Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
Identifieur interne : 000588 ( Ncbi/Merge ); précédent : 000587; suivant : 000589Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
Auteurs : Gabriella D Razi [Italie] ; Mara Cirone [Italie]Source :
- Cancers [ 2072-6694 ] ; 2019.
Abstract
The capability of cancer cells to manage stress induced by hypoxia, nutrient shortage, acidosis, redox imbalance, loss of calcium homeostasis and exposure to drugs is a key factor to ensure cancer survival and chemoresistance. Among the protective mechanisms utilized by cancer cells to cope with stress a pivotal role is played by the activation of heat shock proteins (HSP) response, anti-oxidant response induced by nuclear factor erythroid 2-related factor 2 (NRF2), the hypoxia-inducible factor-1 (HIF-1), the unfolded protein response (UPR) and autophagy, cellular processes strictly interconnected. However, depending on the type, intensity or duration of cellular stress, the balance between pro-survival and pro-death pathways may change, and cell survival may be shifted into cell death. Mutations of p53 (mutp53), occurring in more than 50% of human cancers, may confer oncogenic gain-of-function (GOF) to the protein, mainly due to its stabilization and interaction with the above reported cellular pathways that help cancer cells to adapt to stress. This review will focus on the interplay of mutp53 with HSPs, NRF2, UPR, and autophagy and discuss how the manipulation of these interconnected processes may tip the balance towards cell death or survival, particularly in response to therapies.
Url:
DOI: 10.3390/cancers11050614
PubMed: 31052524
PubMed Central: 6563084
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000886
- to stream Pmc, to step Curation: 000886
- to stream Pmc, to step Checkpoint: 000564
Links to Exploration step
PMC:6563084Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression</title>
<author><name sortKey="D Razi, Gabriella" sort="D Razi, Gabriella" uniqKey="D Razi G" first="Gabriella" last="D Razi">Gabriella D Razi</name>
<affiliation wicri:level="1"><nlm:aff id="af1-cancers-11-00614">Department of Medical Sciences, University ‘G. d’Annunzio’, 66013 Chieti, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences, University ‘G. d’Annunzio’, 66013 Chieti</wicri:regionArea>
<wicri:noRegion>66013 Chieti</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-00614">Department of Research, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Research, IRCCS Regina Elena National Cancer Institute, 00144 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name>
<affiliation wicri:level="1"><nlm:aff id="af3-cancers-11-00614">Department of Experimental Medicine, “Sapienza” University of Rome, 00185 Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, “Sapienza” University of Rome, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cancers-11-00614">Laboratory Affiliated to Pasteur Institute, Italy-Foundation Cenci Bolognetti, 00161 Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory Affiliated to Pasteur Institute, Italy-Foundation Cenci Bolognetti, 00161 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31052524</idno>
<idno type="pmc">6563084</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6563084</idno>
<idno type="RBID">PMC:6563084</idno>
<idno type="doi">10.3390/cancers11050614</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000886</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000886</idno>
<idno type="wicri:Area/Pmc/Curation">000886</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000886</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000564</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000564</idno>
<idno type="wicri:Area/Ncbi/Merge">000588</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression</title>
<author><name sortKey="D Razi, Gabriella" sort="D Razi, Gabriella" uniqKey="D Razi G" first="Gabriella" last="D Razi">Gabriella D Razi</name>
<affiliation wicri:level="1"><nlm:aff id="af1-cancers-11-00614">Department of Medical Sciences, University ‘G. d’Annunzio’, 66013 Chieti, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Medical Sciences, University ‘G. d’Annunzio’, 66013 Chieti</wicri:regionArea>
<wicri:noRegion>66013 Chieti</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af2-cancers-11-00614">Department of Research, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Research, IRCCS Regina Elena National Cancer Institute, 00144 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name>
<affiliation wicri:level="1"><nlm:aff id="af3-cancers-11-00614">Department of Experimental Medicine, “Sapienza” University of Rome, 00185 Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Experimental Medicine, “Sapienza” University of Rome, 00185 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="af4-cancers-11-00614">Laboratory Affiliated to Pasteur Institute, Italy-Foundation Cenci Bolognetti, 00161 Rome, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Laboratory Affiliated to Pasteur Institute, Italy-Foundation Cenci Bolognetti, 00161 Rome</wicri:regionArea>
<placeName><settlement type="city">Rome</settlement>
<region nuts="2">Latium</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancers</title>
<idno type="eISSN">2072-6694</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The capability of cancer cells to manage stress induced by hypoxia, nutrient shortage, acidosis, redox imbalance, loss of calcium homeostasis and exposure to drugs is a key factor to ensure cancer survival and chemoresistance. Among the protective mechanisms utilized by cancer cells to cope with stress a pivotal role is played by the activation of heat shock proteins (HSP) response, anti-oxidant response induced by nuclear factor erythroid 2-related factor 2 (NRF2), the hypoxia-inducible factor-1 (HIF-1), the unfolded protein response (UPR) and autophagy, cellular processes strictly interconnected. However, depending on the type, intensity or duration of cellular stress, the balance between pro-survival and pro-death pathways may change, and cell survival may be shifted into cell death. Mutations of p53 (mutp53), occurring in more than 50% of human cancers, may confer oncogenic gain-of-function (GOF) to the protein, mainly due to its stabilization and interaction with the above reported cellular pathways that help cancer cells to adapt to stress. This review will focus on the interplay of mutp53 with HSPs, NRF2, UPR, and autophagy and discuss how the manipulation of these interconnected processes may tip the balance towards cell death or survival, particularly in response to therapies.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Vousden, K H" uniqKey="Vousden K">K.H. Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reinhardt, H C" uniqKey="Reinhardt H">H.C. Reinhardt</name>
</author>
<author><name sortKey="Schumacher, B" uniqKey="Schumacher B">B. Schumacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bykov, V J N" uniqKey="Bykov V">V.J.N. Bykov</name>
</author>
<author><name sortKey="Eriksson, S E" uniqKey="Eriksson S">S.E. Eriksson</name>
</author>
<author><name sortKey="Bianchi, J" uniqKey="Bianchi J">J. Bianchi</name>
</author>
<author><name sortKey="Wiman, K G" uniqKey="Wiman K">K.G. Wiman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Housman, G" uniqKey="Housman G">G. Housman</name>
</author>
<author><name sortKey="Byler, S" uniqKey="Byler S">S. Byler</name>
</author>
<author><name sortKey="Heerboth, S" uniqKey="Heerboth S">S. Heerboth</name>
</author>
<author><name sortKey="Lapinska, K" uniqKey="Lapinska K">K. Lapinska</name>
</author>
<author><name sortKey="Longacre, M" uniqKey="Longacre M">M. Longacre</name>
</author>
<author><name sortKey="Snyder, N" uniqKey="Snyder N">N. Snyder</name>
</author>
<author><name sortKey="Sarkar, S" uniqKey="Sarkar S">S. Sarkar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zahreddine, H" uniqKey="Zahreddine H">H. Zahreddine</name>
</author>
<author><name sortKey="Borden, K L" uniqKey="Borden K">K.L. Borden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kandoth, C" uniqKey="Kandoth C">C. Kandoth</name>
</author>
<author><name sortKey="Mclellan, M D" uniqKey="Mclellan M">M.D. McLellan</name>
</author>
<author><name sortKey="Vandin, F" uniqKey="Vandin F">F. Vandin</name>
</author>
<author><name sortKey="Ye, K" uniqKey="Ye K">K. Ye</name>
</author>
<author><name sortKey="Niu, B" uniqKey="Niu B">B. Niu</name>
</author>
<author><name sortKey="Lu, C" uniqKey="Lu C">C. Lu</name>
</author>
<author><name sortKey="Xie, M" uniqKey="Xie M">M. Xie</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name>
</author>
<author><name sortKey="Mcmichael, J F" uniqKey="Mcmichael J">J.F. McMichael</name>
</author>
<author><name sortKey="Wyczalkowski, M A" uniqKey="Wyczalkowski M">M.A. Wyczalkowski</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, M P" uniqKey="Kim M">M.P. Kim</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Lozano, G" uniqKey="Lozano G">G. Lozano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, P A" uniqKey="Muller P">P.A. Muller</name>
