Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Identifieur interne : 000159 ( Ncbi/Merge ); précédent : 000158; suivant : 000160Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.
Auteurs : Bennett B. Chin [États-Unis] ; Anita Hjelemand ; Jeremy Rich ; Haijing Song ; Christopher Lascola ; Robert Storms ; Roger Mclendon ; Robert Reiman ; Kim L. Greer ; Scott D. Metzler ; Darryl Mcdougald ; Diana Dai ; Ganesan VaidyanathanSource :
- Current radiopharmaceuticals [ 1874-4729 ] ; 2012.
Descripteurs français
- KwdFr :
- Animaux, Chloroquine (analogues et dérivés), Chloroquine (pharmacocinétique), Dose de radiation, Femelle, Glioblastome (enzymologie), Glioblastome (imagerie diagnostique), Isoenzymes (métabolisme), Leucémie L1210 (enzymologie), Lignée cellulaire tumorale, Mâle, Radio-isotopes de l'iode (pharmacocinétique), Radiopharmaceutiques (pharmacocinétique), Radiopharmaceutiques (synthèse chimique), Retinal dehydrogenase (métabolisme), Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Technique de Western, Tomographie par émission monophotonique (), Tumeurs (enzymologie), Tumeurs (imagerie diagnostique), Tumeurs du cerveau (enzymologie), Tumeurs du cerveau (imagerie diagnostique).
- MESH :
- analogues et dérivés : Chloroquine.
- enzymologie : Glioblastome, Leucémie L1210, Tumeurs, Tumeurs du cerveau.
- imagerie diagnostique : Glioblastome, Tumeurs, Tumeurs du cerveau.
- métabolisme : Isoenzymes, Retinal dehydrogenase.
- pharmacocinétique : Chloroquine, Radio-isotopes de l'iode, Radiopharmaceutiques.
- synthèse chimique : Radiopharmaceutiques.
- Animaux, Dose de radiation, Femelle, Lignée cellulaire tumorale, Mâle, Résistance aux médicaments antinéoplasiques, Souris, Souris nude, Technique de Western, Tomographie par émission monophotonique.
English descriptors
- KwdEn :
- Aldehyde Dehydrogenase 1, Animals, Blotting, Western, Brain Neoplasms (diagnostic imaging), Brain Neoplasms (enzymology), Cell Line, Tumor, Chloroquine (analogs & derivatives), Chloroquine (pharmacokinetics), Drug Resistance, Neoplasm, Female, Glioblastoma (diagnostic imaging), Glioblastoma (enzymology), Iodine Radioisotopes (pharmacokinetics), Isoenzymes (metabolism), Leukemia L1210 (enzymology), Male, Mice, Mice, Nude, Neoplasms (diagnostic imaging), Neoplasms (enzymology), Radiation Dosage, Radiopharmaceuticals (chemical synthesis), Radiopharmaceuticals (pharmacokinetics), Retinal Dehydrogenase (metabolism), Tomography, Emission-Computed, Single-Photon (methods).
- MESH :
- chemical , analogs & derivatives : Chloroquine.
- chemical , chemical synthesis : Radiopharmaceuticals.
- chemical , metabolism : Isoenzymes, Retinal Dehydrogenase.
- chemical , pharmacokinetics : Chloroquine, Iodine Radioisotopes, Radiopharmaceuticals.
- chemical : Aldehyde Dehydrogenase 1.
- diagnostic imaging : Brain Neoplasms, Glioblastoma, Neoplasms.
- enzymology : Brain Neoplasms, Glioblastoma, Leukemia L1210, Neoplasms.
- methods : Tomography, Emission-Computed, Single-Photon.
- Animals, Blotting, Western, Cell Line, Tumor, Drug Resistance, Neoplasm, Female, Male, Mice, Mice, Nude, Radiation Dosage.
Abstract
Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroquine analogue, n.c.a. iodoquine, and the in vitro and in vivo uptake in cells with high ALDH1 content.
DOI: 10.2174/1874471011205010047
PubMed: 21864242
Links toward previous steps (curation, corpus...)
