Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019
Identifieur interne : 000B53 ( Ncbi/Merge ); précédent : 000B52; suivant : 000B54Unmet need in rheumatology: reports from the Targeted Therapies meeting 2019
Auteurs : Kevin L. Winthrop [États-Unis] ; Michael E. Weinblatt [États-Unis] ; Joan Bathon [États-Unis] ; Gerd R. Burmester [Allemagne] ; Philip J. Mease [États-Unis] ; Leslie Crofford [États-Unis] ; Vivian Bykerk [États-Unis] ; Maxime Dougados [France] ; James Todd Rosenbaum [États-Unis] ; Xavier Mariette [France] ; Joachim Sieper [Allemagne] ; Fritz Melchers [Allemagne] ; Bruce N. Cronstein [États-Unis] ; Ferry C. Breedveld [Pays-Bas] ; Joachim Kalden [Allemagne] ; Josef S. Smolen [Autriche] ; Daniel Furst [États-Unis, Italie]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2019.
Abstract
To detail the greatest areas of unmet scientific and clinical needs in rheumatology.
The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20–30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area.
Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases.
Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.
Url:
DOI: 10.1136/annrheumdis-2019-216151
PubMed: 31662322
PubMed Central: 6937409
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Breedveld</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Leiden University Medical Center</institution>,<addr-line content-type="city">Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kalden, Joachim" sort="Kalden, Joachim" uniqKey="Kalden J" first="Joachim" last="Kalden">Joachim Kalden</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>University of Erlangen</institution>,<addr-line content-type="city">Erlangen</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. 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Winthrop</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oregon Health Sciences University</institution>,<addr-line content-type="city">Portland</addr-line>,<addr-line content-type="state">Oregon</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Weinblatt, Michael E" sort="Weinblatt, Michael E" uniqKey="Weinblatt M" first="Michael E" last="Weinblatt">Michael E. Weinblatt</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Brigham and Womens Hospital</institution>,<addr-line content-type="city">Boston</addr-line>,<addr-line content-type="state">Massachusetts</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bathon, Joan" sort="Bathon, Joan" uniqKey="Bathon J" first="Joan" last="Bathon">Joan Bathon</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Columbia University, College of Physicians & Surgeons</institution>,<addr-line content-type="city">New York City</addr-line>,<addr-line content-type="state">New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R" last="Burmester">Gerd R. Burmester</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Charité University Hospital</institution>,<addr-line content-type="city">Berlin</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mease, Philip J" sort="Mease, Philip J" uniqKey="Mease P" first="Philip J" last="Mease">Philip J. Mease</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Swedish Medical Center, University of Washington</institution>,<addr-line content-type="city">Seattle</addr-line>,<addr-line content-type="state">Washington</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Crofford, Leslie" sort="Crofford, Leslie" uniqKey="Crofford L" first="Leslie" last="Crofford">Leslie Crofford</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Vanderbilt University</institution>,<addr-line content-type="city">Nashville</addr-line>,<addr-line content-type="state">Tennessee</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bykerk, Vivian" sort="Bykerk, Vivian" uniqKey="Bykerk V" first="Vivian" last="Bykerk">Vivian Bykerk</name><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Hospital for Special Surgery</institution>,<addr-line content-type="city">New York City</addr-line>,<addr-line content-type="state">New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation wicri:level="1"><nlm:aff id="aff8"><institution>Hôpital Cochin</institution>,<addr-line content-type="city">Paris</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rosenbaum, James Todd" sort="Rosenbaum, James Todd" uniqKey="Rosenbaum J" first="James Todd" last="Rosenbaum">James Todd Rosenbaum</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Oregon Health Sciences University</institution>,<addr-line content-type="city">Portland</addr-line>,<addr-line content-type="state">Oregon</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Legacy Devers Eye Institute</institution>,<addr-line content-type="city">Portland</addr-line>,<addr-line content-type="state">Oregon</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>Paris-Sud University, APHP Université Paris-Saclay, Hôpital Bicêtre</institution>,<addr-line content-type="city">Le Kremlin Bicêtre</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sieper, Joachim" sort="Sieper, Joachim" uniqKey="Sieper J" first="Joachim" last="Sieper">Joachim Sieper</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution content-type="department">Department of Gastroenterology</institution>,<institution>Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité</institution>,<addr-line content-type="city">Berlin</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Melchers, Fritz" sort="Melchers, Fritz" uniqKey="Melchers F" first="Fritz" last="Melchers">Fritz Melchers</name><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Max Planck Institute for Infection Biology</institution>,<addr-line content-type="city">Berlin</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cronstein, Bruce N" sort="Cronstein, Bruce N" uniqKey="Cronstein B" first="Bruce N" last="Cronstein">Bruce N. Cronstein</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>NYU School of Medicine</institution>,<addr-line content-type="city">New York City</addr-line>,<addr-line content-type="state">New York</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Breedveld, Ferry C" sort="Breedveld, Ferry C" uniqKey="Breedveld F" first="Ferry C" last="Breedveld">Ferry C. Breedveld</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Leiden University Medical Center</institution>,<addr-line content-type="city">Leiden</addr-line>,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kalden, Joachim" sort="Kalden, Joachim" uniqKey="Kalden J" first="Joachim" last="Kalden">Joachim Kalden</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>University of Erlangen</institution>,<addr-line content-type="city">Erlangen</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>Division of Rheumatology, Department of Medicine 3, Medical University of, Vienna</institution>,<addr-line content-type="city">Vienna</addr-line>,<country>Austria</country></nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Swedish Medical Center, University of Washington</institution>,<addr-line content-type="city">Seattle</addr-line>,<addr-line content-type="state">Washington</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>University of California, Los Angeles Medical Center</institution>,<addr-line content-type="city">Los Angeles</addr-line>,<addr-line content-type="state">CA</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>University of Florence</institution>,<addr-line content-type="city">Florence</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objectives</title><p>To detail the greatest areas of unmet scientific and clinical needs in rheumatology.</p></sec><sec><title>Methods</title><p>The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20–30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area.</p></sec><sec><title>Results</title><p>Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases.</p></sec><sec><title>Conclusions</title><p>Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.</p></sec></div></front><back><div1 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-id journal-id-type="iso-abbrev">Ann. Rheum. Dis</journal-id><journal-id journal-id-type="hwp">annrheumdis</journal-id><journal-id journal-id-type="publisher-id">ard</journal-id><journal-title-group><journal-title>Annals of the Rheumatic Diseases</journal-title></journal-title-group><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn><publisher><publisher-name>BMJ Publishing Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31662322</article-id><article-id pub-id-type="pmc">6937409</article-id><article-id pub-id-type="publisher-id">annrheumdis-2019-216151</article-id><article-id pub-id-type="doi">10.1136/annrheumdis-2019-216151</article-id><article-categories><subj-group subj-group-type="heading"><subject>Viewpoint</subject></subj-group><subj-group 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contrib-type="author"><name><surname>Rosenbaum</surname><given-names>James Todd</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff9">9</xref></contrib><contrib id="author-66363234" contrib-type="author"><name><surname>Mariette</surname><given-names>Xavier</given-names></name><xref ref-type="aff" rid="aff10">10</xref></contrib><contrib id="author-22407852" contrib-type="author"><name><surname>Sieper</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="aff11">11</xref></contrib><contrib id="author-64434656" contrib-type="author"><name><surname>Melchers</surname><given-names>Fritz</given-names></name><xref ref-type="aff" rid="aff12">12</xref></contrib><contrib id="author-27241686" contrib-type="author"><name><surname>Cronstein</surname><given-names>Bruce N</given-names></name><xref ref-type="aff" rid="aff13">13</xref></contrib><contrib id="author-22407807" contrib-type="author"><name><surname>Breedveld</surname><given-names>Ferry C</given-names></name><xref ref-type="aff" rid="aff14">14</xref></contrib><contrib