Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.
Identifieur interne : 001044 ( Ncbi/Curation ); précédent : 001043; suivant : 001045Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.
Auteurs : E D Cooke ; M H Dawson ; R M Ibbotson ; S A Bowcock ; M E Ainsworth ; M F PilcherSource :
- The Journal of bone and joint surgery. American volume [ 0021-9355 ] ; 1977.
Descripteurs français
- KwdFr :
- Administration par voie orale, Adulte d'âge moyen, Arthroplastie, Articulation de la hanche (), Complications postopératoires (), Embolie pulmonaire (), Embolie pulmonaire (diagnostic), Essais cliniques comme sujet, Femelle, Humains, Hydroxychloroquine (administration et posologie), Hydroxychloroquine (usage thérapeutique), Jambe (), Mâle, Méthode en double aveugle, Placebo, Poids du corps, Scintigraphie, Sujet âgé, Thromboembolie (), Thromboembolie (diagnostic).
- MESH :
- administration et posologie : Hydroxychloroquine.
- diagnostic : Embolie pulmonaire, Thromboembolie.
- usage thérapeutique : Hydroxychloroquine.
- Administration par voie orale, Adulte d'âge moyen, Arthroplastie, Articulation de la hanche, Complications postopératoires, Embolie pulmonaire, Essais cliniques comme sujet, Femelle, Humains, Jambe, Mâle, Méthode en double aveugle, Placebo, Poids du corps, Scintigraphie, Sujet âgé, Thromboembolie.
English descriptors
- KwdEn :
- Administration, Oral, Aged, Arthroplasty, Body Weight, Clinical Trials as Topic, Double-Blind Method, Female, Hip Joint (surgery), Humans, Hydroxychloroquine (administration & dosage), Hydroxychloroquine (therapeutic use), Leg (blood supply), Male, Middle Aged, Placebos, Postoperative Complications (prevention & control), Pulmonary Embolism (diagnosis), Pulmonary Embolism (prevention & control), Radionuclide Imaging, Thromboembolism (diagnosis), Thromboembolism (prevention & control).
- MESH :
- chemical , administration & dosage : Hydroxychloroquine.
- blood supply : Leg.
- diagnosis : Pulmonary Embolism, Thromboembolism.
- prevention & control : Postoperative Complications, Pulmonary Embolism, Thromboembolism.
- surgery : Hip Joint.
- chemical , therapeutic use : Hydroxychloroquine.
- Administration, Oral, Aged, Arthroplasty, Body Weight, Clinical Trials as Topic, Double-Blind Method, Female, Humans, Male, Middle Aged, Placebos, Radionuclide Imaging.
Abstract
In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.
PubMed: 325009
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pubmed:325009Le document en format XML
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<author><name sortKey="Dawson, M H" sort="Dawson, M H" uniqKey="Dawson M" first="M H" last="Dawson">M H Dawson</name>
</author>
<author><name sortKey="Ibbotson, R M" sort="Ibbotson, R M" uniqKey="Ibbotson R" first="R M" last="Ibbotson">R M Ibbotson</name>
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<author><name sortKey="Bowcock, S A" sort="Bowcock, S A" uniqKey="Bowcock S" first="S A" last="Bowcock">S A Bowcock</name>
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<author><name sortKey="Ainsworth, M E" sort="Ainsworth, M E" uniqKey="Ainsworth M" first="M E" last="Ainsworth">M E Ainsworth</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Failure of orally administered hydroxychloroquine sulphate to prevent venous thromboembolism following elective hip operations.</title>
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<author><name sortKey="Dawson, M H" sort="Dawson, M H" uniqKey="Dawson M" first="M H" last="Dawson">M H Dawson</name>
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<author><name sortKey="Ibbotson, R M" sort="Ibbotson, R M" uniqKey="Ibbotson R" first="R M" last="Ibbotson">R M Ibbotson</name>
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<author><name sortKey="Ainsworth, M E" sort="Ainsworth, M E" uniqKey="Ainsworth M" first="M E" last="Ainsworth">M E Ainsworth</name>
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<series><title level="j">The Journal of bone and joint surgery. American volume</title>
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<term>Aged</term>
<term>Arthroplasty</term>
<term>Body Weight</term>
<term>Clinical Trials as Topic</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Hip Joint (surgery)</term>
<term>Humans</term>
<term>Hydroxychloroquine (administration & dosage)</term>
<term>Hydroxychloroquine (therapeutic use)</term>
<term>Leg (blood supply)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Placebos</term>
<term>Postoperative Complications (prevention & control)</term>
<term>Pulmonary Embolism (diagnosis)</term>
<term>Pulmonary Embolism (prevention & control)</term>
<term>Radionuclide Imaging</term>
<term>Thromboembolism (diagnosis)</term>
<term>Thromboembolism (prevention & control)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term>
<term>Adulte d'âge moyen</term>
<term>Arthroplastie</term>
<term>Articulation de la hanche ()</term>
<term>Complications postopératoires ()</term>
<term>Embolie pulmonaire ()</term>
<term>Embolie pulmonaire (diagnostic)</term>
<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Hydroxychloroquine (administration et posologie)</term>
<term>Hydroxychloroquine (usage thérapeutique)</term>
<term>Jambe ()</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Placebo</term>
<term>Poids du corps</term>
<term>Scintigraphie</term>
<term>Sujet âgé</term>
<term>Thromboembolie ()</term>
<term>Thromboembolie (diagnostic)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Hydroxychloroquine</term>
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<keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Leg</term>
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<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Pulmonary Embolism</term>
<term>Thromboembolism</term>
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<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Embolie pulmonaire</term>
<term>Thromboembolie</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Postoperative Complications</term>
<term>Pulmonary Embolism</term>
<term>Thromboembolism</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Hip Joint</term>
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<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Hydroxychloroquine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term>
<term>Aged</term>
<term>Arthroplasty</term>
<term>Body Weight</term>
<term>Clinical Trials as Topic</term>
<term>Double-Blind Method</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Placebos</term>
<term>Radionuclide Imaging</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term>
<term>Adulte d'âge moyen</term>
<term>Arthroplastie</term>
<term>Articulation de la hanche</term>
<term>Complications postopératoires</term>
<term>Embolie pulmonaire</term>
<term>Essais cliniques comme sujet</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jambe</term>
<term>Mâle</term>
<term>Méthode en double aveugle</term>
<term>Placebo</term>
<term>Poids du corps</term>
<term>Scintigraphie</term>
<term>Sujet âgé</term>
<term>Thromboembolie</term>
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<front><div type="abstract" xml:lang="en">In a double-blind, randomized trial of orally administered hydroxychloroquine sulphate in the prevention of venous thromboembolism after elective surgery on the hip, the drug or a placebo was given to fifty consecutive patients. Therapy was commenced on the day before the operation and continued for fourteen days. The diagnosis of deep venous thrombosis was made by daily thermographic scanning of the legs and confirmed by phlebography. The diagnosis of pulmonary embolism was made by perfusion lung scanning. No significant difference in the incidence of thromboembolism was found between treated and control groups. The results provide evidence that substances which reduce the incidence of thromboembolism in general surgery may not be effective in operations on the hip.</div>
</front>
</TEI>
</record>
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