Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?
Identifieur interne : 000B98 ( Ncbi/Merge ); précédent : 000B97; suivant : 000B99Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?
Auteurs : Łukasz Gwadera [Pologne] ; Adam Jerzy Białas [Pologne] ; Mikołaj Aleksander Iwa Ski [Pologne] ; Paweł G Rski [Pologne] ; Wojciech Jerzy Piotrowski [Pologne]Source :
- Chronic Respiratory Disease [ 1479-9723 ] ; 2019.
Abstract
The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.
Url:
DOI: 10.1177/1479973119878713
PubMed: 31718265
PubMed Central: 6854763
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<front><div type="abstract" xml:lang="en"><p>The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Chron Respir Dis</journal-id>
<journal-id journal-id-type="iso-abbrev">Chron Respir Dis</journal-id>
<journal-id journal-id-type="publisher-id">CRD</journal-id>
<journal-id journal-id-type="hwp">spcrd</journal-id>
<journal-title-group><journal-title>Chronic Respiratory Disease</journal-title>
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<issn pub-type="ppub">1479-9723</issn>
<issn pub-type="epub">1479-9731</issn>
<publisher><publisher-name>SAGE Publications</publisher-name>
<publisher-loc>Sage UK: London, England</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31718265</article-id>
<article-id pub-id-type="pmc">6854763</article-id>
<article-id pub-id-type="doi">10.1177/1479973119878713</article-id>
<article-id pub-id-type="publisher-id">10.1177_1479973119878713</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Sarcoidosis and calcium homeostasis disturbances—Do we know where we stand?</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Gwadera</surname>
<given-names>Łukasz</given-names>
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<xref ref-type="aff" rid="aff1-1479973119878713">1</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">https://orcid.org/0000-0002-3501-167X</contrib-id>
<name><surname>Białas</surname>
<given-names>Adam Jerzy</given-names>
</name>
<xref ref-type="aff" rid="aff1-1479973119878713">1</xref>
<xref ref-type="corresp" rid="corresp1-1479973119878713"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Iwański</surname>
<given-names>Mikołaj Aleksander</given-names>
</name>
<xref ref-type="aff" rid="aff1-1479973119878713">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Górski</surname>
<given-names>Paweł</given-names>
</name>
<xref ref-type="aff" rid="aff1-1479973119878713">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Piotrowski</surname>
<given-names>Wojciech Jerzy</given-names>
</name>
<xref ref-type="aff" rid="aff1-1479973119878713">1</xref>
</contrib>
</contrib-group>
<aff id="aff1-1479973119878713"><label>1</label>
Department of Pneumology and Allergy, Chair of Internal Medicine, Medical University of Lodz, Poland</aff>
<author-notes><corresp id="corresp1-1479973119878713">Adam Jerzy Białas, Department of Pneumology and Allergy, Medical University of Lodz, 22 Kopcińskiego Street, 90-153 Lodz, Poland. Email: <email>adam.bialas@umed.lodz.pl</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>13</day>
<month>11</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><season>Jan-Dec</season>
<year>2019</year>
</pub-date>
<volume>16</volume>
<elocation-id>1479973119878713</elocation-id>
<history><date date-type="received"><day>12</day>
<month>3</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>29</day>
<month>8</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>3</day>
<month>9</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2019</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder content-type="sage">SAGE Publications Ltd unless otherwise noted. Manuscript content on this site is licensed under Creative Commons Licenses</copyright-holder>
<license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (<ext-link ext-link-type="uri" xlink:href="http://www.creativecommons.org/licenses/by-nc/4.0/">http://www.creativecommons.org/licenses/by-nc/4.0/</ext-link>
) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (<ext-link ext-link-type="uri" xlink:href="https://us.sagepub.com/en-us/nam/open-access-at-sage">https://us.sagepub.com/en-us/nam/open-access-at-sage</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>The majority of cases involving hypercalcemia in the setting of sarcoidosis are explained by the overproduction of calcitriol by activated macrophages. Vitamin D takes part in the regulation of granuloma formation. However, using vitamin D metabolites to assess the activity of the disease is still problematic, and its usefulness is disputable. In some cases, though, a calcium metabolism disorder could be a valuable tool (i.e. as a marker of extrathoracic sarcoidosis). Although sarcoidosis does not cause a decrease in bone mineral density, increased incidence of vertebral deformities is noted. Despite increasing knowledge about calcium homeostasis disorders in patients with sarcoidosis, there is still a need for clear guidelines regarding calcium and vitamin D supplementation in these patients.</p>
</abstract>
<kwd-group><kwd>Sarcoidosis</kwd>
<kwd>calcium</kwd>
<kwd>vitamin D</kwd>
<kwd>hypercalcemia</kwd>
<kwd>hypercalciuria</kwd>
<kwd>calcitriol</kwd>
<kwd>1,25(OH)<sub>2</sub>
D<sub>3</sub>
</kwd>
<kwd>25(OH)D<sub>3</sub>
</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>cover-date</meta-name>
<meta-value>January-December 2019</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Pologne</li>
</country>
</list>
<tree><country name="Pologne"><noRegion><name sortKey="Gwadera, Lukasz" sort="Gwadera, Lukasz" uniqKey="Gwadera L" first="Łukasz" last="Gwadera">Łukasz Gwadera</name>
</noRegion>
<name sortKey="Bialas, Adam Jerzy" sort="Bialas, Adam Jerzy" uniqKey="Bialas A" first="Adam Jerzy" last="Białas">Adam Jerzy Białas</name>
<name sortKey="G Rski, Pawel" sort="G Rski, Pawel" uniqKey="G Rski P" first="Paweł" last="G Rski">Paweł G Rski</name>
<name sortKey="Iwa Ski, Mikolaj Aleksander" sort="Iwa Ski, Mikolaj Aleksander" uniqKey="Iwa Ski M" first="Mikołaj Aleksander" last="Iwa Ski">Mikołaj Aleksander Iwa Ski</name>
<name sortKey="Piotrowski, Wojciech Jerzy" sort="Piotrowski, Wojciech Jerzy" uniqKey="Piotrowski W" first="Wojciech Jerzy" last="Piotrowski">Wojciech Jerzy Piotrowski</name>
</country>
</tree>
</affiliations>
</record>
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