Treatment approaches to juvenile dermatomyositis (JDM) across North America: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) JDM Treatment Survey.
Identifieur interne : 000137 ( Ncbi/Merge ); précédent : 000136; suivant : 000138Treatment approaches to juvenile dermatomyositis (JDM) across North America: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) JDM Treatment Survey.
Auteurs : Elizabeth Stringer [Canada] ; John Bohnsack ; Suzanne L. Bowyer ; Thomas A. Griffin ; Adam M. Huber ; Bianca Lang ; Carol B. Lindsley ; Sylvia Ota ; Clarissa Pilkington ; Ann M. Reed ; Rosie Scuccimarri ; Brian M. FeldmanSource :
- The Journal of rheumatology [ 0315-162X ] ; 2010.
Descripteurs français
- KwdFr :
- Antirhumatismaux (usage thérapeutique), Arthrite juvénile (traitement médicamenteux), Cyclophosphamide (usage thérapeutique), Dermatomyosite (traitement médicamenteux), Enfant, Expérimentation thérapeutique humaine, Hormones corticosurrénaliennes (usage thérapeutique), Humains, Immunoglobulines par voie veineuse (usage thérapeutique), Méthotrexate (usage thérapeutique), Plan de recherche, Résultat thérapeutique.
- MESH :
- traitement médicamenteux : Arthrite juvénile, Dermatomyosite.
- usage thérapeutique : Antirhumatismaux, Cyclophosphamide, Hormones corticosurrénaliennes, Immunoglobulines par voie veineuse, Méthotrexate.
- Enfant, Expérimentation thérapeutique humaine, Humains, Plan de recherche, Résultat thérapeutique.
English descriptors
- KwdEn :
- Adrenal Cortex Hormones (therapeutic use), Antirheumatic Agents (therapeutic use), Arthritis, Juvenile (drug therapy), Child, Cyclophosphamide (therapeutic use), Dermatomyositis (drug therapy), Humans, Immunoglobulins, Intravenous (therapeutic use), Methotrexate (therapeutic use), Research Design, Therapeutic Human Experimentation, Treatment Outcome.
- MESH :
- chemical , therapeutic use : Adrenal Cortex Hormones, Antirheumatic Agents, Cyclophosphamide, Immunoglobulins, Intravenous, Methotrexate.
- drug therapy : Arthritis, Juvenile, Dermatomyositis.
- Child, Humans, Research Design, Therapeutic Human Experimentation, Treatment Outcome.
Abstract
There are a number of different approaches to the initial treatment of juvenile dermatomyositis (JDM). We assessed the therapeutic approaches of North American pediatric rheumatologists to inform future studies of therapy in JDM.
DOI: 10.3899/jrheum.090953
PubMed: 20595275
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pubmed:20595275Le document en format XML
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Elizabeth.stringer@iwk.nshealth.ca</nlm:affiliation><country wicri:rule="url">Canada</country></affiliation></author><author><name sortKey="Bohnsack, John" sort="Bohnsack, John" uniqKey="Bohnsack J" first="John" last="Bohnsack">John Bohnsack</name></author><author><name sortKey="Bowyer, Suzanne L" sort="Bowyer, Suzanne L" uniqKey="Bowyer S" first="Suzanne L" last="Bowyer">Suzanne L. Bowyer</name></author><author><name sortKey="Griffin, Thomas A" sort="Griffin, Thomas A" uniqKey="Griffin T" first="Thomas A" last="Griffin">Thomas A. Griffin</name></author><author><name sortKey="Huber, Adam M" sort="Huber, Adam M" uniqKey="Huber A" first="Adam M" last="Huber">Adam M. Huber</name></author><author><name sortKey="Lang, Bianca" sort="Lang, Bianca" uniqKey="Lang B" first="Bianca" last="Lang">Bianca Lang</name></author><author><name sortKey="Lindsley, Carol B" sort="Lindsley, Carol B" uniqKey="Lindsley C" first="Carol B" last="Lindsley">Carol B. Lindsley</name></author><author><name sortKey="Ota, Sylvia" sort="Ota, Sylvia" uniqKey="Ota S" first="Sylvia" last="Ota">Sylvia Ota</name></author><author><name sortKey="Pilkington, Clarissa" sort="Pilkington, Clarissa" uniqKey="Pilkington C" first="Clarissa" last="Pilkington">Clarissa Pilkington</name></author><author><name sortKey="Reed, Ann M" sort="Reed, Ann M" uniqKey="Reed A" first="Ann M" last="Reed">Ann M. Reed</name></author><author><name sortKey="Scuccimarri, Rosie" sort="Scuccimarri, Rosie" uniqKey="Scuccimarri R" first="Rosie" last="Scuccimarri">Rosie Scuccimarri</name></author><author><name sortKey="Feldman, Brian M" sort="Feldman, Brian M" uniqKey="Feldman B" first="Brian M" last="Feldman">Brian M. Feldman</name></author></analytic><series><title level="j">The Journal of rheumatology</title><idno type="ISSN">0315-162X</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenal Cortex Hormones (therapeutic use)</term><term>Antirheumatic Agents (therapeutic use)</term><term>Arthritis, Juvenile (drug therapy)</term><term>Child</term><term>Cyclophosphamide (therapeutic use)</term><term>Dermatomyositis (drug therapy)</term><term>Humans</term><term>Immunoglobulins, Intravenous (therapeutic use)</term><term>Methotrexate (therapeutic use)</term><term>Research Design</term><term>Therapeutic Human Experimentation</term><term>Treatment Outcome</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antirhumatismaux (usage thérapeutique)</term><term>Arthrite juvénile (traitement médicamenteux)</term><term>Cyclophosphamide (usage thérapeutique)</term><term>Dermatomyosite (traitement médicamenteux)</term><term>Enfant</term><term>Expérimentation thérapeutique humaine</term><term>Hormones corticosurrénaliennes (usage thérapeutique)</term><term>Humains</term><term>Immunoglobulines par voie veineuse (usage thérapeutique)</term><term>Méthotrexate (usage thérapeutique)</term><term>Plan de recherche</term><term>Résultat thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Adrenal Cortex Hormones</term><term>Antirheumatic Agents</term><term>Cyclophosphamide</term><term>Immunoglobulins, Intravenous</term><term>Methotrexate</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Arthritis, Juvenile</term><term>Dermatomyositis</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Arthrite juvénile</term><term>Dermatomyosite</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antirhumatismaux</term><term>Cyclophosphamide</term><term>Hormones corticosurrénaliennes</term><term>Immunoglobulines par voie veineuse</term><term>Méthotrexate</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Child</term><term>Humans</term><term>Research Design</term><term>Therapeutic Human Experimentation</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Enfant</term><term>Expérimentation thérapeutique humaine</term><term>Humains</term><term>Plan de recherche</term><term>Résultat thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are a number of different approaches to the initial treatment of juvenile dermatomyositis (JDM). We assessed the therapeutic approaches of North American pediatric rheumatologists to inform future studies of therapy in JDM.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">20595275</PMID><DateCompleted><Year>2011</Year><Month>02</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0315-162X</ISSN><JournalIssue CitedMedium="Internet"><Volume>37</Volume><Issue>9</Issue><PubDate><Year>2010</Year><Month>Sep</Month></PubDate></JournalIssue><Title>The Journal of rheumatology</Title><ISOAbbreviation>J. Rheumatol.</ISOAbbreviation></Journal><ArticleTitle>Treatment approaches to juvenile dermatomyositis (JDM) across North America: The Childhood Arthritis and Rheumatology Research Alliance (CARRA) JDM Treatment Survey.</ArticleTitle><Pagination><MedlinePgn>1953-61</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3899/jrheum.090953</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">There are a number of different approaches to the initial treatment of juvenile dermatomyositis (JDM). We assessed the therapeutic approaches of North American pediatric rheumatologists to inform future studies of therapy in JDM.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">A survey describing clinical cases of JDM was sent to pediatric rheumatologists. The cases described children with varying severity of typical disease, disease with atypical features, or refractory disease. Three open-ended questions were asked following each case: (1) What additional investigations would you order; (2) What medicine(s) would you start (dose, route, frequency, adjustment over time); and (3) What nonmedication treatment(s) would you start.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The response rate was 84% (141/167). For typical cases of JDM, regardless of severity, almost all respondents used corticosteroids and another medication, methotrexate (MTX) being the most commonly used. The route and pattern of corticosteroid administration was variable. Intravenous immunoglobulin (IVIG) was used more frequently for more severe disease, for refractory disease, and for prominent cutaneous disease. Hydroxychloroquine was often used in milder cases and cases principally characterized by rash. Cyclophosphamide was reserved for ulcerative disease and JDM complicated by lung disease.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">For the majority of North American pediatric rheumatologists, corticosteroids and MTX appear to be the standard of care for typical cases of JDM. There is variability, however, in the route of administration of corticosteroids and use of IVIG and hydroxychloroquine.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Stringer</LastName><ForeName>Elizabeth</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>IWK Health Centre, 5850 University Avenue, Halifax, Nova Scotia B3K 6R8. Elizabeth.stringer@iwk.nshealth.