ChloroquineV1, Ncbi, Merge, bibRecord, 000108

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.

Identifieur interne : 000108 ( Ncbi/Merge ); précédent : 000107; suivant : 000109

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.

Auteurs : Masakazu Kono [Japon] ; Koichiro Tatsumi ; Alberto M. Imai ; Kengo Saito ; Takayuki Kuriyama ; Hiroshi Shirasawa

Source :

Antiviral research [ 0166-3542 ] ; 2008.

RBID : pubmed:18055026

Descripteurs français

KwdFr :
- Antiviraux (pharmacologie), Cellules épithéliales (virologie), Chloroquine (pharmacologie), Coronavirus humain 229E (), Effet cytopathogène viral (), Extracellular Signal-Regulated MAP Kinases (antagonistes et inhibiteurs), Humains, Imidazoles (pharmacologie), Lignée cellulaire, Poumon (cytologie), Poumon (virologie), Pyridines (pharmacologie), RT-PCR, Réplication virale (), p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs).
MESH :
- antagonistes et inhibiteurs : Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases.
- cytologie : Poumon.
- pharmacologie : Antiviraux, Chloroquine, Imidazoles, Pyridines.
- virologie : Cellules épithéliales, Poumon.
- Coronavirus humain 229E, Effet cytopathogène viral, Humains, Lignée cellulaire, RT-PCR, Réplication virale.

English descriptors

KwdEn :
- Antiviral Agents (pharmacology), Cell Line, Chloroquine (pharmacology), Coronavirus 229E, Human (drug effects), Cytopathogenic Effect, Viral (drug effects), Epithelial Cells (virology), Extracellular Signal-Regulated MAP Kinases (antagonists & inhibitors), Humans, Imidazoles (pharmacology), Lung (cytology), Lung (virology), Pyridines (pharmacology), Reverse Transcriptase Polymerase Chain Reaction, Virus Replication (drug effects), p38 Mitogen-Activated Protein Kinases (antagonists & inhibitors).
MESH :
- chemical , antagonists & inhibitors : Extracellular Signal-Regulated MAP Kinases, p38 Mitogen-Activated Protein Kinases.
- chemical , pharmacology : Antiviral Agents, Chloroquine, Imidazoles, Pyridines.
- cytology : Lung.
- drug effects : Coronavirus 229E, Human, Cytopathogenic Effect, Viral, Virus Replication.
- virology : Epithelial Cells, Lung.
- Cell Line, Humans, Reverse Transcriptase Polymerase Chain Reaction.

Abstract

The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, L132 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.

DOI: 10.1016/j.antiviral.2007.10.011
PubMed: 18055026

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pubmed:18055026

Le document en format XML

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<author><name sortKey="Kono, Masakazu" sort="Kono, Masakazu" uniqKey="Kono M" first="Masakazu" last="Kono">Masakazu Kono</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Molecular Virology, Chiba University School of Medicine, 1-8-1 Inohana, Chiba 260-8670, Japan.</nlm:affiliation>
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<term>Chloroquine (pharmacology)</term>
<term>Coronavirus 229E, Human (drug effects)</term>
<term>Cytopathogenic Effect, Viral (drug effects)</term>
<term>Epithelial Cells (virology)</term>
<term>Extracellular Signal-Regulated MAP Kinases (antagonists & inhibitors)</term>
<term>Humans</term>
<term>Imidazoles (pharmacology)</term>
<term>Lung (cytology)</term>
<term>Lung (virology)</term>
<term>Pyridines (pharmacology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (pharmacologie)</term>
<term>Cellules épithéliales (virologie)</term>
<term>Chloroquine (pharmacologie)</term>
<term>Coronavirus humain 229E ()</term>
<term>Effet cytopathogène viral ()</term>
<term>Extracellular Signal-Regulated MAP Kinases (antagonistes et inhibiteurs)</term>
<term>Humains</term>
<term>Imidazoles (pharmacologie)</term>
<term>Lignée cellulaire</term>
<term>Poumon (cytologie)</term>
<term>Poumon (virologie)</term>
<term>Pyridines (pharmacologie)</term>
<term>RT-PCR</term>
<term>Réplication virale ()</term>
<term>p38 Mitogen-Activated Protein Kinases (antagonistes et inhibiteurs)</term>
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<term>p38 Mitogen-Activated Protein Kinases</term>
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<term>Chloroquine</term>
<term>Imidazoles</term>
<term>Pyridines</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Coronavirus 229E, Human</term>
<term>Cytopathogenic Effect, Viral</term>
<term>Virus Replication</term>
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<term>Reverse Transcriptase Polymerase Chain Reaction</term>
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<term>Humains</term>
<term>Lignée cellulaire</term>
<term>RT-PCR</term>
<term>Réplication virale</term>
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<front><div type="abstract" xml:lang="en">The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, L132 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</div>
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<Abstract><AbstractText>The antiviral effects of chloroquine (CQ) on human coronavirus 229E (HCoV-229E) infection of human fetal lung cell line, L132 are reported. CQ significantly decreased the viral replication at concentrations lower than in clinical usage. We demonstrated that CQ affects the activation of p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK). Furthermore, p38 MAPK inhibitor, SB203580, inhibits CPE induced by HCoV-229E infection and viral replication. Our findings suggest that CQ affects the activation of MAPKs, involved in the replication of HCoV-229E.</AbstractText>
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Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.

Inhibition of human coronavirus 229E infection in human epithelial lung cells (L132) by chloroquine: involvement of p38 MAPK and ERK.

Source :

Descripteurs français

English descriptors

Abstract

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