ChloroquineV1, Ncbi, Merge, bibRecord, 000360

Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion.

Identifieur interne : 000360 ( Ncbi/Merge ); précédent : 000359; suivant : 000361

Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion.

Auteurs : Qian Li [République populaire de Chine] ; Dong-Mei Yuan [République populaire de Chine] ; Li-Hong Ma [République populaire de Chine] ; Chen-Hui Ma [République populaire de Chine] ; Ya-Fang Liu [République populaire de Chine] ; Tang-Feng Lv [République populaire de Chine] ; Yong Song [République populaire de Chine]

Source :

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [ 1423-0380 ] ; 2016.

RBID : pubmed:27771855

Abstract

Malignant pleural effusion (MPE) is associated with a poor prognosis in lung cancer. Currently, no effective cure exists for MPE. Chloroquine (CQ) has been demonstrated to induce vascular normalization and inhibit tumor growth. The aim of this study was to assess whether CQ affects MPE. The xenografts mice were divided into normal saline (NS), CQ, or bevacizumab (BE) group. Tumor growth and microvascular density (MVD) were monitored. We explored the effect of CQ on the proliferation, survival, and proangiogenic signaling of tumor cells in vitro. We further evaluated the effects of CQ on the viability, migration, and tube formation of human umbilical vein endothelial cells (HUVECs). A chicken chorioallantoic membrane (CAM) model was used to elucidate the effects of CQ on angiogenesis. Finally, an MPE mouse model were treated by CQ, BE, or NS. The volume of pleural effusion, tumor foci, and MVD was evaluated. CQ therapy group exhibited decreased tumor volume, tumor weight, and MVD in the mouse xenografts. CQ inhibited the proliferation of the tumor cells. However, the expression of vascular endothelial growth factor was not affected. Additionally, CQ inhibited the proliferation, migration, and tube formation of HUVECs and also restrained angiogenesis in the CAM. Western blot showed that CQ might suppress angiogenesis by downregulating p-Akt, Jagged1, and Ang2 in HUVECs. In MPE mice, the volume of the pleural effusion, the number of pleural tumor foci, and the MVD were significantly reduced in the CQ group. Our work demonstrated that CQ played the role of an efficient treatment for MPE.

DOI: 10.1007/s13277-016-5441-z
PubMed: 27771855

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Malignant pleural effusion (MPE) is associated with a poor prognosis in lung cancer. Currently, no effective cure exists for MPE. Chloroquine (CQ) has been demonstrated to induce vascular normalization and inhibit tumor growth. The aim of this study was to assess whether CQ affects MPE. The xenografts mice were divided into normal saline (NS), CQ, or bevacizumab (BE) group. Tumor growth and microvascular density (MVD) were monitored. We explored the effect of CQ on the proliferation, survival, and proangiogenic signaling of tumor cells in vitro. We further evaluated the effects of CQ on the viability, migration, and tube formation of human umbilical vein endothelial cells (HUVECs). A chicken chorioallantoic membrane (CAM) model was used to elucidate the effects of CQ on angiogenesis. Finally, an MPE mouse model were treated by CQ, BE, or NS. The volume of pleural effusion, tumor foci, and MVD was evaluated. CQ therapy group exhibited decreased tumor volume, tumor weight, and MVD in the mouse xenografts. CQ inhibited the proliferation of the tumor cells. However, the expression of vascular endothelial growth factor was not affected. Additionally, CQ inhibited the proliferation, migration, and tube formation of HUVECs and also restrained angiogenesis in the CAM. Western blot showed that CQ might suppress angiogenesis by downregulating p-Akt, Jagged1, and Ang2 in HUVECs. In MPE mice, the volume of the pleural effusion, the number of pleural tumor foci, and the MVD were significantly reduced in the CQ group. Our work demonstrated that CQ played the role of an efficient treatment for MPE.</div>
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<ArticleTitle>Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion.</ArticleTitle>
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<Abstract><AbstractText>Malignant pleural effusion (MPE) is associated with a poor prognosis in lung cancer. Currently, no effective cure exists for MPE. Chloroquine (CQ) has been demonstrated to induce vascular normalization and inhibit tumor growth. The aim of this study was to assess whether CQ affects MPE. The xenografts mice were divided into normal saline (NS), CQ, or bevacizumab (BE) group. Tumor growth and microvascular density (MVD) were monitored. We explored the effect of CQ on the proliferation, survival, and proangiogenic signaling of tumor cells in vitro. We further evaluated the effects of CQ on the viability, migration, and tube formation of human umbilical vein endothelial cells (HUVECs). A chicken chorioallantoic membrane (CAM) model was used to elucidate the effects of CQ on angiogenesis. Finally, an MPE mouse model were treated by CQ, BE, or NS. The volume of pleural effusion, tumor foci, and MVD was evaluated. CQ therapy group exhibited decreased tumor volume, tumor weight, and MVD in the mouse xenografts. CQ inhibited the proliferation of the tumor cells. However, the expression of vascular endothelial growth factor was not affected. Additionally, CQ inhibited the proliferation, migration, and tube formation of HUVECs and also restrained angiogenesis in the CAM. Western blot showed that CQ might suppress angiogenesis by downregulating p-Akt, Jagged1, and Ang2 in HUVECs. In MPE mice, the volume of the pleural effusion, the number of pleural tumor foci, and the MVD were significantly reduced in the CQ group. Our work demonstrated that CQ played the role of an efficient treatment for MPE.</AbstractText>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Clin Lung Cancer. 2014 Sep;15(5):379-86</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24913066</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Drug Discov. 2006 Mar;5(3):219-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16518375</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respiration. 2012;83(4):277-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22456231</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Thorac Dis. 2015 Jun;7(6):1009-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">26150914</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Biochem Pharmacol. 2000 May 15;59(10):1245-52</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10736425</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2012 Sep 15;186(6):487-92</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22652027</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncol Rep. 2004 Oct;12(4):849-53</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15375511</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Exp Dermatol. 2009 Jul;34(5):570-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19077101</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Cancer. 2008 Apr;8(4):309-16</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18337733</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur J Pharmacol. 2009 Dec 25;625(1-3):220-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19836374</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2014 Mar 15;189(6):697-706</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24410406</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Lancet Oncol. 2010 Apr;11(4):373-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20171141</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Res. 2012 Apr 1;72(7):1773-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22447568</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Med Res Opin. 2015 May;31(5):1009-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25734693</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>FASEB J. 2002 Nov;16(13):1802-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12354694</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Opin Cell Biol. 2010 Apr;22(2):177-80</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20022734</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Mayo Clin Proc. 2008 Feb;83(2):235-50</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18241636</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2014 Aug 11;26(2):190-206</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25117709</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nat Rev Drug Discov. 2011 Jun;10(6):417-27</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21629292</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2014 Nov 10;26(5):605-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25517747</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respirology. 2011 Jan;16(1):53-63</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21044230</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Neuro Oncol. 2010 Apr;12(4):389-400</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20308316</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Pathol. 2000 Dec;157(6):1893-903</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11106562</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Immunol. 1997 Feb 15;158(4):1872-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9029128</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS One. 2013 Nov 11;8(11):e79658</Citation>
<ArticleIdList><ArticleId IdType="pubmed">24244540</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cancer Cell. 2012 Jan 17;21(1):66-81</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22264789</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Oncogene. 2004 Apr 12;23(16):2881-90</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15077151</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Clin Invest. 2015 Jun;125(6):2317-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">25915587</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Ann Oncol. 2006 Dec;17(12):1853</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16790519</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Cell. 2011 Sep 16;146(6):873-87</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21925313</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Nature. 1972 Jan 7;235(5332):50-2</Citation>
<ArticleIdList><ArticleId IdType="pubmed">4550396</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
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<affiliations><list><country><li>République populaire de Chine</li>
</country>
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<tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Qian" sort="Li, Qian" uniqKey="Li Q" first="Qian" last="Li">Qian Li</name>
</noRegion>
<name sortKey="Liu, Ya Fang" sort="Liu, Ya Fang" uniqKey="Liu Y" first="Ya-Fang" last="Liu">Ya-Fang Liu</name>
<name sortKey="Lv, Tang Feng" sort="Lv, Tang Feng" uniqKey="Lv T" first="Tang-Feng" last="Lv">Tang-Feng Lv</name>
<name sortKey="Ma, Chen Hui" sort="Ma, Chen Hui" uniqKey="Ma C" first="Chen-Hui" last="Ma">Chen-Hui Ma</name>
<name sortKey="Ma, Li Hong" sort="Ma, Li Hong" uniqKey="Ma L" first="Li-Hong" last="Ma">Li-Hong Ma</name>
<name sortKey="Song, Yong" sort="Song, Yong" uniqKey="Song Y" first="Yong" last="Song">Yong Song</name>
<name sortKey="Yuan, Dong Mei" sort="Yuan, Dong Mei" uniqKey="Yuan D" first="Dong-Mei" last="Yuan">Dong-Mei Yuan</name>
</country>
</tree>
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	Serveur d'exploration Chloroquine
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Serveur d'exploration Chloroquine

Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion.

Chloroquine inhibits tumor growth and angiogenesis in malignant pleural effusion.

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Abstract

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