Antiprotozoal screening and cytotoxicity of extracts and fractions from the leaves, stem bark and root bark of Alstonia congensis.
Identifieur interne : 000200 ( Ncbi/Merge ); précédent : 000199; suivant : 000201Antiprotozoal screening and cytotoxicity of extracts and fractions from the leaves, stem bark and root bark of Alstonia congensis.
Auteurs : S L Lumpu ; C M Kikueta ; M E Tshodi ; A P Mbenza ; O K Kambu ; B M Mbamu ; P. Cos ; L. Maes ; S. Apers ; L. Pieters ; R K CimangaSource :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2013.
Descripteurs français
- KwdFr :
- Alstonia (), Antiprotozoaires (), Antiprotozoaires (pharmacologie), Concentration inhibitrice 50, Ethnopharmacologie (), Extraits de plantes (), Extraits de plantes (pharmacologie), Fibroblastes (), Humains, Leishmania infantum (), Lignée cellulaire, Phytothérapie (), Plasmodium falciparum (), Poumon (), Tests de sensibilité parasitaire (), Trypanosoma brucei brucei (), Trypanosoma cruzi ().
- MESH :
- pharmacologie : Antiprotozoaires, Extraits de plantes.
- Alstonia, Antiprotozoaires, Concentration inhibitrice 50, Ethnopharmacologie, Extraits de plantes, Fibroblastes, Humains, Leishmania infantum, Lignée cellulaire, Phytothérapie, Plasmodium falciparum, Poumon, Tests de sensibilité parasitaire, Trypanosoma brucei brucei, Trypanosoma cruzi.
English descriptors
- KwdEn :
- Alstonia (chemistry), Antiprotozoal Agents (chemistry), Antiprotozoal Agents (pharmacology), Cell Line, Ethnopharmacology (methods), Fibroblasts (drug effects), Humans, Inhibitory Concentration 50, Leishmania infantum (drug effects), Lung (drug effects), Parasitic Sensitivity Tests (methods), Phytotherapy (methods), Plant Extracts (chemistry), Plant Extracts (pharmacology), Plasmodium falciparum (drug effects), Trypanosoma brucei brucei (drug effects), Trypanosoma cruzi (drug effects).
- MESH :
- chemical , chemistry : Antiprotozoal Agents, Plant Extracts.
- chemistry : Alstonia.
- drug effects : Fibroblasts, Leishmania infantum, Lung, Plasmodium falciparum, Trypanosoma brucei brucei, Trypanosoma cruzi.
- methods : Ethnopharmacology, Parasitic Sensitivity Tests, Phytotherapy.
- chemical , pharmacology : Antiprotozoal Agents, Plant Extracts.
- Cell Line, Humans, Inhibitory Concentration 50.
Abstract
To evaluate the antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Alstonia congensis (Apocynaceae), used in traditional medicine against parasitic diseases.
DOI: 10.1016/j.jep.2013.04.016
PubMed: 23612422
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Cos</name></author><author><name sortKey="Maes, L" sort="Maes, L" uniqKey="Maes L" first="L" last="Maes">L. Maes</name></author><author><name sortKey="Apers, S" sort="Apers, S" uniqKey="Apers S" first="S" last="Apers">S. Apers</name></author><author><name sortKey="Pieters, L" sort="Pieters, L" uniqKey="Pieters L" first="L" last="Pieters">L. Pieters</name></author><author><name sortKey="Cimanga, R K" sort="Cimanga, R K" uniqKey="Cimanga R" first="R K" last="Cimanga">R K Cimanga</name></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alstonia (chemistry)</term><term>Antiprotozoal Agents (chemistry)</term><term>Antiprotozoal Agents (pharmacology)</term><term>Cell Line</term><term>Ethnopharmacology (methods)</term><term>Fibroblasts (drug effects)</term><term>Humans</term><term>Inhibitory Concentration 50</term><term>Leishmania infantum (drug effects)</term><term>Lung (drug effects)</term><term>Parasitic Sensitivity Tests (methods)</term><term>Phytotherapy (methods)</term><term>Plant Extracts (chemistry)</term><term>Plant Extracts (pharmacology)</term><term>Plasmodium falciparum (drug effects)</term><term>Trypanosoma brucei brucei (drug effects)</term><term>Trypanosoma cruzi (drug effects)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alstonia ()</term><term>Antiprotozoaires ()</term><term>Antiprotozoaires (pharmacologie)</term><term>Concentration inhibitrice 50</term><term>Ethnopharmacologie ()</term><term>Extraits de plantes ()</term><term>Extraits de plantes (pharmacologie)</term><term>Fibroblastes ()</term><term>Humains</term><term>Leishmania infantum ()</term><term>Lignée cellulaire</term><term>Phytothérapie ()</term><term>Plasmodium falciparum ()</term><term>Poumon ()</term><term>Tests de sensibilité parasitaire ()</term><term>Trypanosoma brucei brucei ()</term><term>Trypanosoma cruzi ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Antiprotozoal Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Alstonia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Fibroblasts</term><term>Leishmania infantum</term><term>Lung</term><term>Plasmodium falciparum</term><term>Trypanosoma brucei brucei</term><term>Trypanosoma cruzi</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Ethnopharmacology</term><term>Parasitic Sensitivity Tests</term><term>Phytotherapy</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Antiprotozoaires</term><term>Extraits de plantes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antiprotozoal Agents</term><term>Plant Extracts</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cell Line</term><term>Humans</term><term>Inhibitory Concentration 50</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alstonia</term><term>Antiprotozoaires</term><term>Concentration inhibitrice 50</term><term>Ethnopharmacologie</term><term>Extraits de plantes</term><term>Fibroblastes</term><term>Humains</term><term>Leishmania infantum</term><term>Lignée cellulaire</term><term>Phytothérapie</term><term>Plasmodium falciparum</term><term>Poumon</term><term>Tests de sensibilité parasitaire</term><term>Trypanosoma brucei brucei</term><term>Trypanosoma cruzi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To evaluate the antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Alstonia congensis (Apocynaceae), used in traditional medicine against parasitic diseases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23612422</PMID><DateCompleted><Year>2014</Year><Month>03</Month><Day>05</Day></DateCompleted><DateRevised><Year>2013</Year><Month>06</Month><Day>24</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-7573</ISSN><JournalIssue CitedMedium="Internet"><Volume>148</Volume><Issue>2</Issue><PubDate><Year>2013</Year><Month>Jul</Month><Day>09</Day></PubDate></JournalIssue><Title>Journal of ethnopharmacology</Title><ISOAbbreviation>J Ethnopharmacol</ISOAbbreviation></Journal><ArticleTitle>Antiprotozoal screening and cytotoxicity of extracts and fractions from the leaves, stem bark and root bark of Alstonia congensis.</ArticleTitle><Pagination><MedlinePgn>724-7</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jep.2013.04.016</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0378-8741(13)00269-9</ELocationID><Abstract><AbstractText Label="ETHNOPHARMACOLOGICAL RELEVANCE" NlmCategory="BACKGROUND">To evaluate the antiprotozoal activity and cytotoxicity of extracts and fractions from the leaves, root bark and stem bark of Alstonia congensis (Apocynaceae), used in traditional medicine against parasitic diseases.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">The aqueous and 80% MeOH extracts, and a series of fractions and subfractions from the leaves, stem and root bark of Alstonia congensis were tested in vitro for their antiprotozoal activity against Trypanosoma brucei brucei, Trypanosoma cruzi, Lesihamania infantum and the chloroquine and pyrimethamine-resistant K1 strain of Plasmodium falciparum. Their cytotoxicity on MRC-5 cells (human lung fibroblasts) was evaluated as well.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The aqueous and 80% MeOH extracts and a series of subfractions of each plant part exhibited pronounced antiprotozoal activity against the K1 strain of Plasmodium falciparum with IC50 values ranging from 2 to 5 µg/ml, and good activity against Trypanosoma brucei brucei and Trypanosoma cruzi with IC50 values ranging between 5 and 10 µg/ml. The residual 80% MeOH extract from the leaves, and the total alkaloid extract from stem and root bark were the only subfractions active against Leishmania infantum with IC50 values <10 µg/ml. None of the samples from the root bark was cytotoxic against MRC-cell lines (CC50>64 µg/ml). In general, the aqueous extract (traditional decoction) showed the highest selectivity, especially against Plasmodium falciparum.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">These results can partly support and justify the traditional use of these plant parts of Alstonina congensis as raw materials for the preparation of traditional remedies to treat parasitic diseases such as malaria and trypanosomiasis.</AbstractText><CopyrightInformation>Copyright © 2013. Published by Elsevier Ireland Ltd.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lumpu</LastName><ForeName>S L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>Faculty of Pharmaceutical Sciences, University of Kinshasa, PO Box 212, Kinshasa XI, Congo.