[Chloroquine keratopathy as an example of drug-induced phospholipidosis (contribution to the pathogenesis of cornea verticillata) (author's transl)].
Identifieur interne : 000068 ( Ncbi/Merge ); précédent : 000067; suivant : 000069[Chloroquine keratopathy as an example of drug-induced phospholipidosis (contribution to the pathogenesis of cornea verticillata) (author's transl)].
Auteurs : K U Seiler ; H J Thiel ; O. WassermannSource :
- Klinische Monatsblatter fur Augenheilkunde [ 0023-2165 ] ; 1977.
Descripteurs français
- KwdFr :
- Animaux, Chloroquine (effets indésirables), Chlorphentermine (métabolisme), Concentration en ions d'hydrogène, Cytoplasme (ultrastructure), Glandes surrénales (métabolisme), Lipidoses (), Lipidoses (anatomopathologie), Lysosomes (enzymologie), Maladies de la cornée (), Maladies de la cornée (anatomopathologie), Myocarde (métabolisme), Phospholipases (métabolisme), Phospholipides (métabolisme), Poumon (métabolisme), Rats, Rein (métabolisme), Relation structure-activité.
- MESH :
- anatomopathologie : Lipidoses, Maladies de la cornée.
- effets indésirables : Chloroquine.
- enzymologie : Lysosomes.
- métabolisme : Chlorphentermine, Glandes surrénales, Myocarde, Phospholipases, Phospholipides, Poumon, Rein.
- Animaux, Concentration en ions d'hydrogène, Cytoplasme, Lipidoses, Maladies de la cornée, Rats, Relation structure-activité.
English descriptors
- KwdEn :
- Adrenal Glands (metabolism), Animals, Chloroquine (adverse effects), Chlorphentermine (metabolism), Corneal Diseases (chemically induced), Corneal Diseases (pathology), Cytoplasm (ultrastructure), Hydrogen-Ion Concentration, Kidney (metabolism), Lipidoses (chemically induced), Lipidoses (pathology), Lung (metabolism), Lysosomes (enzymology), Myocardium (metabolism), Phospholipases (metabolism), Phospholipids (metabolism), Rats, Structure-Activity Relationship.
- MESH :
- chemical , adverse effects : Chloroquine.
- chemically induced : Corneal Diseases, Lipidoses.
- enzymology : Lysosomes.
- metabolism : Adrenal Glands, Chlorphentermine, Kidney, Lung, Myocardium, Phospholipases, Phospholipids.
- pathology : Corneal Diseases, Lipidoses.
- ultrastructure : Cytoplasm.
- Animals, Hydrogen-Ion Concentration, Rats, Structure-Activity Relationship.
Abstract
Chronic treatment with certain drugs induces morphological alterations in the eye which are histologically and electron microscopically identical with those found in hereditary lipidoses (cornea verticillata, e.g. in M. Fabry). Hereditary storage diseases are the consequence of enzyme defects, the mechanism underlying the side effect of certain drugs, however, is quite different. "Amphiphilic" drugs from completely different pharmacological groups, like chloroquine, amiodarone, chlorpromazine form complexes with cellular phospholipids which cannot be metabolised by lysosomal phospholipases. Thus in all tissues with high phospholipid content or turnover typical intracellular deposites with lamellary or crystalloid structure may occur (myelin figures). Such deposites were observed in different parts of the eye and are known e.g. from the cornea as "cornea verticillata".
PubMed: 15159
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pubmed:15159Le document en format XML
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Wassermann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1977">1977</date><idno type="RBID">pubmed:15159</idno><idno type="pmid">15159</idno><idno type="wicri:Area/PubMed/Corpus">000624</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000624</idno><idno type="wicri:Area/PubMed/Curation">000624</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000624</idno><idno type="wicri:Area/PubMed/Checkpoint">000591</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000591</idno><idno type="wicri:Area/Ncbi/Merge">000068</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Chloroquine keratopathy as an example of drug-induced phospholipidosis (contribution to the pathogenesis of cornea verticillata) (author's transl)].</title><author><name sortKey="Seiler, K U" sort="Seiler, K U" uniqKey="Seiler K" first="K U" last="Seiler">K U Seiler</name></author><author><name sortKey="Thiel, H J" sort="Thiel, H J" uniqKey="Thiel H" first="H J" last="Thiel">H J Thiel</name></author><author><name sortKey="Wassermann, O" sort="Wassermann, O" uniqKey="Wassermann O" first="O" last="Wassermann">O. 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Fabry). Hereditary storage diseases are the consequence of enzyme defects, the mechanism underlying the side effect of certain drugs, however, is quite different. "Amphiphilic" drugs from completely different pharmacological groups, like chloroquine, amiodarone, chlorpromazine form complexes with cellular phospholipids which cannot be metabolised by lysosomal phospholipases. Thus in all tissues with high phospholipid content or turnover typical intracellular deposites with lamellary or crystalloid structure may occur (myelin figures). Such deposites were observed in different parts of the eye and are known e.g. from the cornea as "cornea verticillata".</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15159</PMID><DateCompleted><Year>1977</Year><Month>05</Month><Day>27</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0023-2165</ISSN><JournalIssue CitedMedium="Print"><Volume>170</Volume><Issue>1</Issue><PubDate><Year>1977</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Klinische Monatsblatter fur Augenheilkunde</Title><ISOAbbreviation>Klin Monbl Augenheilkd</ISOAbbreviation></Journal><ArticleTitle>[Chloroquine keratopathy as an example of drug-induced phospholipidosis (contribution to the pathogenesis of cornea verticillata) (author's transl)].</ArticleTitle><Pagination><MedlinePgn>64-73</MedlinePgn></Pagination><Abstract><AbstractText>Chronic treatment with certain drugs induces morphological alterations in the eye which are histologically and electron microscopically identical with those found in hereditary lipidoses (cornea verticillata, e.g. in M. Fabry). Hereditary storage diseases are the consequence of enzyme defects, the mechanism underlying the side effect of certain drugs, however, is quite different. "Amphiphilic" drugs from completely different pharmacological groups, like chloroquine, amiodarone, chlorpromazine form complexes with cellular phospholipids which cannot be metabolised by lysosomal phospholipases. Thus in all tissues with high phospholipid content or turnover typical intracellular deposites with lamellary or crystalloid structure may occur (myelin figures). Such deposites were observed in different parts of the eye and are known e.g. from the cornea as "cornea verticillata".</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Seiler</LastName><ForeName>K U</ForeName><Initials>KU</Initials></Author><Author ValidYN="Y"><LastName>Thiel</LastName><ForeName>H J</ForeName><Initials>HJ</Initials></Author><Author ValidYN="Y"><LastName>Wassermann</LastName><ForeName>O</ForeName><Initials>O</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Die Chloroquinkeratopathie als Beispiel einer arzneimittelinduzierten Phospholipidosis (Zugleich ein Beitrag zur Pathogenese der Cornea verticillata)</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Klin Monbl 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IdType="pubmed">15159</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list></list><tree><noCountry><name sortKey="Seiler, K U" sort="Seiler, K U" uniqKey="Seiler K" first="K U" last="Seiler">K U Seiler</name><name sortKey="Thiel, H J" sort="Thiel, H J" uniqKey="Thiel H" first="H J" last="Thiel">H J Thiel</name><name sortKey="Wassermann, O" sort="Wassermann, O" uniqKey="Wassermann O" first="O" last="Wassermann">O. 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