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bohnsack</LastName><ForeName>John</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bowyer</LastName><ForeName>Suzanne L</ForeName><Initials>SL</Initials></Author><Author ValidYN="Y"><LastName>Griffin</LastName><ForeName>Thomas A</ForeName><Initials>TA</Initials></Author><Author ValidYN="Y"><LastName>Huber</LastName><ForeName>Adam M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Lang</LastName><ForeName>Bianca</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Lindsley</LastName><ForeName>Carol B</ForeName><Initials>CB</Initials></Author><Author ValidYN="Y"><LastName>Ota</LastName><ForeName>Sylvia</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Pilkington</LastName><ForeName>Clarissa</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Reed</LastName><ForeName>Ann M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Scuccimarri</LastName><ForeName>Rosie</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Feldman</LastName><ForeName>Brian M</ForeName><Initials>BM</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>07</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>Canada</Country><MedlineTA>J Rheumatol</MedlineTA><NlmUniqueID>7501984</NlmUniqueID><ISSNLinking>0315-162X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000305">Adrenal Cortex Hormones</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018501">Antirheumatic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016756">Immunoglobulins, Intravenous</NameOfSubstance></Chemical><Chemical><RegistryNumber>8N3DW7272P</RegistryNumber><NameOfSubstance UI="D003520">Cyclophosphamide</NameOfSubstance></Chemical><Chemical><RegistryNumber>YL5FZ2Y5U1</RegistryNumber><NameOfSubstance UI="D008727">Methotrexate</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000305" MajorTopicYN="N">Adrenal Cortex Hormones</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018501" MajorTopicYN="N">Antirheumatic Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001171" MajorTopicYN="N">Arthritis, Juvenile</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003520" MajorTopicYN="N">Cyclophosphamide</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003882" MajorTopicYN="N">Dermatomyositis</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016756" MajorTopicYN="N">Immunoglobulins, Intravenous</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008727" MajorTopicYN="N">Methotrexate</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012107" MajorTopicYN="Y">Research Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D036302" MajorTopicYN="N">Therapeutic Human Experimentation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>2</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">20595275</ArticleId><ArticleId IdType="pii">jrheum.090953</ArticleId><ArticleId IdType="doi">10.3899/jrheum.090953</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Bohnsack, John" sort="Bohnsack, John" uniqKey="Bohnsack J" first="John" last="Bohnsack">John Bohnsack</name><name sortKey="Bowyer, Suzanne L" sort="Bowyer, Suzanne L" uniqKey="Bowyer S" first="Suzanne L" last="Bowyer">Suzanne L. Bowyer</name><name sortKey="Feldman, Brian M" sort="Feldman, Brian M" uniqKey="Feldman B" first="Brian M" last="Feldman">Brian M. Feldman</name><name sortKey="Griffin, Thomas A" sort="Griffin, Thomas A" uniqKey="Griffin T" first="Thomas A" last="Griffin">Thomas A. Griffin</name><name sortKey="Huber, Adam M" sort="Huber, Adam M" uniqKey="Huber A" first="Adam M" last="Huber">Adam M. Huber</name><name sortKey="Lang, Bianca" sort="Lang, Bianca" uniqKey="Lang B" first="Bianca" last="Lang">Bianca Lang</name><name sortKey="Lindsley, Carol B" sort="Lindsley, Carol B" uniqKey="Lindsley C" first="Carol B" last="Lindsley">Carol B. Lindsley</name><name sortKey="Ota, Sylvia" sort="Ota, Sylvia" uniqKey="Ota S" first="Sylvia" last="Ota">Sylvia Ota</name><name sortKey="Pilkington, Clarissa" sort="Pilkington, Clarissa" uniqKey="Pilkington C" first="Clarissa" last="Pilkington">Clarissa Pilkington</name><name sortKey="Reed, Ann M" sort="Reed, Ann M" uniqKey="Reed A" first="Ann M" last="Reed">Ann M. Reed</name><name sortKey="Scuccimarri, Rosie" sort="Scuccimarri, Rosie" uniqKey="Scuccimarri R" first="Rosie" last="Scuccimarri">Rosie Scuccimarri</name></noCountry><country name="Canada"><noRegion><name sortKey="Stringer, Elizabeth" sort="Stringer, Elizabeth" uniqKey="Stringer E" first="Elizabeth" last="Stringer">Elizabeth Stringer</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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