Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics
Identifieur interne : 000800 ( Ncbi/Curation ); précédent : 000799; suivant : 000801Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics
Auteurs : Katie L. Winarski ; Juanjie Tang ; Laura Klenow ; Jeehyun Lee ; Elizabeth M. Coyle ; Jody Manischewitz ; Hannah L. Turner ; Kazuyo Takeda ; Andrew B. Ward ; Hana Golding ; Surender KhuranaSource :
- Proceedings of the National Academy of Sciences of the United States of America [ 0027-8424 ] ; 2019.
Abstract
Next-generation influenza vaccines and broadly neutralizing antibodies (bNAbs) are in clinical development. Some of these do not block virus–receptor interactions and thus are predicted to provide protection via alternative mechanisms at the postentry stage or use Fc-dependent mechanisms. Nonneutralizing antibodies have the potential to mediate enhancement of respiratory disease (ERD). Our study describes ADE with two different functional MAbs that destabilized HA stem domain, increased influenza virus fusion kinetics, and led to enhanced lung pathology and ERD in a dose-dependent manner in a mice model. This study underlines careful preclinical evaluation of next-generation influenza vaccines or antibody-based therapeutics that do not block influenza virus receptor binding.
Url:
DOI: 10.1073/pnas.1821317116
PubMed: 31296560
PubMed Central: 6660725
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000375
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000375
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000A05
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000800
Links to Exploration step
PMC:6660725Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics</title>
<author><name sortKey="Winarski, Katie L" sort="Winarski, Katie L" uniqKey="Winarski K" first="Katie L." last="Winarski">Katie L. Winarski</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tang, Juanjie" sort="Tang, Juanjie" uniqKey="Tang J" first="Juanjie" last="Tang">Juanjie Tang</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klenow, Laura" sort="Klenow, Laura" uniqKey="Klenow L" first="Laura" last="Klenow">Laura Klenow</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Jeehyun" sort="Lee, Jeehyun" uniqKey="Lee J" first="Jeehyun" last="Lee">Jeehyun Lee</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coyle, Elizabeth M" sort="Coyle, Elizabeth M" uniqKey="Coyle E" first="Elizabeth M." last="Coyle">Elizabeth M. Coyle</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Manischewitz, Jody" sort="Manischewitz, Jody" uniqKey="Manischewitz J" first="Jody" last="Manischewitz">Jody Manischewitz</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Turner, Hannah L" sort="Turner, Hannah L" uniqKey="Turner H" first="Hannah L." last="Turner">Hannah L. Turner</name>
<affiliation><nlm:aff id="aff2">Department of Integrative Structural and Computational Biology,<institution>The Scripps Research Institute</institution>
, La Jolla,<addr-line>CA</addr-line>
92037</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Takeda, Kazuyo" sort="Takeda, Kazuyo" uniqKey="Takeda K" first="Kazuyo" last="Takeda">Kazuyo Takeda</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ward, Andrew B" sort="Ward, Andrew B" uniqKey="Ward A" first="Andrew B." last="Ward">Andrew B. Ward</name>
<affiliation><nlm:aff id="aff2">Department of Integrative Structural and Computational Biology,<institution>The Scripps Research Institute</institution>
, La Jolla,<addr-line>CA</addr-line>
92037</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khurana, Surender" sort="Khurana, Surender" uniqKey="Khurana S" first="Surender" last="Khurana">Surender Khurana</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31296560</idno>
<idno type="pmc">6660725</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6660725</idno>
<idno type="RBID">PMC:6660725</idno>
<idno type="doi">10.1073/pnas.1821317116</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000375</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000375</idno>
<idno type="wicri:Area/Pmc/Curation">000375</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000375</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A05</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A05</idno>
<idno type="wicri:Area/Ncbi/Merge">000800</idno>
<idno type="wicri:Area/Ncbi/Curation">000800</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics</title>
<author><name sortKey="Winarski, Katie L" sort="Winarski, Katie L" uniqKey="Winarski K" first="Katie L." last="Winarski">Katie L. Winarski</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Tang, Juanjie" sort="Tang, Juanjie" uniqKey="Tang J" first="Juanjie" last="Tang">Juanjie Tang</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Klenow, Laura" sort="Klenow, Laura" uniqKey="Klenow L" first="Laura" last="Klenow">Laura Klenow</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Lee, Jeehyun" sort="Lee, Jeehyun" uniqKey="Lee J" first="Jeehyun" last="Lee">Jeehyun Lee</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Coyle, Elizabeth M" sort="Coyle, Elizabeth M" uniqKey="Coyle E" first="Elizabeth M." last="Coyle">Elizabeth M. Coyle</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Manischewitz, Jody" sort="Manischewitz, Jody" uniqKey="Manischewitz J" first="Jody" last="Manischewitz">Jody Manischewitz</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Turner, Hannah L" sort="Turner, Hannah L" uniqKey="Turner H" first="Hannah L." last="Turner">Hannah L. Turner</name>
<affiliation><nlm:aff id="aff2">Department of Integrative Structural and Computational Biology,<institution>The Scripps Research Institute</institution>
, La Jolla,<addr-line>CA</addr-line>
92037</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Takeda, Kazuyo" sort="Takeda, Kazuyo" uniqKey="Takeda K" first="Kazuyo" last="Takeda">Kazuyo Takeda</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ward, Andrew B" sort="Ward, Andrew B" uniqKey="Ward A" first="Andrew B." last="Ward">Andrew B. Ward</name>
<affiliation><nlm:aff id="aff2">Department of Integrative Structural and Computational Biology,<institution>The Scripps Research Institute</institution>
, La Jolla,<addr-line>CA</addr-line>
92037</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Golding, Hana" sort="Golding, Hana" uniqKey="Golding H" first="Hana" last="Golding">Hana Golding</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Khurana, Surender" sort="Khurana, Surender" uniqKey="Khurana S" first="Surender" last="Khurana">Surender Khurana</name>
<affiliation><nlm:aff id="aff1">Division of Viral Products, Center for Biologics Evaluation and Research,<institution>Food and Drug Administration</institution>
, Silver Spring,<addr-line>MD</addr-line>
20993;</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Proceedings of the National Academy of Sciences of the United States of America</title>
<idno type="ISSN">0027-8424</idno>
<idno type="eISSN">1091-6490</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><title>Significance</title>
<p>Next-generation influenza vaccines and broadly neutralizing antibodies (bNAbs) are in clinical development. Some of these do not block virus–receptor interactions and thus are predicted to provide protection via alternative mechanisms at the postentry stage or use Fc-dependent mechanisms. Nonneutralizing antibodies have the potential to mediate enhancement of respiratory disease (ERD). Our study describes ADE with two different functional MAbs that destabilized HA stem domain, increased influenza virus fusion kinetics, and led to enhanced lung pathology and ERD in a dose-dependent manner in a mice model. This study underlines careful preclinical evaluation of next-generation influenza vaccines or antibody-based therapeutics that do not block influenza virus receptor binding.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000800 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000800 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:6660725 |texte= Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:31296560" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
This area was generated with Dilib version V0.6.33. |