Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?
Identifieur interne : 000704 ( Ncbi/Curation ); précédent : 000703; suivant : 000705Is TRPA1 Burning Down TRPV1 as Druggable Target for the Treatment of Chronic Pain?
Auteurs : Simona Giorgi ; Magdalena Nikolaeva-Koleva [Espagne] ; David Alarc N-Alarc N ; Laura Butr N ; Sara González-RodríguezSource :
- International Journal of Molecular Sciences [ 1422-0067 ] ; 2019.
Abstract
Over the last decades, a great array of molecular mediators have been identified as potential targets for the treatment of chronic pain. Among these mediators, transient receptor potential (TRP) channel superfamily members have been thoroughly studied. Namely, the nonselective cationic channel, transient receptor potential ankyrin subtype 1 (TRPA1), has been described as a chemical nocisensor involved in noxious cold and mechanical sensation and as rivalling TRPV1, which traditionally has been considered as the most important TRP channel involved in nociceptive transduction. However, few TRPA1-related drugs have succeeded in clinical trials. In the present review, we attempt to discuss the latest data on the topic and future directions for pharmacological intervention.
Url:
DOI: 10.3390/ijms20122906
PubMed: 31197115
PubMed Central: 6627658
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PMC:6627658Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Over the last decades, a great array of molecular mediators have been identified as potential targets for the treatment of chronic pain. Among these mediators, transient receptor potential (TRP) channel superfamily members have been thoroughly studied. Namely, the nonselective cationic channel, transient receptor potential ankyrin subtype 1 (TRPA1), has been described as a chemical nocisensor involved in noxious cold and mechanical sensation and as rivalling TRPV1, which traditionally has been considered as the most important TRP channel involved in nociceptive transduction. However, few TRPA1-related drugs have succeeded in clinical trials. In the present review, we attempt to discuss the latest data on the topic and future directions for pharmacological intervention.</p>
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