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kikueta</LastName><ForeName>C M</ForeName><Initials>CM</Initials></Author><Author ValidYN="Y"><LastName>Tshodi</LastName><ForeName>M E</ForeName><Initials>ME</Initials></Author><Author ValidYN="Y"><LastName>Mbenza</LastName><ForeName>A P</ForeName><Initials>AP</Initials></Author><Author ValidYN="Y"><LastName>Kambu</LastName><ForeName>O K</ForeName><Initials>OK</Initials></Author><Author ValidYN="Y"><LastName>Mbamu</LastName><ForeName>B M</ForeName><Initials>BM</Initials></Author><Author ValidYN="Y"><LastName>Cos</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Maes</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Apers</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Pieters</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Cimanga</LastName><ForeName>R K</ForeName><Initials>RK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>20</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>J Ethnopharmacol</MedlineTA><NlmUniqueID>7903310</NlmUniqueID><ISSNLinking>0378-8741</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000981">Antiprotozoal Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D010936">Plant Extracts</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D031051" MajorTopicYN="N">Alstonia</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="Y">chemistry</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000981" MajorTopicYN="N">Antiprotozoal Agents</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002460" MajorTopicYN="N">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020834" MajorTopicYN="N">Ethnopharmacology</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005347" MajorTopicYN="N">Fibroblasts</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020128" MajorTopicYN="N">Inhibitory Concentration 50</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018314" MajorTopicYN="N">Leishmania infantum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D021261" MajorTopicYN="N">Parasitic Sensitivity Tests</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008517" MajorTopicYN="N">Phytotherapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010936" MajorTopicYN="N">Plant Extracts</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010963" MajorTopicYN="N">Plasmodium falciparum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014346" MajorTopicYN="N">Trypanosoma brucei brucei</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014349" MajorTopicYN="N">Trypanosoma cruzi</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>03</Month><Day>06</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>04</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>04</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>4</Month><Day>25</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>3</Month><Day>7</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23612422</ArticleId><ArticleId IdType="pii">S0378-8741(13)00269-9</ArticleId><ArticleId IdType="doi">10.1016/j.jep.2013.04.016</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Apers, S" sort="Apers, S" uniqKey="Apers S" first="S" last="Apers">S. Apers</name><name sortKey="Cimanga, R K" sort="Cimanga, R K" uniqKey="Cimanga R" first="R K" last="Cimanga">R K Cimanga</name><name sortKey="Cos, P" sort="Cos, P" uniqKey="Cos P" first="P" last="Cos">P. Cos</name><name sortKey="Kambu, O K" sort="Kambu, O K" uniqKey="Kambu O" first="O K" last="Kambu">O K Kambu</name><name sortKey="Kikueta, C M" sort="Kikueta, C M" uniqKey="Kikueta C" first="C M" last="Kikueta">C M Kikueta</name><name sortKey="Lumpu, S L" sort="Lumpu, S L" uniqKey="Lumpu S" first="S L" last="Lumpu">S L Lumpu</name><name sortKey="Maes, L" sort="Maes, L" uniqKey="Maes L" first="L" last="Maes">L. Maes</name><name sortKey="Mbamu, B M" sort="Mbamu, B M" uniqKey="Mbamu B" first="B M" last="Mbamu">B M Mbamu</name><name sortKey="Mbenza, A P" sort="Mbenza, A P" uniqKey="Mbenza A" first="A P" last="Mbenza">A P Mbenza</name><name sortKey="Pieters, L" sort="Pieters, L" uniqKey="Pieters L" first="L" last="Pieters">L. Pieters</name><name sortKey="Tshodi, M E" sort="Tshodi, M E" uniqKey="Tshodi M" first="M E" last="Tshodi">M E Tshodi</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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