Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?
Identifieur interne : 000C75 ( Ncbi/Merge ); précédent : 000C74; suivant : 000C76Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?
Auteurs : George Mattheolabakis [États-Unis] ; Constantinos M. Mikelis [États-Unis]Source :
- Frontiers in Oncology [ 2234-943X ] ; 2019.
Abstract
Tumor-induced angiogenesis has been a significant focus of anti-cancer therapies for several decades. The immature and “leaky” tumor vasculature leads to significant cancer cell intravasation, increasing the metastatic potential, while the disoriented and hypo-perfused tumor vessels hamper the anti-tumor efficacy of immune cells and prevent the efficient diffusion of chemotherapeutic drugs. Therefore, tumor vascular normalization has emerged as a new treatment goal, aiming to provide a mature tumor vasculature, with higher perfusion, decreased cancer cell extravasation, and higher efficacy for anti-cancer therapies. Here we propose an overview of the nanodelivery approaches that target tumor vasculature, aiming to achieve vascular normalization. At the same time, abnormal vascular architecture and leaky tumor vessels have been the cornerstone for nanodelivery approaches through the enhanced permeability and retention (EPR) effect. Vascular normalization presents new opportunities and requirements for efficient nanoparticle delivery against the tumor cells and overall improved anti-cancer therapies.
Url:
DOI: 10.3389/fonc.2019.01227
PubMed: 31799190
PubMed Central: 6863425
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?</title><author><name sortKey="Mattheolabakis, George" sort="Mattheolabakis, George" uniqKey="Mattheolabakis G" first="George" last="Mattheolabakis">George Mattheolabakis</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe</institution>,<addr-line>Monroe, LA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mikelis, Constantinos M" sort="Mikelis, Constantinos M" uniqKey="Mikelis C" first="Constantinos M." last="Mikelis">Constantinos M. Mikelis</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy</institution>,<addr-line>Amarillo, TX</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31799190</idno><idno type="pmc">6863425</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6863425</idno><idno type="RBID">PMC:6863425</idno><idno type="doi">10.3389/fonc.2019.01227</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000984</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000984</idno><idno type="wicri:Area/Pmc/Curation">000984</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000984</idno><idno type="wicri:Area/Pmc/Checkpoint">000553</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000553</idno><idno type="wicri:Area/Ncbi/Merge">000C75</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?</title><author><name sortKey="Mattheolabakis, George" sort="Mattheolabakis, George" uniqKey="Mattheolabakis G" first="George" last="Mattheolabakis">George Mattheolabakis</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe</institution>,<addr-line>Monroe, LA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mikelis, Constantinos M" sort="Mikelis, Constantinos M" uniqKey="Mikelis C" first="Constantinos M." last="Mikelis">Constantinos M. Mikelis</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy</institution>,<addr-line>Amarillo, TX</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Oncology</title><idno type="eISSN">2234-943X</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Tumor-induced angiogenesis has been a significant focus of anti-cancer therapies for several decades. The immature and “leaky” tumor vasculature leads to significant cancer cell intravasation, increasing the metastatic potential, while the disoriented and hypo-perfused tumor vessels hamper the anti-tumor efficacy of immune cells and prevent the efficient diffusion of chemotherapeutic drugs. Therefore, tumor vascular normalization has emerged as a new treatment goal, aiming to provide a mature tumor vasculature, with higher perfusion, decreased cancer cell extravasation, and higher efficacy for anti-cancer therapies. Here we propose an overview of the nanodelivery approaches that target tumor vasculature, aiming to achieve vascular normalization. At the same time, abnormal vascular architecture and leaky tumor vessels have been the cornerstone for nanodelivery approaches through the enhanced permeability and retention (EPR) effect. Vascular normalization presents new opportunities and requirements for efficient nanoparticle delivery against the tumor cells and overall improved anti-cancer therapies.