Recurrent fever of unknown fungal infection in a low-risk patient
Identifieur interne : 000923 ( Ncbi/Merge ); précédent : 000922; suivant : 000924Recurrent fever of unknown fungal infection in a low-risk patient
Auteurs : Tang-Meng Guo [République populaire de Chine] ; Yu Ye ; Li-Li Huang [République populaire de Chine] ; Bei Cheng [République populaire de Chine]Source :
- Medicine [ 0025-7974 ] ; 2019.
Abstract
Fungal infectious disease does not usually occur in low-risk patients. Clinicians tend to ignore the role of fungi in the fevers of low-risk patients. If there is not timely control of fungal infections and associated fever, the disease will continue to worsen, resulting in physical dysfunction or death.
Recurrent fever continued for 1 month in a young adult.
Non-albicans Candida (NAC) species probably was the main pathogen in this case based on the resolution of fever after capsofungin administration.
The fever and the associated indicators, including white blood cell count, C-reaction protein, erythrocyte sedimentation rate, and BDG levels, showed improvement quickly. The patient left the hospital successfully after 18 days of caspofungin treatment. There was no recurrent fever at a follow-up of 1 year.
Clinicians should be aware that the incidence of fungal infection is increasing in low-risk patients. The BDG assay is still an effective tool used to diagnose invasive fungal diseases. Caspofungin is an effective drug for the treatment of some unknown fungal infections.
Url:
DOI: 10.1097/MD.0000000000016908
PubMed: 31415438
PubMed Central: 6831448
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Huangshi</nlm:aff><wicri:noCountry code="subfield">Huangshi</wicri:noCountry></affiliation></author><author><name sortKey="Huang, Li Li" sort="Huang, Li Li" uniqKey="Huang L" first="Li-Li" last="Huang">Li-Li Huang</name><affiliation wicri:level="3"><nlm:aff id="aff4">Department of Clinical Laboratory Medicine, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Cheng, Bei" sort="Cheng, Bei" uniqKey="Cheng B" first="Bei" last="Cheng">Bei 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type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><wicri:orgArea>Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology</wicri:orgArea></affiliation></author><author><name sortKey="Ye, Yu" sort="Ye, Yu" uniqKey="Ye Y" first="Yu" last="Ye">Yu Ye</name><affiliation><nlm:aff id="aff3">MRI room, Central Hospital, Huangshi City, Huangshi</nlm:aff><wicri:noCountry code="subfield">Huangshi</wicri:noCountry></affiliation></author><author><name sortKey="Huang, Li Li" sort="Huang, Li Li" uniqKey="Huang L" first="Li-Li" last="Huang">Li-Li Huang</name><affiliation wicri:level="3"><nlm:aff id="aff4">Department of Clinical Laboratory Medicine, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan, China.</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Department of Clinical Laboratory Medicine, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan</wicri:regionArea><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName></affiliation></author><author><name sortKey="Cheng, Bei" sort="Cheng, Bei" uniqKey="Cheng B" first="Bei" last="Cheng">Bei Cheng</name><affiliation><nlm:aff id="aff1">Department of Geriatrics</nlm:aff></affiliation><affiliation wicri:level="3"><nlm:aff id="aff2">Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan</nlm:aff><country>République populaire de Chine</country><placeName><settlement type="city">Wuhan</settlement><region type="région">Hubei</region></placeName><wicri:orgArea>Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology</wicri:orgArea></affiliation></author></analytic><series><title level="j">Medicine</title><idno type="ISSN">0025-7974</idno><idno type="eISSN">1536-5964</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec><title>Rationale:</title><p>Fungal infectious disease does not usually occur in low-risk patients. Clinicians tend to ignore the role of fungi in the fevers of low-risk patients. If there is not timely control of fungal infections and associated fever, the disease will continue to worsen, resulting in physical dysfunction or death.</p></sec><sec><title>Patient concerns:</title><p>Recurrent fever continued for 1 month in a young adult.</p></sec><sec><title>Diagnoses and interventions:</title><p>Non-albicans Candida (NAC) species probably was the main pathogen in this case based on the resolution of fever after capsofungin administration.</p></sec><sec><title>Outcomes:</title><p>The fever and the associated indicators, including white blood cell count, C-reaction protein, erythrocyte sedimentation rate, and BDG levels, showed improvement quickly. The patient left the hospital successfully after 18 days of caspofungin treatment. There was no recurrent fever at a follow-up of 1 year.</p></sec><sec><title>Lessons:</title><p>Clinicians should be aware that the incidence of fungal infection is increasing in low-risk patients. The BDG assay is still an effective tool used to diagnose invasive fungal diseases. Caspofungin is an effective drug for the treatment of some unknown fungal infections.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Lassflorl, C" uniqKey="Lassflorl C">C Lassflörl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sotello, D" uniqKey="Sotello D">D Sotello</name></author><author><name sortKey="Cappel, M" uniqKey="Cappel M">M Cappel</name></author><author><name sortKey="Huff, T" uniqKey="Huff T">T Huff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Enoch, Da" uniqKey="Enoch D">DA Enoch</name></author><author><name sortKey="Ludlam, Ha" uniqKey="Ludlam H">HA Ludlam</name></author><author><name sortKey="Brown, Nm" uniqKey="Brown N">NM Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nucci, M" uniqKey="Nucci M">M Nucci</name></author><author><name sortKey="Marr, Ka" uniqKey="Marr K">KA Marr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Silva, S" uniqKey="Silva S">S Silva</name></author><author><name sortKey="Negri, M" uniqKey="Negri M">M Negri</name></author><author><name sortKey="Henriques, M" uniqKey="Henriques M">M Henriques</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Azim, A" uniqKey="Azim A">A Azim</name></author><author><name sortKey="Ahmed, A" uniqKey="Ahmed A">A Ahmed</name></author><author><name sortKey="Marak, R" uniqKey="Marak R">R Marak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xiao, M" uniqKey="Xiao M">M Xiao</name></author><author><name sortKey="Fan, X" uniqKey="Fan X">X Fan</name></author><author><name sortKey="Chen, Sca" uniqKey="Chen S">SCA Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hajjeh, Ra" uniqKey="Hajjeh R">RA Hajjeh</name></author><author><name sortKey="Sofair, An" uniqKey="Sofair A">AN Sofair</name></author><author><name sortKey="Harrison, Lh" uniqKey="Harrison L">LH Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guinea, J" uniqKey="Guinea J">J Guinea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abisaid, D" uniqKey="Abisaid D">D Abisaid</name></author><author><name sortKey="Anaissie, E" uniqKey="Anaissie E">E Anaissie</name></author><author><name sortKey="Uzun, O" uniqKey="Uzun O">O Uzun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tran, T" uniqKey="Tran T">T Tran</name></author><author><name sortKey="Beal, Sg" uniqKey="Beal S">SG Beal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angebault, C" uniqKey="Angebault C">C Angebault</name></author><author><name sortKey="Lanternier, F" uniqKey="Lanternier F">F Lanternier</name></author><author><name sortKey="Dalle, F" uniqKey="Dalle F">F Dalle</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Medicine (Baltimore)</journal-id><journal-id journal-id-type="iso-abbrev">Medicine (Baltimore)</journal-id><journal-id journal-id-type="publisher-id">MEDI</journal-id><journal-title-group><journal-title>Medicine</journal-title></journal-title-group><issn pub-type="ppub">0025-7974</issn><issn pub-type="epub">1536-5964</issn><publisher><publisher-name>Wolters Kluwer Health</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31415438</article-id><article-id pub-id-type="pmc">6831448</article-id><article-id pub-id-type="publisher-id">MD-D-18-09107</article-id><article-id pub-id-type="doi">10.1097/MD.0000000000016908</article-id><article-id pub-id-type="art-access-id">16908</article-id><article-categories><subj-group subj-group-type="heading"><subject>4400</subject></subj-group><subj-group><subject>Research Article</subject><subject>Clinical Case Report</subject></subj-group></article-categories><title-group><article-title>Recurrent fever of unknown fungal infection in a low-risk patient</article-title><subtitle>A case report</subtitle></title-group><contrib-group><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Tang-meng</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ye</surname><given-names>Yu</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff3"><sup>c</sup></xref><xref rid="cor1" ref-type="corresp"><sup>∗</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huang</surname><given-names>Li-li</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="aff4"><sup>d</sup></xref><xref rid="cor1" ref-type="corresp"><sup>∗</sup></xref></contrib><contrib contrib-type="author"><name><surname>Cheng</surname><given-names>Bei</given-names></name><degrees>MD, PhD</degrees><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="aff" rid="aff2"><sup>b</sup></xref><xref rid="cor1" ref-type="corresp"><sup>∗</sup></xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>NA.