Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model.
Identifieur interne : 000346 ( Ncbi/Curation ); précédent : 000345; suivant : 000347Stimulation of triple negative breast cancer cell migration and metastases formation is prevented by chloroquine in a pre-irradiated mouse model.
Auteurs : Gina Bouchard [Canada] ; Hélène Therriault [Canada] ; Sameh Geha [Canada] ; Yves Bérubé-Lauzière [Canada] ; Rachel Bujold [Canada] ; Caroline Saucier [Canada] ; Benoit Paquette [Canada]Source :
- BMC cancer [ 1471-2407 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Autophagie (), Cellules MCF-7, Cellules tumorales circulantes (), Chloroquine (administration et posologie), Chloroquine (pharmacologie), Cyclooxygenase 2 (métabolisme), Femelle, Humains, Interleukines (métabolisme), Lignée cellulaire tumorale, Matrix metalloproteinases (métabolisme), Mouvement cellulaire (), Métastase tumorale, Régulation de l'expression des gènes tumoraux (), Résultat thérapeutique, Souris, Tests d'activité antitumorale sur modèle de xénogreffe, Tumeurs du poumon (secondaire), Tumeurs du poumon (traitement médicamenteux), Tumeurs du sein triple-négatives (métabolisme), Tumeurs du sein triple-négatives (radiothérapie), Tumeurs du sein triple-négatives (traitement médicamenteux).
- MESH :
- administration et posologie : Chloroquine.
- métabolisme : Cyclooxygenase 2, Interleukines, Matrix metalloproteinases, Tumeurs du sein triple-négatives.
- pharmacologie : Chloroquine.
- radiothérapie : Tumeurs du sein triple-négatives.
- secondaire : Tumeurs du poumon.
- traitement médicamenteux : Tumeurs du poumon, Tumeurs du sein triple-négatives.
- Animaux, Autophagie, Cellules MCF-7, Cellules tumorales circulantes, Femelle, Humains, Lignée cellulaire tumorale, Mouvement cellulaire, Métastase tumorale, Régulation de l'expression des gènes tumoraux, Résultat thérapeutique, Souris, Tests d'activité antitumorale sur modèle de xénogreffe.
English descriptors
- KwdEn :
- Animals, Autophagy (drug effects), Cell Line, Tumor, Cell Movement (drug effects), Chloroquine (administration & dosage), Chloroquine (pharmacology), Cyclooxygenase 2 (metabolism), Female, Gene Expression Regulation, Neoplastic (drug effects), Humans, Interleukins (metabolism), Lung Neoplasms (drug therapy), Lung Neoplasms (secondary), MCF-7 Cells, Matrix Metalloproteinases (metabolism), Mice, Neoplasm Metastasis, Neoplastic Cells, Circulating (drug effects), Treatment Outcome, Triple Negative Breast Neoplasms (drug therapy), Triple Negative Breast Neoplasms (metabolism), Triple Negative Breast Neoplasms (radiotherapy), Xenograft Model Antitumor Assays.
- MESH :
- chemical , administration & dosage : Chloroquine.
- drug effects : Autophagy, Cell Movement, Gene Expression Regulation, Neoplastic, Neoplastic Cells, Circulating.
- drug therapy : Lung Neoplasms, Triple Negative Breast Neoplasms.
- chemical , metabolism : Cyclooxygenase 2, Interleukins, Matrix Metalloproteinases, Triple Negative Breast Neoplasms.
- chemical , pharmacology : Chloroquine.
- radiotherapy : Triple Negative Breast Neoplasms.
- secondary : Lung Neoplasms.
- Animals, Cell Line, Tumor, Female, Humans, MCF-7 Cells, Mice, Neoplasm Metastasis, Treatment Outcome, Xenograft Model Antitumor Assays.
Abstract
Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment. This rapid relapse has been suggested to be associated with inflammatory mediators induced by radiation in healthy tissues that stimulate cancer cell migration and metastasis formation. In this study, the ability of chloroquine (CQ) to inhibit radiation-stimulated development of metastasis was assessed.
DOI: 10.1186/s12885-016-2393-z
PubMed: 27282478
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(metabolism)</term><term>Lung Neoplasms (drug therapy)</term><term>Lung Neoplasms (secondary)</term><term>MCF-7 Cells</term><term>Matrix Metalloproteinases (metabolism)</term><term>Mice</term><term>Neoplasm Metastasis</term><term>Neoplastic Cells, Circulating (drug effects)</term><term>Treatment Outcome</term><term>Triple Negative Breast Neoplasms (drug therapy)</term><term>Triple Negative Breast Neoplasms (metabolism)</term><term>Triple Negative Breast Neoplasms (radiotherapy)</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Autophagie ()</term><term>Cellules MCF-7</term><term>Cellules tumorales circulantes ()</term><term>Chloroquine (administration et posologie)</term><term>Chloroquine (pharmacologie)</term><term>Cyclooxygenase 2 (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Interleukines (métabolisme)</term><term>Lignée cellulaire tumorale</term><term>Matrix metalloproteinases (métabolisme)</term><term>Mouvement cellulaire ()</term><term>Métastase tumorale</term><term>Régulation de l'expression des gènes tumoraux ()</term><term>Résultat thérapeutique</term><term>Souris</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Tumeurs du poumon (secondaire)</term><term>Tumeurs du poumon (traitement médicamenteux)</term><term>Tumeurs du sein triple-négatives (métabolisme)</term><term>Tumeurs du sein triple-négatives (radiothérapie)</term><term>Tumeurs du sein triple-négatives (traitement médicamenteux)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Autophagy</term><term>Cell Movement</term><term>Gene Expression Regulation, Neoplastic</term><term>Neoplastic Cells, Circulating</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Lung Neoplasms</term><term>Triple Negative Breast Neoplasms</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclooxygenase 2</term><term>Interleukins</term><term>Matrix Metalloproteinases</term><term>Triple Negative Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclooxygenase 2</term><term>Interleukines</term><term>Matrix metalloproteinases</term><term>Tumeurs du sein triple-négatives</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Chloroquine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Chloroquine</term></keywords><keywords scheme="MESH" qualifier="radiotherapy" xml:lang="en"><term>Triple Negative Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="radiothérapie" xml:lang="fr"><term>Tumeurs du sein triple-négatives</term></keywords><keywords scheme="MESH" qualifier="secondaire" xml:lang="fr"><term>Tumeurs du poumon</term></keywords><keywords scheme="MESH" qualifier="secondary" xml:lang="en"><term>Lung Neoplasms</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Tumeurs du poumon</term><term>Tumeurs du sein triple-négatives</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Female</term><term>Humans</term><term>MCF-7 Cells</term><term>Mice</term><term>Neoplasm Metastasis</term><term>Treatment Outcome</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Autophagie</term><term>Cellules MCF-7</term><term>Cellules tumorales circulantes</term><term>Femelle</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Mouvement cellulaire</term><term>Métastase tumorale</term><term>Régulation de l'expression des gènes tumoraux</term><term>Résultat thérapeutique</term><term>Souris</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Some triple negative breast cancer (TNBC) patients are at higher risk of recurrence in the first three years after treatment. This rapid relapse has been suggested to be associated with inflammatory mediators induced by radiation in healthy tissues that stimulate cancer cell migration and metastasis formation. In this study, the ability of chloroquine (CQ) to inhibit radiation-stimulated development of metastasis was assessed.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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