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Folkman, J" uniqKey="Folkman J">J Folkman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carmeliet, P" uniqKey="Carmeliet P">P Carmeliet</name></author><author><name sortKey="Jain, Rk" uniqKey="Jain R">RK Jain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leite De Oliveira, R" uniqKey="Leite De Oliveira R">R Leite de Oliveira</name></author><author><name sortKey="Hamm, A" uniqKey="Hamm A">A Hamm</name></author><author><name sortKey="Mazzone, M" uniqKey="Mazzone M">M Mazzone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wong, Pp" uniqKey="Wong P">PP Wong</name></author><author><name sortKey="Bodrug, N" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Oncol</journal-id><journal-id journal-id-type="iso-abbrev">Front Oncol</journal-id><journal-id journal-id-type="publisher-id">Front. Oncol.</journal-id><journal-title-group><journal-title>Frontiers in Oncology</journal-title></journal-title-group><issn pub-type="epub">2234-943X</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31799190</article-id><article-id pub-id-type="pmc">6863425</article-id><article-id pub-id-type="doi">10.3389/fonc.2019.01227</article-id><article-categories><subj-group subj-group-type="heading"><subject>Oncology</subject><subj-group><subject>Mini Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Nanoparticle Delivery and Tumor Vascular Normalization: The Chicken or The Egg?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mattheolabakis</surname><given-names>George</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="c001"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Mikelis</surname><given-names>Constantinos M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="c002"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/687855/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>School of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana Monroe</institution>,<addr-line>Monroe, LA</addr-line>,<country>United States</country></aff><aff id="aff2"><sup>2</sup><institution>Department of Pharmaceutical Sciences, Texas Tech University Health Sciences Center, School of Pharmacy</institution>,<addr-line>Amarillo, TX</addr-line>,<country>United States</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Erika Ruiz-Garcia, National Institute of Cancerology (INCan), Mexico</p></fn><fn fn-type="edited-by"><p>Reviewed by: Mikhail Durymanov, Moscow Institute of Physics and Technology, Russia; Katarzyna A. Rejniak, Moffitt Cancer Center, United States</p></fn><corresp id="c001">*Correspondence: George Mattheolabakis <email>matthaiolampakis@ulm.edu</email></corresp><corresp id="c002">Constantinos M. Mikelis <email>constantinos.mikelis@ttuhsc.edu</email></corresp><fn fn-type="other" id="fn001"><p>This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Oncology</p></fn></author-notes><pub-date pub-type="epub"><day>12</day><month>11</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>9</volume><elocation-id>1227</elocation-id><history><date date-type="received"><day>19</day><month>8</month><year>2019</year></date><date date-type="accepted"><day>28</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 Mattheolabakis and Mikelis.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Mattheolabakis and Mikelis</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Tumor-induced angiogenesis has been a significant focus of anti-cancer therapies for several decades. The immature and “leaky” tumor vasculature leads to significant cancer cell intravasation, increasing the metastatic potential, while the disoriented and hypo-perfused tumor vessels hamper the anti-tumor efficacy of immune cells and prevent the efficient diffusion of chemotherapeutic drugs. Therefore, tumor vascular normalization has emerged as a new treatment goal, aiming to provide a mature tumor vasculature, with higher perfusion, decreased cancer cell extravasation, and higher efficacy for anti-cancer therapies. Here we propose an overview of the nanodelivery approaches that target tumor vasculature, aiming to achieve vascular normalization. At the same time, abnormal vascular architecture and leaky tumor vessels have been the cornerstone for nanodelivery approaches through the enhanced permeability and retention (EPR) effect. Vascular normalization presents new opportunities and requirements for efficient nanoparticle delivery against the tumor cells and overall improved anti-cancer therapies.</p></abstract><kwd-group><kwd>nanoparticles</kwd><kwd>delivery</kwd><kwd>tumor</kwd><kwd>vessel</kwd><kwd>normalization</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="70"></ref-count><page-count count="8"></page-count><word-count count="5733"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Mattheolabakis, George" sort="Mattheolabakis, George" uniqKey="Mattheolabakis G" first="George" last="Mattheolabakis">George Mattheolabakis</name></noRegion><name sortKey="Mikelis, Constantinos M" sort="Mikelis, Constantinos M" uniqKey="Mikelis C" first="Constantinos M." last="Mikelis">Constantinos M. 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