ChloroquineV1, Ncbi, Merge, bibRecord, 000641

Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus

Identifieur interne : 000641 ( Ncbi/Merge ); précédent : 000640; suivant : 000642

Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus

Auteurs : Nargis Aman [Pakistan] ; Khalid Rauf [Pakistan] ; Shujaat Ali Khan [Pakistan] ; Ahmed Tokhi [Pakistan] ; Naeem-Ur Rehman [Pakistan] ; Muhammad Arfat Yameen [Pakistan]

Source :

International Journal of Nanomedicine [ 1176-9114 ] ; 2019.

RBID : PMC:6503187

Abstract

Purpose: To investigate the effects of zinc oxide nanoparticles (ZnO NPs) on chloroquine (CQ)-induced itching, and overall behavior of mice after oral administration of ZnO NPs of various sizes and doses.

Background: With the wide-spread use of ZnO NPs in pharmaceuticals and cosmetics, concerns about their safety and toxicity are also increasing. Multiple aspects of ZnO NPs regarding cytotoxicity and tolerability are under investigation globally. Still, a clear conclusion about their safety has not been reached. Chloroquine phosphate is an antimalarial with known side effects of itching in humans and animals. In this study, CQ was used to induce itching in mice, and the effects of ZnO NPs on scratching and other neurological behavior of mice were observed.

Methods: Female BALB/c mice were divided into eleven groups of six mice each. ZnO NPs of various sizes and doses were administered orally 1 hour before CQ (32 mg/kg body weight) was administered subcutaneously. The effect of ZnO NPs on CQ-induced pruritus was observed for the next 30 minutes. Simultaneously, overall behavioral changes (socialization and locomotion) were also recorded using a video camera.

Results: A significant reduction (P˂0.001) in scratching bouts was observed at all three doses of ZnO NPs (particle sizes 100, 30 nm, and green synthesized 30 nm). Locomotion was reduced significantly (P˂0.001) in ZnO NPs-treated groups in comparison to normal saline and CQ group, additionally, a significant increase in socialization (P˂0.05) was observed in ZnO NP-treated groups as compared to CQ group.

Conclusion: ZnO NPs, instead of aggravating the dermatological condition, ameliorated the pruritus. All sizes of ZnO NPs used significantly improved socialization among mice and reduced locomotion activity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503187

DOI: 10.2147/IJN.S202256
PubMed: 31118625
PubMed Central: 6503187

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,<addr-line>KPK</addr-line>
,<country>Pakistan</country>
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<author><name sortKey="Rehman, Naeem Ur" sort="Rehman, Naeem Ur" uniqKey="Rehman N" first="Naeem-Ur" last="Rehman">Naeem-Ur Rehman</name>
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,<addr-line>KPK</addr-line>
,<country>Pakistan</country>
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<author><name sortKey="Yameen, Muhammad Arfat" sort="Yameen, Muhammad Arfat" uniqKey="Yameen M" first="Muhammad Arfat" last="Yameen">Muhammad Arfat Yameen</name>
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<front><div type="abstract" xml:lang="en"><p><bold>Purpose:</bold>
 To investigate the effects of zinc oxide nanoparticles (ZnO NPs) on chloroquine (CQ)-induced itching, and overall behavior of mice after oral administration of ZnO NPs of various sizes and doses.</p>
<p><bold>Background:</bold>
 With the wide-spread use of ZnO NPs in pharmaceuticals and cosmetics, concerns about their safety and toxicity are also increasing. Multiple aspects of ZnO NPs regarding cytotoxicity and tolerability are under investigation globally. Still, a clear conclusion about their safety has not been reached. Chloroquine phosphate is an antimalarial with known side effects of itching in humans and animals. In this study, CQ was used to induce itching in mice, and the effects of ZnO NPs on scratching and other neurological behavior of mice were observed.</p>
<p><bold>Methods:</bold>
 Female BALB/c mice were divided into eleven groups of six mice each. ZnO NPs of various sizes and doses were administered orally 1 hour before CQ (32 mg/kg body weight) was administered subcutaneously. The effect of ZnO NPs on CQ-induced pruritus was observed for the next 30 minutes. Simultaneously, overall behavioral changes (socialization and locomotion) were also recorded using a video camera.</p>
<p><bold>Results:</bold>
 A significant reduction (<italic>P</italic>
˂0.001) in scratching bouts was observed at all three doses of ZnO NPs (particle sizes 100, 30 nm, and green synthesized 30 nm). Locomotion was reduced significantly (<italic>P</italic>
˂0.001) in ZnO NPs-treated groups in comparison to normal saline and CQ group, additionally, a significant increase in socialization (<italic>P</italic>
˂0.05) was observed in ZnO NP-treated groups as compared to CQ group.</p>
<p><bold>Conclusion:</bold>
 ZnO NPs, instead of aggravating the dermatological condition, ameliorated the pruritus. All sizes of ZnO NPs used significantly improved socialization among mice and reduced locomotion activity.</p>
</div>
</front>
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  <front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Nanomedicine</journal-id>
<journal-id journal-id-type="iso-abbrev">Int J Nanomedicine</journal-id>
<journal-id journal-id-type="publisher-id">IJN</journal-id>
<journal-id journal-id-type="pmc">intjnano</journal-id>
<journal-title-group><journal-title>International Journal of Nanomedicine</journal-title>
</journal-title-group>
<issn pub-type="ppub">1176-9114</issn>
<issn pub-type="epub">1178-2013</issn>
<publisher><publisher-name>Dove</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31118625</article-id>
<article-id pub-id-type="pmc">6503187</article-id>
<article-id pub-id-type="publisher-id">202256</article-id>
<article-id pub-id-type="doi">10.2147/IJN.S202256</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject>
</subj-group>
</article-categories>
<title-group><article-title>Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus</article-title>
<alt-title alt-title-type="running-authors">Aman et al</alt-title>
<alt-title alt-title-type="running-title">Aman et al</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Aman</surname>
<given-names>Nargis</given-names>
</name>
<xref ref-type="corresp" rid="AN0001"></xref>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rauf</surname>
<given-names>Khalid</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Khan</surname>
<given-names>Shujaat Ali</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Tokhi</surname>
<given-names>Ahmed</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rehman</surname>
<given-names>Naeem-Ur</given-names>
</name>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Yameen</surname>
<given-names>Muhammad Arfat</given-names>
</name>
<xref ref-type="corresp" rid="AN0002"></xref>
<xref ref-type="aff" rid="AFF0001">1</xref>
</contrib>
<aff id="AFF0001"><label>1</label>
<institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>
,<addr-line>Abbottabad</addr-line>
,<addr-line>KPK</addr-line>
,<country>Pakistan</country>
</aff>
</contrib-group>
<author-notes><corresp id="AN0001">Correspondence: Nargis Aman<institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>
, <addr-line>Abbottabad</addr-line>
, <addr-line>KPK</addr-line>
, <country>Pakistan</country>
<phone>Tel +92 332 915 3586</phone>
Email <email xlink:href="nargis.aman@gmail.com">nargis.aman@gmail.com</email>
</corresp>
<corresp id="AN0002">Muhammad Arfat Yameen<institution>Department of Pharmacy, COMSATS University Islamabad</institution>
, <addr-line>Abbottabad Campus</addr-line>
, <addr-line>Abbottabad</addr-line>
, <addr-line>KPK</addr-line>
, <country>Pakistan</country>
<phone>Tel +92 333 576 0361</phone>
Email <email xlink:href="arfatyameen@cuiatd.edu.pk">arfatyameen@cuiatd.edu.pk</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>01</day>
<month>5</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>14</volume>
<fpage>3103</fpage>
<lpage>3110</lpage>
<history><date date-type="received"><day>20</day>
<month>1</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>27</day>
<month>3</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 Aman et al.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Aman et al.</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p>This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
 and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (<ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p><bold>Purpose:</bold>
 To investigate the effects of zinc oxide nanoparticles (ZnO NPs) on chloroquine (CQ)-induced itching, and overall behavior of mice after oral administration of ZnO NPs of various sizes and doses.</p>
<p><bold>Background:</bold>
 With the wide-spread use of ZnO NPs in pharmaceuticals and cosmetics, concerns about their safety and toxicity are also increasing. Multiple aspects of ZnO NPs regarding cytotoxicity and tolerability are under investigation globally. Still, a clear conclusion about their safety has not been reached. Chloroquine phosphate is an antimalarial with known side effects of itching in humans and animals. In this study, CQ was used to induce itching in mice, and the effects of ZnO NPs on scratching and other neurological behavior of mice were observed.</p>
<p><bold>Methods:</bold>
 Female BALB/c mice were divided into eleven groups of six mice each. ZnO NPs of various sizes and doses were administered orally 1 hour before CQ (32 mg/kg body weight) was administered subcutaneously. The effect of ZnO NPs on CQ-induced pruritus was observed for the next 30 minutes. Simultaneously, overall behavioral changes (socialization and locomotion) were also recorded using a video camera.</p>
<p><bold>Results:</bold>
 A significant reduction (<italic>P</italic>
˂0.001) in scratching bouts was observed at all three doses of ZnO NPs (particle sizes 100, 30 nm, and green synthesized 30 nm). Locomotion was reduced significantly (<italic>P</italic>
˂0.001) in ZnO NPs-treated groups in comparison to normal saline and CQ group, additionally, a significant increase in socialization (<italic>P</italic>
˂0.05) was observed in ZnO NP-treated groups as compared to CQ group.</p>
<p><bold>Conclusion:</bold>
 ZnO NPs, instead of aggravating the dermatological condition, ameliorated the pruritus. All sizes of ZnO NPs used significantly improved socialization among mice and reduced locomotion activity.</p>
</abstract>
<kwd-group kwd-group-type="author"><title>Keywords</title>
<kwd>ZnO NPs</kwd>
<kwd>chloroquine-induced pruritus</kwd>
<kwd>CQ</kwd>
<kwd>green synthesized ZnO NPs</kwd>
<kwd>mice</kwd>
</kwd-group>
<counts><fig-count count="5"></fig-count>
<ref-count count="62"></ref-count>
<page-count count="8"></page-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Pakistan</li>
</country>
</list>
<tree><country name="Pakistan"><noRegion><name sortKey="Aman, Nargis" sort="Aman, Nargis" uniqKey="Aman N" first="Nargis" last="Aman">Nargis Aman</name>
</noRegion>
<name sortKey="Khan, Shujaat Ali" sort="Khan, Shujaat Ali" uniqKey="Khan S" first="Shujaat Ali" last="Khan">Shujaat Ali Khan</name>
<name sortKey="Rauf, Khalid" sort="Rauf, Khalid" uniqKey="Rauf K" first="Khalid" last="Rauf">Khalid Rauf</name>
<name sortKey="Rehman, Naeem Ur" sort="Rehman, Naeem Ur" uniqKey="Rehman N" first="Naeem-Ur" last="Rehman">Naeem-Ur Rehman</name>
<name sortKey="Tokhi, Ahmed" sort="Tokhi, Ahmed" uniqKey="Tokhi A" first="Ahmed" last="Tokhi">Ahmed Tokhi</name>
<name sortKey="Yameen, Muhammad Arfat" sort="Yameen, Muhammad Arfat" uniqKey="Yameen M" first="Muhammad Arfat" last="Yameen">Muhammad Arfat Yameen</name>
</country>
</tree>
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</record>

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HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:31118625" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a ChloroquineV1

This area was generated with Dilib version V0.6.33.
Data generation: Wed Mar 25 22:43:59 2020. Site generation: Sun Jan 31 12:44:45 2021

	Serveur d'exploration Chloroquine
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration Chloroquine

Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus

Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus

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