ChloroquineV1, Ncbi, Merge, bibRecord, 000498

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Identifieur interne : 000498 ( Ncbi/Merge ); précédent : 000497; suivant : 000499

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

Auteurs : R Kanyanga Cimanga [Belgique] ; S Lumpu Nsaka ; M Ehata Tshodi ; B Maya Mbamu ; C Munduku Kikweta ; F Bool-Miting Makila ; Paul Cos [Belgique] ; Louis Maes [Belgique] ; Arnold J. Vlietinck [Belgique] ; Vassiliki Exarchou [Belgique] ; Emmy Tuenter [Belgique] ; Luc Pieters [Belgique]

Source :

Journal of ethnopharmacology [ 1872-7573 ] ; 2019.

RBID : pubmed:30763695

Descripteurs français

KwdFr :
- Alstonia, Animaux, Antipaludiques (pharmacologie), Antipaludiques (usage thérapeutique), Composés phytochimiques (analyse), Composés phytochimiques (pharmacologie), Composés phytochimiques (usage thérapeutique), Extraits de plantes (), Extraits de plantes (pharmacologie), Extraits de plantes (usage thérapeutique), Humains, Lignée cellulaire, Paludisme (parasitologie), Paludisme (traitement médicamenteux), Parasitémie (parasitologie), Parasitémie (traitement médicamenteux), Plasmodium (), Racines de plante, Souris, Écorce.
MESH :
- analyse : Composés phytochimiques.
- parasitologie : Paludisme, Parasitémie.
- pharmacologie : Antipaludiques, Composés phytochimiques, Extraits de plantes.
- traitement médicamenteux : Paludisme, Parasitémie.
- usage thérapeutique : Antipaludiques, Composés phytochimiques, Extraits de plantes.
- Alstonia, Animaux, Extraits de plantes, Humains, Lignée cellulaire, Plasmodium, Racines de plante, Souris, Écorce.

English descriptors

KwdEn :
- Alstonia, Animals, Antimalarials (pharmacology), Antimalarials (therapeutic use), Cell Line, Humans, Malaria (drug therapy), Malaria (parasitology), Mice, Parasitemia (drug therapy), Parasitemia (parasitology), Phytochemicals (analysis), Phytochemicals (pharmacology), Phytochemicals (therapeutic use), Plant Bark, Plant Extracts (chemistry), Plant Extracts (pharmacology), Plant Extracts (therapeutic use), Plant Roots, Plasmodium (drug effects).
MESH :
- chemical , analysis : Phytochemicals.
- chemical , chemistry : Plant Extracts.
- chemical , pharmacology : Antimalarials, Phytochemicals, Plant Extracts.
- chemical , therapeutic use : Antimalarials, Phytochemicals, Plant Extracts.
- drug effects : Plasmodium.
- drug therapy : Malaria, Parasitemia.
- parasitology : Malaria, Parasitemia.
- Alstonia, Animals, Cell Line, Humans, Mice, Plant Bark, Plant Roots.

Abstract

An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.

DOI: 10.1016/j.jep.2019.02.019
PubMed: 30763695

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to stream PubMed, to step Corpus: 000064
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pubmed:30763695

Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.</title>
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<author><name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name>
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<author><name sortKey="Exarchou, Vassiliki" sort="Exarchou, Vassiliki" uniqKey="Exarchou V" first="Vassiliki" last="Exarchou">Vassiliki Exarchou</name>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alstonia</term>
<term>Animals</term>
<term>Antimalarials (pharmacology)</term>
<term>Antimalarials (therapeutic use)</term>
<term>Cell Line</term>
<term>Humans</term>
<term>Malaria (drug therapy)</term>
<term>Malaria (parasitology)</term>
<term>Mice</term>
<term>Parasitemia (drug therapy)</term>
<term>Parasitemia (parasitology)</term>
<term>Phytochemicals (analysis)</term>
<term>Phytochemicals (pharmacology)</term>
<term>Phytochemicals (therapeutic use)</term>
<term>Plant Bark</term>
<term>Plant Extracts (chemistry)</term>
<term>Plant Extracts (pharmacology)</term>
<term>Plant Extracts (therapeutic use)</term>
<term>Plant Roots</term>
<term>Plasmodium (drug effects)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Alstonia</term>
<term>Animaux</term>
<term>Antipaludiques (pharmacologie)</term>
<term>Antipaludiques (usage thérapeutique)</term>
<term>Composés phytochimiques (analyse)</term>
<term>Composés phytochimiques (pharmacologie)</term>
<term>Composés phytochimiques (usage thérapeutique)</term>
<term>Extraits de plantes ()</term>
<term>Extraits de plantes (pharmacologie)</term>
<term>Extraits de plantes (usage thérapeutique)</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Paludisme (parasitologie)</term>
<term>Paludisme (traitement médicamenteux)</term>
<term>Parasitémie (parasitologie)</term>
<term>Parasitémie (traitement médicamenteux)</term>
<term>Plasmodium ()</term>
<term>Racines de plante</term>
<term>Souris</term>
<term>Écorce</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Phytochemicals</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimalarials</term>
<term>Phytochemicals</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antimalarials</term>
<term>Phytochemicals</term>
<term>Plant Extracts</term>
</keywords>
<keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Composés phytochimiques</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Plasmodium</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term>
<term>Parasitemia</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Paludisme</term>
<term>Parasitémie</term>
</keywords>
<keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Malaria</term>
<term>Parasitemia</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antipaludiques</term>
<term>Composés phytochimiques</term>
<term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term>
<term>Parasitémie</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antipaludiques</term>
<term>Composés phytochimiques</term>
<term>Extraits de plantes</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alstonia</term>
<term>Animals</term>
<term>Cell Line</term>
<term>Humans</term>
<term>Mice</term>
<term>Plant Bark</term>
<term>Plant Roots</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Alstonia</term>
<term>Animaux</term>
<term>Extraits de plantes</term>
<term>Humains</term>
<term>Lignée cellulaire</term>
<term>Plasmodium</term>
<term>Racines de plante</term>
<term>Souris</term>
<term>Écorce</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30763695</PMID>
<DateCompleted><Year>2020</Year>
<Month>01</Month>
<Day>28</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>01</Month>
<Day>28</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>242</Volume>
<PubDate><Year>2019</Year>
<Month>Oct</Month>
<Day>05</Day>
</PubDate>
</JournalIssue>
<Title>Journal of ethnopharmacology</Title>
<ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation>
</Journal>
<ArticleTitle>In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.</ArticleTitle>
<Pagination><MedlinePgn>111736</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0378-8741(18)34998-5</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2019.02.019</ELocationID>
<Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.</AbstractText>
<AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">Extracts of different polarity and isolated constituents were tested in vitro for their antiplasmodial activity against the chloroquine-resistant strain Plasmodium falciparum K1 and the chloroquine-sensitive strain P. falciparum NF54A19A, as well as for their cytotoxic effects againt MRC-5 cells (human lung fibroblasts). Extracts and fractions were evaluated in vivo against the chloroquine-resistant strain P. yoelii N67 and the chloroquine-sensitive strain P. berghei berghei ANKA.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The aqueous extract, the 80% methanol extract and the alkaloid-enriched extract exhibited strong antiplasmodial activity against P. falciparum K1 with IC<sub>50</sub>
 values < 10 µg/ml and against P. falciparum NF54 A19A with IC<sub>50</sub>
 values < 0.02 µg/ml. In vivo against P. yoelii N67, at the highest oral dose of 400 mg/kg body weight, all extracts produced 70-73% chemosuppression, while against P. berghei berghei, more than 75% chemosuppression was observed. With regard to the isolated constituents, boonein was inactive in vitro against P. falciparum K-1 (IC<sub>50</sub>
 > 64 µM), while echitamine, 6,7-seco-angustilobine B and β-amyrin exhibited moderate activity (IC<sub>50</sub>
 < 30 µM). Against P. falciparum NF54 A19A, boonein was inactive (IC<sub>50</sub>
 > 64 µM), while echitamine, 6,7-secoangustilobine and β-amyrin showed moderate IC<sub>50</sub>
 values of 11.07, 21.26 and 40.70 µM, respectively.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These results demonstrated that all extracts from A. congensis root bark possessed antiplasmodial activity in vitro and in vivo. They can be used as raw materials for the preparation of ameliorated remedies for the treatment of uncomplicated malaria. The observed antiplasmodial activity may be due in part to the presence of indole alkaloids.</AbstractText>
<CopyrightInformation>Copyright © 2019. Published by Elsevier B.V.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Cimanga</LastName>
<ForeName>R Kanyanga</ForeName>
<Initials>RK</Initials>
<AffiliationInfo><Affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo; Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium. Electronic address: kanyanga.cimanga@uantwerpen.be.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Nsaka</LastName>
<ForeName>S Lumpu</ForeName>
<Initials>SL</Initials>
<AffiliationInfo><Affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tshodi</LastName>
<ForeName>M Ehata</ForeName>
<Initials>ME</Initials>
<AffiliationInfo><Affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Mbamu</LastName>
<ForeName>B Maya</ForeName>
<Initials>BM</Initials>
<AffiliationInfo><Affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kikweta</LastName>
<ForeName>C Munduku</ForeName>
<Initials>CM</Initials>
<AffiliationInfo><Affiliation>Department of Medicinal Chemistry and Pharmacognosy, Laboratory of Pharmacognosy and Phytochemistry, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Makila</LastName>
<ForeName>F Bool-Miting</ForeName>
<Initials>FB</Initials>
<AffiliationInfo><Affiliation>Departement of Pharmacology and Pharmacovigilance, Faculty of Pharmaceutical Sciences, University of Kinshasa, P.O. Box 212, Kinshasa XI, Democratic Republic of Congo.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cos</LastName>
<ForeName>Paul</ForeName>
<Initials>P</Initials>
<AffiliationInfo><Affiliation>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Maes</LastName>
<ForeName>Louis</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Vlietinck</LastName>
<ForeName>Arnold J</ForeName>
<Initials>AJ</Initials>
<AffiliationInfo><Affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Exarchou</LastName>
<ForeName>Vassiliki</ForeName>
<Initials>V</Initials>
<AffiliationInfo><Affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Tuenter</LastName>
<ForeName>Emmy</ForeName>
<Initials>E</Initials>
<AffiliationInfo><Affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Pieters</LastName>
<ForeName>Luc</ForeName>
<Initials>L</Initials>
<AffiliationInfo><Affiliation>Natural Products & Food Research and Analysis (NatuRA), Department of Pharmaceutical Sciences, University of Antwerp, Universiteitsplein 1, B-2610 Antwerp, Belgium.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2019</Year>
<Month>02</Month>
<Day>11</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>Ireland</Country>
<MedlineTA>J Ethnopharmacol</MedlineTA>
<NlmUniqueID>7903310</NlmUniqueID>
<ISSNLinking>0378-8741</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000962">Antimalarials</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D064209">Phytochemicals</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D031051" MajorTopicYN="Y">Alstonia</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000962" MajorTopicYN="N">Antimalarials</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008288" MajorTopicYN="N">Malaria</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018512" MajorTopicYN="N">Parasitemia</DescriptorName>
<QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName>
<QualifierName UI="Q000469" MajorTopicYN="N">parasitology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D064209" MajorTopicYN="N">Phytochemicals</DescriptorName>
<QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D024301" MajorTopicYN="N">Plant Bark</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName>
<QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
<QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018517" MajorTopicYN="N">Plant Roots</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010961" MajorTopicYN="N">Plasmodium</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Alstonia congensis</Keyword>
<Keyword MajorTopicYN="N">Antiplasmodial activity</Keyword>
<Keyword MajorTopicYN="N">Apocynaceae</Keyword>
<Keyword MajorTopicYN="N">Malaria</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2018</Year>
<Month>12</Month>
<Day>27</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2019</Year>
<Month>01</Month>
<Day>29</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2019</Year>
<Month>02</Month>
<Day>10</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2019</Year>
<Month>2</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2020</Year>
<Month>1</Month>
<Day>29</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2019</Year>
<Month>2</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">30763695</ArticleId>
<ArticleId IdType="pii">S0378-8741(18)34998-5</ArticleId>
<ArticleId IdType="doi">10.1016/j.jep.2019.02.019</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Belgique</li>
</country>
<region><li>Province d'Anvers</li>
<li>Région flamande</li>
</region>
<settlement><li>Anvers</li>
</settlement>
<orgName><li>Université d'Anvers</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Kikweta, C Munduku" sort="Kikweta, C Munduku" uniqKey="Kikweta C" first="C Munduku" last="Kikweta">C Munduku Kikweta</name>
<name sortKey="Makila, F Bool Miting" sort="Makila, F Bool Miting" uniqKey="Makila F" first="F Bool-Miting" last="Makila">F Bool-Miting Makila</name>
<name sortKey="Mbamu, B Maya" sort="Mbamu, B Maya" uniqKey="Mbamu B" first="B Maya" last="Mbamu">B Maya Mbamu</name>
<name sortKey="Nsaka, S Lumpu" sort="Nsaka, S Lumpu" uniqKey="Nsaka S" first="S Lumpu" last="Nsaka">S Lumpu Nsaka</name>
<name sortKey="Tshodi, M Ehata" sort="Tshodi, M Ehata" uniqKey="Tshodi M" first="M Ehata" last="Tshodi">M Ehata Tshodi</name>
</noCountry>
<country name="Belgique"><noRegion><name sortKey="Cimanga, R Kanyanga" sort="Cimanga, R Kanyanga" uniqKey="Cimanga R" first="R Kanyanga" last="Cimanga">R Kanyanga Cimanga</name>
</noRegion>
<name sortKey="Cos, Paul" sort="Cos, Paul" uniqKey="Cos P" first="Paul" last="Cos">Paul Cos</name>
<name sortKey="Exarchou, Vassiliki" sort="Exarchou, Vassiliki" uniqKey="Exarchou V" first="Vassiliki" last="Exarchou">Vassiliki Exarchou</name>
<name sortKey="Maes, Louis" sort="Maes, Louis" uniqKey="Maes L" first="Louis" last="Maes">Louis Maes</name>
<name sortKey="Pieters, Luc" sort="Pieters, Luc" uniqKey="Pieters L" first="Luc" last="Pieters">Luc Pieters</name>
<name sortKey="Tuenter, Emmy" sort="Tuenter, Emmy" uniqKey="Tuenter E" first="Emmy" last="Tuenter">Emmy Tuenter</name>
<name sortKey="Vlietinck, Arnold J" sort="Vlietinck, Arnold J" uniqKey="Vlietinck A" first="Arnold J" last="Vlietinck">Arnold J. Vlietinck</name>
</country>
</tree>
</affiliations>
</record>

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In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

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