Histamine N-methyl transferase: inhibition by drugs.
Identifieur interne : 000059 ( Ncbi/Merge ); précédent : 000058; suivant : 000060Histamine N-methyl transferase: inhibition by drugs.
Auteurs : G M Pacifici [Italie] ; P. Donatelli ; L. GiulianiSource :
- British journal of clinical pharmacology [ 0306-5251 ] ; 1992.
Descripteurs français
- KwdFr :
- MESH :
- analyse : Histamine N-methyltransferase.
- antagonistes et inhibiteurs : Histamine N-methyltransferase.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Mâle, Répartition dans les tissus, Sujet âgé.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Histamine N-Methyltransferase.
- chemical , antagonists & inhibitors : Histamine N-Methyltransferase.
- Adult, Aged, Female, Humans, Male, Middle Aged, Tissue Distribution.
Abstract
1. Histamine N-methyl transferase activity was measured in samples of human liver, brain, kidney, lung and intestinal mucosa. The mean (+/- s.d.) rate (nmol min-1 mg-1 protein) of histamine N-methylation was 1.78 +/- 0.59 (liver, n = 60), 1.15 +/- 0.38 (renal cortex, n = 8), 0.79 +/- 0.14 (renal medulla, n = 8), 0.35 +/- 0.08 (lung, n = 20), 0.47 +/- 0.18 (human intestine, n = 30) and 0.29 +/- 0.14 (brain, n = 13). 2. Inhibition of histamine N-methyl transferase by 15 drugs was investigated in human liver. The IC50 for the various drugs ranged over three orders of magnitude; chloroquine was the most potent inhibitor. 3. The average IC50 values for chloroquine were 12.6, 22.0, 19.0, 21.6 microM in liver, renal cortex, brain and colon, respectively. These values are lower than the Michaelis-Menten constant for histamine N-methyltransferase in liver (43.8 microM) and kidney (45.5 microM). Chloroquine carried a mixed non-competitive inhibition of hepatic histamine N-methyl transferase. Some side-effects of chloroquine may be explained by inhibition of histamine N-methyl transferase.
DOI: 10.1111/j.1365-2125.1992.tb05637.x
PubMed: 1457266
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000543
- to stream PubMed, to step Curation: 000543
- to stream PubMed, to step Checkpoint: 000520
Links to Exploration step
pubmed:1457266Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Histamine N-methyl transferase: inhibition by drugs.</title><author><name sortKey="Pacifici, G M" sort="Pacifici, G M" uniqKey="Pacifici G" first="G M" last="Pacifici">G M Pacifici</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedicine, Medical School, University of Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedicine, Medical School, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Donatelli, P" sort="Donatelli, P" uniqKey="Donatelli P" first="P" last="Donatelli">P. Donatelli</name></author><author><name sortKey="Giuliani, L" sort="Giuliani, L" uniqKey="Giuliani L" first="L" last="Giuliani">L. Giuliani</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1992">1992</date><idno type="RBID">pubmed:1457266</idno><idno type="pmid">1457266</idno><idno type="doi">10.1111/j.1365-2125.1992.tb05637.x</idno><idno type="wicri:Area/PubMed/Corpus">000543</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000543</idno><idno type="wicri:Area/PubMed/Curation">000543</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000543</idno><idno type="wicri:Area/PubMed/Checkpoint">000520</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000520</idno><idno type="wicri:Area/Ncbi/Merge">000059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Histamine N-methyl transferase: inhibition by drugs.</title><author><name sortKey="Pacifici, G M" sort="Pacifici, G M" uniqKey="Pacifici G" first="G M" last="Pacifici">G M Pacifici</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biomedicine, Medical School, University of Pisa, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Biomedicine, Medical School, University of Pisa</wicri:regionArea><placeName><settlement type="city">Pise</settlement><region type="region" nuts="2">Toscane</region></placeName><orgName type="university">Université de Pise</orgName></affiliation></author><author><name sortKey="Donatelli, P" sort="Donatelli, P" uniqKey="Donatelli P" first="P" last="Donatelli">P. Donatelli</name></author><author><name sortKey="Giuliani, L" sort="Giuliani, L" uniqKey="Giuliani L" first="L" last="Giuliani">L. Giuliani</name></author></analytic><series><title level="j">British journal of clinical pharmacology</title><idno type="ISSN">0306-5251</idno><imprint><date when="1992" type="published">1992</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Histamine N-Methyltransferase (analysis)</term><term>Histamine N-Methyltransferase (antagonists & inhibitors)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tissue Distribution</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Histamine N-methyltransferase (analyse)</term><term>Histamine N-methyltransferase (antagonistes et inhibiteurs)</term><term>Humains</term><term>Mâle</term><term>Répartition dans les tissus</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Histamine N-Methyltransferase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Histamine N-Methyltransferase</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Histamine N-methyltransferase</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Histamine N-methyltransferase</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Tissue Distribution</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Répartition dans les tissus</term><term>Sujet âgé</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Histamine N-methyl transferase activity was measured in samples of human liver, brain, kidney, lung and intestinal mucosa. The mean (+/- s.d.) rate (nmol min-1 mg-1 protein) of histamine N-methylation was 1.78 +/- 0.59 (liver, n = 60), 1.15 +/- 0.38 (renal cortex, n = 8), 0.79 +/- 0.14 (renal medulla, n = 8), 0.35 +/- 0.08 (lung, n = 20), 0.47 +/- 0.18 (human intestine, n = 30) and 0.29 +/- 0.14 (brain, n = 13). 2. Inhibition of histamine N-methyl transferase by 15 drugs was investigated in human liver. The IC50 for the various drugs ranged over three orders of magnitude; chloroquine was the most potent inhibitor. 3. The average IC50 values for chloroquine were 12.6, 22.0, 19.0, 21.6 microM in liver, renal cortex, brain and colon, respectively. These values are lower than the Michaelis-Menten constant for histamine N-methyltransferase in liver (43.8 microM) and kidney (45.5 microM). Chloroquine carried a mixed non-competitive inhibition of hepatic histamine N-methyl transferase. Some side-effects of chloroquine may be explained by inhibition of histamine N-methyl transferase.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">1457266</PMID><DateCompleted><Year>1993</Year><Month>01</Month><Day>12</Day></DateCompleted><DateRevised><Year>2019</Year><Month>05</Month><Day>09</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0306-5251</ISSN><JournalIssue CitedMedium="Print"><Volume>34</Volume><Issue>4</Issue><PubDate><Year>1992</Year><Month>Oct</Month></PubDate></JournalIssue><Title>British journal of clinical pharmacology</Title><ISOAbbreviation>Br J Clin Pharmacol</ISOAbbreviation></Journal><ArticleTitle>Histamine N-methyl transferase: inhibition by drugs.</ArticleTitle><Pagination><MedlinePgn>322-7</MedlinePgn></Pagination><Abstract><AbstractText>1. Histamine N-methyl transferase activity was measured in samples of human liver, brain, kidney, lung and intestinal mucosa. The mean (+/- s.d.) rate (nmol min-1 mg-1 protein) of histamine N-methylation was 1.78 +/- 0.59 (liver, n = 60), 1.15 +/- 0.38 (renal cortex, n = 8), 0.79 +/- 0.14 (renal medulla, n = 8), 0.35 +/- 0.08 (lung, n = 20), 0.47 +/- 0.18 (human intestine, n = 30) and 0.29 +/- 0.14 (brain, n = 13). 2. Inhibition of histamine N-methyl transferase by 15 drugs was investigated in human liver. The IC50 for the various drugs ranged over three orders of magnitude; chloroquine was the most potent inhibitor. 3. The average IC50 values for chloroquine were 12.6, 22.0, 19.0, 21.6 microM in liver, renal cortex, brain and colon, respectively. These values are lower than the Michaelis-Menten constant for histamine N-methyltransferase in liver (43.8 microM) and kidney (45.5 microM). Chloroquine carried a mixed non-competitive inhibition of hepatic histamine N-methyl transferase. Some side-effects of chloroquine may be explained by inhibition of histamine N-methyl transferase.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Pacifici</LastName><ForeName>G M</ForeName><Initials>GM</Initials><AffiliationInfo><Affiliation>Department of Biomedicine, Medical School, University of Pisa, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Donatelli</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Giuliani</LastName><ForeName>L</ForeName><Initials>L</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Br J Clin Pharmacol</MedlineTA><NlmUniqueID>7503323</NlmUniqueID><ISSNLinking>0306-5251</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 2.1.1.8</RegistryNumber><NameOfSubstance UI="D006637">Histamine N-Methyltransferase</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006637" MajorTopicYN="N">Histamine N-Methyltransferase</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName><QualifierName UI="Q000037" MajorTopicYN="Y">antagonists & inhibitors</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014018" MajorTopicYN="N">Tissue Distribution</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1992</Year><Month>10</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1992</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1992</Year><Month>10</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">1457266</ArticleId><ArticleId IdType="pmc">PMC1381414</ArticleId><ArticleId IdType="doi">10.1111/j.1365-2125.1992.tb05637.x</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Agents Actions. 1978 Jun;8(4):359-65</Citation><ArticleIdList><ArticleId IdType="pubmed">28646</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1979;28(2):183-8</Citation><ArticleIdList><ArticleId IdType="pubmed">34400</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1978 Feb 1;27(3):263-71</Citation><ArticleIdList><ArticleId IdType="pubmed">619910</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1978 May 15;27(10):1507-9</Citation><ArticleIdList><ArticleId IdType="pubmed">697892</ArticleId></ArticleIdList></Reference><Reference><Citation>Br J Pharmacol. 1975 Nov;55(3):321-7</Citation><ArticleIdList><ArticleId IdType="pubmed">1203620</ArticleId></ArticleIdList></Reference><Reference><Citation>Xenobiotica. 1991 Sep;21(9):1107-12</Citation><ArticleIdList><ArticleId IdType="pubmed">1788978</ArticleId></ArticleIdList></Reference><Reference><Citation>Dev Pharmacol Ther. 1991;17(1-2):16-23</Citation><ArticleIdList><ArticleId IdType="pubmed">1811918</ArticleId></ArticleIdList></Reference><Reference><Citation>Dev Pharmacol Ther. 1991;17(1-2):8-15</Citation><ArticleIdList><ArticleId IdType="pubmed">1811925</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1990 Feb 1;39(3):415-20</Citation><ArticleIdList><ArticleId IdType="pubmed">1968337</ArticleId></ArticleIdList></Reference><Reference><Citation>Hum Exp Toxicol. 1990 Mar;9(2):65-9</Citation><ArticleIdList><ArticleId IdType="pubmed">2111157</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1990 Sep 15;40(6):1345-50</Citation><ArticleIdList><ArticleId IdType="pubmed">2403387</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1988 Jul 15;37(14):2872-6</Citation><ArticleIdList><ArticleId IdType="pubmed">2899431</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1988 Feb 1;37(3):385-8</Citation><ArticleIdList><ArticleId IdType="pubmed">3337739</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Chim Acta. 1988 Feb 15;171(2-3):247-56</Citation><ArticleIdList><ArticleId IdType="pubmed">3370823</ArticleId></ArticleIdList></Reference><Reference><Citation>Exp Mol Pathol. 1986 Dec;45(3):257-69</Citation><ArticleIdList><ArticleId IdType="pubmed">3792510</ArticleId></ArticleIdList></Reference><Reference><Citation>Clin Chim Acta. 1985 Jul 15;149(2-3):237-51</Citation><ArticleIdList><ArticleId IdType="pubmed">4028443</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1969 Aug 25;244(16):4499-509</Citation><ArticleIdList><ArticleId IdType="pubmed">4896753</ArticleId></ArticleIdList></Reference><Reference><Citation>Agents Actions. 1984 Apr;14(3-4):325-34</Citation><ArticleIdList><ArticleId IdType="pubmed">6428188</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Pharmacol. 1984 May 1;33(9):1547-53</Citation><ArticleIdList><ArticleId IdType="pubmed">6428421</ArticleId></ArticleIdList></Reference><Reference><Citation>Arch Biochem Biophys. 1984 May 15;231(1):253-6</Citation><ArticleIdList><ArticleId IdType="pubmed">6721499</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem J. 1980 Jun 1;187(3):819-28</Citation><ArticleIdList><ArticleId IdType="pubmed">7188427</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1952 May;196(2):469-75</Citation><ArticleIdList><ArticleId IdType="pubmed">12980989</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1952 May;197(1):475-80</Citation><ArticleIdList><ArticleId IdType="pubmed">12981077</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1959 Nov;234:2948-50</Citation><ArticleIdList><ArticleId IdType="pubmed">13804910</ArticleId></ArticleIdList></Reference><Reference><Citation>J Biol Chem. 1951 Nov;193(1):265-75</Citation><ArticleIdList><ArticleId IdType="pubmed">14907713</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Toscane</li></region><settlement><li>Pise</li></settlement><orgName><li>Université de Pise</li></orgName></list><tree><noCountry><name sortKey="Donatelli, P" sort="Donatelli, P" uniqKey="Donatelli P" first="P" last="Donatelli">P. Donatelli</name><name sortKey="Giuliani, L" sort="Giuliani, L" uniqKey="Giuliani L" first="L" last="Giuliani">L. Giuliani</name></noCountry><country name="Italie"><region name="Toscane"><name sortKey="Pacifici, G M" sort="Pacifici, G M" uniqKey="Pacifici G" first="G M" last="Pacifici">G M Pacifici</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000059 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000059 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:1457266
|texte= Histamine N-methyl transferase: inhibition by drugs.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:1457266" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |