Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Identifieur interne : 000524 ( Ncbi/Curation ); précédent : 000523; suivant : 000525Are innovation and new technologies in precision medicine paving a new era in patients centric care?
Auteurs : Attila A. Seyhan [États-Unis] ; Claudio CariniSource :
- Journal of Translational Medicine [ 1479-5876 ] ; 2019.
Abstract
Healthcare is undergoing a transformation, and it is imperative to leverage new technologies to generate new data and support the advent of precision medicine (PM). Recent scientific breakthroughs and technological advancements have improved our understanding of disease pathogenesis and changed the way we diagnose and treat disease leading to more precise, predictable and powerful health care that is customized for the individual patient. Genetic, genomics, and epigenetic alterations appear to be contributing to different diseases. Deep clinical phenotyping, combined with advanced molecular phenotypic profiling, enables the construction of causal network models in which a genomic region is proposed to influence the levels of transcripts, proteins, and metabolites. Phenotypic analysis bears great importance to elucidat the pathophysiology of networks at the molecular and cellular level. Digital biomarkers (BMs) can have several applications beyond clinical trials in diagnostics—to identify patients affected by a disease or to guide treatment. Digital BMs present a big opportunity to measure clinical endpoints in a remote, objective and unbiased manner. However, the use of “omics” technologies and large sample sizes have generated massive amounts of data sets, and their analyses have become a major bottleneck requiring sophisticated computational and statistical methods. With the wealth of information for different diseases and its link to intrinsic biology, the challenge is now to turn the multi-parametric taxonomic classification of a disease into better clinical decision-making by more precisely defining a disease. As a result, the big data revolution has provided an opportunity to apply artificial intelligence (AI) and machine learning algorithms to this vast data set. The advancements in digital health opportunities have also arisen numerous questions and concerns on the future of healthcare practices in particular with what regards the reliability of AI diagnostic tools, the impact on clinical practice and vulnerability of algorithms. AI, machine learning algorithms, computational biology, and digital BMs will offer an opportunity to translate new data into actionable information thus, allowing earlier diagnosis and precise treatment options. A better understanding and cohesiveness of the different components of the knowledge network is a must to fully exploit the potential of it.
Url:
DOI: 10.1186/s12967-019-1864-9
PubMed: 30953518
PubMed Central: 6451233
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<front><div type="abstract" xml:lang="en"><p id="Par1">Healthcare is undergoing a transformation, and it is imperative to leverage new technologies to generate new data and support the advent of precision medicine (PM). Recent scientific breakthroughs and technological advancements have improved our understanding of disease pathogenesis and changed the way we diagnose and treat disease leading to more precise, predictable and powerful health care that is customized for the individual patient. Genetic, genomics, and epigenetic alterations appear to be contributing to different diseases. Deep clinical phenotyping, combined with advanced molecular phenotypic profiling, enables the construction of causal network models in which a genomic region is proposed to influence the levels of transcripts, proteins, and metabolites. Phenotypic analysis bears great importance to elucidat the pathophysiology of networks at the molecular and cellular level. Digital biomarkers (BMs) can have several applications beyond clinical trials in diagnostics—to identify patients affected by a disease or to guide treatment. Digital BMs present a big opportunity to measure clinical endpoints in a remote, objective and unbiased manner. However, the use of “omics” technologies and large sample sizes have generated massive amounts of data sets, and their analyses have become a major bottleneck requiring sophisticated computational and statistical methods. With the wealth of information for different diseases and its link to intrinsic biology, the challenge is now to turn the multi-parametric taxonomic classification of a disease into better clinical decision-making by more precisely defining a disease. As a result, the big data revolution has provided an opportunity to apply artificial intelligence (AI) and machine learning algorithms to this vast data set. The advancements in digital health opportunities have also arisen numerous questions and concerns on the future of healthcare practices in particular with what regards the reliability of AI diagnostic tools, the impact on clinical practice and vulnerability of algorithms. AI, machine learning algorithms, computational biology, and digital BMs will offer an opportunity to translate new data into actionable information thus, allowing earlier diagnosis and precise treatment options. A better understanding and cohesiveness of the different components of the knowledge network is a must to fully exploit the potential of it.</p>
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<biblStruct><analytic><author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cesano, A" uniqKey="Cesano A">A Cesano</name>
</author>
<author><name sortKey="Warren, S" uniqKey="Warren S">S Warren</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Blank, Cu" uniqKey="Blank C">CU Blank</name>
</author>
<author><name sortKey="Haanen, Jb" uniqKey="Haanen J">JB Haanen</name>
</author>
<author><name sortKey="Ribas, A" uniqKey="Ribas A">A Ribas</name>
</author>
<author><name sortKey="Schumacher, Tn" uniqKey="Schumacher T">TN Schumacher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Koelzer, Vh" uniqKey="Koelzer V">VH Koelzer</name>
</author>
<author><name sortKey="Sirinukunwattana, K" uniqKey="Sirinukunwattana K">K Sirinukunwattana</name>
</author>
<author><name sortKey="Rittscher, J" uniqKey="Rittscher J">J Rittscher</name>
</author>
<author><name sortKey="Mertz, Kd" uniqKey="Mertz K">KD Mertz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Hj" uniqKey="Lee H">HJ Lee</name>
</author>
<author><name sortKey="Seo, An" uniqKey="Seo A">AN Seo</name>
</author>
<author><name sortKey="Kim, Ej" uniqKey="Kim E">EJ Kim</name>
</author>
<author><name sortKey="Jang, Mh" uniqKey="Jang M">MH Jang</name>
</author>
<author><name sortKey="Kim, Yj" uniqKey="Kim Y">YJ Kim</name>
</author>
<author><name sortKey="Kim, Jh" uniqKey="Kim J">JH Kim</name>
</author>
<author><name sortKey="Kim, Sw" uniqKey="Kim S">SW Kim</name>
</author>
<author><name sortKey="Ryu, Hs" uniqKey="Ryu H">HS Ryu</name>
</author>
<author><name sortKey="Park, Ia" uniqKey="Park I">IA Park</name>
</author>
<author><name sortKey="Im, Sa" uniqKey="Im S">SA Im</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Selleck, Mj" uniqKey="Selleck M">MJ Selleck</name>
</author>
<author><name sortKey="Senthil, M" uniqKey="Senthil M">M Senthil</name>
</author>
<author><name sortKey="Wall, Nr" uniqKey="Wall N">NR Wall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Poste, G" uniqKey="Poste G">G Poste</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burke, Hb" uniqKey="Burke H">HB Burke</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Butterfield, Lh" uniqKey="Butterfield L">LH Butterfield</name>
</author>
<author><name sortKey="Disis, Ml" uniqKey="Disis M">ML Disis</name>
</author>
<author><name sortKey="Fox, Ba" uniqKey="Fox B">BA Fox</name>
</author>
<author><name sortKey="Lee, Pp" uniqKey="Lee P">PP Lee</name>
</author>
<author><name sortKey="Khleif, Sn" uniqKey="Khleif S">SN Khleif</name>
</author>
<author><name sortKey="Thurin, M" uniqKey="Thurin M">M Thurin</name>
</author>
<author><name sortKey="Trinchieri, G" uniqKey="Trinchieri G">G Trinchieri</name>
</author>
<author><name sortKey="Wang, E" uniqKey="Wang E">E Wang</name>
</author>
<author><name sortKey="Wigginton, J" uniqKey="Wigginton J">J Wigginton</name>
</author>
