Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking
Identifieur interne : 000522 ( Ncbi/Merge ); précédent : 000521; suivant : 000523Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking
Auteurs : Indra Mani ; Kailash N. PandeySource :
- Cellular signalling [ 0898-6568 ] ; 2019.
Abstract
Endocytosis is a prominent clathrin-mediated mechanism for concentrated uptake and internalization of ligand-receptor complexes, also known as cargo. Internalization of cargo is the fundamental mechanism for receptor-dependent regulation of cell membrane function, intracellular signal transduction, and neurotransmission, as well as other biological and physiological activities. However, the intrinsic mechanisms of receptor endocytosis and contemporaneous intracellular signaling are not well understood. We review emerging concepts of receptor endocytosis with concurrent intracellular signaling, using a typical example of guanylyl cyclase/natriuretic peptide receptor-A (NPRA) internalization, subcellular trafficking, and simultaneous generation of second-messenger cGMP and signaling in intact cells. We highlight the role of short-signal motifs located in the carboxyl-terminal regions of membrane receptors during their internalization and subsequent receptor trafficking in organelles that are not traditionally studied in this context, including nuclei and mitochondria. This review sheds light on the importance of future investigations of receptor endocytosis and trafficking in live cells and intact animals
Url:
DOI: 10.1016/j.cellsig.2019.03.022
PubMed: 30951863
PubMed Central: 6836728
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000390
- to stream Pmc, to step Curation: 000390
- to stream Pmc, to step Checkpoint: 000788
Links to Exploration step
PMC:6836728Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking</title>
<author><name sortKey="Mani, Indra" sort="Mani, Indra" uniqKey="Mani I" first="Indra" last="Mani">Indra Mani</name>
</author>
<author><name sortKey="Pandey, Kailash N" sort="Pandey, Kailash N" uniqKey="Pandey K" first="Kailash N." last="Pandey">Kailash N. Pandey</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">30951863</idno>
<idno type="pmc">6836728</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6836728</idno>
<idno type="RBID">PMC:6836728</idno>
<idno type="doi">10.1016/j.cellsig.2019.03.022</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000390</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000390</idno>
<idno type="wicri:Area/Pmc/Curation">000390</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000390</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000788</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000788</idno>
<idno type="wicri:Area/Ncbi/Merge">000522</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking</title>
<author><name sortKey="Mani, Indra" sort="Mani, Indra" uniqKey="Mani I" first="Indra" last="Mani">Indra Mani</name>
</author>
<author><name sortKey="Pandey, Kailash N" sort="Pandey, Kailash N" uniqKey="Pandey K" first="Kailash N." last="Pandey">Kailash N. Pandey</name>
</author>
</analytic>
<series><title level="j">Cellular signalling</title>
<idno type="ISSN">0898-6568</idno>
<idno type="eISSN">1873-3913</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Endocytosis is a prominent clathrin-mediated mechanism for concentrated uptake and internalization of ligand-receptor complexes, also known as cargo. Internalization of cargo is the fundamental mechanism for receptor-dependent regulation of cell membrane function, intracellular signal transduction, and neurotransmission, as well as other biological and physiological activities. However, the intrinsic mechanisms of receptor endocytosis and contemporaneous intracellular signaling are not well understood. We review emerging concepts of receptor endocytosis with concurrent intracellular signaling, using a typical example of guanylyl cyclase/natriuretic peptide receptor-A (NPRA) internalization, subcellular trafficking, and simultaneous generation of second-messenger cGMP and signaling in intact cells. We highlight the role of short-signal motifs located in the carboxyl-terminal regions of membrane receptors during their internalization and subsequent receptor trafficking in organelles that are not traditionally studied in this context, including nuclei and mitochondria. This review sheds light on the importance of future investigations of receptor endocytosis and trafficking in live cells and intact animals <italic>in vivo</italic>
in physiological context.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8904683</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1769</journal-id>
<journal-id journal-id-type="nlm-ta">Cell Signal</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell. Signal.</journal-id>
<journal-title-group><journal-title>Cellular signalling</journal-title>
</journal-title-group>
<issn pub-type="ppub">0898-6568</issn>
<issn pub-type="epub">1873-3913</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">30951863</article-id>
<article-id pub-id-type="pmc">6836728</article-id>
<article-id pub-id-type="doi">10.1016/j.cellsig.2019.03.022</article-id>
<article-id pub-id-type="manuscript">NIHMS1056240</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Mani</surname>
<given-names>Indra</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Pandey</surname>
<given-names>Kailash N.</given-names>
</name>
</contrib>
<aff id="A1">Department of Physiology, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, Louisiana 70112</aff>
</contrib-group>
<author-notes><corresp id="CR1"><bold>Address for correspondence</bold>
: Kailash N. Pandey, Department of Physiology, SL-39, Tulane University Health Sciences Center and School of Medicine, 1430 Tulane Avenue, New Orleans, LA, 70112, Tel: 504-988-1628; Fax: 504-988-2675; <email>kpandey@tulane.edu</email>
</corresp>
<fn fn-type="COI-statement" id="FN1"><p id="P36"><bold>Declarations of interest</bold>
: None</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>25</day>
<month>10</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>03</day>
<month>4</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="ppub"><month>8</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>07</day>
<month>11</month>
<year>2019</year>
</pub-date>
<volume>60</volume>
<fpage>17</fpage>
<lpage>30</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.cellsig.2019.03.022</pmc-comment>
<abstract id="ABS1"><p id="P1">Endocytosis is a prominent clathrin-mediated mechanism for concentrated uptake and internalization of ligand-receptor complexes, also known as cargo. Internalization of cargo is the fundamental mechanism for receptor-dependent regulation of cell membrane function, intracellular signal transduction, and neurotransmission, as well as other biological and physiological activities. However, the intrinsic mechanisms of receptor endocytosis and contemporaneous intracellular signaling are not well understood. We review emerging concepts of receptor endocytosis with concurrent intracellular signaling, using a typical example of guanylyl cyclase/natriuretic peptide receptor-A (NPRA) internalization, subcellular trafficking, and simultaneous generation of second-messenger cGMP and signaling in intact cells. We highlight the role of short-signal motifs located in the carboxyl-terminal regions of membrane receptors during their internalization and subsequent receptor trafficking in organelles that are not traditionally studied in this context, including nuclei and mitochondria. This review sheds light on the importance of future investigations of receptor endocytosis and trafficking in live cells and intact animals <italic>in vivo</italic>
in physiological context.</p>
</abstract>
<kwd-group><kwd>Membrane receptors</kwd>
<kwd>internalization</kwd>
<kwd>intracellular signaling</kwd>
<kwd>subcellular trafficking</kwd>
<kwd>short-signal motifs</kwd>
<kwd>guanylyl cyclase/natriuretic peptide receptor</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Mani, Indra" sort="Mani, Indra" uniqKey="Mani I" first="Indra" last="Mani">Indra Mani</name>
<name sortKey="Pandey, Kailash N" sort="Pandey, Kailash N" uniqKey="Pandey K" first="Kailash N." last="Pandey">Kailash N. Pandey</name>
</noCountry>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000522 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000522 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:6836728 |texte= Emerging concepts of receptor endocytosis and concurrent intracellular signaling: Mechanisms of guanylyl cyclase/natriuretic peptide receptor-A activation and trafficking }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:30951863" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |