Antiproliferative evaluation of various aminoquinoline derivatives.
Identifieur interne : 000B29 ( Ncbi/Merge ); précédent : 000B28; suivant : 000B30Antiproliferative evaluation of various aminoquinoline derivatives.
Auteurs : Branka Zorc [Croatie] ; Zrinka Raji [Croatie] ; Ivana Perkovi [Croatie]Source :
- Acta pharmaceutica (Zagreb, Croatia) [ 1846-9558 ] ; 2019.
Descripteurs français
- KwdFr :
- Aminoquinoléines (pharmacologie), Antinéoplasiques (pharmacologie), Cellules HCT116, Cellules MCF-7, Humains, Lignée cellulaire tumorale, Primaquine (pharmacologie), Prolifération cellulaire (), Tumeurs du côlon (traitement médicamenteux), Tumeurs du poumon (traitement médicamenteux), Tumeurs du sein (traitement médicamenteux), Urée (pharmacologie).
- MESH :
- pharmacologie : Aminoquinoléines, Antinéoplasiques, Primaquine, Urée.
- traitement médicamenteux : Tumeurs du côlon, Tumeurs du poumon, Tumeurs du sein.
- Cellules HCT116, Cellules MCF-7, Humains, Lignée cellulaire tumorale, Prolifération cellulaire.
English descriptors
- KwdEn :
- Aminoquinolines (pharmacology), Antineoplastic Agents (pharmacology), Breast Neoplasms (drug therapy), Cell Line, Tumor, Cell Proliferation (drug effects), Colonic Neoplasms (drug therapy), HCT116 Cells, Humans, Lung Neoplasms (drug therapy), MCF-7 Cells, Primaquine (pharmacology), Urea (pharmacology).
- MESH :
- chemical , pharmacology : Aminoquinolines, Antineoplastic Agents, Primaquine, Urea.
- drug effects : Cell Proliferation.
- drug therapy : Breast Neoplasms, Colonic Neoplasms, Lung Neoplasms.
- Cell Line, Tumor, HCT116 Cells, Humans, MCF-7 Cells.
Abstract
Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.
DOI: 10.2478/acph-2019-0048
PubMed: 31639093
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(traitement médicamenteux)</term><term>Tumeurs du sein (traitement médicamenteux)</term><term>Urée (pharmacologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Aminoquinolines</term><term>Antineoplastic Agents</term><term>Primaquine</term><term>Urea</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Proliferation</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Breast Neoplasms</term><term>Colonic Neoplasms</term><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Aminoquinoléines</term><term>Antinéoplasiques</term><term>Primaquine</term><term>Urée</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du côlon</term><term>Tumeurs du poumon</term><term>Tumeurs du sein</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line, Tumor</term><term>HCT116 Cells</term><term>Humans</term><term>MCF-7 Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HCT116</term><term>Cellules MCF-7</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Prolifération cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">31639093</PMID><DateCompleted><Year>2020</Year><Month>03</Month><Day>02</Day></DateCompleted><DateRevised><Year>2020</Year><Month>03</Month><Day>02</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1846-9558</ISSN><JournalIssue CitedMedium="Internet"><Volume>69</Volume><Issue>4</Issue><PubDate><Year>2019</Year><Month>Dec</Month><Day>01</Day></PubDate></JournalIssue><Title>Acta pharmaceutica (Zagreb, Croatia)</Title><ISOAbbreviation>Acta Pharm</ISOAbbreviation></Journal><ArticleTitle>Antiproliferative evaluation of various aminoquinoline derivatives.</ArticleTitle><Pagination><MedlinePgn>661-672</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.2478/acph-2019-0048</ELocationID><ELocationID EIdType="pii" ValidYN="Y">/j/acph.2019.69.issue-4/acph-2019-0048/acph-2019-0048.xml</ELocationID><Abstract><AbstractText>Four classes of aminoquinoline derivatives were prepared: primaquine ureas 1a-f, primaquine bis-ureas 2a-f, chloroquine fumardiamides 3a-f and mefloquine fumardiamides 4a-f. Their antiproliferative activities against breast adeno-carcinoma (MCF-7), lung carcinoma (H460) and colon carcinoma (HCT 116 and SW620) cell lines were evaluated in vitro, using MTT cell proliferation assay. The results revealed a low activity of primaquine urea and bis-urea derivatives and high activity of all fumardiamides, with IC50 values in low micromolar range against all tested cancer cell lines.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Zorc</LastName><ForeName>Branka</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rajić</LastName><ForeName>Zrinka</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Perković</LastName><ForeName>Ivana</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>University of Zagreb, Faculty of Pharmacy and Biochemistry Department of Medicinal Chemistry 10 000 Zagreb, Croatia.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Croatia</Country><MedlineTA>Acta Pharm</MedlineTA><NlmUniqueID>9303678</NlmUniqueID><ISSNLinking>1330-0075</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000634">Aminoquinolines</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000970">Antineoplastic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>8W8T17847W</RegistryNumber><NameOfSubstance UI="D014508">Urea</NameOfSubstance></Chemical><Chemical><RegistryNumber>MVR3634GX1</RegistryNumber><NameOfSubstance 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MajorTopicYN="N">Colonic Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045325" MajorTopicYN="N">HCT116 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008175" MajorTopicYN="N">Lung Neoplasms</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D061986" MajorTopicYN="N">MCF-7 Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011319" MajorTopicYN="N">Primaquine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014508" MajorTopicYN="N">Urea</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">antiproliferative activity</Keyword><Keyword MajorTopicYN="N">chloroquine</Keyword><Keyword MajorTopicYN="N">fumardiamide</Keyword><Keyword MajorTopicYN="N">mefloquine</Keyword><Keyword MajorTopicYN="N">primaquine</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2019</Year><Month>06</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2019</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2019</Year><Month>10</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>3</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">31639093</ArticleId><ArticleId IdType="doi">10.2478/acph-2019-0048</ArticleId><ArticleId 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