<author><name sortKey="Chaussabel, D" uniqKey="Chaussabel D">D Chaussabel</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lang, L" uniqKey="Lang L">L Lang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moutinho Ribeiro, P" uniqKey="Moutinho Ribeiro P">P Moutinho-Ribeiro</name>
</author>
<author><name sortKey="Macedo, G" uniqKey="Macedo G">G Macedo</name>
</author>
<author><name sortKey="Melo, Sa" uniqKey="Melo S">SA Melo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De La Rica, L" uniqKey="De La Rica L">L de la Rica</name>
</author>
<author><name sortKey="Urquiza, Jm" uniqKey="Urquiza J">JM Urquiza</name>
</author>
<author><name sortKey="Gomez Cabrero, D" uniqKey="Gomez Cabrero D">D Gomez-Cabrero</name>
</author>
<author><name sortKey="Islam, Ab" uniqKey="Islam A">AB Islam</name>
</author>
<author><name sortKey="Lopez Bigas, N" uniqKey="Lopez Bigas N">N Lopez-Bigas</name>
</author>
<author><name sortKey="Tegner, J" uniqKey="Tegner J">J Tegner</name>
</author>
<author><name sortKey="Toes, Re" uniqKey="Toes R">RE Toes</name>
</author>
<author><name sortKey="Ballestar, E" uniqKey="Ballestar E">E Ballestar</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Plenge, Rm" uniqKey="Plenge R">RM Plenge</name>
</author>
<author><name sortKey="Seielstad, M" uniqKey="Seielstad M">M Seielstad</name>
</author>
<author><name sortKey="Padyukov, L" uniqKey="Padyukov L">L Padyukov</name>
</author>
<author><name sortKey="Lee, At" uniqKey="Lee A">AT Lee</name>
</author>
<author><name sortKey="Remmers, Ef" uniqKey="Remmers E">EF Remmers</name>
</author>
<author><name sortKey="Ding, B" uniqKey="Ding B">B Ding</name>
</author>
<author><name sortKey="Liew, A" uniqKey="Liew A">A Liew</name>
</author>
<author><name sortKey="Khalili, H" uniqKey="Khalili H">H Khalili</name>
</author>
<author><name sortKey="Chandrasekaran, A" uniqKey="Chandrasekaran A">A Chandrasekaran</name>
</author>
<author><name sortKey="Davies, Lr" uniqKey="Davies L">LR Davies</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Remmers, Ef" uniqKey="Remmers E">EF Remmers</name>
</author>
<author><name sortKey="Plenge, Rm" uniqKey="Plenge R">RM Plenge</name>
</author>
<author><name sortKey="Lee, At" uniqKey="Lee A">AT Lee</name>
</author>
<author><name sortKey="Graham, Rr" uniqKey="Graham R">RR Graham</name>
</author>
<author><name sortKey="Hom, G" uniqKey="Hom G">G Hom</name>
</author>
<author><name sortKey="Behrens, Tw" uniqKey="Behrens T">TW Behrens</name>
</author>
<author><name sortKey="De Bakker, Pi" uniqKey="De Bakker P">PI de Bakker</name>
</author>
<author><name sortKey="Le, Jm" uniqKey="Le J">JM Le</name>
</author>
<author><name sortKey="Lee, Hs" uniqKey="Lee H">HS Lee</name>
</author>
<author><name sortKey="Batliwalla, F" uniqKey="Batliwalla F">F Batliwalla</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alevizos, I" uniqKey="Alevizos I">I Alevizos</name>
</author>
<author><name sortKey="Illei, Gg" uniqKey="Illei G">GG Illei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hezova, R" uniqKey="Hezova R">R Hezova</name>
</author>
<author><name sortKey="Slaby, O" uniqKey="Slaby O">O Slaby</name>
</author>
<author><name sortKey="Faltejskova, P" uniqKey="Faltejskova P">P Faltejskova</name>
</author>
<author><name sortKey="Mikulkova, Z" uniqKey="Mikulkova Z">Z Mikulkova</name>
</author>
<author><name sortKey="Buresova, I" uniqKey="Buresova I">I Buresova</name>
</author>
<author><name sortKey="Raja, Kr" uniqKey="Raja K">KR Raja</name>
</author>
<author><name sortKey="Hodek, J" uniqKey="Hodek J">J Hodek</name>
</author>
<author><name sortKey="Ovesna, J" uniqKey="Ovesna J">J Ovesna</name>
</author>
<author><name sortKey="Michalek, J" uniqKey="Michalek J">J Michalek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
<author><name sortKey="Nunez Lopez, Yo" uniqKey="Nunez Lopez Y">YO Nunez Lopez</name>
</author>
<author><name sortKey="Xie, H" uniqKey="Xie H">H Xie</name>
</author>
<author><name sortKey="Yi, F" uniqKey="Yi F">F Yi</name>
</author>
<author><name sortKey="Mathews, C" uniqKey="Mathews C">C Mathews</name>
</author>
<author><name sortKey="Pasarica, M" uniqKey="Pasarica M">M Pasarica</name>
</author>
<author><name sortKey="Pratley, Re" uniqKey="Pratley R">RE Pratley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nunez Lopez, Yo" uniqKey="Nunez Lopez Y">YO Nunez Lopez</name>
</author>
<author><name sortKey="Garufi, G" uniqKey="Garufi G">G Garufi</name>
</author>
<author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nunez Lopez, Yo" uniqKey="Nunez Lopez Y">YO Nunez Lopez</name>
</author>
<author><name sortKey="Pittas, Ag" uniqKey="Pittas A">AG Pittas</name>
</author>
<author><name sortKey="Pratley, Re" uniqKey="Pratley R">RE Pratley</name>
</author>
<author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lopez, Yon" uniqKey="Lopez Y">YON Lopez</name>
</author>
<author><name sortKey="Retnakaran, R" uniqKey="Retnakaran R">R Retnakaran</name>
</author>
<author><name sortKey="Zinman, B" uniqKey="Zinman B">B Zinman</name>
</author>
<author><name sortKey="Pratley, Re" uniqKey="Pratley R">RE Pratley</name>
</author>
<author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nunez Lopez, Yo" uniqKey="Nunez Lopez Y">YO Nunez Lopez</name>
</author>
<author><name sortKey="Coen, Pm" uniqKey="Coen P">PM Coen</name>
</author>
<author><name sortKey="Goodpaster, Bh" uniqKey="Goodpaster B">BH Goodpaster</name>
</author>
<author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nunez Lopez, Yo" uniqKey="Nunez Lopez Y">YO Nunez Lopez</name>
</author>
<author><name sortKey="Garufi, G" uniqKey="Garufi G">G Garufi</name>
</author>
<author><name sortKey="Pasarica, M" uniqKey="Pasarica M">M Pasarica</name>
</author>
<author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pachori, As" uniqKey="Pachori A">AS Pachori</name>
</author>
<author><name sortKey="Madan, M" uniqKey="Madan M">M Madan</name>
</author>
<author><name sortKey="Nunez Lopez, Yo" uniqKey="Nunez Lopez Y">YO Nunez Lopez</name>
</author>
<author><name sortKey="Yi, F" uniqKey="Yi F">F Yi</name>
</author>
<author><name sortKey="Meyer, C" uniqKey="Meyer C">C Meyer</name>
</author>
<author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Du, C" uniqKey="Du C">C Du</name>
</author>
<author><name sortKey="Liu, C" uniqKey="Liu C">C Liu</name>
</author>
<author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name>
</author>
<author><name sortKey="Zhao, G" uniqKey="Zhao G">G Zhao</name>
</author>
<author><name sortKey="Ye, Z" uniqKey="Ye Z">Z Ye</name>
</author>
<author><name sortKey="Huang, S" uniqKey="Huang S">S Huang</name>
</author>
<author><name sortKey="Li, Z" uniqKey="Li Z">Z Li</name>
</author>
<author><name sortKey="Wu, Z" uniqKey="Wu Z">Z Wu</name>
</author>
<author><name sortKey="Pei, G" uniqKey="Pei G">G Pei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lindberg, Rl" uniqKey="Lindberg R">RL Lindberg</name>
</author>
<author><name sortKey="Hoffmann, F" uniqKey="Hoffmann F">F Hoffmann</name>
</author>
<author><name sortKey="Mehling, M" uniqKey="Mehling M">M Mehling</name>
</author>
<author><name sortKey="Kuhle, J" uniqKey="Kuhle J">J Kuhle</name>
</author>
<author><name sortKey="Kappos, L" uniqKey="Kappos L">L Kappos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakasa, T" uniqKey="Nakasa T">T Nakasa</name>
</author>
<author><name sortKey="Miyaki, S" uniqKey="Miyaki S">S Miyaki</name>
</author>
<author><name sortKey="Okubo, A" uniqKey="Okubo A">A Okubo</name>
</author>
<author><name sortKey="Hashimoto, M" uniqKey="Hashimoto M">M Hashimoto</name>
</author>
<author><name sortKey="Nishida, K" uniqKey="Nishida K">K Nishida</name>
</author>
<author><name sortKey="Ochi, M" uniqKey="Ochi M">M Ochi</name>
</author>
<author><name sortKey="Asahara, H" uniqKey="Asahara H">H Asahara</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pauley, Km" uniqKey="Pauley K">KM Pauley</name>
</author>
<author><name sortKey="Satoh, M" uniqKey="Satoh M">M Satoh</name>
</author>
<author><name sortKey="Chan, Al" uniqKey="Chan A">AL Chan</name>
</author>
<author><name sortKey="Bubb, Mr" uniqKey="Bubb M">MR Bubb</name>
</author>
<author><name sortKey="Reeves, Wh" uniqKey="Reeves W">WH Reeves</name>
</author>
<author><name sortKey="Chan, Ek" uniqKey="Chan E">EK Chan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Padgett, Ka" uniqKey="Padgett K">KA Padgett</name>
</author>
<author><name sortKey="Lan, Ry" uniqKey="Lan R">RY Lan</name>
</author>
<author><name sortKey="Leung, Pc" uniqKey="Leung P">PC Leung</name>
</author>
<author><name sortKey="Lleo, A" uniqKey="Lleo A">A Lleo</name>
</author>
<author><name sortKey="Dawson, K" uniqKey="Dawson K">K Dawson</name>
</author>
<author><name sortKey="Pfeiff, J" uniqKey="Pfeiff J">J Pfeiff</name>
</author>
<author><name sortKey="Mao, Tk" uniqKey="Mao T">TK Mao</name>
</author>
<author><name sortKey="Coppel, Rl" uniqKey="Coppel R">RL Coppel</name>
</author>
<author><name sortKey="Ansari, Aa" uniqKey="Ansari A">AA Ansari</name>
</author>
<author><name sortKey="Gershwin, Me" uniqKey="Gershwin M">ME Gershwin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tang, Y" uniqKey="Tang Y">Y Tang</name>
</author>
<author><name sortKey="Luo, X" uniqKey="Luo X">X Luo</name>
</author>
<author><name sortKey="Cui, H" uniqKey="Cui H">H Cui</name>
</author>
<author><name sortKey="Ni, X" uniqKey="Ni X">X Ni</name>
</author>
<author><name sortKey="Yuan, M" uniqKey="Yuan M">M Yuan</name>
</author>
<author><name sortKey="Guo, Y" uniqKey="Guo Y">Y Guo</name>
</author>
<author><name sortKey="Huang, X" uniqKey="Huang X">X Huang</name>
</author>
<author><name sortKey="Zhou, H" uniqKey="Zhou H">H Zhou</name>
</author>
<author><name sortKey="De Vries, N" uniqKey="De Vries N">N de Vries</name>
</author>
<author><name sortKey="Tak, Pp" uniqKey="Tak P">PP Tak</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dai, Y" uniqKey="Dai Y">Y Dai</name>
</author>
<author><name sortKey="Sui, W" uniqKey="Sui W">W Sui</name>
</author>
<author><name sortKey="Lan, H" uniqKey="Lan H">H Lan</name>
</author>
<author><name sortKey="Yan, Q" uniqKey="Yan Q">Q Yan</name>
</author>
<author><name sortKey="Huang, H" uniqKey="Huang H">H Huang</name>
</author>
<author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sonkoly, E" uniqKey="Sonkoly E">E Sonkoly</name>
</author>
<author><name sortKey="Wei, T" uniqKey="Wei T">T Wei</name>
</author>
<author><name sortKey="Janson, Pc" uniqKey="Janson P">PC Janson</name>
</author>
<author><name sortKey="Saaf, A" uniqKey="Saaf A">A Saaf</name>
</author>
<author><name sortKey="Lundeberg, L" uniqKey="Lundeberg L">L Lundeberg</name>
</author>
<author><name sortKey="Tengvall Linder, M" uniqKey="Tengvall Linder M">M Tengvall-Linder</name>
</author>
<author><name sortKey="Norstedt, G" uniqKey="Norstedt G">G Norstedt</name>
</author>
<author><name sortKey="Alenius, H" uniqKey="Alenius H">H Alenius</name>
</author>
<author><name sortKey="Homey, B" uniqKey="Homey B">B Homey</name>
</author>
<author><name sortKey="Scheynius, A" uniqKey="Scheynius A">A Scheynius</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chatzikyriakidou, A" uniqKey="Chatzikyriakidou A">A Chatzikyriakidou</name>
</author>
<author><name sortKey="Voulgari, Pv" uniqKey="Voulgari P">PV Voulgari</name>
</author>
<author><name sortKey="Georgiou, I" uniqKey="Georgiou I">I Georgiou</name>
</author>
<author><name sortKey="Drosos, Aa" uniqKey="Drosos A">AA Drosos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alevizos, I" uniqKey="Alevizos I">I Alevizos</name>
</author>
<author><name sortKey="Illei, Gg" uniqKey="Illei G">GG Illei</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alsaleh, G" uniqKey="Alsaleh G">G Alsaleh</name>
</author>
<author><name sortKey="Suffert, G" uniqKey="Suffert G">G Suffert</name>
</author>
<author><name sortKey="Semaan, N" uniqKey="Semaan N">N Semaan</name>
</author>
<author><name sortKey="Juncker, T" uniqKey="Juncker T">T Juncker</name>
</author>
<author><name sortKey="Frenzel, L" uniqKey="Frenzel L">L Frenzel</name>
</author>
<author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name>
</author>
<author><name sortKey="Sibilia, J" uniqKey="Sibilia J">J Sibilia</name>
</author>
<author><name sortKey="Pfeffer, S" uniqKey="Pfeffer S">S Pfeffer</name>
</author>
<author><name sortKey="Wachsmann, D" uniqKey="Wachsmann D">D Wachsmann</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nakamachi, Y" uniqKey="Nakamachi Y">Y Nakamachi</name>
</author>
<author><name sortKey="Kawano, S" uniqKey="Kawano S">S Kawano</name>
</author>
<author><name sortKey="Takenokuchi, M" uniqKey="Takenokuchi M">M Takenokuchi</name>
</author>
<author><name sortKey="Nishimura, K" uniqKey="Nishimura K">K Nishimura</name>
</author>
<author><name sortKey="Sakai, Y" uniqKey="Sakai Y">Y Sakai</name>
</author>
<author><name sortKey="Chin, T" uniqKey="Chin T">T Chin</name>
</author>
<author><name sortKey="Saura, R" uniqKey="Saura R">R Saura</name>
</author>
<author><name sortKey="Kurosaka, M" uniqKey="Kurosaka M">M Kurosaka</name>
</author>
<author><name sortKey="Kumagai, S" uniqKey="Kumagai S">S Kumagai</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
<author><name sortKey="Varadarajan, U" uniqKey="Varadarajan U">U Varadarajan</name>
</author>
<author><name sortKey="Choe, S" uniqKey="Choe S">S Choe</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Ryan, Te" uniqKey="Ryan T">TE Ryan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Seyhan, Aa" uniqKey="Seyhan A">AA Seyhan</name>
</author>
<author><name sortKey="Varadarajan, U" uniqKey="Varadarajan U">U Varadarajan</name>
</author>
<author><name sortKey="Choe, S" uniqKey="Choe S">S Choe</name>
</author>
<author><name sortKey="Liu, Y" uniqKey="Liu Y">Y Liu</name>
</author>
<author><name sortKey="Mcgraw, J" uniqKey="Mcgraw J">J McGraw</name>
</author>
<author><name sortKey="Woods, M" uniqKey="Woods M">M Woods</name>
</author>
<author><name sortKey="Murray, S" uniqKey="Murray S">S Murray</name>
</author>
<author><name sortKey="Eckert, A" uniqKey="Eckert A">A Eckert</name>
</author>
<author><name sortKey="Liu, W" uniqKey="Liu W">W Liu</name>
</author>
<author><name sortKey="Ryan, Te" uniqKey="Ryan T">TE Ryan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chen, Ds" uniqKey="Chen D">DS Chen</name>
</author>
<author><name sortKey="Mellman, I" uniqKey="Mellman I">I Mellman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nagarsheth, N" uniqKey="Nagarsheth N">N Nagarsheth</name>
</author>
<author><name sortKey="Wicha, Ms" uniqKey="Wicha M">MS Wicha</name>
</author>
<author><name sortKey="Zou, Wp" uniqKey="Zou W">WP Zou</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Torous, J" uniqKey="Torous J">J Torous</name>
</author>
<author><name sortKey="Andersson, G" uniqKey="Andersson G">G Andersson</name>
</author>
<author><name sortKey="Bertagnoli, A" uniqKey="Bertagnoli A">A Bertagnoli</name>
</author>
<author><name sortKey="Christensen, H" uniqKey="Christensen H">H Christensen</name>
</author>
<author><name sortKey="Cuijpers, P" uniqKey="Cuijpers P">P Cuijpers</name>
</author>
<author><name sortKey="Firth, J" uniqKey="Firth J">J Firth</name>
</author>
<author><name sortKey="Haim, A" uniqKey="Haim A">A Haim</name>
</author>
<author><name sortKey="Hsin, H" uniqKey="Hsin H">H Hsin</name>
</author>
<author><name sortKey="Hollis, C" uniqKey="Hollis C">C Hollis</name>
</author>
<author><name sortKey="Lewis, S" uniqKey="Lewis S">S Lewis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boulos, Mn" uniqKey="Boulos M">MN Boulos</name>
</author>
<author><name sortKey="Brewer, Ac" uniqKey="Brewer A">AC Brewer</name>
</author>
<author><name sortKey="Karimkhani, C" uniqKey="Karimkhani C">C Karimkhani</name>
</author>
<author><name sortKey="Buller, Db" uniqKey="Buller D">DB Buller</name>
</author>
<author><name sortKey="Dellavalle, Rp" uniqKey="Dellavalle R">RP Dellavalle</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Capper, D" uniqKey="Capper D">D Capper</name>
</author>
<author><name sortKey="Jones, Dtw" uniqKey="Jones D">DTW Jones</name>
</author>
<author><name sortKey="Sill, M" uniqKey="Sill M">M Sill</name>
</author>
<author><name sortKey="Hovestadt, V" uniqKey="Hovestadt V">V Hovestadt</name>
</author>
<author><name sortKey="Schrimpf, D" uniqKey="Schrimpf D">D Schrimpf</name>
</author>
<author><name sortKey="Sturm, D" uniqKey="Sturm D">D Sturm</name>
</author>
<author><name sortKey="Koelsche, C" uniqKey="Koelsche C">C Koelsche</name>
</author>
<author><name sortKey="Sahm, F" uniqKey="Sahm F">F Sahm</name>
</author>
<author><name sortKey="Chavez, L" uniqKey="Chavez L">L Chavez</name>
</author>
<author><name sortKey="Reuss, De" uniqKey="Reuss D">DE Reuss</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Moran, S" uniqKey="Moran S">S Moran</name>
</author>
<author><name sortKey="Martinez Cardus, A" uniqKey="Martinez Cardus A">A Martinez-Cardus</name>
</author>
<author><name sortKey="Sayols, S" uniqKey="Sayols S">S Sayols</name>
</author>
<author><name sortKey="Musulen, E" uniqKey="Musulen E">E Musulen</name>
</author>
<author><name sortKey="Balana, C" uniqKey="Balana C">C Balana</name>
</author>
<author><name sortKey="Estival Gonzalez, A" uniqKey="Estival Gonzalez A">A Estival-Gonzalez</name>
</author>
<author><name sortKey="Moutinho, C" uniqKey="Moutinho C">C Moutinho</name>
</author>
<author><name sortKey="Heyn, H" uniqKey="Heyn H">H Heyn</name>
</author>
<author><name sortKey="Diaz Lagares, A" uniqKey="Diaz Lagares A">A Diaz-Lagares</name>
</author>
<author><name sortKey="De Moura, Mc" uniqKey="De Moura M">MC de Moura</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Diniz, Bs" uniqKey="Diniz B">BS Diniz</name>
</author>
<author><name sortKey="Pinto Junior, Ja" uniqKey="Pinto Junior J">JA Pinto Junior</name>
</author>
<author><name sortKey="Forlenza, Ov" uniqKey="Forlenza O">OV Forlenza</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cavagnaro, Ja" uniqKey="Cavagnaro J">JA Cavagnaro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name>
</author>
<author><name sortKey="Rocha, Np" uniqKey="Rocha N">NP Rocha</name>
</author>
<author><name sortKey="Salem, H" uniqKey="Salem H">H Salem</name>
</author>
<author><name sortKey="Diniz, Bs" uniqKey="Diniz B">BS Diniz</name>
</author>
<author><name sortKey="Teixeira, Al" uniqKey="Teixeira A">AL Teixeira</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Azuaje, F" uniqKey="Azuaje F">F Azuaje</name>
</author>
<author><name sortKey="Devaux, Y" uniqKey="Devaux Y">Y Devaux</name>
</author>
<author><name sortKey="Wagner, D" uniqKey="Wagner D">D Wagner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Camargo, A" uniqKey="Camargo A">A Camargo</name>
</author>
<author><name sortKey="Azuaje, F" uniqKey="Azuaje F">F Azuaje</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Frank, E" uniqKey="Frank E">E Frank</name>
</author>
<author><name sortKey="Hall, M" uniqKey="Hall M">M Hall</name>
</author>
<author><name sortKey="Trigg, L" uniqKey="Trigg L">L Trigg</name>
</author>
<author><name sortKey="Holmes, G" uniqKey="Holmes G">G Holmes</name>
</author>
<author><name sortKey="Witten, Ih" uniqKey="Witten I">IH Witten</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Saeys, Y" uniqKey="Saeys Y">Y Saeys</name>
</author>
<author><name sortKey="Inza, I" uniqKey="Inza I">I Inza</name>
</author>
<author><name sortKey="Larranaga, P" uniqKey="Larranaga P">P Larranaga</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Deschamps, Am" uniqKey="Deschamps A">AM Deschamps</name>
</author>
<author><name sortKey="Spinale, Fg" uniqKey="Spinale F">FG Spinale</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Camargo, A" uniqKey="Camargo A">A Camargo</name>
</author>
<author><name sortKey="Azuaje, F" uniqKey="Azuaje F">F Azuaje</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ginsburg, Gs" uniqKey="Ginsburg G">GS Ginsburg</name>
</author>
<author><name sortKey="Seo, D" uniqKey="Seo D">D Seo</name>
</author>
<author><name sortKey="Frazier, C" uniqKey="Frazier C">C Frazier</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ideker, T" uniqKey="Ideker T">T Ideker</name>
</author>
<author><name sortKey="Sharan, R" uniqKey="Sharan R">R Sharan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mcgee, P" uniqKey="Mcgee P">P McGee</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Coudray, N" uniqKey="Coudray N">N Coudray</name>
</author>
<author><name sortKey="Ocampo, Ps" uniqKey="Ocampo P">PS Ocampo</name>
</author>
<author><name sortKey="Sakellaropoulos, T" uniqKey="Sakellaropoulos T">T Sakellaropoulos</name>
</author>
<author><name sortKey="Narula, N" uniqKey="Narula N">N Narula</name>
</author>
<author><name sortKey="Snuderl, M" uniqKey="Snuderl M">M Snuderl</name>
</author>
<author><name sortKey="Fenyo, D" uniqKey="Fenyo D">D Fenyö</name>
</author>
<author><name sortKey="Moreira, Al" uniqKey="Moreira A">AL Moreira</name>
</author>
<author><name sortKey="Razavian, N" uniqKey="Razavian N">N Razavian</name>
</author>
<author><name sortKey="Tsirigos, A" uniqKey="Tsirigos A">A Tsirigos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Leiserson, Mdm" uniqKey="Leiserson M">MDM Leiserson</name>
</author>
<author><name sortKey="Syrgkanis, V" uniqKey="Syrgkanis V">V Syrgkanis</name>
</author>
<author><name sortKey="Gilson, A" uniqKey="Gilson A">A Gilson</name>
</author>
<author><name sortKey="Dudik, M" uniqKey="Dudik M">M Dudik</name>
</author>
<author><name sortKey="Gillett, S" uniqKey="Gillett S">S Gillett</name>
</author>
<author><name sortKey="Chayes, J" uniqKey="Chayes J">J Chayes</name>
</author>
<author><name sortKey="Borgs, C" uniqKey="Borgs C">C Borgs</name>
</author>
<author><name sortKey="Bajorin, Df" uniqKey="Bajorin D">DF Bajorin</name>
</author>
<author><name sortKey="Rosenberg, Je" uniqKey="Rosenberg J">JE Rosenberg</name>
</author>
<author><name sortKey="Funt, S" uniqKey="Funt S">S Funt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Snyder, A" uniqKey="Snyder A">A Snyder</name>
</author>
<author><name sortKey="Nathanson, T" uniqKey="Nathanson T">T Nathanson</name>
</author>
<author><name sortKey="Funt, Sa" uniqKey="Funt S">SA Funt</name>
</author>
<author><name sortKey="Ahuja, A" uniqKey="Ahuja A">A Ahuja</name>
</author>
<author><name sortKey="Buros Novik, J" uniqKey="Buros Novik J">J Buros Novik</name>
</author>
<author><name sortKey="Hellmann, Md" uniqKey="Hellmann M">MD Hellmann</name>
</author>
<author><name sortKey="Chang, E" uniqKey="Chang E">E Chang</name>
</author>
<author><name sortKey="Aksoy, Ba" uniqKey="Aksoy B">BA Aksoy</name>
</author>
<author><name sortKey="Al Ahmadie, H" uniqKey="Al Ahmadie H">H Al-Ahmadie</name>
</author>
<author><name sortKey="Yusko, E" uniqKey="Yusko E">E Yusko</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Breiman, L" uniqKey="Breiman L">L Breiman</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Robinson, Pn" uniqKey="Robinson P">PN Robinson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schadt, Ee" uniqKey="Schadt E">EE Schadt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Feldman, I" uniqKey="Feldman I">I Feldman</name>
</author>
<author><name sortKey="Rzhetsky, A" uniqKey="Rzhetsky A">A Rzhetsky</name>
</author>
<author><name sortKey="Vitkup, D" uniqKey="Vitkup D">D Vitkup</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goh, Ki" uniqKey="Goh K">KI Goh</name>
</author>
<author><name sortKey="Cusick, Me" uniqKey="Cusick M">ME Cusick</name>
</author>
<author><name sortKey="Valle, D" uniqKey="Valle D">D Valle</name>
</author>
<author><name sortKey="Childs, B" uniqKey="Childs B">B Childs</name>
</author>
<author><name sortKey="Vidal, M" uniqKey="Vidal M">M Vidal</name>
</author>
<author><name sortKey="Barabasi, Al" uniqKey="Barabasi A">AL Barabasi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Robinson, Pn" uniqKey="Robinson P">PN Robinson</name>
</author>
<author><name sortKey="Kohler, S" uniqKey="Kohler S">S Kohler</name>
</author>
<author><name sortKey="Bauer, S" uniqKey="Bauer S">S Bauer</name>
</author>
<author><name sortKey="Seelow, D" uniqKey="Seelow D">D Seelow</name>
</author>
<author><name sortKey="Horn, D" uniqKey="Horn D">D Horn</name>
</author>
<author><name sortKey="Mundlos, S" uniqKey="Mundlos S">S Mundlos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kohler, S" uniqKey="Kohler S">S Kohler</name>
</author>
<author><name sortKey="Bauer, S" uniqKey="Bauer S">S Bauer</name>
</author>
<author><name sortKey="Horn, D" uniqKey="Horn D">D Horn</name>
</author>
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<author><name sortKey="Dash, D" uniqKey="Dash D">D Dash</name>
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<author><name sortKey="Buchan, I" uniqKey="Buchan I">I Buchan</name>
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<author><name sortKey="Diaz, C" uniqKey="Diaz C">C Diaz</name>
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<author><name sortKey="Sanz, F" uniqKey="Sanz F">F Sanz</name>
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