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Links to Exploration step
pubmed:21864242Le document en format XML
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Greer</name></author><author><name sortKey="Metzler, Scott D" sort="Metzler, Scott D" uniqKey="Metzler S" first="Scott D" last="Metzler">Scott D. Metzler</name></author><author><name sortKey="Mcdougald, Darryl" sort="Mcdougald, Darryl" uniqKey="Mcdougald D" first="Darryl" last="Mcdougald">Darryl Mcdougald</name></author><author><name sortKey="Dai, Diana" sort="Dai, Diana" uniqKey="Dai D" first="Diana" last="Dai">Diana Dai</name></author><author><name sortKey="Vaidyanathan, Ganesan" sort="Vaidyanathan, Ganesan" uniqKey="Vaidyanathan G" first="Ganesan" last="Vaidyanathan">Ganesan Vaidyanathan</name></author></analytic><series><title level="j">Current radiopharmaceuticals</title><idno type="eISSN">1874-4729</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aldehyde Dehydrogenase 1</term><term>Animals</term><term>Blotting, Western</term><term>Brain Neoplasms (diagnostic imaging)</term><term>Brain Neoplasms (enzymology)</term><term>Cell Line, Tumor</term><term>Chloroquine (analogs & derivatives)</term><term>Chloroquine (pharmacokinetics)</term><term>Drug Resistance, Neoplasm</term><term>Female</term><term>Glioblastoma (diagnostic imaging)</term><term>Glioblastoma (enzymology)</term><term>Iodine Radioisotopes (pharmacokinetics)</term><term>Isoenzymes (metabolism)</term><term>Leukemia L1210 (enzymology)</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Neoplasms (diagnostic imaging)</term><term>Neoplasms (enzymology)</term><term>Radiation Dosage</term><term>Radiopharmaceuticals (chemical synthesis)</term><term>Radiopharmaceuticals (pharmacokinetics)</term><term>Retinal Dehydrogenase (metabolism)</term><term>Tomography, Emission-Computed, Single-Photon (methods)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Chloroquine (analogues et dérivés)</term><term>Chloroquine (pharmacocinétique)</term><term>Dose de radiation</term><term>Femelle</term><term>Glioblastome (enzymologie)</term><term>Glioblastome (imagerie diagnostique)</term><term>Isoenzymes (métabolisme)</term><term>Leucémie L1210 (enzymologie)</term><term>Lignée cellulaire tumorale</term><term>Mâle</term><term>Radio-isotopes de l'iode (pharmacocinétique)</term><term>Radiopharmaceutiques (pharmacocinétique)</term><term>Radiopharmaceutiques (synthèse chimique)</term><term>Retinal dehydrogenase (métabolisme)</term><term>Résistance aux médicaments antinéoplasiques</term><term>Souris</term><term>Souris nude</term><term>Technique de Western</term><term>Tomographie par émission monophotonique ()</term><term>Tumeurs (enzymologie)</term><term>Tumeurs (imagerie diagnostique)</term><term>Tumeurs du cerveau (enzymologie)</term><term>Tumeurs du cerveau (imagerie diagnostique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemical synthesis" xml:lang="en"><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Isoenzymes</term><term>Retinal Dehydrogenase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacokinetics" xml:lang="en"><term>Chloroquine</term><term>Iodine Radioisotopes</term><term>Radiopharmaceuticals</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Aldehyde Dehydrogenase 1</term></keywords><keywords scheme="MESH" qualifier="analogues et dérivés" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="diagnostic imaging" xml:lang="en"><term>Brain Neoplasms</term><term>Glioblastoma</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Glioblastome</term><term>Leucémie L1210</term><term>Tumeurs</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Brain Neoplasms</term><term>Glioblastoma</term><term>Leukemia L1210</term><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="imagerie diagnostique" xml:lang="fr"><term>Glioblastome</term><term>Tumeurs</term><term>Tumeurs du cerveau</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Tomography, Emission-Computed, Single-Photon</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Isoenzymes</term><term>Retinal dehydrogenase</term></keywords><keywords scheme="MESH" qualifier="pharmacocinétique" xml:lang="fr"><term>Chloroquine</term><term>Radio-isotopes de l'iode</term><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" qualifier="synthèse chimique" xml:lang="fr"><term>Radiopharmaceutiques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Blotting, Western</term><term>Cell Line, Tumor</term><term>Drug Resistance, Neoplasm</term><term>Female</term><term>Male</term><term>Mice</term><term>Mice, Nude</term><term>Radiation Dosage</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Dose de radiation</term><term>Femelle</term><term>Lignée cellulaire tumorale</term><term>Mâle</term><term>Résistance aux médicaments antinéoplasiques</term><term>Souris</term><term>Souris nude</term><term>Technique de Western</term><term>Tomographie par émission monophotonique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroquine analogue, n.c.a. iodoquine, and the in vitro and in vivo uptake in cells with high ALDH1 content.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21864242</PMID><DateCompleted><Year>2012</Year><Month>06</Month><Day>08</Day></DateCompleted><DateRevised><Year>2019</Year><Month>12</Month><Day>10</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1874-4729</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Current radiopharmaceuticals</Title><ISOAbbreviation>Curr Radiopharm</ISOAbbreviation></Journal><ArticleTitle>Synthesis and preliminary evaluation of n.c.a. iodoquine: a novel radiotracer with high uptake in cells with high ALDH1 expression.</ArticleTitle><Pagination><MedlinePgn>47-58</MedlinePgn></Pagination><Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">Chloroquine has demonstrated high affinity for aldehyde dehydrogenase 1A1 (ALDH1), an enzyme expressed in the highly tumorigenic CD133+ brain tumor initiating subpopulation. The purpose of this study is to report the novel synthesis of a chloroquine analogue, n.c.a. iodoquine, and the in vitro and in vivo uptake in cells with high ALDH1 content.</AbstractText><AbstractText Label="METHODS AND MATERIALS" NlmCategory="METHODS">Iodoquine was synthesized in novel no-carrier-added forms (n.c.a.) for both 125I and 123I. I25I IQ and 18F FDG cell uptake assays were performed in the L1210 and L1210cpa (cyclophosphamide resistant), A549, and MG456 glioblastoma cell lines. Uptake was expressed as a percent of the administered activity. 125I IQ biodistribution studies assessed organ uptake at 1, 4, and 24 hours after IV administration (n= 15 total; 5 mice/timepoint). Radiation dosimetry estimates were calculated using standard OLINDA/EXM software. In vivo imaging of 123I IQ uptake in MG456 glioblastoma mouse model (n=10) was performed with small animal high resolution micro-SPECT. Autoradiography and histology co-localized radiotracer and tumor biodistribution. Uptake in MG456 glioblastoma tumors was quantified with gamma counting.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">L1210 cpa (high ALDH1) showed significantly higher 125I IQ uptake compared to the parental L1210 (low ALDH1) for all time points through 4 hours (20.7% ± 1.4% versus 11.0% ± 0.5%; 21.3% ± 0.9% versus 11.0% ± 0.4%; 20.6% ± 0.7% versus 9.4% ± 0.3%; and 15.7% ± 0.7% versus 7.5% + 0.4% at 30 minutes, and 1, 2 and 4 hours, respectively; p < 0.001 for all time points). In the CD133+ fraction of MG456 glioblastoma cell line, IQ uptake was significantly higher compared to FDG at all time points through 4 hours (81.5% ± 0.9% versus 1.3% ± 0.1%; 88.8% ± 0.4% versus 1.3% ± 0.1%; 87.8% ± 2.1% versus 1.7% ± 0.2%; and 87.0% ± 2.4% versus 1.8% ± 0.1 at 30 minutes, and 1, 2 and 4 hours, respectively; p > 0.001 for all time points). The A549 lung cancer cell line also showed high IQ uptake through 4 hours. IQ normal biodistribution studies showed rapid renal excretion and very low normal background brain activity after IV administration. In vivo micro-SPECT images showed mild uptake in larger MG456 glioblastomas (n=6) as verified with autoradiography and histology. Gamma well counter uptake in large tumors was 2.3% ± 0.48% ID/g (n=5).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Iodoquine localizes to cells with high ALDH1 content. Cell assays show high 125I IQ uptake in the MG456 cell line, and in vivo micro-SPECT imaging showed mild 123I IQ uptake in MG456 glioblastomas. Further studies are necessary to investigate 131I IQ as a potential therapeutic agent targeting the highly tumorigenic CD133+ brain tumor stem cell subpopulation.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chin</LastName><ForeName>Bennett B</ForeName><Initials>BB</Initials><AffiliationInfo><Affiliation>Duke University Medical Center, DUMC, Durham, NC 27710, USA. chin0004@mc.duke.edu</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hjelemand</LastName><ForeName>Anita</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rich</LastName><ForeName>Jeremy</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Song</LastName><ForeName>Haijing</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Lascola</LastName><ForeName>Christopher</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Storms</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>McLendon</LastName><ForeName>Roger</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Reiman</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Greer</LastName><ForeName>Kim L</ForeName><Initials>KL</Initials></Author><Author ValidYN="Y"><LastName>Metzler</LastName><ForeName>Scott D</ForeName><Initials>SD</Initials></Author><Author ValidYN="Y"><LastName>McDougald</LastName><ForeName>Darryl</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Dai</LastName><ForeName>Diana</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Vaidyanathan</LastName><ForeName>Ganesan</ForeName><Initials>G</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United Arab Emirates</Country><MedlineTA>Curr Radiopharm</MedlineTA><NlmUniqueID>101468718</NlmUniqueID><ISSNLinking>1874-4710</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000080924">Aldehyde Dehydrogenase 1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007457">Iodine Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007527">Isoenzymes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019275">Radiopharmaceuticals</NameOfSubstance></Chemical><Chemical><RegistryNumber>886U3H6UFF</RegistryNumber><NameOfSubstance UI="D002738">Chloroquine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.2.1.36</RegistryNumber><NameOfSubstance UI="C000630769">Aldh1 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.2.1.36</RegistryNumber><NameOfSubstance UI="D050697">Retinal Dehydrogenase</NameOfSubstance></Chemical><Chemical><RegistryNumber>WH4356H14H</RegistryNumber><NameOfSubstance UI="C572571">iodoquine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000080924" MajorTopicYN="N">Aldehyde Dehydrogenase 1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015153" MajorTopicYN="N">Blotting, Western</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001932" MajorTopicYN="N">Brain Neoplasms</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D045744" MajorTopicYN="N">Cell Line, Tumor</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002738" MajorTopicYN="N">Chloroquine</DescriptorName><QualifierName UI="Q000031" MajorTopicYN="Y">analogs & derivatives</QualifierName><QualifierName UI="Q000493" MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019008" MajorTopicYN="N">Drug Resistance, Neoplasm</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005909" MajorTopicYN="N">Glioblastoma</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="N">diagnostic imaging</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007457" MajorTopicYN="N">Iodine Radioisotopes</DescriptorName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007527" MajorTopicYN="N">Isoenzymes</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007939" MajorTopicYN="N">Leukemia L1210</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008819" MajorTopicYN="N">Mice, Nude</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000000981" MajorTopicYN="Y">diagnostic imaging</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011829" MajorTopicYN="N">Radiation Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019275" MajorTopicYN="N">Radiopharmaceuticals</DescriptorName><QualifierName UI="Q000138" MajorTopicYN="N">chemical synthesis</QualifierName><QualifierName UI="Q000493" MajorTopicYN="Y">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D050697" MajorTopicYN="N">Retinal Dehydrogenase</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015899" MajorTopicYN="N">Tomography, Emission-Computed, Single-Photon</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2011</Year><Month>04</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2011</Year><Month>07</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2011</Year><Month>07</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2011</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2011</Year><Month>8</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>6</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">21864242</ArticleId><ArticleId IdType="pii">BSP/CRP/E-Pub/06</ArticleId><ArticleId IdType="doi">10.2174/1874471011205010047</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Caroline du Nord</li></region></list><tree><noCountry><name sortKey="Dai, Diana" sort="Dai, Diana" uniqKey="Dai D" first="Diana" last="Dai">Diana Dai</name><name sortKey="Greer, Kim L" sort="Greer, Kim L" uniqKey="Greer K" first="Kim L" last="Greer">Kim L. Greer</name><name sortKey="Hjelemand, Anita" sort="Hjelemand, Anita" uniqKey="Hjelemand A" first="Anita" last="Hjelemand">Anita Hjelemand</name><name sortKey="Lascola, Christopher" sort="Lascola, Christopher" uniqKey="Lascola C" first="Christopher" last="Lascola">Christopher Lascola</name><name sortKey="Mcdougald, Darryl" sort="Mcdougald, Darryl" uniqKey="Mcdougald D" first="Darryl" last="Mcdougald">Darryl Mcdougald</name><name sortKey="Mclendon, Roger" sort="Mclendon, Roger" uniqKey="Mclendon R" first="Roger" last="Mclendon">Roger Mclendon</name><name sortKey="Metzler, Scott D" sort="Metzler, Scott D" uniqKey="Metzler S" first="Scott D" last="Metzler">Scott D. Metzler</name><name sortKey="Reiman, Robert" sort="Reiman, Robert" uniqKey="Reiman R" first="Robert" last="Reiman">Robert Reiman</name><name sortKey="Rich, Jeremy" sort="Rich, Jeremy" uniqKey="Rich J" first="Jeremy" last="Rich">Jeremy Rich</name><name sortKey="Song, Haijing" sort="Song, Haijing" uniqKey="Song H" first="Haijing" last="Song">Haijing Song</name><name sortKey="Storms, Robert" sort="Storms, Robert" uniqKey="Storms R" first="Robert" last="Storms">Robert Storms</name><name sortKey="Vaidyanathan, Ganesan" sort="Vaidyanathan, Ganesan" uniqKey="Vaidyanathan G" first="Ganesan" last="Vaidyanathan">Ganesan Vaidyanathan</name></noCountry><country name="États-Unis"><region name="Caroline du Nord"><name sortKey="Chin, Bennett B" sort="Chin, Bennett B" uniqKey="Chin B" first="Bennett B" last="Chin">Bennett B. Chin</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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