id="author-64434768" contrib-type="author"><name><surname>Kalden</surname><given-names>Joachim</given-names></name><xref ref-type="aff" rid="aff15">15</xref></contrib><contrib id="author-65340205" contrib-type="author"><name><surname>Smolen</surname><given-names>Josef S</given-names></name><xref ref-type="aff" rid="aff16">16</xref></contrib><contrib id="author-71957288" contrib-type="author"><name><surname>Furst</surname><given-names>Daniel</given-names></name><xref ref-type="aff" rid="aff5">5</xref><xref ref-type="aff" rid="aff17">17</xref><xref ref-type="aff" rid="aff18">18</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution>Oregon Health Sciences University</institution>,<addr-line content-type="city">Portland</addr-line>,<addr-line content-type="state">Oregon</addr-line>,<country>USA</country></aff><aff id="aff2"><label>2</label><institution>Brigham and Womens Hospital</institution>,<addr-line content-type="city">Boston</addr-line>,<addr-line content-type="state">Massachusetts</addr-line>,<country>USA</country></aff><aff id="aff3"><label>3</label><institution>Columbia University, College of Physicians & Surgeons</institution>,<addr-line content-type="city">New York City</addr-line>,<addr-line content-type="state">New York</addr-line>,<country>USA</country></aff><aff id="aff4"><label>4</label><institution>Charité University Hospital</institution>,<addr-line content-type="city">Berlin</addr-line>,<country>Germany</country></aff><aff id="aff5"><label>5</label><institution>Swedish Medical Center, University of Washington</institution>,<addr-line content-type="city">Seattle</addr-line>,<addr-line content-type="state">Washington</addr-line>,<country>USA</country></aff><aff id="aff6"><label>6</label><institution>Vanderbilt University</institution>,<addr-line content-type="city">Nashville</addr-line>,<addr-line content-type="state">Tennessee</addr-line>,<country>USA</country></aff><aff id="aff7"><label>7</label><institution>Hospital for Special Surgery</institution>,<addr-line content-type="city">New York City</addr-line>,<addr-line content-type="state">New York</addr-line>,<country>USA</country></aff><aff id="aff8"><label>8</label><institution>Hôpital Cochin</institution>,<addr-line content-type="city">Paris</addr-line>,<country>France</country></aff><aff id="aff9"><label>9</label><institution>Legacy Devers Eye Institute</institution>,<addr-line content-type="city">Portland</addr-line>,<addr-line content-type="state">Oregon</addr-line>,<country>USA</country></aff><aff id="aff10"><label>10</label><institution>Paris-Sud University, APHP Université Paris-Saclay, Hôpital Bicêtre</institution>,<addr-line content-type="city">Le Kremlin Bicêtre</addr-line>,<country>France</country></aff><aff id="aff11"><label>11</label><institution content-type="department">Department of Gastroenterology</institution>,<institution>Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité</institution>,<addr-line content-type="city">Berlin</addr-line>,<country>Germany</country></aff><aff id="aff12"><label>12</label><institution>Max Planck Institute for Infection Biology</institution>,<addr-line content-type="city">Berlin</addr-line>,<country>Germany</country></aff><aff id="aff13"><label>13</label><institution>NYU School of Medicine</institution>,<addr-line content-type="city">New York City</addr-line>,<addr-line content-type="state">New York</addr-line>,<country>USA</country></aff><aff id="aff14"><label>14</label><institution>Leiden University Medical Center</institution>,<addr-line content-type="city">Leiden</addr-line>,<country>The Netherlands</country></aff><aff id="aff15"><label>15</label><institution>University of Erlangen</institution>,<addr-line content-type="city">Erlangen</addr-line>,<country>Germany</country></aff><aff id="aff16"><label>16</label><institution>Division of Rheumatology, Department of Medicine 3, Medical University of, Vienna</institution>,<addr-line content-type="city">Vienna</addr-line>,<country>Austria</country></aff><aff id="aff17"><label>17</label><institution>University of California, Los Angeles Medical Center</institution>,<addr-line content-type="city">Los Angeles</addr-line>,<addr-line content-type="state">CA</addr-line>,<country>USA</country></aff><aff id="aff18"><label>18</label><institution>University of Florence</institution>,<addr-line content-type="city">Florence</addr-line>,<country>Italy</country></aff><author-notes><corresp><label>Correspondence to</label> Dr Kevin L Winthrop, Oregon Health Sciences University, Portland, OR 97239, USA; <email>winthrop@ohsu.edu</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2020</year></pub-date><pub-date pub-type="epub"><day>29</day><month>10</month><year>2019</year></pub-date><volume>79</volume><issue>1</issue><fpage>88</fpage><lpage>93</lpage><history><date date-type="received"><day>08</day><month>8</month><year>2019</year></date><date date-type="accepted"><day>04</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement>© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</copyright-statement><copyright-year>2020</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="annrheumdis-2019-216151.pdf"></self-uri><abstract><sec><title>Objectives</title><p>To detail the greatest areas of unmet scientific and clinical needs in rheumatology.