Systemic sclerosis – multidisciplinary disease: clinical features and treatment
Identifieur interne : 000A45 ( Ncbi/Merge ); précédent : 000A44; suivant : 000A46Systemic sclerosis – multidisciplinary disease: clinical features and treatment
Auteurs : Piotr Sobolewski [Pologne] ; Maria Ma Li Ska [Pologne] ; Marta Wieczorek [Pologne] ; Zuzanna Łagun [Pologne] ; Aleksandra Malewska [Pologne] ; Marek Roszkiewicz [Pologne] ; Raman Nitskovich [Pologne] ; El Bieta Szyma Ska [Pologne] ; Irena Walecka [Pologne]Source :
- Reumatologia [ 0034-6233 ] ; 2019.
Abstract
Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features. Systemic sclerosis has specific subsets with different autoantibodies, and differences in the affected skin areas. The suspicion of systemic sclerosis and establishing the diagnosis will be facilitated by the criteria created by EULAR/ACR experts. The treatment of this autoimmune disease remains a challenge for clinicians and new therapeutic options are constantly sought. The occurrence of various symptoms and the involvement of many organs and systems make systemic sclerosis a multidisciplinary disease and require a holistic approach. The present article summarizes different clinical features of systemic sclerosis and the profile of autoantibodies and discusses recent rules and future perspectives in disease management.
Url:
DOI: 10.5114/reum.2019.87619
PubMed: 31548749
PubMed Central: 6753596
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PMC:6753596Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features. Systemic sclerosis has specific subsets with different autoantibodies, and differences in the affected skin areas. The suspicion of systemic sclerosis and establishing the diagnosis will be facilitated by the criteria created by EULAR/ACR experts. The treatment of this autoimmune disease remains a challenge for clinicians and new therapeutic options are constantly sought. The occurrence of various symptoms and the involvement of many organs and systems make systemic sclerosis a multidisciplinary disease and require a holistic approach. The present article summarizes different clinical features of systemic sclerosis and the profile of autoantibodies and discusses recent rules and future perspectives in disease management.</p>
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</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Reumatologia</journal-id>
<journal-id journal-id-type="iso-abbrev">Reumatologia</journal-id>
<journal-id journal-id-type="publisher-id">RU</journal-id>
<journal-title-group><journal-title>Reumatologia</journal-title>
</journal-title-group>
<issn pub-type="ppub">0034-6233</issn>
<issn pub-type="epub">2084-9834</issn>
<publisher><publisher-name>Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31548749</article-id>
<article-id pub-id-type="pmc">6753596</article-id>
<article-id pub-id-type="publisher-id">87619</article-id>
<article-id pub-id-type="doi">10.5114/reum.2019.87619</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Systemic sclerosis – multidisciplinary disease: clinical features and treatment</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Sobolewski</surname>
<given-names>Piotr</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Maślińska</surname>
<given-names>Maria</given-names>
</name>
<xref ref-type="aff" rid="aff0002">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wieczorek</surname>
<given-names>Marta</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Łagun</surname>
<given-names>Zuzanna</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Malewska</surname>
<given-names>Aleksandra</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Roszkiewicz</surname>
<given-names>Marek</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nitskovich</surname>
<given-names>Raman</given-names>
</name>
<xref ref-type="aff" rid="aff0003">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Szymańska</surname>
<given-names>Elżbieta</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Walecka</surname>
<given-names>Irena</given-names>
</name>
<xref ref-type="aff" rid="aff0001">1</xref>
</contrib>
</contrib-group>
<aff id="aff0001"><label>1</label>
Clinic of Dermatology, Centre of Postgraduate Medical Education, Central Clinical Hospital of the Ministry of the Interior, Warsaw, Poland</aff>
<aff id="aff0002"><label>2</label>
Clinic of Early Arthritis, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland</aff>
<aff id="aff0003"><label>3</label>
Medical University of Warsaw, Poland</aff>
<author-notes><corresp id="cor1"><bold>Address for correspondence:</bold>
Maria Maślińska, Clinic of Early Arthritis, National Institute of Geriatrics, Rheumatology and Rehabilitation, 1 Spartańska St., 02-637 Warsaw, Poland. e-mail: <email xlink:href="maslinskam@gmail.com">maslinskam@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>31</day>
<month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="ppub"><year>2019</year>
</pub-date>
<volume>57</volume>
<issue>4</issue>
<fpage>221</fpage>
<lpage>233</lpage>
<history><date date-type="received"><day>11</day>
<month>7</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>19</day>
<month>8</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2019 Narodowy Instytut Geriatrii, Reumatologii i Rehabilitacji w Warszawie</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license.</license-p>
</license>
</permissions>
<abstract><p>Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features. Systemic sclerosis has specific subsets with different autoantibodies, and differences in the affected skin areas. The suspicion of systemic sclerosis and establishing the diagnosis will be facilitated by the criteria created by EULAR/ACR experts. The treatment of this autoimmune disease remains a challenge for clinicians and new therapeutic options are constantly sought. The occurrence of various symptoms and the involvement of many organs and systems make systemic sclerosis a multidisciplinary disease and require a holistic approach. The present article summarizes different clinical features of systemic sclerosis and the profile of autoantibodies and discusses recent rules and future perspectives in disease management.</p>
</abstract>
<kwd-group><kwd>systemic sclerosis</kwd>
<kwd>fibrosis</kwd>
<kwd>new therapies</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Pologne</li>
</country>
</list>
<tree><country name="Pologne"><noRegion><name sortKey="Sobolewski, Piotr" sort="Sobolewski, Piotr" uniqKey="Sobolewski P" first="Piotr" last="Sobolewski">Piotr Sobolewski</name>
</noRegion>
<name sortKey="Lagun, Zuzanna" sort="Lagun, Zuzanna" uniqKey="Lagun Z" first="Zuzanna" last="Łagun">Zuzanna Łagun</name>
<name sortKey="Ma Li Ska, Maria" sort="Ma Li Ska, Maria" uniqKey="Ma Li Ska M" first="Maria" last="Ma Li Ska">Maria Ma Li Ska</name>
<name sortKey="Malewska, Aleksandra" sort="Malewska, Aleksandra" uniqKey="Malewska A" first="Aleksandra" last="Malewska">Aleksandra Malewska</name>
<name sortKey="Nitskovich, Raman" sort="Nitskovich, Raman" uniqKey="Nitskovich R" first="Raman" last="Nitskovich">Raman Nitskovich</name>
<name sortKey="Roszkiewicz, Marek" sort="Roszkiewicz, Marek" uniqKey="Roszkiewicz M" first="Marek" last="Roszkiewicz">Marek Roszkiewicz</name>
<name sortKey="Szyma Ska, El Bieta" sort="Szyma Ska, El Bieta" uniqKey="Szyma Ska E" first="El Bieta" last="Szyma Ska">El Bieta Szyma Ska</name>
<name sortKey="Walecka, Irena" sort="Walecka, Irena" uniqKey="Walecka I" first="Irena" last="Walecka">Irena Walecka</name>
<name sortKey="Wieczorek, Marta" sort="Wieczorek, Marta" uniqKey="Wieczorek M" first="Marta" last="Wieczorek">Marta Wieczorek</name>
</country>
</tree>
</affiliations>
</record>
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