</author>
<author><name sortKey="Vousden, K H" uniqKey="Vousden K">K.H. Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, J" uniqKey="Xu J">J. Xu</name>
</author>
<author><name sortKey="Reumers, J" uniqKey="Reumers J">J. Reumers</name>
</author>
<author><name sortKey="Couceiro, J R" uniqKey="Couceiro J">J.R. Couceiro</name>
</author>
<author><name sortKey="De Smet, F" uniqKey="De Smet F">F. De Smet</name>
</author>
<author><name sortKey="Gallardo, R" uniqKey="Gallardo R">R. Gallardo</name>
</author>
<author><name sortKey="Rudyak, S" uniqKey="Rudyak S">S. Rudyak</name>
</author>
<author><name sortKey="Cornelis, A" uniqKey="Cornelis A">A. Cornelis</name>
</author>
<author><name sortKey="Rozenski, J" uniqKey="Rozenski J">J. Rozenski</name>
</author>
<author><name sortKey="Zwolinska, A" uniqKey="Zwolinska A">A. Zwolinska</name>
</author>
<author><name sortKey="Marine, J C" uniqKey="Marine J">J.C. Marine</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garcia, P B" uniqKey="Garcia P">P.B. Garcia</name>
</author>
<author><name sortKey="Attardi, L D" uniqKey="Attardi L">L.D. Attardi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schulz Heddergott, R" uniqKey="Schulz Heddergott R">R. Schulz-Heddergott</name>
</author>
<author><name sortKey="Moll, U M" uniqKey="Moll U">U.M. Moll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, M P" uniqKey="Kim M">M.P. Kim</name>
</author>
<author><name sortKey="Lozano, G" uniqKey="Lozano G">G. Lozano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cordani, M" uniqKey="Cordani M">M. Cordani</name>
</author>
<author><name sortKey="Pacchiana, R" uniqKey="Pacchiana R">R. Pacchiana</name>
</author>
<author><name sortKey="Butera, G" uniqKey="Butera G">G. Butera</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
<author><name sortKey="Scarpa, A" uniqKey="Scarpa A">A. Scarpa</name>
</author>
<author><name sortKey="Donadelli, M" uniqKey="Donadelli M">M. Donadelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gurtner, A" uniqKey="Gurtner A">A. Gurtner</name>
</author>
<author><name sortKey="Falcone, E" uniqKey="Falcone E">E. Falcone</name>
</author>
<author><name sortKey="Garibaldi, F" uniqKey="Garibaldi F">F. Garibaldi</name>
</author>
<author><name sortKey="Piaggio, G" uniqKey="Piaggio G">G. Piaggio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mantovani, F" uniqKey="Mantovani F">F. Mantovani</name>
</author>
<author><name sortKey="Collavin, L" uniqKey="Collavin L">L. Collavin</name>
</author>
<author><name sortKey="Del Sal, G" uniqKey="Del Sal G">G. Del Sal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Riha, R" uniqKey="Riha R">R. Riha</name>
</author>
<author><name sortKey="Gupta Saraf, P" uniqKey="Gupta Saraf P">P. Gupta-Saraf</name>
</author>
<author><name sortKey="Bhanja, P" uniqKey="Bhanja P">P. Bhanja</name>
</author>
<author><name sortKey="Badkul, S" uniqKey="Badkul S">S. Badkul</name>
</author>
<author><name sortKey="Saha, S" uniqKey="Saha S">S. Saha</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sane, S" uniqKey="Sane S">S. Sane</name>
</author>
<author><name sortKey="Rezvani, K" uniqKey="Rezvani K">K. Rezvani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, P A J" uniqKey="Muller P">P.A.J. Muller</name>
</author>
<author><name sortKey="Vousden, K H" uniqKey="Vousden K">K.H. Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Joerger, A C" uniqKey="Joerger A">A.C. Joerger</name>
</author>
<author><name sortKey="Fersht, A R" uniqKey="Fersht A">A.R. Fersht</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lukashchuk, N" uniqKey="Lukashchuk N">N. Lukashchuk</name>
</author>
<author><name sortKey="Vousden, K H" uniqKey="Vousden K">K.H. Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name>
</author>
<author><name sortKey="Marchencko, N D" uniqKey="Marchencko N">N.D. Marchencko</name>
</author>
<author><name sortKey="Moll, U M" uniqKey="Moll U">U.M. Moll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alexandrova, E M" uniqKey="Alexandrova E">E.M. Alexandrova</name>
</author>
<author><name sortKey="Moll, U M" uniqKey="Moll U">U.M. Moll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Peng, Y" uniqKey="Peng Y">Y. Peng</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
<author><name sortKey="Li, C" uniqKey="Li C">C. Li</name>
</author>
<author><name sortKey="Lu, W" uniqKey="Lu W">W. Lu</name>
</author>
<author><name sortKey="Chen, J" uniqKey="Chen J">J. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name>
</author>
<author><name sortKey="Marchenko, N D" uniqKey="Marchenko N">N.D. Marchenko</name>
</author>
<author><name sortKey="Schultz, R" uniqKey="Schultz R">R. Schultz</name>
</author>
<author><name sortKey="Fischer, V" uniqKey="Fischer V">V. Fischer</name>
</author>
<author><name sortKey="Velasco Hernandez, T" uniqKey="Velasco Hernandez T">T. Velasco-Hernandez</name>
</author>
<author><name sortKey="Talos, F" uniqKey="Talos F">F. Talos</name>
</author>
<author><name sortKey="Moll, U M" uniqKey="Moll U">U.M. Moll</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Trepel, J" uniqKey="Trepel J">J. Trepel</name>
</author>
<author><name sortKey="Mollapour, M" uniqKey="Mollapour M">M. Mollapour</name>
</author>
<author><name sortKey="Gaccone, G" uniqKey="Gaccone G">G. Gaccone</name>
</author>
<author><name sortKey="Neckers, L" uniqKey="Neckers L">L. Neckers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Whitesell, L" uniqKey="Whitesell L">L. Whitesell</name>
</author>
<author><name sortKey="Sutphin, P D" uniqKey="Sutphin P">P.D. Sutphin</name>
</author>
<author><name sortKey="Pulcini, E J" uniqKey="Pulcini E">E.J. Pulcini</name>
</author>
<author><name sortKey="Martinez, J D" uniqKey="Martinez J">J.D. Martinez</name>
</author>
<author><name sortKey="Cook, P H" uniqKey="Cook P">P.H. Cook</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Proia, D A" uniqKey="Proia D">D.A. Proia</name>
</author>
<author><name sortKey="Bates, R C" uniqKey="Bates R">R.C. Bates</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Solarova, Z" uniqKey="Solarova Z">Z. Solárová</name>
</author>
<author><name sortKey="Mojzis, J" uniqKey="Mojzis J">J. Mojžiš</name>
</author>
<author><name sortKey="Solar, P" uniqKey="Solar P">P. Solár</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kr Mer, O H" uniqKey="Kr Mer O">O.H. Krämer</name>
</author>
<author><name sortKey="Mahboobi, S" uniqKey="Mahboobi S">S. Mahboobi</name>
</author>
<author><name sortKey="Sellmer, A" uniqKey="Sellmer A">A. Sellmer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name>
</author>
<author><name sortKey="Ozog, L" uniqKey="Ozog L">L. Ozog</name>
</author>
<author><name sortKey="Marchenko, N" uniqKey="Marchenko N">N. Marchenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gomez Pastor, R" uniqKey="Gomez Pastor R">R. Gomez-Pastor</name>
</author>
<author><name sortKey="Burchfiel, E T" uniqKey="Burchfiel E">E.T. Burchfiel</name>
</author>
<author><name sortKey="Thiele, D J" uniqKey="Thiele D">D.J. Thiele</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Home, T" uniqKey="Home T">T. Home</name>
</author>
<author><name sortKey="Jensen, R A" uniqKey="Jensen R">R.A. Jensen</name>
</author>
<author><name sortKey="Rap, R" uniqKey="Rap R">R. Rap</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharma, C" uniqKey="Sharma C">C. Sharma</name>
</author>
<author><name sortKey="Seo, Y H" uniqKey="Seo Y">Y.H. Seo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dai, C" uniqKey="Dai C">C. Dai</name>
</author>
<author><name sortKey="Santagata, S" uniqKey="Santagata S">S. Santagata</name>
</author>
<author><name sortKey="Tang, Z" uniqKey="Tang Z">Z. Tang</name>
</author>
<author><name sortKey="Shi, J" uniqKey="Shi J">J. Shi</name>
</author>
<author><name sortKey="Cao, J" uniqKey="Cao J">J. Cao</name>
</author>
<author><name sortKey="Kwon, H" uniqKey="Kwon H">H. Kwon</name>
</author>
<author><name sortKey="Bronson, R T" uniqKey="Bronson R">R.T. Bronson</name>
</author>
<author><name sortKey="Whitesell, L" uniqKey="Whitesell L">L. Whitesell</name>
</author>
<author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S. Lindquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Muller, P A" uniqKey="Muller P">P.A. Muller</name>
</author>
<author><name sortKey="Caswell, P T" uniqKey="Caswell P">P.T. Caswell</name>
</author>
<author><name sortKey="Doyle, B" uniqKey="Doyle B">B. Doyle</name>
</author>
<author><name sortKey="Iwanicki, M P" uniqKey="Iwanicki M">M.P. Iwanicki</name>
</author>
<author><name sortKey="Tan, E H" uniqKey="Tan E">E.H. Tan</name>
</author>
<author><name sortKey="Karim, S" uniqKey="Karim S">S. Karim</name>
</author>
<author><name sortKey="Lukashchuk, N" uniqKey="Lukashchuk N">N. Lukashchuk</name>
</author>
<author><name sortKey="Gillespie, D A" uniqKey="Gillespie D">D.A. Gillespie</name>
</author>
<author><name sortKey="Ludwig, R L" uniqKey="Ludwig R">R.L. Ludwig</name>
</author>
<author><name sortKey="Gosselin, P" uniqKey="Gosselin P">P. Gosselin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yarden, Y" uniqKey="Yarden Y">Y. Yarden</name>
</author>
