Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
Identifieur interne : 000654 ( Ncbi/Curation ); précédent : 000653; suivant : 000655Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
Auteurs : Elizabeth K. Benedikz [Royaume-Uni] ; Dalan Bailey [Royaume-Uni] ; Charlotte N. L. Cook [Royaume-Uni] ; Daniel Gonçalves-Carneiro [Royaume-Uni] ; Michelle M. C. Buckner [Royaume-Uni] ; Jessica M. A. Blair [Royaume-Uni] ; Timothy J. Wells [Royaume-Uni] ; Nicola F. Fletcher [Royaume-Uni] ; Margaret Goodall [Royaume-Uni] ; Adriana Flores-Langarica [Royaume-Uni] ; Robert A. Kingsley [Royaume-Uni] ; Jens Madsen [Royaume-Uni] ; Jessica Teeling [Royaume-Uni] ; Sebastian L. Johnston [Royaume-Uni] ; Calman A. Maclennan [Royaume-Uni] ; Peter Balfe [Royaume-Uni] ; Ian R. Henderson [Royaume-Uni] ; Laura J. V. Piddock [Royaume-Uni] ; Adam F. Cunningham [Royaume-Uni] ; Jane A. Mckeating [Royaume-Uni]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Viruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host can potentiate infection through poorly understood mechanisms. Here, we investigated whether diverse bacterial species could modulate virus internalization into host cells, often a rate-limiting step in establishing infections. Lentiviral pseudoviruses expressing influenza, measles, Ebola, Lassa or vesicular stomatitis virus envelope glycoproteins enabled us to study entry of viruses that exploit diverse internalization pathways.
Url:
DOI: 10.1038/s41598-019-44263-7
PubMed: 31133714
PubMed Central: 6536546
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000175
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000175
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000949
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000654
Links to Exploration step
PMC:6536546Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway</title><author><name sortKey="Benedikz, Elizabeth K" sort="Benedikz, Elizabeth K" uniqKey="Benedikz E" first="Elizabeth K." last="Benedikz">Elizabeth K. Benedikz</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Bailey, Dalan" sort="Bailey, Dalan" uniqKey="Bailey D" first="Dalan" last="Bailey">Dalan Bailey</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0388 7540</institution-id><institution-id institution-id-type="GRID">grid.63622.33</institution-id><institution>The Pirbright Institute, Guildford,</institution></institution-wrap>Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Surrey</wicri:regionArea></affiliation></author><author><name sortKey="Cook, Charlotte N L" sort="Cook, Charlotte N L" uniqKey="Cook C" first="Charlotte N. L." last="Cook">Charlotte N. L. Cook</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves Carneiro, Daniel" sort="Goncalves Carneiro, Daniel" uniqKey="Goncalves Carneiro D" first="Daniel" last="Gonçalves-Carneiro">Daniel Gonçalves-Carneiro</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Buckner, Michelle M C" sort="Buckner, Michelle M C" uniqKey="Buckner M" first="Michelle M. C." last="Buckner">Michelle M. C. Buckner</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Blair, Jessica M A" sort="Blair, Jessica M A" uniqKey="Blair J" first="Jessica M. A." last="Blair">Jessica M. A. Blair</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Wells, Timothy J" sort="Wells, Timothy J" uniqKey="Wells T" first="Timothy J." last="Wells">Timothy J. Wells</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Fletcher, Nicola F" sort="Fletcher, Nicola F" uniqKey="Fletcher N" first="Nicola F." last="Fletcher">Nicola F. Fletcher</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Goodall, Margaret" sort="Goodall, Margaret" uniqKey="Goodall M" first="Margaret" last="Goodall">Margaret Goodall</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Flores Langarica, Adriana" sort="Flores Langarica, Adriana" uniqKey="Flores Langarica A" first="Adriana" last="Flores-Langarica">Adriana Flores-Langarica</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Kingsley, Robert A" sort="Kingsley, Robert A" uniqKey="Kingsley R" first="Robert A." last="Kingsley">Robert A. Kingsley</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9347 0159</institution-id><institution-id institution-id-type="GRID">grid.40368.39</institution-id><institution>Institute of Food Research,</institution></institution-wrap>Norwich, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Norwich</wicri:regionArea></affiliation></author><author><name sortKey="Madsen, Jens" sort="Madsen, Jens" uniqKey="Madsen J" first="Jens" last="Madsen">Jens Madsen</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9297</institution-id><institution-id institution-id-type="GRID">grid.5491.9</institution-id><institution>Department of Child Health,</institution><institution>University of Southampton,</institution></institution-wrap>Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Teeling, Jessica" sort="Teeling, Jessica" uniqKey="Teeling J" first="Jessica" last="Teeling">Jessica Teeling</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.430506.4</institution-id><institution>Biological Sciences, University Hospital Southampton NHS Foundation Trust,</institution></institution-wrap>Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L." last="Johnston">Sebastian L. Johnston</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id><institution-id institution-id-type="GRID">grid.7445.2</institution-id><institution>National Heart and Lung Institute, Imperial College London,</institution></institution-wrap>London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Maclennan, Calman A" sort="Maclennan, Calman A" uniqKey="Maclennan C" first="Calman A." last="Maclennan">Calman A. Maclennan</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Jenner Institute, Nuffield Department of Medicine, University of Oxford,</institution></institution-wrap>Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Balfe, Peter" sort="Balfe, Peter" uniqKey="Balfe P" first="Peter" last="Balfe">Peter Balfe</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Ian R" sort="Henderson, Ian R" uniqKey="Henderson I" first="Ian R." last="Henderson">Ian R. Henderson</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Piddock, Laura J V" sort="Piddock, Laura J V" uniqKey="Piddock L" first="Laura J. V." last="Piddock">Laura J. V. Piddock</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Cunningham, Adam F" sort="Cunningham, Adam F" uniqKey="Cunningham A" first="Adam F." last="Cunningham">Adam F. Cunningham</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Mckeating, Jane A" sort="Mckeating, Jane A" uniqKey="Mckeating J" first="Jane A." last="Mckeating">Jane A. Mckeating</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Nuffield Department of Medicine, University of Oxford,</institution></institution-wrap>Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31133714</idno><idno type="pmc">6536546</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6536546</idno><idno type="RBID">PMC:6536546</idno><idno type="doi">10.1038/s41598-019-44263-7</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000175</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000175</idno><idno type="wicri:Area/Pmc/Curation">000175</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000175</idno><idno type="wicri:Area/Pmc/Checkpoint">000949</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000949</idno><idno type="wicri:Area/Ncbi/Merge">000654</idno><idno type="wicri:Area/Ncbi/Curation">000654</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway</title><author><name sortKey="Benedikz, Elizabeth K" sort="Benedikz, Elizabeth K" uniqKey="Benedikz E" first="Elizabeth K." last="Benedikz">Elizabeth K. Benedikz</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Bailey, Dalan" sort="Bailey, Dalan" uniqKey="Bailey D" first="Dalan" last="Bailey">Dalan Bailey</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 0388 7540</institution-id><institution-id institution-id-type="GRID">grid.63622.33</institution-id><institution>The Pirbright Institute, Guildford,</institution></institution-wrap>Surrey, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Surrey</wicri:regionArea></affiliation></author><author><name sortKey="Cook, Charlotte N L" sort="Cook, Charlotte N L" uniqKey="Cook C" first="Charlotte N. L." last="Cook">Charlotte N. L. Cook</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Goncalves Carneiro, Daniel" sort="Goncalves Carneiro, Daniel" uniqKey="Goncalves Carneiro D" first="Daniel" last="Gonçalves-Carneiro">Daniel Gonçalves-Carneiro</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Buckner, Michelle M C" sort="Buckner, Michelle M C" uniqKey="Buckner M" first="Michelle M. C." last="Buckner">Michelle M. C. Buckner</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Blair, Jessica M A" sort="Blair, Jessica M A" uniqKey="Blair J" first="Jessica M. A." last="Blair">Jessica M. A. Blair</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Wells, Timothy J" sort="Wells, Timothy J" uniqKey="Wells T" first="Timothy J." last="Wells">Timothy J. Wells</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Fletcher, Nicola F" sort="Fletcher, Nicola F" uniqKey="Fletcher N" first="Nicola F." last="Fletcher">Nicola F. Fletcher</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Goodall, Margaret" sort="Goodall, Margaret" uniqKey="Goodall M" first="Margaret" last="Goodall">Margaret Goodall</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Flores Langarica, Adriana" sort="Flores Langarica, Adriana" uniqKey="Flores Langarica A" first="Adriana" last="Flores-Langarica">Adriana Flores-Langarica</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Kingsley, Robert A" sort="Kingsley, Robert A" uniqKey="Kingsley R" first="Robert A." last="Kingsley">Robert A. Kingsley</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9347 0159</institution-id><institution-id institution-id-type="GRID">grid.40368.39</institution-id><institution>Institute of Food Research,</institution></institution-wrap>Norwich, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Norwich</wicri:regionArea></affiliation></author><author><name sortKey="Madsen, Jens" sort="Madsen, Jens" uniqKey="Madsen J" first="Jens" last="Madsen">Jens Madsen</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9297</institution-id><institution-id institution-id-type="GRID">grid.5491.9</institution-id><institution>Department of Child Health,</institution><institution>University of Southampton,</institution></institution-wrap>Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Teeling, Jessica" sort="Teeling, Jessica" uniqKey="Teeling J" first="Jessica" last="Teeling">Jessica Teeling</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.430506.4</institution-id><institution>Biological Sciences, University Hospital Southampton NHS Foundation Trust,</institution></institution-wrap>Southampton, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Southampton</wicri:regionArea></affiliation></author><author><name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L." last="Johnston">Sebastian L. Johnston</name><affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id><institution-id institution-id-type="GRID">grid.7445.2</institution-id><institution>National Heart and Lung Institute, Imperial College London,</institution></institution-wrap>London, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London</wicri:regionArea></affiliation></author><author><name sortKey="Maclennan, Calman A" sort="Maclennan, Calman A" uniqKey="Maclennan C" first="Calman A." last="Maclennan">Calman A. Maclennan</name><affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Jenner Institute, Nuffield Department of Medicine, University of Oxford,</institution></institution-wrap>Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author><author><name sortKey="Balfe, Peter" sort="Balfe, Peter" uniqKey="Balfe P" first="Peter" last="Balfe">Peter Balfe</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Henderson, Ian R" sort="Henderson, Ian R" uniqKey="Henderson I" first="Ian R." last="Henderson">Ian R. Henderson</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Piddock, Laura J V" sort="Piddock, Laura J V" uniqKey="Piddock L" first="Laura J. V." last="Piddock">Laura J. V. Piddock</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Cunningham, Adam F" sort="Cunningham, Adam F" uniqKey="Cunningham A" first="Adam F." last="Cunningham">Adam F. Cunningham</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Microbiology and Infection, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation></author><author><name sortKey="Mckeating, Jane A" sort="Mckeating, Jane A" uniqKey="Mckeating J" first="Jane A." last="Mckeating">Jane A. Mckeating</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id><institution-id institution-id-type="GRID">grid.6572.6</institution-id><institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution></institution-wrap>Birmingham, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Birmingham</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id><institution-id institution-id-type="GRID">grid.4991.5</institution-id><institution>Nuffield Department of Medicine, University of Oxford,</institution></institution-wrap>Oxford, UK</nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Oxford</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Viruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host can potentiate infection through poorly understood mechanisms. Here, we investigated whether diverse bacterial species could modulate virus internalization into host cells, often a rate-limiting step in establishing infections. Lentiviral pseudoviruses expressing influenza, measles, Ebola, Lassa or vesicular stomatitis virus envelope glycoproteins enabled us to study entry of viruses that exploit diverse internalization pathways. <italic>Salmonella</italic> Typhimurium, <italic>Escherichia coli</italic> and <italic>Pseudomonas aeruginosa</italic> significantly increased viral uptake, even at low bacterial frequencies. This did not require bacterial contact with or invasion of host cells. Studies determined that the bacterial antigen responsible for this pro-viral activity was the Toll-Like Receptor 5 (TLR5) agonist flagellin. Exposure to flagellin increased virus attachment to epithelial cells in a temperature-dependent manner via TLR5-dependent activation of NF-ΚB. Importantly, this phenotype was both long lasting and detectable at low multiplicities of infection. Flagellin is shed from bacteria and our studies uncover a new bystander role for this protein in regulating virus entry. This highlights a new aspect of viral-bacterial interplay with significant implications for our understanding of polymicrobial-associated pathogenesis.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Pfeiffer, J K" uniqKey="Pfeiffer J">J. K. Pfeiffer</name></author><author><name sortKey="Virgin, H W" uniqKey="Virgin H">H. W. Virgin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="O Rien, Kl" uniqKey="O Rien K">KL O’Brien</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ampofo, K" uniqKey="Ampofo K">K Ampofo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hament, Jm" uniqKey="Hament J">JM Hament</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Avadhanula, V" uniqKey="Avadhanula V">V Avadhanula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Dt" uniqKey="Nguyen D">DT Nguyen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tang, Ac" uniqKey="Tang A">AC Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Varkey, Jb" uniqKey="Varkey J">JB Varkey</name></author><author><name sortKey="Varkey, B" uniqKey="Varkey B">B Varkey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cook, Ch" uniqKey="Cook C">CH Cook</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Walton, Ah" uniqKey="Walton A">AH Walton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weerkamp, N" uniqKey="Weerkamp N">N Weerkamp</name></author><author><name sortKey="Van De Beek, D" uniqKey="Van De Beek D">D van de Beek</name></author><author><name sortKey="De Gans, J" uniqKey="De Gans J">J de Gans</name></author><author><name sortKey="Koehler, Pj" uniqKey="Koehler P">PJ Koehler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cossart, P" uniqKey="Cossart P">P. Cossart</name></author><author><name sortKey="Helenius, A" uniqKey="Helenius A">A. Helenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Delorme Axford, E" uniqKey="Delorme Axford E">E Delorme-Axford</name></author><author><name sortKey="Coyne, Cb" uniqKey="Coyne C">CB Coyne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amieva, Mr" uniqKey="Amieva M">MR Amieva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mcnamara, N" uniqKey="Mcnamara N">N McNamara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gewirtz, At" uniqKey="Gewirtz A">AT Gewirtz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, C" uniqKey="Levy C">C Levy</name></author><author><name sortKey="Verhoeyen, E" uniqKey="Verhoeyen E">E Verhoeyen</name></author><author><name sortKey="Cosset, Fl" uniqKey="Cosset F">FL Cosset</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mee, Cj" uniqKey="Mee C">CJ Mee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Skehel, Jj" uniqKey="Skehel J">JJ Skehel</name></author><author><name sortKey="Wiley, Dc" uniqKey="Wiley D">DC Wiley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Palgen, Jl" uniqKey="Palgen J">JL Palgen</name></author><author><name sortKey="Jurgens, Em" uniqKey="Jurgens E">EM Jurgens</name></author><author><name sortKey="Moscona, A" uniqKey="Moscona A">A Moscona</name></author><author><name sortKey="Porotto, M" uniqKey="Porotto M">M Porotto</name></author><author><name sortKey="Palermo, L" uniqKey="Palermo L">L Palermo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moller Tank, S" uniqKey="Moller Tank S">S Moller-Tank</name></author><author><name sortKey="Maury, W" uniqKey="Maury W">W Maury</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Jong, Hk" uniqKey="De Jong H">HK de Jong</name></author><author><name sortKey="Parry, Cm" uniqKey="Parry C">CM Parry</name></author><author><name sortKey="Van Der Poll, T" uniqKey="Van Der Poll T">T van der Poll</name></author><author><name sortKey="Wiersinga, Wj" uniqKey="Wiersinga W">WJ Wiersinga</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bobat, S" uniqKey="Bobat S">S Bobat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pizzato, M" uniqKey="Pizzato M">M Pizzato</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cunningham, Af" uniqKey="Cunningham A">AF Cunningham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lopez Yglesias, Ah" uniqKey="Lopez Yglesias A">AH Lopez-Yglesias</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Godbersen, Jc" uniqKey="Godbersen J">JC Godbersen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Fm" uniqKey="Chang F">FM Chang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, N F" uniqKey="Fletcher N">N. F Fletcher</name></author><author><name sortKey="Clark, A R" uniqKey="Clark A">A. R Clark</name></author><author><name sortKey="Balfe, P" uniqKey="Balfe P">P Balfe</name></author><author><name sortKey="Mckeating, J A" uniqKey="Mckeating J">J. A McKeating</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guttenplan, Sb" uniqKey="Guttenplan S">SB Guttenplan</name></author><author><name sortKey="Shaw, S" uniqKey="Shaw S">S Shaw</name></author><author><name sortKey="Kearns, Db" uniqKey="Kearns D">DB Kearns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Greber, Ufv" uniqKey="Greber U">UFV Greber</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harris, Hj" uniqKey="Harris H">HJ Harris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, Nf" uniqKey="Fletcher N">NF Fletcher</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fletcher, Nf" uniqKey="Fletcher N">NF Fletcher</name></author><author><name sortKey="Clark, Ar" uniqKey="Clark A">AR Clark</name></author><author><name sortKey="Balfe, P" uniqKey="Balfe P">P Balfe</name></author><author><name sortKey="Mckeating, Ja" uniqKey="Mckeating J">JA McKeating</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Letran, Se" uniqKey="Letran S">SE Letran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Corbiere, V" uniqKey="Corbiere V">V Corbiere</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gewirtz, At" uniqKey="Gewirtz A">AT Gewirtz</name></author><author><name sortKey="Navas, Ta" uniqKey="Navas T">TA Navas</name></author><author><name sortKey="Lyons, S" uniqKey="Lyons S">S Lyons</name></author><author><name sortKey="Godowski, Pj" uniqKey="Godowski P">PJ Godowski</name></author><author><name sortKey="Madara, Jl" uniqKey="Madara J">JL Madara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vijayan, A" uniqKey="Vijayan A">A Vijayan</name></author><author><name sortKey="Rumbo, M" uniqKey="Rumbo M">M Rumbo</name></author><author><name sortKey="Carnoy, C" uniqKey="Carnoy C">C Carnoy</name></author><author><name sortKey="Sirard, Jc" uniqKey="Sirard J">JC Sirard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van Maele, L" uniqKey="Van Maele L">L Van Maele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flores Langarica, A" uniqKey="Flores Langarica A">A Flores-Langarica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Flores Langarica, A" uniqKey="Flores Langarica A">A Flores-Langarica</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Oh, Jz" uniqKey="Oh J">JZ Oh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Porte, R" uniqKey="Porte R">R Porte</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, B" uniqKey="Zhang B">B Zhang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Jr" uniqKey="Kim J">JR Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brichacek, Beda" uniqKey="Brichacek B">Beda Brichacek</name></author><author><name sortKey="Vanpouille, Christophe" uniqKey="Vanpouille C">Christophe Vanpouille</name></author><author><name sortKey="Kiselyeva, Yana" uniqKey="Kiselyeva Y">Yana Kiselyeva</name></author><author><name sortKey="Biancotto, Angelique" uniqKey="Biancotto A">Angelique Biancotto</name></author><author><name sortKey="Merbah, Melanie" uniqKey="Merbah M">Melanie Merbah</name></author><author><name sortKey="Hirsch, Ivan" uniqKey="Hirsch I">Ivan Hirsch</name></author><author><name sortKey="Lisco, Andrea" uniqKey="Lisco A">Andrea Lisco</name></author><author><name sortKey="Grivel, Jean Charles" uniqKey="Grivel J">Jean Charles Grivel</name></author><author><name sortKey="Margolis, Leonid" uniqKey="Margolis L">Leonid Margolis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thibault, S" uniqKey="Thibault S">S Thibault</name></author><author><name sortKey="Imbeault, M" uniqKey="Imbeault M">M Imbeault</name></author><author><name sortKey="Tardif, Mr" uniqKey="Tardif M">MR Tardif</name></author><author><name sortKey="Tremblay, Mj" uniqKey="Tremblay M">MJ Tremblay</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tunney, Mm" uniqKey="Tunney M">MM Tunney</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gao, Yh" uniqKey="Gao Y">YH Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wolfgang, Mc" uniqKey="Wolfgang M">MC Wolfgang</name></author><author><name sortKey="Jyot, J" uniqKey="Jyot J">J Jyot</name></author><author><name sortKey="Goodman, Al" uniqKey="Goodman A">AL Goodman</name></author><author><name sortKey="Ramphal, R" uniqKey="Ramphal R">R Ramphal</name></author><author><name sortKey="Lory, S" uniqKey="Lory S">S Lory</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hawn, Tr" uniqKey="Hawn T">TR Hawn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="West, Te" uniqKey="West T">TE West</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kollmann, Tr" uniqKey="Kollmann T">TR Kollmann</name></author><author><name sortKey="Levy, O" uniqKey="Levy O">O Levy</name></author><author><name sortKey="Montgomery, Rr" uniqKey="Montgomery R">RR Montgomery</name></author><author><name sortKey="Goriely, S" uniqKey="Goriely S">S Goriely</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liberati, Nt" uniqKey="Liberati N">NT Liberati</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hsu, M" uniqKey="Hsu M">M Hsu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Paal, T" uniqKey="Paal T">T Paal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ishikawa, H" uniqKey="Ishikawa H">H Ishikawa</name></author><author><name sortKey="Meng, F" uniqKey="Meng F">F Meng</name></author><author><name sortKey="Kondo, N" uniqKey="Kondo N">N Kondo</name></author><author><name sortKey="Iwamoto, A" uniqKey="Iwamoto A">A Iwamoto</name></author><author><name sortKey="Matsuda, Z" uniqKey="Matsuda Z">Z Matsuda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hashimoto, K" uniqKey="Hashimoto K">K Hashimoto</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000654 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000654 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= PMC:6536546
|texte= Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:31133714" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |