Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
Identifieur interne : 000654 ( Ncbi/Curation ); précédent : 000653; suivant : 000655Bacterial flagellin promotes viral entry via an NF-kB and Toll Like Receptor 5 dependent pathway
Auteurs : Elizabeth K. Benedikz [Royaume-Uni] ; Dalan Bailey [Royaume-Uni] ; Charlotte N. L. Cook [Royaume-Uni] ; Daniel Gonçalves-Carneiro [Royaume-Uni] ; Michelle M. C. Buckner [Royaume-Uni] ; Jessica M. A. Blair [Royaume-Uni] ; Timothy J. Wells [Royaume-Uni] ; Nicola F. Fletcher [Royaume-Uni] ; Margaret Goodall [Royaume-Uni] ; Adriana Flores-Langarica [Royaume-Uni] ; Robert A. Kingsley [Royaume-Uni] ; Jens Madsen [Royaume-Uni] ; Jessica Teeling [Royaume-Uni] ; Sebastian L. Johnston [Royaume-Uni] ; Calman A. Maclennan [Royaume-Uni] ; Peter Balfe [Royaume-Uni] ; Ian R. Henderson [Royaume-Uni] ; Laura J. V. Piddock [Royaume-Uni] ; Adam F. Cunningham [Royaume-Uni] ; Jane A. Mckeating [Royaume-Uni]Source :
- Scientific Reports [ 2045-2322 ] ; 2019.
Abstract
Viruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host can potentiate infection through poorly understood mechanisms. Here, we investigated whether diverse bacterial species could modulate virus internalization into host cells, often a rate-limiting step in establishing infections. Lentiviral pseudoviruses expressing influenza, measles, Ebola, Lassa or vesicular stomatitis virus envelope glycoproteins enabled us to study entry of viruses that exploit diverse internalization pathways.
Url:
DOI: 10.1038/s41598-019-44263-7
PubMed: 31133714
PubMed Central: 6536546
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PMC:6536546Le document en format XML
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<author><name sortKey="Fletcher, Nicola F" sort="Fletcher, Nicola F" uniqKey="Fletcher N" first="Nicola F." last="Fletcher">Nicola F. Fletcher</name>
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<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Goodall, Margaret" sort="Goodall, Margaret" uniqKey="Goodall M" first="Margaret" last="Goodall">Margaret Goodall</name>
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<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Flores Langarica, Adriana" sort="Flores Langarica, Adriana" uniqKey="Flores Langarica A" first="Adriana" last="Flores-Langarica">Adriana Flores-Langarica</name>
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<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Kingsley, Robert A" sort="Kingsley, Robert A" uniqKey="Kingsley R" first="Robert A." last="Kingsley">Robert A. Kingsley</name>
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<institution-id institution-id-type="GRID">grid.40368.39</institution-id>
<institution>Institute of Food Research,</institution>
</institution-wrap>
Norwich, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Norwich</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Madsen, Jens" sort="Madsen, Jens" uniqKey="Madsen J" first="Jens" last="Madsen">Jens Madsen</name>
<affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 9297</institution-id>
<institution-id institution-id-type="GRID">grid.5491.9</institution-id>
<institution>Department of Child Health,</institution>
<institution>University of Southampton,</institution>
</institution-wrap>
Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Teeling, Jessica" sort="Teeling, Jessica" uniqKey="Teeling J" first="Jessica" last="Teeling">Jessica Teeling</name>
<affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.430506.4</institution-id>
<institution>Biological Sciences, University Hospital Southampton NHS Foundation Trust,</institution>
</institution-wrap>
Southampton, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Southampton</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johnston, Sebastian L" sort="Johnston, Sebastian L" uniqKey="Johnston S" first="Sebastian L." last="Johnston">Sebastian L. Johnston</name>
<affiliation wicri:level="1"><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2113 8111</institution-id>
<institution-id institution-id-type="GRID">grid.7445.2</institution-id>
<institution>National Heart and Lung Institute, Imperial College London,</institution>
</institution-wrap>
London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>London</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Maclennan, Calman A" sort="Maclennan, Calman A" uniqKey="Maclennan C" first="Calman A." last="Maclennan">Calman A. Maclennan</name>
<affiliation wicri:level="1"><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Jenner Institute, Nuffield Department of Medicine, University of Oxford,</institution>
</institution-wrap>
Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Balfe, Peter" sort="Balfe, Peter" uniqKey="Balfe P" first="Peter" last="Balfe">Peter Balfe</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id>
<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henderson, Ian R" sort="Henderson, Ian R" uniqKey="Henderson I" first="Ian R." last="Henderson">Ian R. Henderson</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id>
<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Microbiology and Infection, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Piddock, Laura J V" sort="Piddock, Laura J V" uniqKey="Piddock L" first="Laura J. V." last="Piddock">Laura J. V. Piddock</name>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id>
<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Microbiology and Infection, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Cunningham, Adam F" sort="Cunningham, Adam F" uniqKey="Cunningham A" first="Adam F." last="Cunningham">Adam F. Cunningham</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id>
<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id>
<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Microbiology and Infection, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mckeating, Jane A" sort="Mckeating, Jane A" uniqKey="Mckeating J" first="Jane A." last="Mckeating">Jane A. Mckeating</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 7486</institution-id>
<institution-id institution-id-type="GRID">grid.6572.6</institution-id>
<institution>Institute of Immunology and Immunotherapy, University of Birmingham,</institution>
</institution-wrap>
Birmingham, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Birmingham</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1936 8948</institution-id>
<institution-id institution-id-type="GRID">grid.4991.5</institution-id>
<institution>Nuffield Department of Medicine, University of Oxford,</institution>
</institution-wrap>
Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Oxford</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Scientific Reports</title>
<idno type="eISSN">2045-2322</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><p id="Par1">Viruses and bacteria colonize hosts by invading epithelial barriers. Recent studies have shown that interactions between the microbiota, pathogens and the host can potentiate infection through poorly understood mechanisms. Here, we investigated whether diverse bacterial species could modulate virus internalization into host cells, often a rate-limiting step in establishing infections. Lentiviral pseudoviruses expressing influenza, measles, Ebola, Lassa or vesicular stomatitis virus envelope glycoproteins enabled us to study entry of viruses that exploit diverse internalization pathways. <italic>Salmonella</italic>
Typhimurium, <italic>Escherichia coli</italic>
and <italic>Pseudomonas aeruginosa</italic>
significantly increased viral uptake, even at low bacterial frequencies. This did not require bacterial contact with or invasion of host cells. Studies determined that the bacterial antigen responsible for this pro-viral activity was the Toll-Like Receptor 5 (TLR5) agonist flagellin. Exposure to flagellin increased virus attachment to epithelial cells in a temperature-dependent manner via TLR5-dependent activation of NF-ΚB. Importantly, this phenotype was both long lasting and detectable at low multiplicities of infection. Flagellin is shed from bacteria and our studies uncover a new bystander role for this protein in regulating virus entry. This highlights a new aspect of viral-bacterial interplay with significant implications for our understanding of polymicrobial-associated pathogenesis.</p>
</div>
</front>
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