<author><name sortKey="Pines, G" uniqKey="Pines G">G. Pines</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dai, C" uniqKey="Dai C">C. Dai</name>
</author>
<author><name sortKey="Whitesell, L" uniqKey="Whitesell L">L. Whitesell</name>
</author>
<author><name sortKey="Rogers, A B" uniqKey="Rogers A">A.B. Rogers</name>
</author>
<author><name sortKey="Lindquist, S" uniqKey="Lindquist S">S. Lindquist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Parrales, A" uniqKey="Parrales A">A. Parrales</name>
</author>
<author><name sortKey="Ranjan, A" uniqKey="Ranjan A">A. Ranjan</name>
</author>
<author><name sortKey="Iyer, S V" uniqKey="Iyer S">S.V. Iyer</name>
</author>
<author><name sortKey="Padhye, S" uniqKey="Padhye S">S. Padhye</name>
</author>
<author><name sortKey="Weir, S J" uniqKey="Weir S">S.J. Weir</name>
</author>
<author><name sortKey="Roy, A" uniqKey="Roy A">A. Roy</name>
</author>
<author><name sortKey="Iwakuma, T" uniqKey="Iwakuma T">T. Iwakuma</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wiech, M" uniqKey="Wiech M">M. Wiech</name>
</author>
<author><name sortKey="Olszewski, M B" uniqKey="Olszewski M">M.B. Olszewski</name>
</author>
<author><name sortKey="Tracz Gaszewska, Z" uniqKey="Tracz Gaszewska Z">Z. Tracz-Gaszewska</name>
</author>
<author><name sortKey="Wawrzynow, B" uniqKey="Wawrzynow B">B. Wawrzynow</name>
</author>
<author><name sortKey="Zylicz, M" uniqKey="Zylicz M">M. Zylicz</name>
</author>
<author><name sortKey="Zylicz, A" uniqKey="Zylicz A">A. Zylicz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Freed Pastor, W A" uniqKey="Freed Pastor W">W.A. Freed-Pastor</name>
</author>
<author><name sortKey="Mizuno, H" uniqKey="Mizuno H">H. Mizuno</name>
</author>
<author><name sortKey="Zhao, X" uniqKey="Zhao X">X. Zhao</name>
</author>
<author><name sortKey="Langer D, A" uniqKey="Langer D A">A. Langerød</name>
</author>
<author><name sortKey="Moon, S H" uniqKey="Moon S">S.H. Moon</name>
</author>
<author><name sortKey="Rodriguez Barrueco, R" uniqKey="Rodriguez Barrueco R">R. Rodriguez-Barrueco</name>
</author>
<author><name sortKey="Barsotti, A" uniqKey="Barsotti A">A. Barsotti</name>
</author>
<author><name sortKey="Chicas, A" uniqKey="Chicas A">A. Chicas</name>
</author>
<author><name sortKey="Li, W" uniqKey="Li W">W. Li</name>
</author>
<author><name sortKey="Polotskaia, A" uniqKey="Polotskaia A">A. Polotskaia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mullen, P J" uniqKey="Mullen P">P.J. Mullen</name>
</author>
<author><name sortKey="Yu, R" uniqKey="Yu R">R. Yu</name>
</author>
<author><name sortKey="Longo, J" uniqKey="Longo J">J. Longo</name>
</author>
<author><name sortKey="Archer, M C" uniqKey="Archer M">M.C. Archer</name>
</author>
<author><name sortKey="Penn, L Z" uniqKey="Penn L">L.Z. Penn</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sorrentino, G" uniqKey="Sorrentino G">G. Sorrentino</name>
</author>
<author><name sortKey="Ruggeri, N" uniqKey="Ruggeri N">N. Ruggeri</name>
</author>
<author><name sortKey="Specchia, V" uniqKey="Specchia V">V. Specchia</name>
</author>
<author><name sortKey="Cordenonsi, M" uniqKey="Cordenonsi M">M. Cordenonsi</name>
</author>
<author><name sortKey="Mano, M" uniqKey="Mano M">M. Mano</name>
</author>
<author><name sortKey="Dupont, S" uniqKey="Dupont S">S. Dupont</name>
</author>
<author><name sortKey="Manfrin, A" uniqKey="Manfrin A">A. Manfrin</name>
</author>
<author><name sortKey="Ingallina, E" uniqKey="Ingallina E">E. Ingallina</name>
</author>
<author><name sortKey="Sommaggio, R" uniqKey="Sommaggio R">R. Sommaggio</name>
</author>
<author><name sortKey="Piazza, S" uniqKey="Piazza S">S. Piazza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ingallina, E" uniqKey="Ingallina E">E. Ingallina</name>
</author>
<author><name sortKey="Sorrentino, G" uniqKey="Sorrentino G">G. Sorrentino</name>
</author>
<author><name sortKey="Bertolio, R" uniqKey="Bertolio R">R. Bertolio</name>
</author>
<author><name sortKey="Lisek, K" uniqKey="Lisek K">K. Lisek</name>
</author>
<author><name sortKey="Zannini, A" uniqKey="Zannini A">A. Zannini</name>
</author>
<author><name sortKey="Azzolin, L" uniqKey="Azzolin L">L. Azzolin</name>
</author>
<author><name sortKey="Severino, L U" uniqKey="Severino L">L.U. Severino</name>
</author>
<author><name sortKey="Scaini, D" uniqKey="Scaini D">D. Scaini</name>
</author>
<author><name sortKey="Mano, M" uniqKey="Mano M">M. Mano</name>
</author>
<author><name sortKey="Mantovani, F" uniqKey="Mantovani F">F. Mantovani</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moon, S H" uniqKey="Moon S">S.H. Moon</name>
</author>
<author><name sortKey="Huang, C H" uniqKey="Huang C">C.H. Huang</name>
</author>
<author><name sortKey="Houlihan, S L" uniqKey="Houlihan S">S.L. Houlihan</name>
</author>
<author><name sortKey="Regunath, K" uniqKey="Regunath K">K. Regunath</name>
</author>
<author><name sortKey="Freed Pastor, W A" uniqKey="Freed Pastor W">W.A. Freed-Pastor</name>
</author>
<author><name sortKey="Morris, J P" uniqKey="Morris J">J.P. Morris</name>
</author>
<author><name sortKey="Tschaharganeh, D F" uniqKey="Tschaharganeh D">D.F. Tschaharganeh</name>
</author>
<author><name sortKey="Kastenhuber, E R" uniqKey="Kastenhuber E">E.R. Kastenhuber</name>
</author>
<author><name sortKey="Barsotti, A M" uniqKey="Barsotti A">A.M. Barsotti</name>
</author>
<author><name sortKey="Culp Hill, R" uniqKey="Culp Hill R">R. Culp-Hill</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alexandrova, E M" uniqKey="Alexandrova E">E.M. Alexandrova</name>
</author>
<author><name sortKey="Marchenko, N D" uniqKey="Marchenko N">N.D. Marchenko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walter, P" uniqKey="Walter P">P. Walter</name>
</author>
<author><name sortKey="Gilmore, R" uniqKey="Gilmore R">R. Gilmore</name>
</author>
<author><name sortKey="Blobel, G" uniqKey="Blobel G">G. Blobel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hetz, C" uniqKey="Hetz C">C. Hetz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walter, P" uniqKey="Walter P">P. Walter</name>
</author>
<author><name sortKey="Ron, D" uniqKey="Ron D">D. Ron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Donnelly, N" uniqKey="Donnelly N">N. Donnelly</name>
</author>
<author><name sortKey="Storchov, Z" uniqKey="Storchov Z">Z. Storchov</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deegan, S" uniqKey="Deegan S">S. Deegan</name>
</author>
<author><name sortKey="Saveljeva, S" uniqKey="Saveljeva S">S. Saveljeva</name>
</author>
<author><name sortKey="Gorman, A M" uniqKey="Gorman A">A.M. Gorman</name>
</author>
<author><name sortKey="Samali, A" uniqKey="Samali A">A. Samali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name>
</author>
<author><name sortKey="Zhou, L" uniqKey="Zhou L">L. Zhou</name>
</author>
<author><name sortKey="Chen, Z" uniqKey="Chen Z">Z. Chen</name>
</author>
<author><name sortKey="Nice, E C" uniqKey="Nice E">E.C. Nice</name>
</author>
<author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Avril, T" uniqKey="Avril T">T. Avril</name>
</author>
<author><name sortKey="Vauleon, E" uniqKey="Vauleon E">E. Vauleon</name>
</author>
<author><name sortKey="Chevet, E" uniqKey="Chevet E">E. Chevet</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chevet, E" uniqKey="Chevet E">E. Chevet</name>
</author>
<author><name sortKey="Hetz, C" uniqKey="Hetz C">C. Hetz</name>
</author>
<author><name sortKey="Samali, A" uniqKey="Samali A">A. Samali</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yadav, R K" uniqKey="Yadav R">R.K. Yadav</name>
</author>
<author><name sortKey="Chae, S W" uniqKey="Chae S">S.W. Chae</name>
</author>
<author><name sortKey="Kim, H R" uniqKey="Kim H">H.R. Kim</name>
</author>
<author><name sortKey="Char, J" uniqKey="Char J">J. Char</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bertolotti, A" uniqKey="Bertolotti A">A. Bertolotti</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Hendershot, L M" uniqKey="Hendershot L">L.M. Hendershot</name>
</author>
<author><name sortKey="Harding, H P" uniqKey="Harding H">H.P. Harding</name>
</author>
<author><name sortKey="Ron, D" uniqKey="Ron D">D. Ron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shen, J" uniqKey="Shen J">J. Shen</name>
</author>
<author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name>
</author>
<author><name sortKey="Hendershot, L" uniqKey="Hendershot L">L. Hendershot</name>
</author>
<author><name sortKey="Prywes, R" uniqKey="Prywes R">R. Prywes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yoshida, H" uniqKey="Yoshida H">H. Yoshida</name>
</author>
<author><name sortKey="Matsui, T" uniqKey="Matsui T">T. Matsui</name>
</author>
<author><name sortKey="Yamamoto, A" uniqKey="Yamamoto A">A. Yamamoto</name>
</author>
<author><name sortKey="Okada, T" uniqKey="Okada T">T. Okada</name>
</author>
<author><name sortKey="Mori, K" uniqKey="Mori K">K. Mori</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Acosta Alvear, D" uniqKey="Acosta Alvear D">D. Acosta-Alvear</name>
</author>
<author><name sortKey="Zhou, Y" uniqKey="Zhou Y">Y. Zhou</name>
</author>
<author><name sortKey="Blais, A" uniqKey="Blais A">A. Blais</name>
</author>
<author><name sortKey="Tsikitis, M" uniqKey="Tsikitis M">M. Tsikitis</name>
</author>
<author><name sortKey="Lents, N H" uniqKey="Lents N">N.H. Lents</name>
</author>
<author><name sortKey="Arias, C" uniqKey="Arias C">C. Arias</name>
</author>
<author><name sortKey="Lennon, C J" uniqKey="Lennon C">C.J. Lennon</name>
</author>
<author><name sortKey="Kluger, Y" uniqKey="Kluger Y">Y. Kluger</name>
</author>
<author><name sortKey="Dynlacht, B D" uniqKey="Dynlacht B">B.D. Dynlacht</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Senft, D" uniqKey="Senft D">D. Senft</name>
</author>
<author><name sortKey="Ronai, Z A" uniqKey="Ronai Z">Z.A. Ronai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Urra, H" uniqKey="Urra H">H. Urra</name>
</author>
<author><name sortKey="Dufey, E" uniqKey="Dufey E">E. Dufey</name>
</author>
<author><name sortKey="Avril, T" uniqKey="Avril T">T. Avril</name>
</author>
<author><name sortKey="Chevet, E" uniqKey="Chevet E">E. Chevet</name>
</author>
<author><name sortKey="Hetx, C" uniqKey="Hetx C">C. Hetx</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shajahan, A N" uniqKey="Shajahan A">A.N. Shajahan</name>
</author>
<author><name sortKey="Riggings, R B" uniqKey="Riggings R">R.B. Riggings</name>
</author>
<author><name sortKey="Clarke, R" uniqKey="Clarke R">R. Clarke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Namba, T" uniqKey="Namba T">T. Namba</name>
</author>
<author><name sortKey="Chu, K" uniqKey="Chu K">K. Chu</name>
</author>
<author><name sortKey="Kodama, R" uniqKey="Kodama R">R. Kodama</name>
</author>
<author><name sortKey="Byun, S" uniqKey="Byun S">S. Byun</name>
</author>
<author><name sortKey="Wan Yoon, K" uniqKey="Wan Yoon K">K. Wan Yoon</name>
</author>
<author><name sortKey="Hiraki, M" uniqKey="Hiraki M">M. Hiraki</name>
</author>
<author><name sortKey="Mandinova, A" uniqKey="Mandinova A">A. Mandinova</name>
</author>
<author><name sortKey="Lee, S W" uniqKey="Lee S">S.W. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Luo, B" uniqKey="Luo B">B. Luo</name>
</author>
<author><name sortKey="Lee, A S" uniqKey="Lee A">A.S. Lee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dai, C" uniqKey="Dai C">C. Dai</name>
</author>
<author><name sortKey="Dai, S" uniqKey="Dai S">S. Dai</name>
</author>
<author><name sortKey="Cao, J" uniqKey="Cao J">J. Cao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Marcu, M G" uniqKey="Marcu M">M.G. Marcu</name>
</author>
<author><name sortKey="Doyle, M" uniqKey="Doyle M">M. Doyle</name>
</author>
<author><name sortKey="Bertolotti, A" uniqKey="Bertolotti A">A. Bertolotti</name>
</author>
<author><name sortKey="Ron, D" uniqKey="Ron D">D. Ron</name>
</author>
<author><name sortKey="Hendershot, L" uniqKey="Hendershot L">L. Hendershot</name>
</author>
<author><name sortKey="Neckers, L" uniqKey="Neckers L">L. Neckers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schultze, T W" uniqKey="Schultze T">T.W. Schultze</name>
</author>
<author><name sortKey="Blagosklonny, M V" uniqKey="Blagosklonny M">M.V. Blagosklonny</name>
</author>
<author><name sortKey="Ingui, C" uniqKey="Ingui C">C. Ingui</name>
</author>
<author><name sortKey="Neckers, L" uniqKey="Neckers L">L. Neckers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sato, S" uniqKey="Sato S">S. Sato</name>
</author>
<author><name sortKey="Fujita, N" uniqKey="Fujita N">N. Fujita</name>
</author>
<author><name sortKey="Tsuruo, T" uniqKey="Tsuruo T">T. Tsuruo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Donze, O" uniqKey="Donze O">O. Donze</name>
</author>
<author><name sortKey="Abbas Terki, T" uniqKey="Abbas Terki T">T. Abbas-Terki</name>
</author>
<author><name sortKey="Picard, D" uniqKey="Picard D">D. Picard</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xu, W" uniqKey="Xu W">W. Xu</name>
</author>
<author><name sortKey="Mimmaugh, E" uniqKey="Mimmaugh E">E. Mimmaugh</name>
</author>
<author><name sortKey="Rosser, M F" uniqKey="Rosser M">M.F. Rosser</name>
</author>
<author><name sortKey="Nicchitta, C" uniqKey="Nicchitta C">C. Nicchitta</name>
</author>
<author><name sortKey="Marcu, M" uniqKey="Marcu M">M. Marcu</name>
</author>
<author><name sortKey="Yarden, Y" uniqKey="Yarden Y">Y. Yarden</name>
</author>
<author><name sortKey="Neckers, L" uniqKey="Neckers L">L. Neckers</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vogiatzi, F" uniqKey="Vogiatzi F">F. Vogiatzi</name>
</author>
<author><name sortKey="Brandt, D T" uniqKey="Brandt D">D.T. Brandt</name>
</author>
<author><name sortKey="Schneikert, J" uniqKey="Schneikert J">J. Schneikert</name>
</author>
<author><name sortKey="Fuchs, J" uniqKey="Fuchs J">J. Fuchs</name>
</author>
<author><name sortKey="Grikscheit, K" uniqKey="Grikscheit K">K. Grikscheit</name>
</author>
<author><name sortKey="Wanzel, M" uniqKey="Wanzel M">M. Wanzel</name>
</author>
<author><name sortKey="Pavlakis, E" uniqKey="Pavlakis E">E. Pavlakis</name>
</author>
<author><name sortKey="Charles, J P" uniqKey="Charles J">J.P. Charles</name>
</author>
<author><name sortKey="Timofeev, O" uniqKey="Timofeev O">O. Timofeev</name>
</author>
<author><name sortKey="Nist, A" uniqKey="Nist A">A. Nist</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rojo De La Vega, M" uniqKey="Rojo De La Vega M">M. Rojo de la Vega</name>
</author>
<author><name sortKey="Chapman, E" uniqKey="Chapman E">E. Chapman</name>
</author>
<author><name sortKey="Zhang, D D" uniqKey="Zhang D">D.D. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dayalan Naidu, S" uniqKey="Dayalan Naidu S">S. Dayalan Naidu</name>
</author>
<author><name sortKey="Kostov, R V" uniqKey="Kostov R">R.V. Kostov</name>
</author>
<author><name sortKey="Dinkova Kostova, A T" uniqKey="Dinkova Kostova A">A.T. Dinkova-Kostova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, S" uniqKey="Wu S">S. Wu</name>
</author>
<author><name sortKey="Lu, H" uniqKey="Lu H">H. Lu</name>
</author>
<author><name sortKey="Bai, Y" uniqKey="Bai Y">Y. Bai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, X J" uniqKey="Wang X">X.J. Wang</name>
</author>
<author><name sortKey="Sun, Z" uniqKey="Sun Z">Z. Sun</name>
</author>
<author><name sortKey="Villeneuve, N F" uniqKey="Villeneuve N">N.F. Villeneuve</name>
</author>
<author><name sortKey="Zhang, S" uniqKey="Zhang S">S. Zhang</name>
</author>
<author><name sortKey="Zhao, F" uniqKey="Zhao F">F. Zhao</name>
</author>
<author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name>
</author>
<author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name>
</author>
<author><name sortKey="Yi, X" uniqKey="Yi X">X. Yi</name>
</author>
<author><name sortKey="Zheng, W" uniqKey="Zheng W">W. Zheng</name>
</author>
<author><name sortKey="Wondrak, G T" uniqKey="Wondrak G">G.T. Wondrak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lau, A" uniqKey="Lau A">A. Lau</name>
</author>
<author><name sortKey="Villeneuve, N F" uniqKey="Villeneuve N">N.F. Villeneuve</name>
</author>
<author><name sortKey="Sun, Z" uniqKey="Sun Z">Z. Sun</name>
</author>
<author><name sortKey="Wong, P K" uniqKey="Wong P">P.K. Wong</name>
</author>
<author><name sortKey="Zhang, D D" uniqKey="Zhang D">D.D. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menegon, S" uniqKey="Menegon S">S. Menegon</name>
</author>
<author><name sortKey="Columbano, A" uniqKey="Columbano A">A. Columbano</name>
</author>
<author><name sortKey="Giordano, S" uniqKey="Giordano S">S. Giordano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H. Yang</name>
</author>
<author><name sortKey="Villani, R M" uniqKey="Villani R">R.M. Villani</name>
</author>
<author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name>
</author>
<author><name sortKey="Simpson, M J" uniqKey="Simpson M">M.J. Simpson</name>
</author>
<author><name sortKey="Roberts, M S" uniqKey="Roberts M">M.S. Roberts</name>
</author>
<author><name sortKey="Tang, M" uniqKey="Tang M">M. Tang</name>
</author>
<author><name sortKey="Liang, X" uniqKey="Liang X">X. Liang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="No, J H" uniqKey="No J">J.H. No</name>
</author>
<author><name sortKey="Kim, Y B" uniqKey="Kim Y">Y.B. Kim</name>
</author>
<author><name sortKey="Song, Y S" uniqKey="Song Y">Y.S. Song</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glorieux, V" uniqKey="Glorieux V">V. Glorieux</name>
</author>
<author><name sortKey="Calderon, P B" uniqKey="Calderon P">P.B. Calderon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Glorieux, C" uniqKey="Glorieux C">C. Glorieux</name>
</author>
<author><name sortKey="Calderon, P B" uniqKey="Calderon P">P.B. Calderon</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zeekpudsa, P" uniqKey="Zeekpudsa P">P. Zeekpudsa</name>
</author>
<author><name sortKey="Kukongviriyapan, V" uniqKey="Kukongviriyapan V">V. Kukongviriyapan</name>
</author>
<author><name sortKey="Senggunprai, L" uniqKey="Senggunprai L">L. Senggunprai</name>
</author>
<author><name sortKey="Sripa, B" uniqKey="Sripa B">B. Sripa</name>
</author>
<author><name sortKey="Prawan, A" uniqKey="Prawan A">A. Prawan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y. Yang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y. Zhang</name>
</author>
<author><name sortKey="Wu, Q" uniqKey="Wu Q">Q. Wu</name>
</author>
<author><name sortKey="Cui, X" uniqKey="Cui X">X. Cui</name>
</author>
<author><name sortKey="Lin, Z" uniqKey="Lin Z">Z. Lin</name>
</author>
<author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name>
</author>
<author><name sortKey="Chen, L" uniqKey="Chen L">L. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Doherty, J" uniqKey="Doherty J">J. Doherty</name>
</author>
<author><name sortKey="Baehrcke, E H" uniqKey="Baehrcke E">E.H. Baehrcke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pankiv, S" uniqKey="Pankiv S">S. Pankiv</name>
</author>
<author><name sortKey="Clausen, T H" uniqKey="Clausen T">T.H. Clausen</name>
</author>
<author><name sortKey="Lamark, T" uniqKey="Lamark T">T. Lamark</name>
</author>
<author><name sortKey="Brech, A" uniqKey="Brech A">A. Brech</name>
</author>
<author><name sortKey="Bruun, J A" uniqKey="Bruun J">J.A. Bruun</name>
</author>
<author><name sortKey="Outzen, H" uniqKey="Outzen H">H. Outzen</name>
</author>
<author><name sortKey="Overvatn, A" uniqKey="Overvatn A">A. Overvatn</name>
</author>
<author><name sortKey="Bjorkoy, G" uniqKey="Bjorkoy G">G. Bjorkoy</name>
</author>
<author><name sortKey="Johansen, T" uniqKey="Johansen T">T. Johansen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Klionsky, D J" uniqKey="Klionsky D">D.J. Klionsky</name>
</author>
<author><name sortKey="Abdelmohsen, K" uniqKey="Abdelmohsen K">K. Abdelmohsen</name>
</author>
<author><name sortKey="Abe, A" uniqKey="Abe A">A. Abe</name>
</author>
<author><name sortKey="Abedin, M J" uniqKey="Abedin M">M.J. Abedin</name>
</author>
<author><name sortKey="Abeliovich, H" uniqKey="Abeliovich H">H. Abeliovich</name>
</author>
<author><name sortKey="Acevedo Arozena, A" uniqKey="Acevedo Arozena A">A. Acevedo Arozena</name>
</author>
<author><name sortKey="Adachi, H" uniqKey="Adachi H">H. Adachi</name>
</author>
<author><name sortKey="Adams, C M" uniqKey="Adams C">C.M. Adams</name>
</author>
<author><name sortKey="Adams, P D" uniqKey="Adams P">P.D. Adams</name>
</author>
<author><name sortKey="Adeli, K" uniqKey="Adeli K">K. Adeli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Harder, B" uniqKey="Harder B">B. Harder</name>
</author>
<author><name sortKey="Rojo De La Vega, M" uniqKey="Rojo De La Vega M">M. Rojo de la Vega</name>
</author>
<author><name sortKey="Wong, P K" uniqKey="Wong P">P.K. Wong</name>
</author>
<author><name sortKey="Chapman, E" uniqKey="Chapman E">E. Chapman</name>
</author>
<author><name sortKey="Zhand, D D" uniqKey="Zhand D">D.D. Zhand</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, W" uniqKey="Chen W">W. Chen</name>
</author>
<author><name sortKey="Sun, Z" uniqKey="Sun Z">Z. Sun</name>
</author>
<author><name sortKey="Wang, X J" uniqKey="Wang X">X.J. Wang</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Huang, Z" uniqKey="Huang Z">Z. Huang</name>
</author>
<author><name sortKey="Fang, D" uniqKey="Fang D">D. Fang</name>
</author>
<author><name sortKey="Zhang, D D" uniqKey="Zhang D">D.D. Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cullinan, S B" uniqKey="Cullinan S">S.B. Cullinan</name>
</author>
<author><name sortKey="Zhang, D" uniqKey="Zhang D">D. Zhang</name>
</author>
<author><name sortKey="Hannink, M" uniqKey="Hannink M">M. Hannink</name>
</author>
<author><name sortKey="Arvisais, E" uniqKey="Arvisais E">E. Arvisais</name>
</author>
<author><name sortKey="Kaufman, R J" uniqKey="Kaufman R">R.J. Kaufman</name>
</author>
<author><name sortKey="Diehl, J A" uniqKey="Diehl J">J.A. Diehl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harding, H P" uniqKey="Harding H">H.P. Harding</name>
</author>
<author><name sortKey="Zhangm, Y" uniqKey="Zhangm Y">Y. Zhangm</name>
</author>
<author><name sortKey="Bertolottim, A" uniqKey="Bertolottim A">A. Bertolottim</name>
</author>
<author><name sortKey="Zeng, H" uniqKey="Zeng H">H. Zeng</name>
</author>
<author><name sortKey="Ron, D" uniqKey="Ron D">D. Ron</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kalo, E" uniqKey="Kalo E">E. Kalo</name>
</author>
<author><name sortKey="Kogan Sakin, I" uniqKey="Kogan Sakin I">I. Kogan-Sakin</name>
</author>
<author><name sortKey="Solomon, H" uniqKey="Solomon H">H. Solomon</name>
</author>
<author><name sortKey="Bar Nathan, E" uniqKey="Bar Nathan E">E. Bar-Nathan</name>
</author>
<author><name sortKey="Shay, M" uniqKey="Shay M">M. Shay</name>
</author>
<author><name sortKey="Shetzer, Y" uniqKey="Shetzer Y">Y. Shetzer</name>
</author>
<author><name sortKey="Dekel, E" uniqKey="Dekel E">E. Dekel</name>
</author>
<author><name sortKey="Goldfinger, N" uniqKey="Goldfinger N">N. Goldfinger</name>
</author>
<author><name sortKey="Buganim, Y" uniqKey="Buganim Y">Y. Buganim</name>
</author>
<author><name sortKey="Stambolsky, P" uniqKey="Stambolsky P">P. Stambolsky</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lisek, K" uniqKey="Lisek K">K. Lisek</name>
</author>
<author><name sortKey="Campaner, E" uniqKey="Campaner E">E. Campaner</name>
</author>
<author><name sortKey="Ciani, Y" uniqKey="Ciani Y">Y. Ciani</name>
</author>
<author><name sortKey="Walerych, D" uniqKey="Walerych D">D. Walerych</name>
</author>
<author><name sortKey="Del Sal, G" uniqKey="Del Sal G">G. Del Sal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hamada, S" uniqKey="Hamada S">S. Hamada</name>
</author>
<author><name sortKey="Taguchi, K" uniqKey="Taguchi K">K. Taguchi</name>
</author>
<author><name sortKey="Masamume, A" uniqKey="Masamume A">A. Masamume</name>
</author>
<author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name>
</author>
<author><name sortKey="Shimosegawa, T" uniqKey="Shimosegawa T">T. Shimosegawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Walerych, D" uniqKey="Walerych D">D. Walerych</name>
</author>
<author><name sortKey="Lisek, K" uniqKey="Lisek K">K. Lisek</name>
</author>
<author><name sortKey="Sommaggio, R" uniqKey="Sommaggio R">R. Sommaggio</name>
</author>
<author><name sortKey="Piazza, S" uniqKey="Piazza S">S. Piazza</name>
</author>
<author><name sortKey="Ciani, Y" uniqKey="Ciani Y">Y. Ciani</name>
</author>
<author><name sortKey="Dalla, E" uniqKey="Dalla E">E. Dalla</name>
</author>
<author><name sortKey="Rajkowska, K" uniqKey="Rajkowska K">K. Rajkowska</name>
</author>
<author><name sortKey="Gaweda Walerych, K" uniqKey="Gaweda Walerych K">K. Gaweda-Walerych</name>
</author>
<author><name sortKey="Ingallina, E" uniqKey="Ingallina E">E. Ingallina</name>
</author>
<author><name sortKey="Tonelli, C" uniqKey="Tonelli C">C. Tonelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, G L" uniqKey="Wang G">G.L. Wang</name>
</author>
<author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name>
</author>
<author><name sortKey="Rue, E A" uniqKey="Rue E">E.A. Rue</name>
</author>
<author><name sortKey="Semenza, G L" uniqKey="Semenza G">G.L. Semenza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Soni, S" uniqKey="Soni S">S. Soni</name>
</author>
<author><name sortKey="Padwad, Y S" uniqKey="Padwad Y">Y.S. Padwad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yu, T" uniqKey="Yu T">T. Yu</name>
</author>
<author><name sortKey="Tang, B" uniqKey="Tang B">B. Tang</name>
</author>
<author><name sortKey="Sun, X" uniqKey="Sun X">X. Sun</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Amelio, I" uniqKey="Amelio I">I. Amelio</name>
</author>
<author><name sortKey="Mancini, M" uniqKey="Mancini M">M. Mancini</name>
</author>
<author><name sortKey="Petrova, V" uniqKey="Petrova V">V. Petrova</name>
</author>
<author><name sortKey="Cairns, R A" uniqKey="Cairns R">R.A. Cairns</name>
</author>
<author><name sortKey="Vikhreva, P" uniqKey="Vikhreva P">P. Vikhreva</name>
</author>
<author><name sortKey="Nicolai, S" uniqKey="Nicolai S">S. Nicolai</name>
</author>
<author><name sortKey="Marini, A" uniqKey="Marini A">A. Marini</name>
</author>
<author><name sortKey="Antonov, A A" uniqKey="Antonov A">A.A. Antonov</name>
</author>
<author><name sortKey="Le Quesne, J" uniqKey="Le Quesne J">J. Le Quesne</name>
</author>
<author><name sortKey="Baena Acevedo, J D" uniqKey="Baena Acevedo J">J.D. Baena Acevedo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Toth, R K" uniqKey="Toth R">R.K. Toth</name>
</author>
<author><name sortKey="Warfel, N A" uniqKey="Warfel N">N.A. Warfel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ren, D" uniqKey="Ren D">D. Ren</name>
</author>
<author><name sortKey="Villeneuve, N F" uniqKey="Villeneuve N">N.F. Villeneuve</name>
</author>
<author><name sortKey="Jiang, T" uniqKey="Jiang T">T. Jiang</name>
</author>
<author><name sortKey="Wu, T" uniqKey="Wu T">T. Wu</name>
</author>
<author><name sortKey="Lau, A" uniqKey="Lau A">A. Lau</name>
</author>
<author><name sortKey="Toppin, H A" uniqKey="Toppin H">H.A. Toppin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y. Xiang</name>
</author>
<author><name sortKey="Ye, W" uniqKey="Ye W">W. Ye</name>
</author>
<author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
<author><name sortKey="Lou, B" uniqKey="Lou B">B. Lou</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Yu, D" uniqKey="Yu D">D. Yu</name>
</author>
<author><name sortKey="Huang, X" uniqKey="Huang X">X. Huang</name>
</author>
<author><name sortKey="Chen, B" uniqKey="Chen B">B. Chen</name>
</author>
<author><name sortKey="Zhou, M" uniqKey="Zhou M">M. Zhou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Xiang, Y" uniqKey="Xiang Y">Y. Xiang</name>
</author>
<author><name sortKey="Ye, W" uniqKey="Ye W">W. Ye</name>
</author>
<author><name sortKey="Huang, C" uniqKey="Huang C">C. Huang</name>
</author>
<author><name sortKey="Yu, D" uniqKey="Yu D">D. Yu</name>
</author>
<author><name sortKey="Chen, H" uniqKey="Chen H">H. Chen</name>
</author>
<author><name sortKey="Deng, T" uniqKey="Deng T">T. Deng</name>
</author>
<author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name>
</author>
<author><name sortKey="Lou, B" uniqKey="Lou B">B. Lou</name>
</author>
<author><name sortKey="Zhang, J" uniqKey="Zhang J">J. Zhang</name>
</author>
<author><name sortKey="Shi, K" uniqKey="Shi K">K. Shi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, F" uniqKey="Chen F">F. Chen</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y. Liu</name>
</author>
<author><name sortKey="Wang, S" uniqKey="Wang S">S. Wang</name>
</author>
<author><name sortKey="Guo, X" uniqKey="Guo X">X. Guo</name>
</author>
<author><name sortKey="Shi, P" uniqKey="Shi P">P. Shi</name>
</author>
<author><name sortKey="Wang, W" uniqKey="Wang W">W. Wang</name>
</author>
<author><name sortKey="Xu, B" uniqKey="Xu B">B. Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mitsuishi, Y" uniqKey="Mitsuishi Y">Y. Mitsuishi</name>
</author>
<author><name sortKey="Taguchi, K" uniqKey="Taguchi K">K. Taguchi</name>
</author>
<author><name sortKey="Kawatani, Y" uniqKey="Kawatani Y">Y. Kawatani</name>
</author>
<author><name sortKey="Shibata, T" uniqKey="Shibata T">T. Shibata</name>
</author>
<author><name sortKey="Nukiwa, T" uniqKey="Nukiwa T">T. Nukiwa</name>
</author>
<author><name sortKey="Aburatani, H" uniqKey="Aburatani H">H. Aburatani</name>
</author>
<author><name sortKey="Yamamoto, M" uniqKey="Yamamoto M">M. Yamamoto</name>
</author>
<author><name sortKey="Motohash, H" uniqKey="Motohash H">H. Motohash</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Denicola, G M" uniqKey="Denicola G">G.M. DeNicola</name>
</author>
<author><name sortKey="Chen, P H" uniqKey="Chen P">P.H. Chen</name>
</author>
<author><name sortKey="Mullarky, E" uniqKey="Mullarky E">E. Mullarky</name>
</author>
<author><name sortKey="Sudderth, J A" uniqKey="Sudderth J">J.A. Sudderth</name>
</author>
<author><name sortKey="Hu, Z" uniqKey="Hu Z">Z. Hu</name>
</author>
<author><name sortKey="Wu, D" uniqKey="Wu D">D. Wu</name>
</author>
<author><name sortKey="Tang, H" uniqKey="Tang H">H. Tang</name>
</author>
<author><name sortKey="Xie, Y" uniqKey="Xie Y">Y. Xie</name>
</author>
<author><name sortKey="Asara, J M" uniqKey="Asara J">J.M. Asara</name>
</author>
<author><name sortKey="Huffman, K E" uniqKey="Huffman K">K.E. Huffman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wolpaw, A J" uniqKey="Wolpaw A">A.J. Wolpaw</name>
</author>
<author><name sortKey="Dang, C V" uniqKey="Dang C">C.V. Dang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Liu, J" uniqKey="Liu J">J. Liu</name>
</author>
<author><name sortKey="Zhang, C" uniqKey="Zhang C">C. Zhang</name>
</author>
<author><name sortKey="Hu, W" uniqKey="Hu W">W. Hu</name>
</author>
<author><name sortKey="Feng, Z" uniqKey="Feng Z">Z. Feng</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yang, J" uniqKey="Yang J">J. Yang</name>
</author>
<author><name sortKey="Altahan, A" uniqKey="Altahan A">A. AlTahan</name>
</author>
<author><name sortKey="Jones, D T" uniqKey="Jones D">D.T. Jones</name>
</author>
<author><name sortKey="Buffa, F M" uniqKey="Buffa F">F.M. Buffa</name>
</author>
<author><name sortKey="Bridges, E" uniqKey="Bridges E">E. Bridges</name>
</author>
<author><name sortKey="Interiano, R B" uniqKey="Interiano R">R.B. Interiano</name>
</author>
<author><name sortKey="Quc, C" uniqKey="Quc C">C. Quc</name>
</author>
<author><name sortKey="Vogt, N" uniqKey="Vogt N">N. Vogt</name>
</author>
<author><name sortKey="Lia, J L" uniqKey="Lia J">J.-L. Lia</name>
</author>
<author><name sortKey="Baban, D" uniqKey="Baban D">D. Baban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shanle, E K" uniqKey="Shanle E">E.K. Shanle</name>
</author>
<author><name sortKey="Xu, W" uniqKey="Xu W">W. Xu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X. Chen</name>
</author>
<author><name sortKey="Iliopoulos, D" uniqKey="Iliopoulos D">D. Iliopoulos</name>
</author>
<author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name>
</author>
<author><name sortKey="Tang, Q" uniqKey="Tang Q">Q. Tang</name>
</author>
<author><name sortKey="Greenblatt, M B" uniqKey="Greenblatt M">M.B. Greenblatt</name>
</author>
<author><name sortKey="Hatziapostolou, M" uniqKey="Hatziapostolou M">M. Hatziapostolou</name>
</author>
<author><name sortKey="Lim, E" uniqKey="Lim E">E. Lim</name>
</author>
<author><name sortKey="Tam, W L" uniqKey="Tam W">W.L. Tam</name>
</author>
<author><name sortKey="Ni, M" uniqKey="Ni M">M. Ni</name>
</author>
<author><name sortKey="Chen, Y" uniqKey="Chen Y">Y. Chen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Menendez, D" uniqKey="Menendez D">D. Menendez</name>
</author>
<author><name sortKey="Inga, A" uniqKey="Inga A">A. Inga</name>
</author>
<author><name sortKey="Resnick, M A" uniqKey="Resnick M">M.A. Resnick</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cook, K L" uniqKey="Cook K">K.L. Cook</name>
</author>
<author><name sortKey="Clarke, P A G" uniqKey="Clarke P">P.A.G. Clarke</name>
</author>
<author><name sortKey="Parmar, J" uniqKey="Parmar J">J. Parmar</name>
</author>
<author><name sortKey="Hu, R" uniqKey="Hu R">R. Hu</name>
</author>
<author><name sortKey="Schwartz Roberts, J L" uniqKey="Schwartz Roberts J">J.L. Schwartz-Roberts</name>
</author>
<author><name sortKey="Abu Asab, M" uniqKey="Abu Asab M">M. Abu-Asab</name>
</author>
<author><name sortKey="Warri, A" uniqKey="Warri A">A. Warri</name>
</author>
<author><name sortKey="Baumann, W T" uniqKey="Baumann W">W.T. Baumann</name>
</author>
<author><name sortKey="Clarke, R" uniqKey="Clarke R">R. Clarke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garufi, A" uniqKey="Garufi A">A. Garufi</name>
</author>
<author><name sortKey="Trisciuoglio, D" uniqKey="Trisciuoglio D">D. Trisciuoglio</name>
</author>
<author><name sortKey="Porru, M" uniqKey="Porru M">M. Porru</name>
</author>
<author><name sortKey="Leonetti, C" uniqKey="Leonetti C">C. Leonetti</name>
</author>
<author><name sortKey="Stoppacciaro, A" uniqKey="Stoppacciaro A">A. Stoppacciaro</name>
</author>
<author><name sortKey="D Razi, V" uniqKey="D Razi V">V. D’Orazi</name>
</author>
<author><name sortKey="Avantaggiati, M" uniqKey="Avantaggiati M">M. Avantaggiati</name>
</author>
<author><name sortKey="Crispini, A" uniqKey="Crispini A">A. Crispini</name>
</author>
<author><name sortKey="Pucci, D" uniqKey="Pucci D">D. Pucci</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garufi, A" uniqKey="Garufi A">A. Garufi</name>
</author>
<author><name sortKey="Pucci, D" uniqKey="Pucci D">D. Pucci</name>
</author>
<author><name sortKey="D Razi, V" uniqKey="D Razi V">V. D’Orazi</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
<author><name sortKey="Bossi, G" uniqKey="Bossi G">G. Bossi</name>
</author>
<author><name sortKey="Avantaggiati, M L" uniqKey="Avantaggiati M">M.L. Avantaggiati</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garufi, A" uniqKey="Garufi A">A. Garufi</name>
</author>
<author><name sortKey="D Razi, V" uniqKey="D Razi V">V. D’Orazi</name>
</author>
<author><name sortKey="Crispini, A" uniqKey="Crispini A">A. Crispini</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garufi, A" uniqKey="Garufi A">A. Garufi</name>
</author>
<author><name sortKey="Pistritto, G" uniqKey="Pistritto G">G. Pistritto</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Garufi, A" uniqKey="Garufi A">A. Garufi</name>
</author>
<author><name sortKey="Pistritto, G" uniqKey="Pistritto G">G. Pistritto</name>
</author>
<author><name sortKey="Baldari, S" uniqKey="Baldari S">S. Baldari</name>
</author>
<author><name sortKey="Toietta, G" uniqKey="Toietta G">G. Toietta</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thongrakard, V" uniqKey="Thongrakard V">V. Thongrakard</name>
</author>
<author><name sortKey="Titone, R" uniqKey="Titone R">R. Titone</name>
</author>
<author><name sortKey="Follo, C" uniqKey="Follo C">C. Follo</name>
</author>
<author><name sortKey="Morani, F" uniqKey="Morani F">F. Morani</name>
</author>
<author><name sortKey="Suksamrarn, A" uniqKey="Suksamrarn A">A. Suksamrarn</name>
</author>
<author><name sortKey="Tencomanao, T" uniqKey="Tencomanao T">T. Tencomanao</name>
</author>
<author><name sortKey="Isidoro, C" uniqKey="Isidoro C">C. Isidoro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Foggetti, G" uniqKey="Foggetti G">G. Foggetti</name>
</author>
<author><name sortKey="Ottaggio, L" uniqKey="Ottaggio L">L. Ottaggio</name>
</author>
<author><name sortKey="Russo, D" uniqKey="Russo D">D. Russo</name>
