Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility
Identifieur interne : 000755 ( Ncbi/Curation ); précédent : 000754; suivant : 000756Gene polymorphism of cytochrome P450 significantly affects lung cancer susceptibility
Auteurs : Meng Li ; Anqi Li ; Ruiqing He ; Wenhui Dang ; Xinyu Liu ; Tian Yang ; Puyu Shi ; Xiang Bu ; Dan Gao ; Ning Zhang ; Shuli Du ; Tianbo Jin ; Mingwei ChenSource :
- Cancer Medicine [ 2045-7634 ] ; 2019.
Abstract
Cytochrome P450 (CYPs) are heme proteins involved in the metabolism of a variety of endogenous and exogenous substances and play an important role in the carcinogenesis mechanisms of environmental and hereditary factors. The objective of this study was to investigate how polymorphisms of CYPs correlate with lung cancer (LC) susceptibility.
Six single nucleotide polymorphisms (SNPs) were genotyped in this study. The chi‐square test and unconditional logistic regression model were used to evaluate the correlation between SNPs and LC susceptibility. The expressions and survival data of genes in patients with LC were mined using Oncomine and Kaplan‐Meier Plotter database.
Four SNPs were found to be significantly associated with the risk of LC development (
This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population;
Url:
DOI: 10.1002/cam4.2367
PubMed: 31264381
PubMed Central: 6712450
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<author><name sortKey="Dang, Wenhui" sort="Dang, Wenhui" uniqKey="Dang W" first="Wenhui" last="Dang">Wenhui Dang</name>
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<author><name sortKey="Jin, Tianbo" sort="Jin, Tianbo" uniqKey="Jin T" first="Tianbo" last="Jin">Tianbo Jin</name>
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<author><name sortKey="Chen, Mingwei" sort="Chen, Mingwei" uniqKey="Chen M" first="Mingwei" last="Chen">Mingwei Chen</name>
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<series><title level="j">Cancer Medicine</title>
<idno type="eISSN">2045-7634</idno>
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<front><div type="abstract" xml:lang="en"><title>Abstract</title>
<sec id="cam42367-sec-0001"><title>Background</title>
<p>Cytochrome P450 (CYPs) are heme proteins involved in the metabolism of a variety of endogenous and exogenous substances and play an important role in the carcinogenesis mechanisms of environmental and hereditary factors. The objective of this study was to investigate how polymorphisms of CYPs correlate with lung cancer (LC) susceptibility.</p>
</sec>
<sec id="cam42367-sec-0002"><title>Methods</title>
<p>Six single nucleotide polymorphisms (SNPs) were genotyped in this study. The chi‐square test and unconditional logistic regression model were used to evaluate the correlation between SNPs and LC susceptibility. The expressions and survival data of genes in patients with LC were mined using Oncomine and Kaplan‐Meier Plotter database.</p>
</sec>
<sec id="cam42367-sec-0003"><title>Results</title>
<p>Four SNPs were found to be significantly associated with the risk of LC development (<italic>P </italic>
< 0.05). The most significant correlation was that the A allele and AA genotype of <italic>CYP2D6</italic>
rs1065852 were associated with increased risk of LC development (adjusted odds ratio [OR] = 1.35, 95% confidence interval [95%CI] = 1.13‐1.60, <italic>P </italic>
= 9.04e‐4; OR = 1.83, 95%CI = 1.29‐2.59, <italic>P </italic>
= 0.001 respectively). Similar association of this variant was also found in the subgroups of male patients, cases in III‐IV stages, positive lymph node, squamous cell carcinomas and adenocarcinomas. Whereas rs1065852 was considered as protective factor in females (adjusted OR = 0.33, 95% CI = 0.16‐0.70, <italic>P </italic>
= 0.004). In stratified analyses, the association of <italic>CYP24A1</italic>
rs2762934, <italic>CYP24A1</italic>
rs6068816, <italic>CYP20A1</italic>
rs2043449 polymorphism with LC risk appeared stronger in some subgroups. <italic>CYP2D6</italic>
, <italic>CYP24A1</italic>
and <italic>CYP20A</italic>
1 are overexpressed in some pathological types of LC (<italic>P </italic>
< 0.05), and high levels of <italic>CYP2D6</italic>
and <italic>CYP20A1</italic>
indicate poor and good prognosis of LC, respectively.</p>
</sec>
<sec id="cam42367-sec-0004"><title>Conclusion</title>
<p>This study revealed that rs1065852, rs2043449, rs2762s934, and rs6068816 of CYPs were associated with LC susceptibility in the Northwestern Chinese Han population; <italic>CYP2D6</italic>
and <italic>CYP20A</italic>
1 were overexpressed and correlated with prognosis of LC.</p>
</sec>
</div>
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