ChloroquineV1, Ncbi, Merge, bibRecord, 000227

The expression and relaxant effect of bitter taste receptors in human bronchi.

Identifieur interne : 000227 ( Ncbi/Merge ); précédent : 000226; suivant : 000228

The expression and relaxant effect of bitter taste receptors in human bronchi.

Auteurs : Stanislas Grassin-Delyle [France] ; Charlotte Abrial ; Sarah Fayad-Kobeissi ; Marion Brollo ; Christophe Faisy ; Jean-Claude Alvarez ; Emmanuel Naline ; Philippe Devillier

Source :

Respiratory research [ 1465-993X ] ; 2013.

RBID : pubmed:24266887

Descripteurs français

English descriptors

KwdEn :
- Adult, Aged, Aged, 80 and over, Bronchi (drug effects), Bronchi (metabolism), Bronchoconstriction (drug effects), Bronchoconstriction (physiology), Bronchodilator Agents (metabolism), Caffeine (pharmacology), Chloroquine (pharmacology), Female, Humans, Male, Middle Aged, Piperidines (pharmacology), Receptors, Cell Surface (agonists), Receptors, Cell Surface (drug effects), Receptors, Cell Surface (metabolism), Receptors, G-Protein-Coupled (agonists), Receptors, G-Protein-Coupled (drug effects), Receptors, G-Protein-Coupled (metabolism), Signal Transduction (drug effects), Signal Transduction (physiology), Strychnine (pharmacology), Taste (physiology).
MESH :
- chemical , agonists : Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- chemical , drug effects : Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- chemical , metabolism : Bronchodilator Agents, Receptors, Cell Surface, Receptors, G-Protein-Coupled.
- drug effects : Bronchi, Bronchoconstriction, Signal Transduction.
- metabolism : Bronchi.
- chemical , pharmacology : Caffeine, Chloroquine, Piperidines, Strychnine.
- physiology : Bronchoconstriction, Signal Transduction, Taste.
- Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged.

Abstract

Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood leucocytes from asthmatic children. We sought to identify and characterize the TAS2Rs expressed in isolated human bronchi and the subtypes involved in relaxation.

DOI: 10.1186/1465-9921-14-134
PubMed: 24266887

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 000314
to stream PubMed, to step Curation: 000314
to stream PubMed, to step Checkpoint: 000312

