Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target
Identifieur interne : 000F33 ( Ncbi/Curation ); précédent : 000F32; suivant : 000F34Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target
Auteurs : Liyuan Fan [République populaire de Chine] ; Juan Wang [République populaire de Chine] ; Qiang Cao [République populaire de Chine] ; Xiuping Ding [République populaire de Chine] ; Baosheng Li [République populaire de Chine]Source :
- American Journal of Cancer Research [ 2156-6976 ] ; 2020.
Abstract
Radiosensitivity varies among patients with non-small cell lung cancer (NSCLC). In this work, we aimed to investigate microRNAs associated with this heterogeneity among individuals. We selected miR-1246 from the microRNAs that were revealed by microarray experiments to be differentially expressed between radioresistant and parental cell lines. Both intracellular and extracellular miR-1246 was found to be upregulated after irradiation in a time-dependent pattern, resulting in increased radioresistance of NSCLC cells. We found that mTOR was a direct target gene of miR-1246, which mediated miR-1246-induced autophagy activation. Yin Yang-1 (YY1) was demonstrated to be a new transcription factor that regulates miR-1246 and CDR1as was found to be a circular RNA that sequesters miR-1246, which was confirmed in NSCLC cells and clinical samples. Finally, combining these data with the results from The Cancer Genome Atlas (TCGA), we verified that miR-1246 could be used as a biomarker to predict NSCLC patients’ radiosensitivity and prognosis. Overall, our study fully investigated the effect of miR-1246 on radiosensitivity and comprehensively investigated the potential of miR-1246 as a prognostic biomarker and radiotherapy sensitization target.
Url:
PubMed: 32064170
PubMed Central: 7017745
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000348
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000348
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000208
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000F33
Links to Exploration step
PMC:7017745Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target</title>
<author><name sortKey="Fan, Liyuan" sort="Fan, Liyuan" uniqKey="Fan L" first="Liyuan" last="Fan">Liyuan Fan</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Cheeloo College of Medicine, Shandong University</institution>
<addr-line>Jinan 250112, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250112</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cao, Qiang" sort="Cao, Qiang" uniqKey="Cao Q" first="Qiang" last="Cao">Qiang Cao</name>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>School of Computer Science and Engineering, Southeast University</institution>
<addr-line>Nanjing 211189, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanjing 211189</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ding, Xiuping" sort="Ding, Xiuping" uniqKey="Ding X" first="Xiuping" last="Ding">Xiuping Ding</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Baosheng" sort="Li, Baosheng" uniqKey="Li B" first="Baosheng" last="Li">Baosheng Li</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Cheeloo College of Medicine, Shandong University</institution>
<addr-line>Jinan 250112, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250112</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">32064170</idno>
<idno type="pmc">7017745</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7017745</idno>
<idno type="RBID">PMC:7017745</idno>
<date when="2020">2020</date>
<idno type="wicri:Area/Pmc/Corpus">000348</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000348</idno>
<idno type="wicri:Area/Pmc/Curation">000348</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000348</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000208</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000208</idno>
<idno type="wicri:Area/Ncbi/Merge">000F33</idno>
<idno type="wicri:Area/Ncbi/Curation">000F33</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target</title>
<author><name sortKey="Fan, Liyuan" sort="Fan, Liyuan" uniqKey="Fan L" first="Liyuan" last="Fan">Liyuan Fan</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Cheeloo College of Medicine, Shandong University</institution>
<addr-line>Jinan 250112, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250112</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Wang, Juan" sort="Wang, Juan" uniqKey="Wang J" first="Juan" last="Wang">Juan Wang</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cao, Qiang" sort="Cao, Qiang" uniqKey="Cao Q" first="Qiang" last="Cao">Qiang Cao</name>
<affiliation wicri:level="1"><nlm:aff id="au3"><institution>School of Computer Science and Engineering, Southeast University</institution>
<addr-line>Nanjing 211189, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanjing 211189</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Ding, Xiuping" sort="Ding, Xiuping" uniqKey="Ding X" first="Xiuping" last="Ding">Xiuping Ding</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Li, Baosheng" sort="Li, Baosheng" uniqKey="Li B" first="Baosheng" last="Li">Baosheng Li</name>
<affiliation wicri:level="1"><nlm:aff id="au1"><institution>Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences</institution>
<addr-line>Jinan 250117, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250117</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="au2"><institution>Cheeloo College of Medicine, Shandong University</institution>
<addr-line>Jinan 250112, China</addr-line>
</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Jinan 250112</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">American Journal of Cancer Research</title>
<idno type="eISSN">2156-6976</idno>
<imprint><date when="2020">2020</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Radiosensitivity varies among patients with non-small cell lung cancer (NSCLC). In this work, we aimed to investigate microRNAs associated with this heterogeneity among individuals. We selected miR-1246 from the microRNAs that were revealed by microarray experiments to be differentially expressed between radioresistant and parental cell lines. Both intracellular and extracellular miR-1246 was found to be upregulated after irradiation in a time-dependent pattern, resulting in increased radioresistance of NSCLC cells. We found that mTOR was a direct target gene of miR-1246, which mediated miR-1246-induced autophagy activation. Yin Yang-1 (YY1) was demonstrated to be a new transcription factor that regulates miR-1246 and CDR1as was found to be a circular RNA that sequesters miR-1246, which was confirmed in NSCLC cells and clinical samples. Finally, combining these data with the results from The Cancer Genome Atlas (TCGA), we verified that miR-1246 could be used as a biomarker to predict NSCLC patients’ radiosensitivity and prognosis. Overall, our study fully investigated the effect of miR-1246 on radiosensitivity and comprehensively investigated the potential of miR-1246 as a prognostic biomarker and radiotherapy sensitization target.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F33 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000F33 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:7017745 |texte= Aberrant miR-1246 expression promotes radioresistance in non-small cell lung cancer: a potential prognostic biomarker and radiotherapy sensitization target }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:32064170" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |