Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells
Identifieur interne : 000529 ( Ncbi/Curation ); précédent : 000528; suivant : 000530Treatment of refractory secondary hemophagocytic lymphohistiocytosis with umbilical cord mesenchymal stem cells
Auteurs : Xiaoyang Yang [République populaire de Chine] ; Shufang Zhang [République populaire de Chine] ; Denggao Huang [République populaire de Chine] ; Zhiming Wang [République populaire de Chine] ; Xiaoxia Chen [République populaire de Chine] ; Xiansheng Luo [République populaire de Chine] ; Meiqing Lei [République populaire de Chine] ; Feng Yu [République populaire de Chine] ; Xiaobo Chen [République populaire de Chine] ; Peilong Huang [République populaire de Chine]Source :
- The Journal of International Medical Research [ 0300-0605 ] ; 2019.
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Mesenchymal stem cells (MSCs) generate an immunosuppressive microenvironment by secreting cytokines and have been used to treat autoimmune diseases. We report the first case of refractory secondary HLH treated with umbilical cord MSCs. A 52-year-old Chinese female patient with a history of type 2 diabetes was diagnosed with refractory secondary HLH based upon the HLH-2004 protocol and was treated by infusion of third-party umbilical cord MSCs (1.4 × 106 cells/kg of body weight, 70 × 106 cells in total) from the stem cell bank of Hainan Province. Body temperature recovered to normal on the sixth day after infusion with umbilical cord MSCs, and the levels of inflammatory factors macrophage inflammatory protein (MIP)-1α, interleukin (IL)-12p70, stromal cell-derived factor (SDF)-1α, and IL-7 decreased significantly. Blood glucose levels were significantly lower than before treatment, and the amount of insulin needed was significantly reduced. Umbilical cord MSCs can relieve the symptoms of refractory secondary HLH and have a therapeutic effect on insulin resistance in type 2 diabetes mellitus.
Url:
DOI: 10.1177/0300060519836533
PubMed: 30961409
PubMed Central: 6567783
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<front><div type="abstract" xml:lang="en"><p>Hemophagocytic lymphohistiocytosis (HLH) is an aggressive and life-threatening syndrome of excessive immune activation. Mesenchymal stem cells (MSCs) generate an immunosuppressive microenvironment by secreting cytokines and have been used to treat autoimmune diseases. We report the first case of refractory secondary HLH treated with umbilical cord MSCs. A 52-year-old Chinese female patient with a history of type 2 diabetes was diagnosed with refractory secondary HLH based upon the HLH-2004 protocol and was treated by infusion of third-party umbilical cord MSCs (1.4 × 10<sup>6</sup>
cells/kg of body weight, 70 × 10<sup>6</sup>
cells in total) from the stem cell bank of Hainan Province. Body temperature recovered to normal on the sixth day after infusion with umbilical cord MSCs, and the levels of inflammatory factors macrophage inflammatory protein (MIP)-1α, interleukin (IL)-12p70, stromal cell-derived factor (SDF)-1α, and IL-7 decreased significantly. Blood glucose levels were significantly lower than before treatment, and the amount of insulin needed was significantly reduced. Umbilical cord MSCs can relieve the symptoms of refractory secondary HLH and have a therapeutic effect on insulin resistance in type 2 diabetes mellitus.</p>
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</author>
<author><name sortKey="Horne, A" uniqKey="Horne A">A Horne</name>
</author>
<author><name sortKey="Arico, M" uniqKey="Arico M">M Arico</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Marsh, Ra" uniqKey="Marsh R">RA Marsh</name>
</author>
<author><name sortKey="Jordan, Mb" uniqKey="Jordan M">MB Jordan</name>
</author>
<author><name sortKey="Talano, Ja" uniqKey="Talano J">JA Talano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mougiakakos, D" uniqKey="Mougiakakos D">D Mougiakakos</name>
</author>
<author><name sortKey="Machaczka, M" uniqKey="Machaczka M">M Machaczka</name>
</author>
<author><name sortKey="Jitschin, R" uniqKey="Jitschin R">R Jitschin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wysocki, Ca" uniqKey="Wysocki C">CA. Wysocki</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, X" uniqKey="Chen X">X Chen</name>
</author>
<author><name sortKey="Wang, F" uniqKey="Wang F">F Wang</name>
</author>
<author><name sortKey="Zhang, Y" uniqKey="Zhang Y">Y Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mccarthy, Lc" uniqKey="Mccarthy L">LC McCarthy</name>
</author>
<author><name sortKey="Fernandez, Ks" uniqKey="Fernandez K">KS Fernandez</name>
</author>
<author><name sortKey="Antony, R" uniqKey="Antony R">R. Antony</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sepulveda, Fe" uniqKey="Sepulveda F">FE Sepulveda</name>
</author>
<author><name sortKey="De Saint Basile, G" uniqKey="De Saint Basile G">G. de Saint Basile</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Filipovich, A" uniqKey="Filipovich A">A Filipovich</name>
</author>
<author><name sortKey="Mcclain, K" uniqKey="Mcclain K">K McClain</name>
</author>
<author><name sortKey="Grom, A" uniqKey="Grom A">A. Grom</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Risma, K" uniqKey="Risma K">K Risma</name>
</author>
<author><name sortKey="Jordan, Mb" uniqKey="Jordan M">MB. Jordan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ishii, E" uniqKey="Ishii E">E Ishii</name>
</author>
<author><name sortKey="Ueda, I" uniqKey="Ueda I">I Ueda</name>
</author>
<author><name sortKey="Shirakawa, R" uniqKey="Shirakawa R">R Shirakawa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dalal, Bi" uniqKey="Dalal B">BI Dalal</name>
</author>
<author><name sortKey="Vakil, Ap" uniqKey="Vakil A">AP Vakil</name>
</author>
<author><name sortKey="Khare, Ns" uniqKey="Khare N">NS Khare</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Slostad, J" uniqKey="Slostad J">J Slostad</name>
</author>
<author><name sortKey="Hoversten, P" uniqKey="Hoversten P">P Hoversten</name>
</author>
<author><name sortKey="Haddox, Cl" uniqKey="Haddox C">CL Haddox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Fakih, R" uniqKey="El Fakih R">R El Fakih</name>
</author>
<author><name sortKey="Mohamed, Sy" uniqKey="Mohamed S">SY Mohamed</name>
</author>
<author><name sortKey="Alnounou, R" uniqKey="Alnounou R">R Alnounou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kotas, Me" uniqKey="Kotas M">ME Kotas</name>
</author>
<author><name sortKey="Matthay, Ma" uniqKey="Matthay M">MA. Matthay</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mohr, A" uniqKey="Mohr A">A Mohr</name>
</author>
<author><name sortKey="Zwacka, R" uniqKey="Zwacka R">R. Zwacka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Li, X" uniqKey="Li X">X Li</name>
</author>
<author><name sortKey="Huang, M" uniqKey="Huang M">M Huang</name>
</author>
<author><name sortKey="Zhao, R" uniqKey="Zhao R">R Zhao</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mai, S" uniqKey="Mai S">S Mai</name>
</author>
<author><name sortKey="Zou, L" uniqKey="Zou L">L Zou</name>
</author>
<author><name sortKey="Tian, X" uniqKey="Tian X">X Tian</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cantore, S" uniqKey="Cantore S">S Cantore</name>
</author>
<author><name sortKey="Crincoli, V" uniqKey="Crincoli V">V Crincoli</name>
</author>
<author><name sortKey="Boccaccio, A" uniqKey="Boccaccio A">A Boccaccio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kruk, D" uniqKey="Kruk D">D Kruk</name>
</author>
<author><name sortKey="Heijink, Ih" uniqKey="Heijink I">IH Heijink</name>
</author>
<author><name sortKey="Slebos, Dj" uniqKey="Slebos D">DJ Slebos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kadry, Sm" uniqKey="Kadry S">SM Kadry</name>
</author>
<author><name sortKey="El Dakdoky, Mh" uniqKey="El Dakdoky M">MH El-Dakdoky</name>
</author>
<author><name sortKey="Haggag, Nz" uniqKey="Haggag N">NZ Haggag</name>
</author>
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