Links to Exploration step

pubmed:24266887

Le document en format XML

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<author><name sortKey="Alvarez, Jean Claude" sort="Alvarez, Jean Claude" uniqKey="Alvarez J" first="Jean-Claude" last="Alvarez">Jean-Claude Alvarez</name>
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<term>Bronchi (metabolism)</term>
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<term>Bronchoconstriction (physiology)</term>
<term>Bronchodilator Agents (metabolism)</term>
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<term>Receptors, G-Protein-Coupled (drug effects)</term>
<term>Receptors, G-Protein-Coupled (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Signal Transduction (physiology)</term>
<term>Strychnine (pharmacology)</term>
<term>Taste (physiology)</term>
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<term>Adulte d'âge moyen</term>
<term>Bronches ()</term>
<term>Bronches (métabolisme)</term>
<term>Bronchoconstriction ()</term>
<term>Bronchoconstriction (physiologie)</term>
<term>Bronchodilatateurs (métabolisme)</term>
<term>Caféine (pharmacologie)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Femelle</term>
<term>Goût (physiologie)</term>
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<term>Pipéridines (pharmacologie)</term>
<term>Récepteurs couplés aux protéines G ()</term>
<term>Récepteurs couplés aux protéines G (agonistes)</term>
<term>Récepteurs couplés aux protéines G (métabolisme)</term>
<term>Récepteurs de surface cellulaire ()</term>
<term>Récepteurs de surface cellulaire (agonistes)</term>
<term>Récepteurs de surface cellulaire (métabolisme)</term>
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<term>Sujet âgé de 80 ans ou plus</term>
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<term>Transduction du signal (physiologie)</term>
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<term>Receptors, G-Protein-Coupled</term>
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<term>Récepteurs de surface cellulaire</term>
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<term>Bronchoconstriction</term>
<term>Signal Transduction</term>
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<term>Bronchodilatateurs</term>
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<term>Récepteurs de surface cellulaire</term>
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<term>Chloroquine</term>
<term>Pipéridines</term>
<term>Strychnine</term>
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<term>Chloroquine</term>
<term>Piperidines</term>
<term>Strychnine</term>
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<term>Goût</term>
<term>Transduction du signal</term>
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<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bronchoconstriction</term>
<term>Signal Transduction</term>
<term>Taste</term>
</keywords>
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<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
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<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Bronches</term>
<term>Bronchoconstriction</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Récepteurs couplés aux protéines G</term>
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<front><div type="abstract" xml:lang="en">Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood leucocytes from asthmatic children. We sought to identify and characterize the TAS2Rs expressed in isolated human bronchi and the subtypes involved in relaxation.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24266887</PMID>
<DateCompleted><Year>2014</Year>
<Month>07</Month>
<Day>08</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1465-993X</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>14</Volume>
<PubDate><Year>2013</Year>
<Month>Nov</Month>
<Day>22</Day>
</PubDate>
</JournalIssue>
<Title>Respiratory research</Title>
<ISOAbbreviation>Respir. Res.</ISOAbbreviation>
</Journal>
<ArticleTitle>The expression and relaxant effect of bitter taste receptors in human bronchi.</ArticleTitle>
<Pagination><MedlinePgn>134</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/1465-9921-14-134</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Bitter-taste receptors (TAS2Rs) have recently been involved in the relaxation of mouse and guinea pig airways, and increased expression of TAS2Rs was shown in blood leucocytes from asthmatic children. We sought to identify and characterize the TAS2Rs expressed in isolated human bronchi and the subtypes involved in relaxation.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Human bronchi were isolated from resected lungs and TAS2R transcripts were assessed with RT-qPCR. Relaxation to TAS2R agonists was tested in organ bath in the presence or absence of pharmacological modulators of the signalling pathways involved in bronchial relaxation.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">We detected the expression of TAS2R transcripts in human bronchi. The non-selective agonists chloroquine, quinine, caffeine, strychnine and diphenidol produced a bronchial relaxation as effective and potent as theophylline but much less potent than formoterol and isoproterenol. Denatonium, saccharin and colchicine did not produce relaxation. Receptor expression analysis together with the use of selective agonists suggest a predominant role for TAS2R5, 10 and 14 in bitter taste agonist-induced relaxation. The mechanism of relaxation was independent of the signalling pathways modulated by conventional bronchodilators and may be partly explained by the inhibition of phosphatidylinositol-3-kinases.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The TAS2Rs may constitute a new therapeutic target in chronic obstructive lung diseases such as asthma.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Grassin-Delyle</LastName>
<ForeName>Stanislas</ForeName>
<Initials>S</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Pharmacologie Respiratoire UPRES EA220, Hôpital Foch, 11 rue Guillaume Lenoir, F-92150 Suresnes, Paris, France. s.grassindelyle@hopital-foch.org.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Abrial</LastName>
<ForeName>Charlotte</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fayad-Kobeissi</LastName>
<ForeName>Sarah</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Brollo</LastName>
<ForeName>Marion</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Faisy</LastName>
<ForeName>Christophe</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Alvarez</LastName>
<ForeName>Jean-Claude</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Naline</LastName>
<ForeName>Emmanuel</ForeName>
<Initials>E</Initials>
</Author>
<Author ValidYN="Y"><LastName>Devillier</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType>
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<ArticleDate DateType="Electronic"><Year>2013</Year>
<Month>11</Month>
<Day>22</Day>
</ArticleDate>
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<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Respir Res</MedlineTA>
<NlmUniqueID>101090633</NlmUniqueID>
<ISSNLinking>1465-9921</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D001993">Bronchodilator Agents</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D010880">Piperidines</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D043562">Receptors, G-Protein-Coupled</NameOfSubstance>
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<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="C568609">TAS2R1 protein, human</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>3G6A5W338E</RegistryNumber>
<NameOfSubstance UI="D002110">Caffeine</NameOfSubstance>
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<Chemical><RegistryNumber>886U3H6UFF</RegistryNumber>
<NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>H9Y79VD43J</RegistryNumber>
<NameOfSubstance UI="D013331">Strychnine</NameOfSubstance>
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<Chemical><RegistryNumber>NQO8R319LY</RegistryNumber>
<NameOfSubstance UI="C004858">diphenidol</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001980" MajorTopicYN="N">Bronchi</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016084" MajorTopicYN="N">Bronchoconstriction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D001993" MajorTopicYN="N">Bronchodilator Agents</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002110" MajorTopicYN="N">Caffeine</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010880" MajorTopicYN="N">Piperidines</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011956" MajorTopicYN="N">Receptors, Cell Surface</DescriptorName>
<QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D043562" MajorTopicYN="N">Receptors, G-Protein-Coupled</DescriptorName>
<QualifierName UI="Q000819" MajorTopicYN="N">agonists</QualifierName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName>
<QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013331" MajorTopicYN="N">Strychnine</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013649" MajorTopicYN="N">Taste</DescriptorName>
<QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName>
</MeshHeading>
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The expression and relaxant effect of bitter taste receptors in human bronchi.

The expression and relaxant effect of bitter taste receptors in human bronchi.

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