（cancer procoagulant, CP）、组织因子（tissue factor, TF）、炎症因子等，或是激活血小板、炎性细胞等相关细胞，直接或间接地活化凝血过程，引起血液高凝状态，从而促进VTE的发生。同时，相关的生物标记物也可反映肺癌患者围术期的凝血状态，这有助于更准确地筛选VTE高危患者，更精准地予以预防策略。</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Li, H" uniqKey="Li H">H Li</name></author><author><name sortKey="Jiang, Gn" uniqKey="Jiang G">GN Jiang</name></author><author><name sortKey="China National Research Collaborative 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Zhongguo Fei Ai Za Zhi</journal-id><journal-id journal-id-type="iso-abbrev">Zhongguo Fei Ai Za Zhi</journal-id><journal-id journal-id-type="publisher-id">ZGFAZZ</journal-id><journal-title-group><journal-title>Chinese Journal of Lung Cancer</journal-title></journal-title-group><issn pub-type="ppub">1009-3419</issn><issn pub-type="epub">1999-6187</issn><publisher><publisher-name>中国肺癌杂志编辑部</publisher-name><publisher-loc>天津市和平区南京路228号300020</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31874669</article-id><article-id pub-id-type="pmc">6935033</article-id><article-id pub-id-type="publisher-id">zgfazz-22-12-752</article-id><article-id pub-id-type="doi">10.3779/j.issn.1009-3419.2019.12.03</article-id><article-categories><subj-group subj-group-type="heading"><subject>专家视点</subject></subj-group></article-categories><title-group><article-title>《胸部恶性肿瘤围术期静脉血栓栓塞症预防中国专家共识（2018版）》解读之围术期高凝状态篇</article-title><trans-title-group xml:lang="en"><trans-title xml:lang="en">Perioperative Venous Thromboembolism (VTE) Prophylaxis in Thoracic Cancer Patients: Chinese Experts Consensus- Interpretation of Perioperative Hypercoagulable State</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name name-style="eastern"><surname>崔</surname><given-names>松平</given-names></name><name xml:lang="en"><surname>CUI</surname><given-names>Songping</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name-alternatives><name name-style="eastern"><surname>李</surname><given-names>辉</given-names></name><name xml:lang="en"><surname>LI</surname><given-names>Hui</given-names></name></name-alternatives><email>huilee@vip.sina.com</email><xref ref-type="aff" rid="aff1"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="aff1"><label></label><addr-line>北京，首都医科大学附属北京朝阳医院胸外科</addr-line><addr-line xml:lang="en">Department of Thoracic Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020, China</addr-line></aff><author-notes><corresp id="cor1">李辉, Hui LI, E-mail: <email>huilee@vip.sina.com</email></corresp></author-notes><pub-date pub-type="ppub"><day>20</day><month>12</month><year>2019</year></pub-date><volume>22</volume><issue>12</issue><fpage>752</fpage><lpage>756</lpage><history><date date-type="received"><day>13</day><month>11</month><year>2019</year></date><date date-type="rev-recd"><day>23</day><month>11</month><year>2019</year></date><date date-type="accepted"><day>27</day><month>11</month><year>2019</year></date></history><permissions><copyright-statement>版权所有©《中国肺癌杂志》编辑部2019</copyright-statement><copyright-statement xml:lang="en">Copyright ©2019 Chinese Journal of Lung Cancer. All rights reserved.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access" xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/</license-p></license></permissions><abstract><p>静脉血栓栓塞症（venous thromboembolism, VTE）是肺癌围术期常见的并发症，也是导致院内非预期死亡的重要原因。VTE临床相关的高危因素包括：患者自身的因素（高龄、肥胖等）、肿瘤相关因素（分型、分期等）、治疗相关因素（化疗、手术等）。除此之外，肿瘤细胞会表达癌性促凝因子（cancer procoagulant, CP）、组织因子（tissue factor, TF）、炎症因子等，或是激活血小板、炎性细胞等相关细胞，直接或间接地活化凝血过程，引起血液高凝状态，从而促进VTE的发生。同时，相关的生物标记物也可反映肺癌患者围术期的凝血状态，这有助于更准确地筛选VTE高危患者，更精准地予以预防策略。</p></abstract><trans-abstract xml:lang="en"><p>Venous thromboembolism (VTE) is a common perioperative complication of lung cancer and a major cause of unexpected death in hospital. The clinical risk factors of VTE include: patients' factors (advanced age, obesity, <italic>etc.</italic>), tumor-related factors (classification, staging, <italic>etc.</italic>), treatment-related factors (chemotherapy, surgery, <italic>etc.</italic>). In addition, tumor cells express cancer procoagulant (CP), tissue factor (TF), inflammatory factors or activate platelets, inflammatory cells and other related cells, directly or indirectly activate the coagulation process, and cause blood hypercoagulable state, thus promote the occurrence of VTE. At the same time, the relevant biomarkers can also reflect the perioperative coagulation status of patients, which is helpful to more accurately identify high-risk subgroups to establish more accurate and targeted anticoagulation strategies to prevent thrombosis in lung cancer patients.</p></trans-abstract><kwd-group kwd-group-type="author-created"><kwd>肺肿瘤</kwd><kwd>静脉血栓栓塞症</kwd><kwd>高凝状态</kwd><kwd>生物标记物</kwd></kwd-group><kwd-group kwd-group-type="author-created" xml:lang="en"><kwd>Lung neoplasms</kwd><kwd>Venous thromboembolism</kwd><kwd>Hypercoagulable state</kwd><kwd>Biomarker</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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