</p></sec><sec><title>Methods</title><p>The 21st annual international Advances in Targeted Therapies meeting brought together more than 100 leading basic scientists and clinical researchers in rheumatology, immunology, epidemiology, molecular biology and other specialties. During the meeting, breakout sessions were convened, consisting of 5 disease-specific groups with 20–30 experts assigned to each group based on expertise. Specific groups included: rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus and other systemic autoimmune rheumatic diseases. In each group, experts were asked to identify unmet clinical and translational research needs in general and then to prioritise and detail the most important specific needs within each disease area.</p></sec><sec><title>Results</title><p>Overarching themes across all disease states included the need to innovate clinical trial design with emphasis on studying patients with refractory disease, the development of trials that take into account disease endotypes and patients with overlapping inflammatory diseases, the need to better understand the prevalence and incidence of inflammatory diseases in developing regions of the world and ultimately to develop therapies that can cure inflammatory autoimmune diseases.</p></sec><sec><title>Conclusions</title><p>Unmet needs for new therapies and trial designs, particularly for those with treatment refractory disease, remain a top priority in rheumatology.</p></sec></abstract><kwd-group><kwd>rheumatoid arthritis</kwd><kwd>psoriatic arthritis</kwd><kwd>ankylosing spondylitis</kwd><kwd>spondyloarthritis</kwd><kwd>systemic lupus erythematosus</kwd><kwd>systemic sclerosis</kwd><kwd>Sjögren’s syndrome</kwd><kwd>inflammatory myopathies</kwd><kwd>vasculitis</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>special-feature</meta-name><meta-value>unlocked</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Autriche</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Winthrop, Kevin L" sort="Winthrop, Kevin L" uniqKey="Winthrop K" first="Kevin L" last="Winthrop">Kevin L. Winthrop</name></noRegion><name sortKey="Bathon, Joan" sort="Bathon, Joan" uniqKey="Bathon J" first="Joan" last="Bathon">Joan Bathon</name><name sortKey="Bykerk, Vivian" sort="Bykerk, Vivian" uniqKey="Bykerk V" first="Vivian" last="Bykerk">Vivian Bykerk</name><name sortKey="Crofford, Leslie" sort="Crofford, Leslie" uniqKey="Crofford L" first="Leslie" last="Crofford">Leslie Crofford</name><name sortKey="Cronstein, Bruce N" sort="Cronstein, Bruce N" uniqKey="Cronstein B" first="Bruce N" last="Cronstein">Bruce N. Cronstein</name><name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name><name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name><name sortKey="Mease, Philip J" sort="Mease, Philip J" uniqKey="Mease P" first="Philip J" last="Mease">Philip J. Mease</name><name sortKey="Rosenbaum, James Todd" sort="Rosenbaum, James Todd" uniqKey="Rosenbaum J" first="James Todd" last="Rosenbaum">James Todd Rosenbaum</name><name sortKey="Rosenbaum, James Todd" sort="Rosenbaum, James Todd" uniqKey="Rosenbaum J" first="James Todd" last="Rosenbaum">James Todd Rosenbaum</name><name sortKey="Weinblatt, Michael E" sort="Weinblatt, Michael E" uniqKey="Weinblatt M" first="Michael E" last="Weinblatt">Michael E. Weinblatt</name></country><country name="Allemagne"><noRegion><name sortKey="Burmester, Gerd R" sort="Burmester, Gerd R" uniqKey="Burmester G" first="Gerd R" last="Burmester">Gerd R. Burmester</name></noRegion><name sortKey="Kalden, Joachim" sort="Kalden, Joachim" uniqKey="Kalden J" first="Joachim" last="Kalden">Joachim Kalden</name><name sortKey="Melchers, Fritz" sort="Melchers, Fritz" uniqKey="Melchers F" first="Fritz" last="Melchers">Fritz Melchers</name><name sortKey="Sieper, Joachim" sort="Sieper, Joachim" uniqKey="Sieper J" first="Joachim" last="Sieper">Joachim Sieper</name></country><country name="France"><noRegion><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name></noRegion><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name></country><country name="Pays-Bas"><noRegion><name sortKey="Breedveld, Ferry C" sort="Breedveld, Ferry C" uniqKey="Breedveld F" first="Ferry C" last="Breedveld">Ferry C. Breedveld</name></noRegion></country><country name="Autriche"><noRegion><name sortKey="Smolen, Josef S" sort="Smolen, Josef S" uniqKey="Smolen J" first="Josef S" last="Smolen">Josef S. Smolen</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Furst, Daniel" sort="Furst, Daniel" uniqKey="Furst D" first="Daniel" last="Furst">Daniel Furst</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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