Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis.
Identifieur interne : 000204 ( Ncbi/Curation ); précédent : 000203; suivant : 000205Chloroquine relieves acute lung injury in rats with acute hemorrhagic necrotizing pancreatitis.
Auteurs : Lei Zhang [République populaire de Chine] ; Yan Chen [République populaire de Chine] ; Lin Wang [République populaire de Chine] ; Xiao-Ping Chen [République populaire de Chine] ; Wan-Guang Zhang [République populaire de Chine] ; Chun-You Wang [République populaire de Chine] ; He-Shui Wu [République populaire de Chine]Source :
- Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban [ 1672-0733 ] ; 2013.
Descripteurs français
- KwdFr :
- Animaux, Chloroquine (usage thérapeutique), Cytokines (immunologie), Lésion pulmonaire aigüe (anatomopathologie), Lésion pulmonaire aigüe (immunologie), Lésion pulmonaire aigüe (traitement médicamenteux), Mâle, Pancréatite aigüe nécrotique (), Pancréatite aigüe nécrotique (anatomopathologie), Rat Wistar, Rats, Récepteur de type Toll-4 (immunologie), Résultat thérapeutique.
- MESH :
- anatomopathologie : Lésion pulmonaire aigüe, Pancréatite aigüe nécrotique.
- immunologie : Cytokines, Lésion pulmonaire aigüe, Récepteur de type Toll-4.
- traitement médicamenteux : Lésion pulmonaire aigüe.
- usage thérapeutique : Chloroquine.
- Animaux, Mâle, Pancréatite aigüe nécrotique, Rat Wistar, Rats, Résultat thérapeutique.
English descriptors
- KwdEn :
- Acute Lung Injury (drug therapy), Acute Lung Injury (immunology), Acute Lung Injury (pathology), Animals, Chloroquine (therapeutic use), Cytokines (immunology), Male, Pancreatitis, Acute Necrotizing (complications), Pancreatitis, Acute Necrotizing (pathology), Rats, Rats, Wistar, Toll-Like Receptor 4 (immunology), Treatment Outcome.
- MESH :
- chemical , immunology : Cytokines, Toll-Like Receptor 4.
- chemical , therapeutic use : Chloroquine.
- complications : Pancreatitis, Acute Necrotizing.
- drug therapy : Acute Lung Injury.
- immunology : Acute Lung Injury.
- pathology : Acute Lung Injury, Pancreatitis, Acute Necrotizing.
- Animals, Male, Rats, Rats, Wistar, Treatment Outcome.
Abstract
This study preliminarily investigated the mechanism by which chloroquine (CQ) relieves acute lung injury (ALI) complicated in acute hemorrhagic necrotizing pancreatitis (AHNP). Sixty male Wistar rats were randomized into sham-operated group (group A, n=10), AHNP group (group B, n=10), L-arginine-treated group (group C, n=10), L-N-nitro-L-arginine methyl ester (NAME)-treated group (group D, n=10), CQ-treated group (group E, n=10) and CQ+L-NAME-treated group (group F, n=10). TLR4 expression was measured by using real time-PCR and Western blotting respectively. The results showed that, in the group B, the expression of TLR4 and the levels of TNF-α and IL-6 in the lungs were significantly increased, and the nitric oxide (NO) concentration was reduced, as compared with those in the group A (P<0.05 or P<0.01). Lung injury was aggravated with the increased expression of TLR4. When the inhibitor and stimulator of TLR4, namely L-Arg and L-NAME, were added respectively, lung injury was correspondingly relieved or aggravated (P<0.05 or P<0.01). In the group E, TLR4 expression was substantially lower and NO concentration higher than those in the group B (P<0.05 or P<0.01). However, in the group F, NO concentration was markedly decreased, and the inhibitory effect of CQ on TLR4 expression and the relief of lung injury were weakened when compared with those in the group E (P<0.05 or P<0.01). It was concluded that TLR4 may play an important role in the pathogenesis and development of ALI complicated in AHNP. CQ could relieve ALI by decreasing the TLR4 expression and increasing the NO release.
DOI: 10.1007/s11596-013-1124-9
PubMed: 23771660
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pubmed:23771660Le document en format XML
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<series><title level="j">Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban</title>
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<term>Acute Lung Injury (immunology)</term>
<term>Acute Lung Injury (pathology)</term>
<term>Animals</term>
<term>Chloroquine (therapeutic use)</term>
<term>Cytokines (immunology)</term>
<term>Male</term>
<term>Pancreatitis, Acute Necrotizing (complications)</term>
<term>Pancreatitis, Acute Necrotizing (pathology)</term>
<term>Rats</term>
<term>Rats, Wistar</term>
<term>Toll-Like Receptor 4 (immunology)</term>
<term>Treatment Outcome</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Chloroquine (usage thérapeutique)</term>
<term>Cytokines (immunologie)</term>
<term>Lésion pulmonaire aigüe (anatomopathologie)</term>
<term>Lésion pulmonaire aigüe (immunologie)</term>
<term>Lésion pulmonaire aigüe (traitement médicamenteux)</term>
<term>Mâle</term>
<term>Pancréatite aigüe nécrotique ()</term>
<term>Pancréatite aigüe nécrotique (anatomopathologie)</term>
<term>Rat Wistar</term>
<term>Rats</term>
<term>Récepteur de type Toll-4 (immunologie)</term>
<term>Résultat thérapeutique</term>
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<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Lésion pulmonaire aigüe</term>
<term>Pancréatite aigüe nécrotique</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Pancreatitis, Acute Necrotizing</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Acute Lung Injury</term>
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<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cytokines</term>
<term>Lésion pulmonaire aigüe</term>
<term>Récepteur de type Toll-4</term>
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<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Acute Lung Injury</term>
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<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Acute Lung Injury</term>
<term>Pancreatitis, Acute Necrotizing</term>
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<front><div type="abstract" xml:lang="en">This study preliminarily investigated the mechanism by which chloroquine (CQ) relieves acute lung injury (ALI) complicated in acute hemorrhagic necrotizing pancreatitis (AHNP). Sixty male Wistar rats were randomized into sham-operated group (group A, n=10), AHNP group (group B, n=10), L-arginine-treated group (group C, n=10), L-N-nitro-L-arginine methyl ester (NAME)-treated group (group D, n=10), CQ-treated group (group E, n=10) and CQ+L-NAME-treated group (group F, n=10). TLR4 expression was measured by using real time-PCR and Western blotting respectively. The results showed that, in the group B, the expression of TLR4 and the levels of TNF-α and IL-6 in the lungs were significantly increased, and the nitric oxide (NO) concentration was reduced, as compared with those in the group A (P<0.05 or P<0.01). Lung injury was aggravated with the increased expression of TLR4. When the inhibitor and stimulator of TLR4, namely L-Arg and L-NAME, were added respectively, lung injury was correspondingly relieved or aggravated (P<0.05 or P<0.01). In the group E, TLR4 expression was substantially lower and NO concentration higher than those in the group B (P<0.05 or P<0.01). However, in the group F, NO concentration was markedly decreased, and the inhibitory effect of CQ on TLR4 expression and the relief of lung injury were weakened when compared with those in the group E (P<0.05 or P<0.01). It was concluded that TLR4 may play an important role in the pathogenesis and development of ALI complicated in AHNP. CQ could relieve ALI by decreasing the TLR4 expression and increasing the NO release.</div>
</front>
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