ChloroquineV1, Ncbi, Merge, bibRecord, 000363

[Dermatomyositis associated with anti-MDA5 antibodies and pneumocystis pneumonia: Two lethal cases].

Identifieur interne : 000363 ( Ncbi/Merge ); précédent : 000362; suivant : 000364

[Dermatomyositis associated with anti-MDA5 antibodies and pneumocystis pneumonia: Two lethal cases].

Auteurs : M. Aymonier [France] ; S. Abed [France] ; T. Boyé [France] ; H. Barazzutti [France] ; B. Fournier [France] ; J-J Morand [France]

Source :

Annales de dermatologie et de venereologie [ 0151-9638 ] ; 2017.

RBID : pubmed:27839728

Descripteurs français

English descriptors

KwdEn :
- Antibodies, Antinuclear (immunology), Autoantibodies (blood), Autoantibodies (immunology), Coinfection, Dermatomyositis (complications), Dermatomyositis (immunology), Disease Susceptibility, Fatal Outcome, Female, Humans, Immunocompromised Host, Immunosuppressive Agents (therapeutic use), Interferon-Induced Helicase, IFIH1 (blood), Interferon-Induced Helicase, IFIH1 (immunology), Male, Middle Aged, Pneumonia, Bacterial (diagnostic imaging), Pneumonia, Bacterial (etiology), Pneumonia, Pneumocystis (diagnostic imaging), Pneumonia, Pneumocystis (etiology), Prognosis, Pseudomonas Infections (diagnostic imaging), Pseudomonas Infections (etiology), Respiratory Distress Syndrome, Adult (etiology), Tomography, X-Ray Computed.
MESH :
- chemical , blood : Autoantibodies, Interferon-Induced Helicase, IFIH1.
- chemical , immunology : Antibodies, Antinuclear, Autoantibodies, Interferon-Induced Helicase, IFIH1.
- complications : Dermatomyositis.
- diagnostic imaging : Pneumonia, Bacterial, Pneumonia, Pneumocystis, Pseudomonas Infections.
- etiology : Pneumonia, Bacterial, Pneumonia, Pneumocystis, Pseudomonas Infections, Respiratory Distress Syndrome, Adult.
- immunology : Dermatomyositis.
- chemical , therapeutic use : Immunosuppressive Agents.
- Coinfection, Disease Susceptibility, Fatal Outcome, Female, Humans, Immunocompromised Host, Male, Middle Aged, Prognosis, Tomography, X-Ray Computed.

Abstract

Dermatomyositis associated with anti-MDA-5 autoantibodies is a recently-described clinical entity. Herein we report two lethal cases involving pneumocystis pneumonia.

DOI: 10.1016/j.annder.2016.09.677
PubMed: 27839728

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000188
to stream PubMed, to step Curation: 000188
to stream PubMed, to step Checkpoint: 000136

Links to Exploration step

pubmed:27839728

Le document en format XML

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<term>Autoantibodies (immunology)</term>
<term>Coinfection</term>
<term>Dermatomyositis (complications)</term>
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<term>Fatal Outcome</term>
<term>Female</term>
<term>Humans</term>
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<term>Immunosuppressive Agents (therapeutic use)</term>
<term>Interferon-Induced Helicase, IFIH1 (blood)</term>
<term>Interferon-Induced Helicase, IFIH1 (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pneumonia, Bacterial (diagnostic imaging)</term>
<term>Pneumonia, Bacterial (etiology)</term>
<term>Pneumonia, Pneumocystis (diagnostic imaging)</term>
<term>Pneumonia, Pneumocystis (etiology)</term>
<term>Prognosis</term>
<term>Pseudomonas Infections (diagnostic imaging)</term>
<term>Pseudomonas Infections (etiology)</term>
<term>Respiratory Distress Syndrome, Adult (etiology)</term>
<term>Tomography, X-Ray Computed</term>
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<term>Anticorps antinucléaires (immunologie)</term>
<term>Autoanticorps (immunologie)</term>
<term>Autoanticorps (sang)</term>
<term>Co-infection</term>
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<term>Dermatomyosite (immunologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hélicase  IFIH1 inductrice de l'interféron (immunologie)</term>
<term>Hélicase  IFIH1 inductrice de l'interféron (sang)</term>
<term>Immunosuppresseurs (usage thérapeutique)</term>
<term>Infections à Pseudomonas (imagerie diagnostique)</term>
<term>Infections à Pseudomonas (étiologie)</term>
<term>Issue fatale</term>
<term>Mâle</term>
<term>Pneumonie à Pneumocystis (imagerie diagnostique)</term>
<term>Pneumonie à Pneumocystis (étiologie)</term>
<term>Pneumopathie bactérienne (imagerie diagnostique)</term>
<term>Pneumopathie bactérienne (étiologie)</term>
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<term>Sujet immunodéprimé</term>
<term>Susceptibilité à une maladie</term>
<term>Syndrome de détresse respiratoire de l'adulte (étiologie)</term>
<term>Tomodensitométrie</term>
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<term>Interferon-Induced Helicase, IFIH1</term>
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<term>Interferon-Induced Helicase, IFIH1</term>
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<term>Pneumonia, Pneumocystis</term>
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<term>Autoanticorps</term>
<term>Dermatomyosite</term>
<term>Hélicase  IFIH1 inductrice de l'interféron</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Dermatomyositis</term>
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<term>Pneumopathie bactérienne</term>
<term>Syndrome de détresse respiratoire de l'adulte</term>
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<term>Disease Susceptibility</term>
<term>Fatal Outcome</term>
<term>Female</term>
<term>Humans</term>
<term>Immunocompromised Host</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Prognosis</term>
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<term>Co-infection</term>
<term>Dermatomyosite</term>
<term>Femelle</term>
<term>Humains</term>
<term>Issue fatale</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en">Dermatomyositis associated with anti-MDA-5 autoantibodies is a recently-described clinical entity. Herein we report two lethal cases involving pneumocystis pneumonia.</div>
</front>
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<DateCompleted><Year>2018</Year>
<Month>02</Month>
<Day>20</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>02</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0151-9638</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>144</Volume>
<Issue>4</Issue>
<PubDate><Year>2017</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Annales de dermatologie et de venereologie</Title>
<ISOAbbreviation>Ann Dermatol Venereol</ISOAbbreviation>
</Journal>
<ArticleTitle>[Dermatomyositis associated with anti-MDA5 antibodies and pneumocystis pneumonia: Two lethal cases].</ArticleTitle>
<Pagination><MedlinePgn>279-283</MedlinePgn>
</Pagination>
<ELocationID EIdType="pii" ValidYN="Y">S0151-9638(16)31090-0</ELocationID>
<ELocationID EIdType="doi" ValidYN="Y">10.1016/j.annder.2016.09.677</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Dermatomyositis associated with anti-MDA-5 autoantibodies is a recently-described clinical entity. Herein we report two lethal cases involving pneumocystis pneumonia.</AbstractText>
<AbstractText Label="PATIENTS AND METHODS" NlmCategory="METHODS">Case n<sup>o</sup>
 1. A 56-year-old male patient developed cutaneous symptoms consistent with dermatomyositis without muscular involvement. Antinuclear antibodies were present and anti-MDA5 auto-antibodies were identified. The scan showed interstitial lung disease without infection. Significant improvement was obtained with corticosteroids. One month later, the patient presented acute respiratory illness (hypoxemia: PaO<sub>2</sub>
 60mmHg, exacerbation of lung disease evidenced by a scan, and diagnosis of pneumocystis pneumonia on bronchoalveolar lavage). He died despite appropriate antibiotic therapy and immunosuppressant therapy. Case n<sup>o</sup>
 2. The second case concerned a 52-year-old Vietnamese man who developed more atypical cutaneous symptoms of dermatomyositis without muscular involvement. ANAb responses were positive (1/400) and MDA5 was present. The patient was treated with corticosteroids (40mg/d), hydroxychloroquine, and intravenous immunoglobulin. After significant improvement, the patient developed an acute respiratory illness due to superinfection with pneumocystis and he died despite specific treatment and cyclophosphamide bolus.</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In dermatomyositis, anti-MDA5 antibody screening is essential for the prognosis since the disease carries a risk of complication with severe lung disease. Bronchial fibroscopy with bronchoalveolar lavage should be considered at the time of diagnosis. Our two cases suggest the need for early screening for pneumocystis pneumonia in the event of respiratory distress and possibly for prophylactic treatment at the start of immunosuppressant therapy.</AbstractText>
<CopyrightInformation>Copyright © 2016 Elsevier Masson SAS. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Aymonier</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Service de dermatologie, hôpital militaire Ste-Anne, 83800 Toulon, France.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>S</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Service de dermatologie, hôpital militaire Ste-Anne, 83800 Toulon, France.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>T</ForeName>
<Initials>T</Initials>
<AffiliationInfo><Affiliation>Service de dermatologie, hôpital militaire Ste-Anne, 83800 Toulon, France.</Affiliation>
</AffiliationInfo>
</Author>
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<ForeName>H</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Service de pneumologie, hôpital militaire Ste-Anne, 83800 Toulon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Fournier</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Service de dermatologie, hôpital militaire Ste-Anne, 83800 Toulon, France.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Morand</LastName>
<ForeName>J-J</ForeName>
<Initials>JJ</Initials>
<AffiliationInfo><Affiliation>Service de dermatologie, hôpital militaire Ste-Anne, 83800 Toulon, France. Electronic address: morandjj@aol.com.</Affiliation>
</AffiliationInfo>
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<VernacularTitle>Dermatomyosite associée aux anticorps anti-MDA5 et pneumocystose pulmonaire : deux cas d’évolution fatale.</VernacularTitle>
<ArticleDate DateType="Electronic"><Year>2016</Year>
<Month>11</Month>
<Day>10</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>France</Country>
<MedlineTA>Ann Dermatol Venereol</MedlineTA>
<NlmUniqueID>7702013</NlmUniqueID>
<ISSNLinking>0151-9638</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D000974">Antibodies, Antinuclear</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001323">Autoantibodies</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.1.-</RegistryNumber>
<NameOfSubstance UI="C452815">IFIH1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>EC 3.6.4.13</RegistryNumber>
<NameOfSubstance UI="D000072640">Interferon-Induced Helicase, IFIH1</NameOfSubstance>
</Chemical>
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<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D060085" MajorTopicYN="N">Coinfection</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003882" MajorTopicYN="N">Dermatomyositis</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004198" MajorTopicYN="N">Disease Susceptibility</DescriptorName>
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<MeshHeading><DescriptorName UI="D017809" MajorTopicYN="N">Fatal Outcome</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016867" MajorTopicYN="N">Immunocompromised Host</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D000072640" MajorTopicYN="N">Interferon-Induced Helicase, IFIH1</DescriptorName>
<QualifierName UI="Q000097" MajorTopicYN="N">blood</QualifierName>
<QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName>
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<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018410" MajorTopicYN="N">Pneumonia, Bacterial</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011020" MajorTopicYN="N">Pneumonia, Pneumocystis</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011552" MajorTopicYN="N">Pseudomonas Infections</DescriptorName>
<QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012128" MajorTopicYN="N">Respiratory Distress Syndrome, Adult</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anti-MDA5 auto-antibodies</Keyword>
<Keyword MajorTopicYN="N">Anticorps anti-MDA5</Keyword>
<Keyword MajorTopicYN="N">Dermatomyosite</Keyword>
<Keyword MajorTopicYN="N">Dermatomyositis</Keyword>
<Keyword MajorTopicYN="N">Pneumocystis pneumonia</Keyword>
<Keyword MajorTopicYN="N">Pneumocystose pulmonaire</Keyword>
</KeywordList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year>
<Month>04</Month>
<Day>05</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="revised"><Year>2016</Year>
<Month>07</Month>
<Day>11</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="accepted"><Year>2016</Year>
<Month>09</Month>
<Day>21</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2016</Year>
<Month>11</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2018</Year>
<Month>2</Month>
<Day>21</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2016</Year>
<Month>11</Month>
<Day>15</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">27839728</ArticleId>
<ArticleId IdType="pii">S0151-9638(16)31090-0</ArticleId>
<ArticleId IdType="doi">10.1016/j.annder.2016.09.677</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Toulon</li>
</settlement>
</list>
<tree><country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Aymonier, M" sort="Aymonier, M" uniqKey="Aymonier M" first="M" last="Aymonier">M. Aymonier</name>
</region>
<name sortKey="Abed, S" sort="Abed, S" uniqKey="Abed S" first="S" last="Abed">S. Abed</name>
<name sortKey="Barazzutti, H" sort="Barazzutti, H" uniqKey="Barazzutti H" first="H" last="Barazzutti">H. Barazzutti</name>
<name sortKey="Boye, T" sort="Boye, T" uniqKey="Boye T" first="T" last="Boyé">T. Boyé</name>
<name sortKey="Fournier, B" sort="Fournier, B" uniqKey="Fournier B" first="B" last="Fournier">B. Fournier</name>
<name sortKey="Morand, J J" sort="Morand, J J" uniqKey="Morand J" first="J-J" last="Morand">J-J Morand</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   [Dermatomyositis associated with anti-MDA5 antibodies and pneumocystis pneumonia: Two lethal cases].
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[Dermatomyositis associated with anti-MDA5 antibodies and pneumocystis pneumonia: Two lethal cases].

[Dermatomyositis associated with anti-MDA5 antibodies and pneumocystis pneumonia: Two lethal cases].

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