Polymyalgia rheumatica-like syndrome from checkpoint inhibitor therapy: case series and systematic review of the literature
Identifieur interne : 000674 ( Ncbi/Merge ); précédent : 000673; suivant : 000675Polymyalgia rheumatica-like syndrome from checkpoint inhibitor therapy: case series and systematic review of the literature
Auteurs : Cassandra Calabrese [États-Unis] ; Laura C. Cappelli [États-Unis] ; Marie Kostine [France] ; Elizabeth Kirchner [États-Unis] ; Tawnie Braaten [États-Unis] ; Leonard Calabrese [États-Unis]Source :
- RMD Open [ 2056-5933 ] ; 2019.
Abstract
To assess whether the polymyalgia rheumatica (PMR)-like syndrome reported as an immune related adverse event (irAE) from checkpoint inhibitor therapy is consistent with the 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) provisional criteria for PMR.
The cases were derived from two sources. Group 1 represents reported cases from three contributing centres. Group 2 was derived from a systematic review of the literature searching for all cases reported as PMR or PMR-like illness associated with checkpoint inhibitor therapy. Cases were assessed for the quality of reporting and then analysed to determine whether they fulfilled the 2012 EULAR/ACR provisional criteria for PMR.
A total of 49 patients were included for analysis. Among the entire group, 37 (75%) were designated ‘complete’ indicating that they had sufficient data to reliably apply the 2012 EULAR/ACR criteria. 28 (75%) cases fulfilled complete criteria for PMR. A number of cases also demonstrated some clinical features unusual for idiopathic PMR.
This study suggests a high proportion of reported cases of checkpoint inhibitor-related PMR fulfil preliminary criteria for PMR, yet in one quarter clinical details were incomplete making verification problematic. Furthermore, in the absence of a gold standard for the diagnosis of PMR, the relationship of checkpoint inhibitor-related PMR to the idiopathic form remains unclear.
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DOI: 10.1136/rmdopen-2019-000906
PubMed: 31168414
PubMed Central: 6525600
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Cappelli</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Division of Rheumatology</institution>,<institution>Johns Hopkins School of Medicine</institution>,<addr-line content-type="city">Baltimore</addr-line>,<addr-line content-type="state">Maryland</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Rheumatology Department</institution>,<institution>Centre Hospitalier Universitaire de Bordeaux</institution>,<addr-line content-type="city">Bordeaux</addr-line>,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Kirchner, Elizabeth" sort="Kirchner, Elizabeth" uniqKey="Kirchner E" first="Elizabeth" last="Kirchner">Elizabeth Kirchner</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Rheumatic & Immunologic Disease</institution>,<institution>Cleveland Clinic</institution>,<addr-line content-type="city">Cleveland</addr-line>,<addr-line content-type="state">Ohio</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Braaten, Tawnie" sort="Braaten, Tawnie" uniqKey="Braaten T" first="Tawnie" last="Braaten">Tawnie Braaten</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution content-type="department">Division of Rheumatology</institution>,<institution>Johns Hopkins School of Medicine</institution>,<addr-line content-type="city">Baltimore</addr-line>,<addr-line content-type="state">Maryland</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Calabrese, Leonard" sort="Calabrese, Leonard" uniqKey="Calabrese L" first="Leonard" last="Calabrese">Leonard Calabrese</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution content-type="department">Rheumatic & Immunologic Disease</institution>,<institution>Cleveland Clinic</institution>,<addr-line content-type="city">Cleveland</addr-line>,<addr-line content-type="state">Ohio</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">RMD Open</title><idno type="eISSN">2056-5933</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>To assess whether the polymyalgia rheumatica (PMR)-like syndrome reported as an immune related adverse event (irAE) from checkpoint inhibitor therapy is consistent with the 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) provisional criteria for PMR.</p></sec><sec><title>Methods</title><p>The cases were derived from two sources. Group 1 represents reported cases from three contributing centres. Group 2 was derived from a systematic review of the literature searching for all cases reported as PMR or PMR-like illness associated with checkpoint inhibitor therapy. Cases were assessed for the quality of reporting and then analysed to determine whether they fulfilled the 2012 EULAR/ACR provisional criteria for PMR.</p></sec><sec><title>Results</title><p>A total of 49 patients were included for analysis. Among the entire group, 37 (75%) were designated ‘complete’ indicating that they had sufficient data to reliably apply the 2012 EULAR/ACR criteria. 28 (75%) cases fulfilled complete criteria for PMR. A number of cases also demonstrated some clinical features unusual for idiopathic PMR.</p></sec><sec><title>Conclusion</title><p>This study suggests a high proportion of reported cases of checkpoint inhibitor-related PMR fulfil preliminary criteria for PMR, yet in one quarter clinical details were incomplete making verification problematic. Furthermore, in the absence of a gold standard for the diagnosis of PMR, the relationship of checkpoint inhibitor-related PMR to the idiopathic form remains unclear.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="June, Ch" uniqKey="June C">CH June</name></author><author><name sortKey="Warshauer, Jt" uniqKey="Warshauer J">JT Warshauer</name></author><author><name sortKey="Bluestone, Ja" uniqKey="Bluestone J">JA Bluestone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cappelli, Lc" uniqKey="Cappelli L">LC Cappelli</name></author><author><name sortKey="Gutierrez, Ak" uniqKey="Gutierrez A">AK Gutierrez</name></author><author><name sortKey="Bingham, Co" uniqKey="Bingham C">CO Bingham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suarez Almazor, Me" uniqKey="Suarez Almazor M">ME Suarez-Almazor</name></author><author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name></author><author><name sortKey="Abdel Wahab, N" uniqKey="Abdel Wahab N">N Abdel-Wahab</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Calabrese, C" uniqKey="Calabrese C">C Calabrese</name></author><author><name sortKey="Kirchner, E" uniqKey="Kirchner E">E Kirchner</name></author><author><name sortKey="Kontzias, K" uniqKey="Kontzias K">K Kontzias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dasgupta, B" uniqKey="Dasgupta B">B Dasgupta</name></author><author><name sortKey="Cimmino, Ma" uniqKey="Cimmino M">MA Cimmino</name></author><author><name sortKey="Maradit Kremers, H" uniqKey="Maradit Kremers H">H Maradit-Kremers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Salem, J E" uniqKey="Salem J">J-E Salem</name></author><author><name sortKey="Manouchehri, A" uniqKey="Manouchehri A">A Manouchehri</name></author><author><name sortKey="Moey, M" uniqKey="Moey M">M Moey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cappelli, Lc" uniqKey="Cappelli L">LC Cappelli</name></author><author><name sortKey="Gutierrez, Ak" uniqKey="Gutierrez A">AK Gutierrez</name></author><author><name sortKey="Baer, An" uniqKey="Baer A">AN Baer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Smith, Mh" uniqKey="Smith M">MH Smith</name></author><author><name sortKey="Bass, Ar" uniqKey="Bass A">AR Bass</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, St" uniqKey="Kim S">ST Kim</name></author><author><name sortKey="Tayer, J" uniqKey="Tayer J">J Tayer</name></author><author><name sortKey="Trinh, Va" uniqKey="Trinh V">VA Trinh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stroud, Cr" uniqKey="Stroud C">CR Stroud</name></author><author><name sortKey="Hedge, A" uniqKey="Hedge A">A Hedge</name></author><author><name sortKey="Cherry, C" uniqKey="Cherry C">C Cherry</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="systematic-review"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">RMD Open</journal-id><journal-id journal-id-type="iso-abbrev">RMD Open</journal-id><journal-id journal-id-type="hwp">rmdopen</journal-id><journal-id journal-id-type="publisher-id">rmdopen</journal-id><journal-title-group><journal-title>RMD Open</journal-title></journal-title-group><issn pub-type="epub">2056-5933</issn><publisher><publisher-name>BMJ Publishing Group</publisher-name><publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31168414</article-id><article-id pub-id-type="pmc">6525600</article-id><article-id pub-id-type="publisher-id">rmdopen-2019-000906</article-id><article-id pub-id-type="doi">10.1136/rmdopen-2019-000906</article-id><article-categories><subj-group subj-group-type="heading"><subject>Miscellaneous</subject></subj-group><subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject></subj-group><series-title>Original article</series-title></article-categories><title-group><article-title>Polymyalgia rheumatica-like syndrome from checkpoint inhibitor therapy: case series and systematic review of the literature</article-title></title-group><contrib-group><contrib id="author-51319636" contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0002-8773-7739</contrib-id><name><surname>Calabrese</surname><given-names>Cassandra</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib id="author-50718541" contrib-type="author"><name><surname>Cappelli</surname><given-names>Laura C</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-62392306" contrib-type="author"><name><surname>Kostine</surname><given-names>Marie</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib id="author-52246950" contrib-type="author"><name><surname>Kirchner</surname><given-names>Elizabeth</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib id="author-67531706" contrib-type="author"><name><surname>Braaten</surname><given-names>Tawnie</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib id="author-22407901" contrib-type="author" corresp="yes"><name><surname>Calabrese</surname><given-names>Leonard</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label><institution content-type="department">Rheumatic & Immunologic Disease</institution>,<institution>Cleveland Clinic</institution>,<addr-line content-type="city">Cleveland</addr-line>,<addr-line content-type="state">Ohio</addr-line>,<country>USA</country></aff><aff id="aff2"><label>2</label><institution content-type="department">Division of Rheumatology</institution>,<institution>Johns Hopkins School of Medicine</institution>,<addr-line content-type="city">Baltimore</addr-line>,<addr-line content-type="state">Maryland</addr-line>,<country>USA</country></aff><aff id="aff3"><label>3</label><institution content-type="department">Rheumatology Department</institution>,<institution>Centre Hospitalier Universitaire de Bordeaux</institution>,<addr-line content-type="city">Bordeaux</addr-line>,<country>France</country></aff><author-notes><corresp><label>Correspondence to</label> Dr Leonard Calabrese; <email>calabrl@ccf.org</email></corresp></author-notes><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>25</day><month>4</month><year>2019</year></pub-date><volume>5</volume><issue>1</issue><elocation-id>e000906</elocation-id><history><date date-type="received"><day>14</day><month>1</month><year>2019</year></date><date date-type="rev-recd"><day>12</day><month>3</month><year>2019</year></date><date date-type="accepted"><day>27</day><month>3</month><year>2019</year></date></history><permissions><copyright-statement>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</copyright-statement><copyright-year>2019</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="rmdopen-2019-000906.pdf"></self-uri><abstract><sec><title>Objective</title><p>To assess whether the polymyalgia rheumatica (PMR)-like syndrome reported as an immune related adverse event (irAE) from checkpoint inhibitor therapy is consistent with the 2012 European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) provisional criteria for PMR.</p></sec><sec><title>Methods</title><p>The cases were derived from two sources. Group 1 represents reported cases from three contributing centres. Group 2 was derived from a systematic review of the literature searching for all cases reported as PMR or PMR-like illness associated with checkpoint inhibitor therapy. Cases were assessed for the quality of reporting and then analysed to determine whether they fulfilled the 2012 EULAR/ACR provisional criteria for PMR.</p></sec><sec><title>Results</title><p>A total of 49 patients were included for analysis. Among the entire group, 37 (75%) were designated ‘complete’ indicating that they had sufficient data to reliably apply the 2012 EULAR/ACR criteria. 28 (75%) cases fulfilled complete criteria for PMR. A number of cases also demonstrated some clinical features unusual for idiopathic PMR.</p></sec><sec><title>Conclusion</title><p>This study suggests a high proportion of reported cases of checkpoint inhibitor-related PMR fulfil preliminary criteria for PMR, yet in one quarter clinical details were incomplete making verification problematic. Furthermore, in the absence of a gold standard for the diagnosis of PMR, the relationship of checkpoint inhibitor-related PMR to the idiopathic form remains unclear.</p></sec></abstract><kwd-group><kwd>polymyalgia rheumatica</kwd><kwd>inflammation</kwd><kwd>autoimmune diseases</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>special-feature</meta-name><meta-value>unlocked</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>France</li><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Calabrese, Cassandra" sort="Calabrese, Cassandra" uniqKey="Calabrese C" first="Cassandra" last="Calabrese">Cassandra Calabrese</name></noRegion><name sortKey="Braaten, Tawnie" sort="Braaten, Tawnie" uniqKey="Braaten T" first="Tawnie" last="Braaten">Tawnie Braaten</name><name sortKey="Calabrese, Leonard" sort="Calabrese, Leonard" uniqKey="Calabrese L" first="Leonard" last="Calabrese">Leonard Calabrese</name><name sortKey="Cappelli, Laura C" sort="Cappelli, Laura C" uniqKey="Cappelli L" first="Laura C" last="Cappelli">Laura C. Cappelli</name><name sortKey="Kirchner, Elizabeth" sort="Kirchner, Elizabeth" uniqKey="Kirchner E" first="Elizabeth" last="Kirchner">Elizabeth Kirchner</name></country><country name="France"><noRegion><name sortKey="Kostine, Marie" sort="Kostine, Marie" uniqKey="Kostine M" first="Marie" last="Kostine">Marie Kostine</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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