</author>
<author><name sortKey="Monti, P" uniqKey="Monti P">P. Monti</name>
</author>
<author><name sortKey="Degan, P" uniqKey="Degan P">P. Degan</name>
</author>
<author><name sortKey="Fronza, G" uniqKey="Fronza G">G. Fronza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wang, J" uniqKey="Wang J">J. Wang</name>
</author>
<author><name sortKey="Zhao, Q" uniqKey="Zhao Q">Q. Zhao</name>
</author>
<author><name sortKey="Qi, Q" uniqKey="Qi Q">Q. Qi</name>
</author>
<author><name sortKey="Gu, H Y" uniqKey="Gu H">H.Y. Gu</name>
</author>
<author><name sortKey="Rong, J J" uniqKey="Rong J">J.J. Rong</name>
</author>
<author><name sortKey="Mu, R" uniqKey="Mu R">R. Mu</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aggarwal, M" uniqKey="Aggarwal M">M. Aggarwal</name>
</author>
<author><name sortKey="Saxena, R" uniqKey="Saxena R">R. Saxena</name>
</author>
<author><name sortKey="Sinclair, E" uniqKey="Sinclair E">E. Sinclair</name>
</author>
<author><name sortKey="Fu, Y" uniqKey="Fu Y">Y. Fu</name>
</author>
<author><name sortKey="Jacobs, A" uniqKey="Jacobs A">A. Jacobs</name>
</author>
<author><name sortKey="Dyba, M" uniqKey="Dyba M">M. Dyba</name>
</author>
<author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name>
</author>
<author><name sortKey="Berry, D" uniqKey="Berry D">D. Berry</name>
</author>
<author><name sortKey="Kallakury, B" uniqKey="Kallakury B">B. Kallakury</name>
</author>
<author><name sortKey="Mueller, S C" uniqKey="Mueller S">S.C. Mueller</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Granato, M" uniqKey="Granato M">M. Granato</name>
</author>
<author><name sortKey="Gilardini Montani, M S" uniqKey="Gilardini Montani M">M.S. Gilardini Montani</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
<author><name sortKey="Faggioni, A" uniqKey="Faggioni A">A. Faggioni</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rodriguez, O C" uniqKey="Rodriguez O">O.C. Rodriguez</name>
</author>
<author><name sortKey="Choudhury, S" uniqKey="Choudhury S">S. Choudhury</name>
</author>
<author><name sortKey="Kolukula, V" uniqKey="Kolukula V">V. Kolukula</name>
</author>
<author><name sortKey="Vietsch, E E" uniqKey="Vietsch E">E.E. Vietsch</name>
</author>
<author><name sortKey="Catania, J" uniqKey="Catania J">J. Catania</name>
</author>
<author><name sortKey="Preet, A" uniqKey="Preet A">A. Preet</name>
</author>
<author><name sortKey="Reynoso, K" uniqKey="Reynoso K">K. Reynoso</name>
</author>
<author><name sortKey="Bargonetti, J" uniqKey="Bargonetti J">J. Bargonetti</name>
</author>
<author><name sortKey="Wellstein, A" uniqKey="Wellstein A">A. Wellstein</name>
</author>
<author><name sortKey="Albanese, C" uniqKey="Albanese C">C. Albanese</name>
</author>
<author><name sortKey="Avantaggiati, M L" uniqKey="Avantaggiati M">M.L. Avantaggiati</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vakifahmetoglu Norberg, H" uniqKey="Vakifahmetoglu Norberg H">H. Vakifahmetoglu-Norberg</name>
</author>
<author><name sortKey="Kim, M" uniqKey="Kim M">M. Kim</name>
</author>
<author><name sortKey="Xia, H G" uniqKey="Xia H">H.G. Xia</name>
</author>
<author><name sortKey="Iwanicki, M P" uniqKey="Iwanicki M">M.P. Iwanicki</name>
</author>
<author><name sortKey="Ofengeim, D" uniqKey="Ofengeim D">D. Ofengeim</name>
</author>
<author><name sortKey="Coloff, J L" uniqKey="Coloff J">J.L. Coloff</name>
</author>
<author><name sortKey="Pan, L" uniqKey="Pan L">L. Pan</name>
</author>
<author><name sortKey="Ince, T A" uniqKey="Ince T">T.A. Ince</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
<author><name sortKey="Brugge, J S" uniqKey="Brugge J">J.S. Brugge</name>
</author>
<author><name sortKey="Yuan, J" uniqKey="Yuan J">J. Yuan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baldari, S" uniqKey="Baldari S">S. Baldari</name>
</author>
<author><name sortKey="Ubertini, V" uniqKey="Ubertini V">V. Ubertini</name>
</author>
<author><name sortKey="Garufi, A" uniqKey="Garufi A">A. Garufi</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
<author><name sortKey="Bossi, G" uniqKey="Bossi G">G. Bossi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cordani, M" uniqKey="Cordani M">M. Cordani</name>
</author>
<author><name sortKey="Butera, G" uniqKey="Butera G">G. Butera</name>
</author>
<author><name sortKey="Pacchiana, R" uniqKey="Pacchiana R">R. Pacchiana</name>
</author>
<author><name sortKey="Donadelli, M" uniqKey="Donadelli M">M. Donadelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cordani, M" uniqKey="Cordani M">M. Cordani</name>
</author>
<author><name sortKey="Oppici, E" uniqKey="Oppici E">E. Oppici</name>
</author>
<author><name sortKey="Dando, I" uniqKey="Dando I">I. Dando</name>
</author>
<author><name sortKey="Buttirini, E" uniqKey="Buttirini E">E. Buttirini</name>
</author>
<author><name sortKey="Dalla Pozza, E" uniqKey="Dalla Pozza E">E. Dalla Pozza</name>
</author>
<author><name sortKey="Nadal Serrano, M" uniqKey="Nadal Serrano M">M. Nadal-Serrano</name>
</author>
<author><name sortKey="Oliver, J" uniqKey="Oliver J">J. Oliver</name>
</author>
<author><name sortKey="Roca, P" uniqKey="Roca P">P. Roca</name>
</author>
<author><name sortKey="Mariotto, S" uniqKey="Mariotto S">S. Mariotto</name>
</author>
<author><name sortKey="Cellini, B" uniqKey="Cellini B">B. Cellini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dando, I" uniqKey="Dando I">I. Dando</name>
</author>
<author><name sortKey="Cordani, M" uniqKey="Cordani M">M. Cordani</name>
</author>
<author><name sortKey="Donadelli, M" uniqKey="Donadelli M">M. Donadelli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wullschleger, S" uniqKey="Wullschleger S">S. Wullschleger</name>
</author>
<author><name sortKey="Loewith, R" uniqKey="Loewith R">R. Loewith</name>
</author>
<author><name sortKey="Hall, M N" uniqKey="Hall M">M.N. Hall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paquette, M" uniqKey="Paquette M">M. Paquette</name>
</author>
<author><name sortKey="El Houjeiri, L" uniqKey="El Houjeiri L">L. El-Houjeiri</name>
</author>
<author><name sortKey="Pause, A" uniqKey="Pause A">A. Pause</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kim, G G" uniqKey="Kim G">G.G. Kim</name>
</author>
<author><name sortKey="Buel, G R" uniqKey="Buel G">G.R. Buel</name>
</author>
<author><name sortKey="Blenis, J" uniqKey="Blenis J">J. Blenis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jewell, J L" uniqKey="Jewell J">J.L. Jewell</name>
</author>
<author><name sortKey="Guan, K L" uniqKey="Guan K">K.L. Guan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Catena, V" uniqKey="Catena V">V. Catena</name>
</author>
<author><name sortKey="Fanciulli, M" uniqKey="Fanciulli M">M. Fanciulli</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pietrocola, F" uniqKey="Pietrocola F">F. Pietrocola</name>
</author>
<author><name sortKey="Bravo San Pedro, J M" uniqKey="Bravo San Pedro J">J.M. Bravo-San Pedro</name>
</author>
<author><name sortKey="Galluzzi, L" uniqKey="Galluzzi L">L. Galluzzi</name>
</author>
<author><name sortKey="Kroemer, G" uniqKey="Kroemer G">G. Kroemer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Granato, M" uniqKey="Granato M">M. Granato</name>
</author>
<author><name sortKey="Rizzello, C" uniqKey="Rizzello C">C. Rizzello</name>
</author>
<author><name sortKey="Romeo, M A" uniqKey="Romeo M">M.A. Romeo</name>
</author>
<author><name sortKey="Yadav, S" uniqKey="Yadav S">S. Yadav</name>
</author>
<author><name sortKey="Santarelli, R" uniqKey="Santarelli R">R. Santarelli</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
<author><name sortKey="Faggioni, A" uniqKey="Faggioni A">A. Faggioni</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Masuelli, L" uniqKey="Masuelli L">L. Masuelli</name>
</author>
<author><name sortKey="Granato, M" uniqKey="Granato M">M. Granato</name>
</author>
<author><name sortKey="Benvenuto, M" uniqKey="Benvenuto M">M. Benvenuto</name>
</author>
<author><name sortKey="Mattera, R" uniqKey="Mattera R">R. Mattera</name>
</author>
<author><name sortKey="Bernardini, R" uniqKey="Bernardini R">R. Bernardini</name>
</author>
<author><name sortKey="Mattei, M" uniqKey="Mattei M">M. Mattei</name>
</author>
<author><name sortKey="D Mati, G" uniqKey="D Mati G">G. d’Amati</name>
</author>
<author><name sortKey="D Razi, G" uniqKey="D Razi G">G. D’Orazi</name>
</author>
<author><name sortKey="Faggioni, A" uniqKey="Faggioni A">A. Faggioni</name>
</author>
<author><name sortKey="Bei, R" uniqKey="Bei R">R. Bei</name>
</author>
<author><name sortKey="Cirone, M" uniqKey="Cirone M">M. Cirone</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, E" uniqKey="White E">E. White</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gurpinar, E" uniqKey="Gurpinar E">E. Gurpinar</name>
</author>
<author><name sortKey="Vousden, K H" uniqKey="Vousden K">K.H. Vousden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blandino, G" uniqKey="Blandino G">G. Blandino</name>
</author>
<author><name sortKey="Di Agostino, S" uniqKey="Di Agostino S">S. Di Agostino</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cancers (Basel)</journal-id>