</surname><given-names></given-names></name></contrib></contrib-group><aff id="aff1"><label>a</label>Department of Geriatrics</aff><aff id="aff2"><label>b</label>Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan</aff><aff id="aff3"><label>c</label>MRI room, Central Hospital, Huangshi City, Huangshi</aff><aff id="aff4"><label>d</label>Department of Clinical Laboratory Medicine, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, Wuhan, China.</aff><author-notes id="cor1"><corresp><label>∗</label>Correspondence: Bei Cheng, Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Institute of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China (e-mail: <email>chengbei2014@126.com</email>); Li-li Huang, Department of Clinical Laboratory Medicine, People's Hospital of Dongxihu District Wuhan City and Union Dongxihu Hospital, Huazhong University of Science and Technology, 81 HuanShan Road, Wuhan 430040, China (e-mail: <email>huanglili987@163.com</email>); Yu Ye, MRI room, Central Hospital, Huangshi city, 141 Tianjin Road, Huangshi 435000, China (e-mail: <email>yeyuyeyu2@163.com</email>).</corresp></author-notes><pub-date pub-type="collection"><month>8</month><year>2019</year></pub-date><pub-date pub-type="epub"><day>16</day><month>8</month><year>2019</year></pub-date><volume>98</volume><issue>33</issue><elocation-id>e16908</elocation-id><history><date date-type="received"><day>18</day><month>12</month><year>2018</year></date><date date-type="rev-recd"><day>20</day><month>6</month><year>2019</year></date><date date-type="accepted"><day>29</day><month>7</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0">http://creativecommons.org/licenses/by-nc-nd/4.0</ext-link></license-p></license></permissions><self-uri xlink:type="simple" xlink:href="medi-98-e16908.pdf"></self-uri><abstract><title>Abstract</title><sec><title>Rationale:</title><p>Fungal infectious disease does not usually occur in low-risk patients. Clinicians tend to ignore the role of fungi in the fevers of low-risk patients. If there is not timely control of fungal infections and associated fever, the disease will continue to worsen, resulting in physical dysfunction or death.</p></sec><sec><title>Patient concerns:</title><p>Recurrent fever continued for 1 month in a young adult.</p></sec><sec><title>Diagnoses and interventions:</title><p>Non-albicans Candida (NAC) species probably was the main pathogen in this case based on the resolution of fever after capsofungin administration.</p></sec><sec><title>Outcomes:</title><p>The fever and the associated indicators, including white blood cell count, C-reaction protein, erythrocyte sedimentation rate, and BDG levels, showed improvement quickly. The patient left the hospital successfully after 18 days of caspofungin treatment. There was no recurrent fever at a follow-up of 1 year.</p></sec><sec><title>Lessons:</title><p>Clinicians should be aware that the incidence of fungal infection is increasing in low-risk patients. The BDG assay is still an effective tool used to diagnose invasive fungal diseases. Caspofungin is an effective drug for the treatment of some unknown fungal infections.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>(1,3)-β-D-glucan</kwd><kwd>caspofungin</kwd><kwd>fever</kwd><kwd>low-risk patient</kwd><kwd>non-albicans Candida</kwd><kwd>unknown fungal infection</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Hubei</li></region><settlement><li>Wuhan</li></settlement></list><tree><noCountry><name sortKey="Ye, Yu" sort="Ye, Yu" uniqKey="Ye Y" first="Yu" last="Ye">Yu Ye</name></noCountry><country name="République populaire de Chine"><region name="Hubei"><name sortKey="Guo, Tang Meng" sort="Guo, Tang Meng" uniqKey="Guo T" first="Tang-Meng" last="Guo">Tang-Meng Guo</name></region><name sortKey="Cheng, Bei" sort="Cheng, Bei" uniqKey="Cheng B" first="Bei" last="Cheng">Bei Cheng</name><name sortKey="Huang, Li Li" sort="Huang, Li Li" uniqKey="Huang L" first="Li-Li" last="Huang">Li-Li Huang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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