<journal-id journal-id-type="iso-abbrev">Cancers (Basel)</journal-id>
<journal-id journal-id-type="publisher-id">cancers</journal-id>
<journal-title-group><journal-title>Cancers</journal-title>
</journal-title-group>
<issn pub-type="epub">2072-6694</issn>
<publisher><publisher-name>MDPI</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31052524</article-id>
<article-id pub-id-type="pmc">6563084</article-id>
<article-id pub-id-type="doi">10.3390/cancers11050614</article-id>
<article-id pub-id-type="publisher-id">cancers-11-00614</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review</subject>
</subj-group>
</article-categories>
<title-group><article-title>Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0001-6876-9105</contrib-id>
<name><surname>D’Orazi</surname>
<given-names>Gabriella</given-names>
</name>
<xref ref-type="aff" rid="af1-cancers-11-00614">1</xref>
<xref ref-type="aff" rid="af2-cancers-11-00614">2</xref>
<xref rid="c1-cancers-11-00614" ref-type="corresp">*</xref>
</contrib>
<contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="true">https://orcid.org/0000-0002-2207-9624</contrib-id>
<name><surname>Cirone</surname>
<given-names>Mara</given-names>
</name>
<xref ref-type="aff" rid="af3-cancers-11-00614">3</xref>
<xref ref-type="aff" rid="af4-cancers-11-00614">4</xref>
<xref rid="c1-cancers-11-00614" ref-type="corresp">*</xref>
</contrib>
</contrib-group>
<aff id="af1-cancers-11-00614"><label>1</label>
Department of Medical Sciences, University ‘G. d’Annunzio’, 66013 Chieti, Italy</aff>
<aff id="af2-cancers-11-00614"><label>2</label>
Department of Research, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy</aff>
<aff id="af3-cancers-11-00614"><label>3</label>
Department of Experimental Medicine, “Sapienza” University of Rome, 00185 Rome, Italy</aff>
<aff id="af4-cancers-11-00614"><label>4</label>
Laboratory Affiliated to Pasteur Institute, Italy-Foundation Cenci Bolognetti, 00161 Rome, Italy</aff>
<author-notes><corresp id="c1-cancers-11-00614"><label>*</label>
Correspondence: <email>gdorazi@unich.it</email>
(G.D.); <email>mara.cirone@uniroma1.it</email>
(M.C.)</corresp>
</author-notes>
<pub-date pub-type="epub"><day>02</day>
<month>5</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><month>5</month>
<year>2019</year>
</pub-date>
<volume>11</volume>
<issue>5</issue>
<elocation-id>614</elocation-id>
<history><date date-type="received"><day>16</day>
<month>4</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>01</day>
<month>5</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© 2019 by the authors.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access"><license-p>Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>
).</license-p>
</license>
</permissions>
<abstract><p>The capability of cancer cells to manage stress induced by hypoxia, nutrient shortage, acidosis, redox imbalance, loss of calcium homeostasis and exposure to drugs is a key factor to ensure cancer survival and chemoresistance. Among the protective mechanisms utilized by cancer cells to cope with stress a pivotal role is played by the activation of heat shock proteins (HSP) response, anti-oxidant response induced by nuclear factor erythroid 2-related factor 2 (NRF2), the hypoxia-inducible factor-1 (HIF-1), the unfolded protein response (UPR) and autophagy, cellular processes strictly interconnected. However, depending on the type, intensity or duration of cellular stress, the balance between pro-survival and pro-death pathways may change, and cell survival may be shifted into cell death. Mutations of p53 (mutp53), occurring in more than 50% of human cancers, may confer oncogenic gain-of-function (GOF) to the protein, mainly due to its stabilization and interaction with the above reported cellular pathways that help cancer cells to adapt to stress. This review will focus on the interplay of mutp53 with HSPs, NRF2, UPR, and autophagy and discuss how the manipulation of these interconnected processes may tip the balance towards cell death or survival, particularly in response to therapies.</p>
</abstract>
<kwd-group><kwd>mutant p53 (mutp53)</kwd>
<kwd>gain-of-function (GOF)</kwd>
<kwd>autophagy</kwd>
<kwd>endoplasmic reticulum (ER) stress</kwd>
<kwd>unfolded protein response (UPR)</kwd>
<kwd>antioxidant response</kwd>
<kwd>heat shock protein (HSP)</kwd>
<kwd>nuclear factor erythroid 2-related factor 2 (NRF2)</kwd>
<kwd>hypoxia-inducible factor 1 (HIF-1)</kwd>
<kwd>anticancer therapy</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="cancers-11-00614-f001" orientation="portrait" position="float"><label>Figure 1</label>
<caption><p>Mutant p53 and heat shock proteins (HSP) machinery. (<bold>a</bold>
) Mutp53 protein binds the cellular chaperone HSP90 that protects it from MDM2-dependent degradation. Activation of HSP90 includes deacetylation by HDAC6. Mutp53 stabilization is achieved also by the interaction with chaperone HSP40 and HSP70, that protect mutp53 from CHIP-mediated degradation and cooperate with HSP90 in stabilizing mutp53. The mutp53 hyperstability is necessary for mutp53 oncogenic functions (GOF). Inhibitors of HSP90 and HDAC6 are indicated and allow mutp53 degradation. (<bold>b</bold>
) HSP90 transcription is mediated by HSF1. Mutp53 interacts with activated p-Ser326 HSF1 stimulating its transcriptional activity toward HSP90. Then, HSP90 stabilizes mutp53 itself by inhibiting MDM2. Mutp53 drives enhanced recycling of EGFR to the cancer cell surface activating the MAPK and PI3K signaling cascade leading to HSF1 phosphoactivation.</p>
</caption>
<graphic xlink:href="cancers-11-00614-g001"></graphic>
</fig>
<fig id="cancers-11-00614-f002" orientation="portrait" position="float"><label>Figure 2</label>
<caption><p>Molecular mechanisms of ER stress unfolded protein response (UPR) pathways. Following internal or external stimuli that induce ER stress, BiP detaches from the three main sensors of UPR, localized at the ER membrane, and active them: inositol-requiring enzyme 1α (IRE1α), PKR-like ER kinase (PERK), and activating transcription factor 6 (ATF6). IRE1α activation induces XBP1(S) transcription factor, PERK phosphorylates and activates NRF2 and eIF2α, ATF6 is translocated to and is processed at the Golgi apparatus to create a highly active transcription factor. All three transcription factors upregulate chaperones and specific targets genes involved in protein folding, antioxidant response, autophagy, and apoptosis, to restore ER homeostasis or to induce cell death pathways. HSP90, which is involved in mutp53 stabilization, may modulate UPR through its association with the cytoplasmic domain of IRE1 and PERK. Mutp53 may activate HSF1 to promote HSP90 induction, highlighting a link between mup53, HSF1/HSP, and UPR.</p>
</caption>
<graphic xlink:href="cancers-11-00614-g002"></graphic>
</fig>
<fig id="cancers-11-00614-f003" orientation="portrait" position="float"><label>Figure 3</label>
<caption><p>Mutant p53 and the NRF2 signaling. (<bold>a</bold>
) NRF2 undergoes protein degradation following interaction with KEAP1 that can be released by oxidative stress and reactive oxygen species (ROS) generation or by p62- and p21-induced noncanonical KEAP1 degradation. (<bold>b</bold>
) Mutp53 may interact with NRF2 and bind the antioxidant response elements (ARE) of target genes and differentially modulate NRF2 transcriptional activity, increasing thioredoxin (TXN) and reducing NAD(P)H:quinone oxidoreductase 1 (NQO1) and heme oxygenase 1 (HO-1) expression.</p>
</caption>
<graphic xlink:href="cancers-11-00614-g003"></graphic>
</fig>
<fig id="cancers-11-00614-f004" orientation="portrait" position="float"><label>Figure 4</label>
<caption><p>Interplay between mutp53 and autophagy and the effect of mutp53 stability/degradation. (<bold>a</bold>
) Mutual interplay between autophagy and mutp53: autophagy degrades mutp53 and mutp53 inhibits autophagy counteracting its own elimination. (<bold>b</bold>
) Schematic representation of mutp53 GOF depending on mutp53 expression: the reduction of mutp53 expression (green triangle) reduces GOF while increased mutp53 expression (red triangle) increases GOF.</p>
</caption>
<graphic xlink:href="cancers-11-00614-g004"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>Italie</li>
</country>
<region><li>Latium</li>
</region>
<settlement><li>Rome</li>
</settlement>
</list>
<tree><country name="Italie"><noRegion><name sortKey="D Razi, Gabriella" sort="D Razi, Gabriella" uniqKey="D Razi G" first="Gabriella" last="D Razi">Gabriella D Razi</name>
</noRegion>
<name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name>
<name sortKey="Cirone, Mara" sort="Cirone, Mara" uniqKey="Cirone M" first="Mara" last="Cirone">Mara Cirone</name>
<name sortKey="D Razi, Gabriella" sort="D Razi, Gabriella" uniqKey="D Razi G" first="Gabriella" last="D Razi">Gabriella D Razi</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000588 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000588 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:6563084 |texte= Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:31052524" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |